Evaluating postoperative complications in radical cystectomy and ileal conduit for bladder cancer using the clavien-dindo grading system.

IF 0.8 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Journal of the Pakistan Medical Association Pub Date : 2025-07-01 DOI:10.47391/JPMA.11614

Shuah Ullah, Laraib Gul, Shariq Bin Yousuf, Bazgha Hassan, Tanzeel-Ur-Rahman Gazder, Asad Shahzad Hassan

{"title":"Evaluating postoperative complications in radical cystectomy and ileal conduit for bladder cancer using the clavien-dindo grading system.","authors":"Shuah Ullah, Laraib Gul, Shariq Bin Yousuf, Bazgha Hassan, Tanzeel-Ur-Rahman Gazder, Asad Shahzad Hassan","doi":"10.47391/JPMA.11614","DOIUrl":null,"url":null,"abstract":"Objective: To determine the frequency of postoperative complications after radical cystectomy with ileal conduit surgery in patients diagnosed with urinary bladder cancer.Methods: This prospective observational study was conducted at the Department of Urology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, from 30TH December 2019 to 30TH June 2020, following approval from the SIUT Ethics Review Board. The study comprised patients aged 25-70 years diagnosed with urinary bladder cancer who underwent elective radical cystectomy with ileal conduit. Complications were compared with respect to preoperative characteristics, such as disease stage, chemotherapy, radiotherapy, and intraoperative variables, like operation time, predicted blood loss, and the requirement for blood transfusion, as well as postoperative therapies. All postoperative complications occurring within a 60-day period were classified using the Clavien-Dindo grading system. Data was analysed using SPSS 22.Results: Of the 34 patients, 22(64.7%) were males and 12(35.3%) were females. The overall mean age was 51.00±12.84 years. Grade 0 complications were observed in 14(41.18%) patients, grade 1 13(28.24%), grade 2 3(8.82%), grade 3a 2(5.88%), and grade 4a 2(5.88%). The severity was significantly associated with female gender, preoperative irradiation, larger volume of blood loss, and the requirement of numerous transfusions (p<0.05).Conclusions: The early complications of radical cystectomy and urinary diversion had a substantial impact on the overall success of the procedure.","PeriodicalId":54369,"journal":{"name":"Journal of the Pakistan Medical Association","volume":"75 7","pages":"1053-1057"},"PeriodicalIF":0.8000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Pakistan Medical Association","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.47391/JPMA.11614","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To determine the frequency of postoperative complications after radical cystectomy with ileal conduit surgery in patients diagnosed with urinary bladder cancer.

Methods: This prospective observational study was conducted at the Department of Urology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, from 30TH December 2019 to 30TH June 2020, following approval from the SIUT Ethics Review Board. The study comprised patients aged 25-70 years diagnosed with urinary bladder cancer who underwent elective radical cystectomy with ileal conduit. Complications were compared with respect to preoperative characteristics, such as disease stage, chemotherapy, radiotherapy, and intraoperative variables, like operation time, predicted blood loss, and the requirement for blood transfusion, as well as postoperative therapies. All postoperative complications occurring within a 60-day period were classified using the Clavien-Dindo grading system. Data was analysed using SPSS 22.

Results: Of the 34 patients, 22(64.7%) were males and 12(35.3%) were females. The overall mean age was 51.00±12.84 years. Grade 0 complications were observed in 14(41.18%) patients, grade 1 13(28.24%), grade 2 3(8.82%), grade 3a 2(5.88%), and grade 4a 2(5.88%). The severity was significantly associated with female gender, preoperative irradiation, larger volume of blood loss, and the requirement of numerous transfusions (p<0.05).

Conclusions: The early complications of radical cystectomy and urinary diversion had a substantial impact on the overall success of the procedure.

查看原文本刊更多论文

应用clavien-dindo分级系统评价膀胱癌根治性膀胱切除术和回肠导管术后并发症。

目的：了解膀胱癌根治性膀胱切除术合并回肠导管手术后并发症的发生率。方法：经SIUT伦理审查委员会批准，本前瞻性观察性研究于2019年12月30日至2020年6月30日在卡拉奇Sindh泌尿外科和移植研究所（SIUT）泌尿外科进行。该研究包括年龄在25-70岁之间的诊断为膀胱癌的患者，他们接受了选择性根治性膀胱切除术和回肠导管。比较并发症的术前特征，如疾病分期，化疗，放疗，术中变量，如手术时间，预测出血量，输血需求，以及术后治疗。使用Clavien-Dindo分级系统对60天内发生的所有术后并发症进行分类。数据采用SPSS 22进行分析。结果：34例患者中，男性22例（64.7%），女性12例（35.3%）。总体平均年龄51.00±12.84岁。0级并发症14例（41.18%），1级13例（28.24%），2级3例（8.82%），3a级2例（5.88%），4a级2例（5.88%）。严重程度与女性、术前放疗、出血量大、需要大量输血等因素显著相关(结论：根治性膀胱切除术和尿改道的早期并发症对手术的整体成功有重大影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of the Pakistan Medical Association Medicine-General Medicine

CiteScore

1.10

自引率

11.10%

发文量

983

审稿时长

3-6 weeks

期刊介绍： Primarily being a medical journal, JPMA publishes scholarly research focusing on the various fields in the areas of health and medical education. It publishes original research describing recent advances in health particularly clinical studies, clinical trials, assessments of pathogens of diagnostic importance, medical genetics and epidemiological studies. Review articles highlighting importance of various issues in the domain of public health, drug research and medical education are also accepted. As a leading journal of South Asia, JPMA remains cognizant of the recent advances in the rapidly growing fields of biomedical sciences, it invites and encourages scholars to write short reviews and invited editorials on the emerging issues. We particularly aim to promote health standards of developing countries by encouraging manuscript submissions on issues affecting the public health and health delivery services.