Role of mean platelet volume in diagnosis of neonatal sepsis.

IF 0.8 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Journal of the Pakistan Medical Association Pub Date : 2025-07-01 DOI:10.47391/JPMA.9612

Awais Tahir, Rabia Aziz, Rabia Tabassum, Fasih Hashmi, Muhammad Almas Hashmi, Sayed Ibrar Hussain

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引用次数: 0

Abstract

Objective: To assess the role of mean platelet volume in the detection of neonatal sepsis, and to work out its cut-off value.

Methods: The comparative, cross-sectional study was conducted from December 2020 to June 2022 at the Neonatal Department of the Fauji Foundation Hospital, Rawalpindi, Pakistan, and comprised neonates in group A who were confirmed cases of sepsis diagnosed on the basis of blood culture test, and those in control group B who were healthy neonates with respect to sepsis. Blood samples were taken for the assessment of complete blood count, including mean platelet volume, total leucocyte count, neutrophil count, haemoglobin level and blood culture. Receiver operating characteristic curve was used to determine the optimum cut-off value of mean platelet volume. Data was analysed using SPSS 22.

Results: Of the 100 subjects, 50(50%) were in group A; 30(60%) boys and 20(40%) girls with mean age 1.78±1.50 days. There were 50(50%) subjects in group B; 34(68%) boys and 16(32%) girls with mean age 1.24±0.56 days. Age was significantly different between the groups (p=0.01). Mean neutrophil count was significantly different between the groups (p<0.05). Mean platelet volume in group A was 11.29±1.37fL compared to 9.69±1.11fL in group B (p<0.05). The cut-off value of the mean platelet volume was 10fL.

Conclusions: The mean platelet volume was found to be a reliable marker for the diagnosis of neonatal sepsis with a cut-off value of 10.0fL.

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平均血小板体积在新生儿败血症诊断中的作用。

目的：探讨平均血小板体积在新生儿脓毒症诊断中的作用，并确定其临界值。方法：对比横断面研究于2020年12月至2022年6月在巴基斯坦拉瓦尔品第福吉基金会医院新生儿科进行，A组为经血培养试验确诊为败血症的新生儿，对照组B组为败血症的健康新生儿。采集血样评估全血细胞计数，包括平均血小板体积、白细胞总数、中性粒细胞计数、血红蛋白水平和血培养。采用受试者工作特征曲线确定血小板平均体积的最佳临界值。数据采用SPSS 22进行分析。结果：100例受试者中，A组50例（50%）；男孩30例（60%），女孩20例（40%），平均年龄1.78±1.50天。B组50例（50%）；男孩34例（68%），女孩16例（32%），平均年龄1.24±0.56天。年龄组间差异有统计学意义（p=0.01）。结论：平均血小板体积是诊断新生儿脓毒症的可靠指标，临界值为10.0fL。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the Pakistan Medical Association Medicine-General Medicine

CiteScore

1.10

自引率

11.10%

发文量

983

审稿时长

3-6 weeks

期刊介绍： Primarily being a medical journal, JPMA publishes scholarly research focusing on the various fields in the areas of health and medical education. It publishes original research describing recent advances in health particularly clinical studies, clinical trials, assessments of pathogens of diagnostic importance, medical genetics and epidemiological studies. Review articles highlighting importance of various issues in the domain of public health, drug research and medical education are also accepted. As a leading journal of South Asia, JPMA remains cognizant of the recent advances in the rapidly growing fields of biomedical sciences, it invites and encourages scholars to write short reviews and invited editorials on the emerging issues. We particularly aim to promote health standards of developing countries by encouraging manuscript submissions on issues affecting the public health and health delivery services.