Dialogues in Clinical Neuroscience最新文献

Societal perspectives on psychedelics use in clinical context: Development of Concerns and Openness towards Psychedelic Scale (COPS). 在临床环境中使用致幻剂的社会观点：对致幻剂量表（COPS）的关注和开放。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-03-06 DOI: 10.1080/19585969.2025.2470426

Paweł Holas, Justyna Kamińska, Marcin Zajenkowski

{"title":"Societal perspectives on psychedelics use in clinical context: Development of Concerns and Openness towards Psychedelic Scale (COPS).","authors":"Paweł Holas, Justyna Kamińska, Marcin Zajenkowski","doi":"10.1080/19585969.2025.2470426","DOIUrl":"10.1080/19585969.2025.2470426","url":null,"abstract":"Introduction: Psychedelics are gaining recognition for their therapeutic potential in mental health treatment, yet societal attitudes remain divided, influenced by both skepticism and curiosity. This study aimed to develop and validate a scale assessing attitudes toward psychedelics.Methods: Study 1 (n = 1000, convenience sample) explored the factor structure, identifying two dimensions: Openness toward Psychedelics and Concerns toward Psychedelics. Study 2 (n = 843, representative Polish sample) confirmed the scale's validity.Results: The Concerns factor negatively correlated with meaning in life, while the Openness factor was positively associated with openness to experience, agreeableness, conscientiousness, mindfulness, meaning in life, and nature-relatedness. These associations suggest that individuals with greater openness and psychological flexibility may hold more favorable views on psychedelics.Discussion: The Concerns and Openness towards Psychedelics Scale (COPS) is a psychometrically sound tool for assessing attitudes toward psychedelics. Its meaningful correlations with established psychological constructs underscore its utility in research and public health. By providing insight into societal perceptions, COPS may help inform discussions on psychedelic therapy, policy, and education, ultimately fostering a more nuanced understanding of their potential benefits and risks.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"11-21"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of electrical vestibular stimulation (VeNS) on adults with insomnia: A double-blind, randomized, sham-controlled trial. 前庭电刺激（VeNS）对成人失眠的疗效：一项双盲、随机、假对照试验。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-07-11 DOI: 10.1080/19585969.2025.2526547

Teris Cheung, Joyce Yuen Ting Lam, Kwan Hin Fong, Calvin Pak-Wing Cheng, Yu-Tao Xiang, Tim Man Ho Li

{"title":"Efficacy of electrical vestibular stimulation (VeNS) on adults with insomnia: A double-blind, randomized, sham-controlled trial.","authors":"Teris Cheung, Joyce Yuen Ting Lam, Kwan Hin Fong, Calvin Pak-Wing Cheng, Yu-Tao Xiang, Tim Man Ho Li","doi":"10.1080/19585969.2025.2526547","DOIUrl":"10.1080/19585969.2025.2526547","url":null,"abstract":"Introduction: Insomnia, a widespread sleep disorder, affects a significant portion of the global population. This study is the first in Asia to evaluate the efficacy of electrical vestibular stimulation (VeNS) as a treatment for insomnia in Hong Kong adults, addressing a gap in non-pharmacological interventions.Methods: A double-blind, randomized, sham-controlled trial was conducted with 101 adults exhibiting insomnia symptoms. Participants were randomized into active VeNS or sham groups (1:1 ratio) and underwent twenty 30-minute VeNS sessions over four weeks. Psychological outcomes, including insomnia severity, sleep quality, and quality of life were assessed at baseline (T1), post-intervention (T2). Follow-up assessments were conducted at one- (T3) and three-month (T4) to evaluate the sustainability of VeNS effects.Results: Of 83 participants (40 VeNS and 43 sham-VeNS), the VeNS group showed significant reductions in insomnia severity at T2 (p = 0.03, d = -0.47) and T4 (p = 0.02, d = -0.32), alongside improved quality of life (i.e., role-physical) at T2.Conclusion: VeNS is a novel, non-invasive and safe neuromodulation device that may serve as an adjunct treatment for primary insomnia. The present findings provide a foundation for future multisite comparison studies to further evaluate VeNS efficacy.Trial registration: ClinicalTrials.gov Identifier: NCT04452981.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"236-248"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

5-HT6 receptors: Contemporary views on their neurobiological and pharmacological relevance in neuropsychiatric disorders. 5-HT6受体：其在神经精神疾病中的神经生物学和药理学相关性的当代观点

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-05-10 DOI: 10.1080/19585969.2025.2502028

Abdeslam Chagraoui, Florence Thibaut, Philippe De Deurwaerdère

{"title":"5-HT6 receptors: Contemporary views on their neurobiological and pharmacological relevance in neuropsychiatric disorders.","authors":"Abdeslam Chagraoui, Florence Thibaut, Philippe De Deurwaerdère","doi":"10.1080/19585969.2025.2502028","DOIUrl":"https://doi.org/10.1080/19585969.2025.2502028","url":null,"abstract":"Despite the relatively limited number of serotonergic neurons in humans, serotonin plays a key role in neurophysiological functions, including sleep, pain perception, learning, memory, cognition, emotion, reward, and mood regulation. Altered serotonergic neurotransmission is linked to conditions such as anxiety, depression, anorexia, migraine, insomnia, schizophrenia, Alzheimer's disease (AD), and cognitive impairments. The 5-HT6 receptor (5-HT6R), mainly found in brain regions involved in cognition, is a promising therapeutic target for cognitive deficits in neuropsychiatric disorders, particularly AD and schizophrenia. Preclinical studies have shown that 5-HT6R antagonists improve cognitive function. 5-HT6R interacts dynamically with an extensive intracellular protein network, regulating the localisation, trafficking, and signalling of these proteins. Proteomic and genetic studies have revealed interactions with mTOR kinase and neurofibromin, both of which are crucial for synaptic plasticity, learning, and memory. Fyn kinase is also associated with 5-HT6Rs, reinforcing receptor expression and G-protein coupling. Notably, the G protein-regulated inducer of neurite outgrowth 1 (GPRIN1) interacts with 5-HT6Rs independently of agonists, enhancing receptor activity. This review highlights the clinical testing of 5-HT6R ligands as regulators of these complex signalling properties, underscoring their therapeutic potential in addressing cognitive impairments associated with neuropsychiatric disorders.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"112-128"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep learning with ensemble-based hybrid AI model for bipolar and unipolar depression detection using demographic and behavioral based on time-series data. 基于时间序列数据的人口统计和行为的基于集成的混合AI模型的深度学习双相和单相抑郁症检测。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-06-30 DOI: 10.1080/19585969.2025.2524337

Naga Raju Kanchapogu, Sachi Nandan Mohanty

{"title":"Deep learning with ensemble-based hybrid AI model for bipolar and unipolar depression detection using demographic and behavioral based on time-series data.","authors":"Naga Raju Kanchapogu, Sachi Nandan Mohanty","doi":"10.1080/19585969.2025.2524337","DOIUrl":"10.1080/19585969.2025.2524337","url":null,"abstract":"Background: Depression, including Bipolar and Unipolar types, is a widespread mental health issue. Conventional diagnostic methods rely on subjective assessments, leading to possible underreporting and bias. Machine learning (ML) and deep learning (DL) offer automated approaches to detect depression using behavioral and demographic data.Methods: This study proposes a hybrid AI framework combining structured demographic features with synthetic actigraph time-series data. Demographic data is modeled using an XGBoost ensemble, while temporal data is analyzed through a deep convolutional neural network (CNN). The training pipeline includes stratified k-fold cross-validation, hyperparameter tuning, and statistical testing. Model explainability is enhanced using SHAP (XGBoost) and Grad-CAM (CNN).Results: The hybrid model demonstrated strong classification performance across metrics like accuracy, sensitivity, and specificity. Integrating temporal and static features improved prediction of Bipolar and Unipolar Depression. Interpretability tools revealed key features and time patterns influencing predictions.Conclusions: This work introduces a robust and interpretable framework for depression classification using synthetic multimodal data. While not clinically validated, the model serves as a methodological foundation for future research with real-world datasets.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"16-35"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12210415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An integrative model of perseverative thinking. 持续性思维的综合模式。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-05-23 DOI: 10.1080/19585969.2025.2481658

Lorenzo Mattioni, Ana V Nikčević, Francesca Ferri, Marcantonio M Spada, Carlo Sestieri

{"title":"An integrative model of perseverative thinking.","authors":"Lorenzo Mattioni, Ana V Nikčević, Francesca Ferri, Marcantonio M Spada, Carlo Sestieri","doi":"10.1080/19585969.2025.2481658","DOIUrl":"10.1080/19585969.2025.2481658","url":null,"abstract":"People spend most of their waking hours detached from external stimuli, remembering the past, foreseeing the future, imagining situations in which they did not attend or that have never existed, or, simply, thinking. Such a process is crucial for mental health. A common feature of many mental disorders is recurrent stress-related thoughts, the so-called 'perseverative thinking'. In this review, we describe how perseverative thinking represents a dysfunctional self-regulatory strategy that maintains and increases the effects of mental suffering and arises from the maladaptive interplay between discrepancy monitoring, strategy selection, executive regulation, and information representation. We further argue that perseverative thinking can change how the mind represents the world through memory updating, resulting in an increased perceived need for regulation of the external and internal inputs. Lastly, we propose a new integrated model incorporating the different features of perseverative thinking, offering a more unified perspective on psychopathology.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"34-54"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The flow cytometric analysis of depression focusing on modern-type depression and hikikomori: Exploring the link between subtypes of depression and immunological imbalances. 抑郁症的流式细胞分析聚焦于现代型抑郁症和隐蔽青年：探索抑郁症亚型与免疫失衡之间的联系。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-01-20 DOI: 10.1080/19585969.2025.2452842

Keitaro Matsuo, Mitsuru Watanabe, Shogo Inamine, Toshio Matsushima, Sota Kyuragi, Yasuhiro Maeda, Ryoko Katsuki, Masahiro Ohgidani, Ryo Yamasaki, Noriko Isobe, Tomohiro Nakao, Takahiro A Kato

{"title":"The flow cytometric analysis of depression focusing on modern-type depression and hikikomori: Exploring the link between subtypes of depression and immunological imbalances.","authors":"Keitaro Matsuo, Mitsuru Watanabe, Shogo Inamine, Toshio Matsushima, Sota Kyuragi, Yasuhiro Maeda, Ryoko Katsuki, Masahiro Ohgidani, Ryo Yamasaki, Noriko Isobe, Tomohiro Nakao, Takahiro A Kato","doi":"10.1080/19585969.2025.2452842","DOIUrl":"10.1080/19585969.2025.2452842","url":null,"abstract":"Introduction: Depression includes different phenotypes. Modern-type depression (MTD) is a gateway disorder to pathological social withdrawal, known as hikikomori. Adverse childhood experiences (ACEs) are also important aetiologies of depression. Recently, immune imbalance has been proposed as a biological basis of depression. We hypothesised that peripheral immunological characteristics may be involved in subtyping of depression.Methods: 21 patients with major depressive disorder (MDD) and 24 healthy controls (HC) were recruited. Peripheral blood mononuclear cells (PBMCs) were examined for surface antigens by flow cytometry. Participants were administered psychological scales such as Patient Health Questionnaire (PHQ)-9, Modern-Type Depression Trait Scale (TACS-22), Hikikomori Questionnaire (HQ-25), Child Abuse and Trauma Scale (CATS).Results: MDD group showed significantly higher percentage of B cells than HC group (p = 0.032). MDD group presented a negative correlation between: PHQ-9 and CD8 T effector memory cells (r= -0.639, p = 0.002), TACS-22 and monocytes (r= -0.459, p = 0.036), HQ-25 and NK T cells (r= -0.638, p = 0.004), CATS and Intermediate monocytes (r= -0.594, p = 0.009).Conclusions: MTD traits, hikikomori tendencies, and ACEs were correlated with specific characteristics of peripheral immune cells. Our results suggest that immune imbalance influences the diverse presentations of depression. Further validation is warranted by large-scale prospective studies.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"13-25"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of light therapy on amygdala connectivity and serotoninergic system in young adults with subthreshold depression. 光治疗对阈下抑郁症年轻人杏仁核连通性和血清素能系统的影响。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-06-01 DOI: 10.1080/19585969.2025.2503367

Pan Chen, Guanmao Chen, Guixian Tang, Zibin Yang, Wenhao Ma, Chao Chen, Shilin Sun, Yuan Zhang, Shu Zhang, Zhangzhang Qi, Wenjie Fang, Lijun Jiang, Li Huang, Junxian Ma, Qian Tao, Ying Wang

{"title":"Effects of light therapy on amygdala connectivity and serotoninergic system in young adults with subthreshold depression.","authors":"Pan Chen, Guanmao Chen, Guixian Tang, Zibin Yang, Wenhao Ma, Chao Chen, Shilin Sun, Yuan Zhang, Shu Zhang, Zhangzhang Qi, Wenjie Fang, Lijun Jiang, Li Huang, Junxian Ma, Qian Tao, Ying Wang","doi":"10.1080/19585969.2025.2503367","DOIUrl":"10.1080/19585969.2025.2503367","url":null,"abstract":"Background: Bright light therapy (BLT) demonstrates efficacy in alleviating subthreshold depression (StD) among young adults. The amygdala plays a critical role in depression.Methods: StD subjects were divided into BLT group (N=47) and placebo group (N=42). Depression severity was assessed using HAM-D, Centre for Epidemiologic Studies Depression Scale (CES-D) and Beck Depression Inventory (BDI) pre-/post-8-week intervention. Structural/resting-state fMRI scan was conducted. Seed-based static FC (sFC) and dynamic FC (dFC) analyses of the bilateral amygdala and their subfields were conducted.Results: Compared to placebo, BLT showed reduced depression scale, and increased sFC of right basolateral amygdala (BLA)/superficial amygdala (SFA)-right middle temporal gyrus (MTG) and dFC of right centralmedial amygdala (CMA) and right inferior orbital frontal gyrus, and decreased sFC of right amygdalostriatal transition/CMA- left thalamus and dFC of right SFA- right medial prefrontal cortex after intervention; while the whole amygdala and its subnuclei volume did not change significantly after BLT. Right BLA-MTG sFC changes positively correlated with BDI improvement. Baseline amygdala sFC/dFC predicted post-BLT symptom changes. BLT-induced right BLA sFC alterations spatially correlated with 5-HT1A/5-HT2A receptor distributions, and right CMA dFC changes with 5-HT1A.Conclusions: Findings suggest BLT modulates amygdala-thalamocortical circuits and serotonergic pathways, highlighting FC biomarkers for treatment efficacy assessment.Trial registration clinicaltrials.gov identifier: ChiCTR2000032633.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"184-200"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12128131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyberdelics: Virtual reality hallucinations modulate cognitive-affective processes. 网络幻觉：虚拟现实幻觉调节认知情感过程。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-05-23 DOI: 10.1080/19585969.2025.2499459

Giulia Brizzi, Chiara Pupillo, Clara Rastelli, Antonino Greco, Luca Bernardelli, Anna Flavia Di Natale, Silvia Francesca Maria Pizzoli, Elena Sajno, Fabio Frisone, Daniele Di Lernia, Giuseppe Riva

{"title":"Cyberdelics: Virtual reality hallucinations modulate cognitive-affective processes.","authors":"Giulia Brizzi, Chiara Pupillo, Clara Rastelli, Antonino Greco, Luca Bernardelli, Anna Flavia Di Natale, Silvia Francesca Maria Pizzoli, Elena Sajno, Fabio Frisone, Daniele Di Lernia, Giuseppe Riva","doi":"10.1080/19585969.2025.2499459","DOIUrl":"10.1080/19585969.2025.2499459","url":null,"abstract":"Introduction: Psychedelics were explored for their potential in the mental health field. However, research was delayed by concerns over short-term side effects and long-term consequences of substance use. Technological advances enabled the development of Hallucinatory Visual Virtual Experiences (HVVEs), namely psychedelic experiences simulations in immersive virtual reality. This study investigated HVVEs' impact on cognitive flexibility, affective response, and autonomic activity.Methods: 50 healthy participants underwent assessments of cognitive flexibility, control inhibition, emotional response, and autonomic activity at baseline. Participants were then exposed to two 10-minute immersive virtual reality (IVR) experiences: 'The Secret Garden' and its hallucinated counterpart created using Google DeepDream algorithm. All measures were presented after each video, in addition to the flow experience assessment.Results: Post-HVVE, participants demonstrated enhanced cognitive flexibility and inhibitory control. They reported increased flow-absorption and decreased flow-fluency. Both IVR experiences reduced positive affects and state anxiety compared to baseline; additionally, IVR reduced heart rate and sympathetic activity compared to baseline.Conclusions: HVVEs produced psychedelic positive effects on cognitive and emotional functioning. The complex emotional and autonomic profile mimicked awakened relaxation that, in conjunction with the cognitive flexibility enhancement, could offer the unique opportunity to exploit psychedelic advantages while mitigating risks, opening new avenues for therapeutic approaches.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"1-12"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of perceived side-effects of psychotropic treatments on quality of life in patients with severe mental illness. 精神药物治疗的副作用对严重精神疾病患者生活质量的影响

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-02-11 DOI: 10.1080/19585969.2025.2463443

Théo Korchia, Mélanie Faugère, Vincent Achour, Eloïse Maakaron, Christelle Andrieu-Haller, Guillaume Fond, Christophe Lançon

{"title":"Impact of perceived side-effects of psychotropic treatments on quality of life in patients with severe mental illness.","authors":"Théo Korchia, Mélanie Faugère, Vincent Achour, Eloïse Maakaron, Christelle Andrieu-Haller, Guillaume Fond, Christophe Lançon","doi":"10.1080/19585969.2025.2463443","DOIUrl":"10.1080/19585969.2025.2463443","url":null,"abstract":"Background: Psychotropic medications are critical in managing severe mental illnesses (SMI) such as schizophrenia, major depressive disorder (MDD) and bipolar disorder. However, these treatments often lead to adverse side effects that can impair patients' quality of life (QoL) and affect treatment adherence.Objective: This study aims to investigate the specific side effects of psychotropic treatments that contribute to a decline in QoL among patients with SMI, independently of treatment adherence.Methods: We conducted a cross-sectional study with 1248 patients diagnosed with SMI, recruited from a university psychiatric unit in Marseille, France. QoL was assessed using the Schizophrenia Quality of Life Scale (SQoL-18), and side effects were measured using the UKU Side Effect Rating Scale. Treatment adherence was evaluated using the Medication Adherence Rating Scale (MARS). Statistical analyses included Pearson correlations and multiple linear regression models to identify predictors of QoL.Results: The study found that side effects, as identified by the UKU scores, could significantly predict a reduction in QoL across multiple domains, including multiple dimensions of QoL and the overall QoL index, independent of treatment adherence. Patients on antipsychotics and benzodiazepines reported higher levels of adverse side effects, which correlated with lower QoL scores. An increase in the number of psychotropic treatment classes was also associated with a significant decline in QoL (p < 0.001).Conclusion: Managing psychic side effects and minimising polypharmacy are critical to improving QoL in patients with SMI. Clinicians should consider these factors when developing personalised treatment strategies to enhance patient outcomes.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"10-19"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11816623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analysis of emotional factors in patients with somatic symptom disorder and panic disorder. 躯体症状障碍与惊恐障碍患者情绪因素的比较分析。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-03-25 DOI: 10.1080/19585969.2025.2482123

Hye Youn Park, Yuna Jang, Arum Hong, EKyong Yoon, In-Young Yoon

{"title":"Comparative analysis of emotional factors in patients with somatic symptom disorder and panic disorder.","authors":"Hye Youn Park, Yuna Jang, Arum Hong, EKyong Yoon, In-Young Yoon","doi":"10.1080/19585969.2025.2482123","DOIUrl":"10.1080/19585969.2025.2482123","url":null,"abstract":"Objective: This study investigated the emotional symptom profiles and treatment responses in patients exhibiting overlapping physical symptoms to compare differences between Somatic Symptom Disorder (SSD) and Panic Disorder (PD).Methods: Pharmacotherapy outcomes were analysed in 208 outpatients with SSD (n = 94) and PD (n = 114). Stepwise multivariable logistic regression identified predictors of treatment response, considering variables such as the Clinical Global Impression-Severity (CGI-S), Beck Depression Inventory-II (BDI-II), State-Trait Anxiety Inventory, and State-Trait Anger Expression Inventory. Network analysis explored emotional patterns by estimating network structures for each group.Results: The overall response rate to pharmacotherapy was 23.6% (49/208), with no significant difference between groups. Baseline CGI-S and BDI-II scores were significant predictors of treatment response in both groups, while social phobia score was a significant predictor in PD. Depression and anxiety were related to physical symptoms in both groups, but anger was significantly associated only in SSD. Network analysis revealed that depression was central to other symptoms in SSD, while anxiety was the core symptom in PD, indicating different emotional drivers between the disorders.Conclusions: This study suggests the differences in emotional symptom profiles between SSD and PD. Findings suggest different mechanisms, considering the role of anger in SSD, highlighting the need for more personalised treatments for each disorder.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"56-67"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0