Dialogues in Clinical Neuroscience最新文献

Causal links between gut microbiota, plasma metabolites, and insomnia: Insights from Mendelian randomization. 肠道菌群、血浆代谢物和失眠之间的因果关系：来自孟德尔随机化的见解。

IF 8.9 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2026-12-01 Epub Date: 2026-02-27 DOI: 10.1080/19585969.2026.2636470

XuWen Zheng, Jin Xu, JinNan Yin, JinNuo Fan, Yan Gong, JianMin Yang

{"title":"Causal links between gut microbiota, plasma metabolites, and insomnia: Insights from Mendelian randomization.","authors":"XuWen Zheng, Jin Xu, JinNan Yin, JinNuo Fan, Yan Gong, JianMin Yang","doi":"10.1080/19585969.2026.2636470","DOIUrl":"10.1080/19585969.2026.2636470","url":null,"abstract":"Objectives: This study explored the plasma metabolites' mediation effect between gut microbiomes and insomnia through Mendelian randomisation (MR).Methods: Using publicly accessible GWAS data from 5959 individuals for gut microbiota and 8299 individuals for plasma metabolites, we employed MR analysis to explore their causal effects on insomnia. Insomnia outcome data were obtained from Pan-UKB, GERA, and FinnGen, covering 9007 cases and 871,802 controls. Mediation effects of identified bacterial taxa on insomnia through plasma metabolites were computed using the product of coefficients approach.Results: Our MR analysis included participants with a mean age of 45.7 years (SD = 11.5) for gut microbiota and 63 years (range 45-85) for plasma metabolites. The analysis identified 10 gut microbiomes and 35 plasma metabolites potentially associated with insomnia respectively. Specifically, increased abundances of certain gut microbiomes, such as species CAG-145 sp000435615, were linked to a higher risk of insomnia. Mediation analysis revealed that the plasma metabolite 3-ethylcatechol sulphate levels significantly mediated the effects of these microbiomes on insomnia, explaining up to 31.49% of the total effect.Conclusion: This study highlights the role of gut microbiota in influencing insomnia risk, mediated through specific plasma metabolites. These findings provide valuable insights into the gut-brain axis and may inform the development of therapeutic targets for managing sleep disorders.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"28 1","pages":"85-94"},"PeriodicalIF":8.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional brain alterations in anxious depression: Insights from whole-brain fMRI and meta-analysis. 焦虑性抑郁症的脑功能改变：全脑功能磁共振成像和荟萃分析的见解。

IF 8.9 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2026-12-01 Epub Date: 2026-01-20 DOI: 10.1080/19585969.2026.2612918

Hao Huang, Zhiwei Guo, Xiqin Yang, Linzi Qin

{"title":"Functional brain alterations in anxious depression: Insights from whole-brain fMRI and meta-analysis.","authors":"Hao Huang, Zhiwei Guo, Xiqin Yang, Linzi Qin","doi":"10.1080/19585969.2026.2612918","DOIUrl":"10.1080/19585969.2026.2612918","url":null,"abstract":"Objective: The aim of our study was to investigate neurobiological markers and gender difference for diagnosing anxious major depressive disorder (aMDD) through a meta-analysis.Methods: We systematically searched multiple databases for whole-brain neuroimaging studies comparing anxious major depression disorder (aMDD), pure MDD, and healthy controls, with publication dates through December 2024. We extracted brain coordinates and their corresponding peaks, for further analysis using the Seed-based d Mapping software package.Results: A total of 11 studies were included in this study, encompassing 829 aMDD patients, 681 MDD patients, and 865 healthy controls. The meta-analysis revealed that aMDD patients exhibited increased functional alteration in the left middle temporal gyrus compared to individuals diagnosed with MDD. In the comparison between individuals with aMDD and healthy controls, the meta-analysis revealed increased functional alteration in the anterior commissure and decreased functional alteration the right middle frontal gyrus. Furthermore, the meta-regression analysis revealed heightened neural activity of the left middle cingulate gyrus and right anterior thalamic regions, as well as weakened neural activity of the left rolandic operculum in females with aMDD compared to the control group.Conclusions: We identified specific functional alterations in brain regions that may serve as potential neurobiological markers for aMDD and associated differences.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"28 1","pages":"32-45"},"PeriodicalIF":8.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12821352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Migraines and the association of cognitive impairment: a one- and two-sample mendelian randomization analysis. 偏头痛与认知障碍的关联：单样本和双样本孟德尔随机化分析。

IF 8.9 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2026-12-01 Epub Date: 2026-03-09 DOI: 10.1080/19585969.2026.2636459

Chyi-Huey Bai, Hsien-Yu Fan, Hui-An Lin, Sheng-Feng Lin

{"title":"Migraines and the association of cognitive impairment: a one- and two-sample mendelian randomization analysis.","authors":"Chyi-Huey Bai, Hsien-Yu Fan, Hui-An Lin, Sheng-Feng Lin","doi":"10.1080/19585969.2026.2636459","DOIUrl":"10.1080/19585969.2026.2636459","url":null,"abstract":"Background: Cognitive impairment is widely reported in migraineurs. A Mendelian randomisation (MR) approach, similar to a randomised-controlled trial, employs single-nucleotide polymorphisms (SNPs) to investigate causal relationships.Methods: This study comprised one- and two-sample MR analyses of the Taiwan Biobank. Three strategies were used to obtain causal estimates: (1) a polygenic risk score (PRS) method-several SNPs associated with migraines were constructed as a single instrument variable; (2) a meta-analysis of genome-wide association study (GWAS) statistics for traits of migraines and cognitive impairment in the framework of a one-sample MR; and (3) a two-sample MR analysis with a meta-analysis of GWAS statistics in two distinct datasets (IEU GWAS database and the Taiwan Biobank).Results: In strategy 1, the PRS constructed by 18 selected SNPs exhibited a causal association with cognitive impairment (β = -2.31, 95% confidence interval [CI]: -4.56 to -0.06). In strategy 2, a one-sample MR showed migraines were causally associated with cognitive impairment (inverse-variance weighted [IVW] estimator β = 2.90; 95% CI: 0.90-4.89). In strategy 3, a two-sample MR validated migraines to be causally associated with cognitive impairment (IVW estimator β = 2.43; 95% CI: 1.08-3.78).Conclusions: Migraine, a polygenic disorder, is causally associated with cognitive impairment.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"28 1","pages":"107-118"},"PeriodicalIF":8.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12973854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unravelling the role of the gut microbiome in antipsychotic-induced weight gain and metabolic dysfunction in humans and rodents: A systematic review. 揭示肠道微生物组在人类和啮齿动物抗精神病药物诱导的体重增加和代谢功能障碍中的作用：一项系统综述。

IF 8.9 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2026-12-01 Epub Date: 2026-03-10 DOI: 10.1080/19585969.2026.2637716

Maximilian Tufvesson-Alm, Louise Walsh, Sinead Pierce, Finola Keohane, Gerard Clarke, Karen O'Connor, John F Cryan, Harriet Schellekens

{"title":"Unravelling the role of the gut microbiome in antipsychotic-induced weight gain and metabolic dysfunction in humans and rodents: A systematic review.","authors":"Maximilian Tufvesson-Alm, Louise Walsh, Sinead Pierce, Finola Keohane, Gerard Clarke, Karen O'Connor, John F Cryan, Harriet Schellekens","doi":"10.1080/19585969.2026.2637716","DOIUrl":"10.1080/19585969.2026.2637716","url":null,"abstract":"Second-generation antipsychotics are frequently linked to weight gain and metabolic dysfunction, yet the mechanisms driving these effects remain elusive. The gut microbiome has been proposed as a potential mediator of these adverse outcomes. This study aimed to investigate the role of the gut microbiota in antipsychotic-induced weight gain. A systematic search of PubMed and Embase was conducted. In total, 24 publications were included in this review, including clinical and preclinical observational and intervention studies. Collectively, there is strong evidence that atypical antipsychotic-induced weight gain and metabolic dysfunction is accompanied by microbiota alterations. However, there is a lack of consensus with regards to the exact mechanisms and involvement of the microbiome in antipsychotic-induced weight gain. Nevertheless, a few patterns and common observations were found across studies, such as reduced diversity, increased Firmicutes/Bacteroidetes ratio and a reduction in Akkermansia species. While microbiota-targeted interventions had generally weak effects on weight gain and metabolic dysfunction in clinical cohorts, the use of specific probiotic strains and microbiota metabolites showed promise in preclinical studies. Thus, while the relationship between antipsychotic-induced weight gain, metabolic dysfunction, and changes in the gut microbiome are evident, further research is warranted to establish definitive causal relationships and to aid in the development of precision microbiota-targeted interventions to counteract these adverse effects.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"28 1","pages":"131-144"},"PeriodicalIF":8.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12978182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147391616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Arabic Generalized Anxiety Disorder 2 (GAD-2): Psychometric evaluation among mothers of children with intellectual disabilities. 阿拉伯广泛性焦虑障碍2 (GAD-2)：智力障碍儿童母亲的心理测量评估。

IF 8.9 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2026-12-01 Epub Date: 2026-05-05 DOI: 10.1080/19585969.2026.2650296

Amira Mohammed Ali, Saeed A Al-Dossary, Feten Fekih-Romdhane, Carlos Laranjeira, Haitham Khatatbeh, Heba Emad El-Gazar, Ahmad Ayed, Abdulmajeed A Alkhamees, Musheer A Aljaberi, Rasmieh Alamer, Annamaria Pakai, Mohamed Ali Zoromba

{"title":"The Arabic Generalized Anxiety Disorder 2 (GAD-2): Psychometric evaluation among mothers of children with intellectual disabilities.","authors":"Amira Mohammed Ali, Saeed A Al-Dossary, Feten Fekih-Romdhane, Carlos Laranjeira, Haitham Khatatbeh, Heba Emad El-Gazar, Ahmad Ayed, Abdulmajeed A Alkhamees, Musheer A Aljaberi, Rasmieh Alamer, Annamaria Pakai, Mohamed Ali Zoromba","doi":"10.1080/19585969.2026.2650296","DOIUrl":"https://doi.org/10.1080/19585969.2026.2650296","url":null,"abstract":"Introduction: Disruptive behaviours of children with intellectual disabilities predispose mothers to mental and physical morbidities, leading to caregiving burnout, lower childcare quality, and poor child progress.Methods: This cross-sectional study investigated the psychometrics of the Arabic version of the Generalised Anxiety Disorder 2-item scale (GAD-2) among 85 Saudi mothers of children with intellectual disabilities through latent variable model and receiver-operating characteristic curve analyses.Results: The unidimensional GAD-2 demonstrated good construct validity, invariance at the configural, metric, and scalar levels across age groups, and adequate convergent/divergent validity-It was negatively predicted by high mood and happiness and positively predicted by stress, and it mediated the effect of stress and happiness on depression. Its known-group validity was determined by elevated anxiety levels among mothers using psychotropic drugs. Two cut-offs (≥2.5 and ≥3.5) flagged the best trade-off between sensitivity and specificity for predicting low mood, poor sleep quality, nightmares, high stress, low general physical health, and willingness to join a psychological support program. The positive predictive value for the cut-off ≥3.5 was higher for all outcomes than that of the cut-off ≥2.5.Discussion: The GAD-2 is a valid and reliable tool, which at thresholds ≥3.5 can identify anxious mothers, aiding early diagnosis and intervention.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"28 1","pages":"21-31"},"PeriodicalIF":8.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13148081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reproductive health - a blind spot in psychotherapeutic treatment? Evidence of insufficient consideration of reproductive factors in routine care. 生殖健康——心理治疗的盲点？常规护理中对生殖因素考虑不足的证据。

IF 8.9 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2026-12-01 Epub Date: 2026-04-19 DOI: 10.1080/19585969.2026.2653598

Sinha Engel, Jana Saskia Langer, Enno Maaß, Jan Richter

{"title":"Reproductive health - a blind spot in psychotherapeutic treatment? Evidence of insufficient consideration of reproductive factors in routine care.","authors":"Sinha Engel, Jana Saskia Langer, Enno Maaß, Jan Richter","doi":"10.1080/19585969.2026.2653598","DOIUrl":"10.1080/19585969.2026.2653598","url":null,"abstract":"Introduction: Reproductive health impacts mental health. Consequently, reproductive factors should be assessed in psychotherapy to ensure correct differential diagnosis, precise case conceptualisation and efficient treatment. It has not been analysed to which extent psychotherapists assess reproductive factors in routine care.Methods: Analyses were based on data from Germany-wide surveys with n = 390 psychotherapists and n = 291 patients. From their respective perspective, we examined how frequently psychotherapists proactively assessed whether patients experienced a menstrual cycle, menopause, used hormonal contraception, experienced a pregnancy, fertility treatment, or birth, whether these factors were associated with patients' symptoms, and how relevant they were perceived to be. Further, we examined how psychotherapists acquired knowledge about the reproductive factors and which psychotherapist characteristics increased the likelihood of considering them.Results: We identified a gap between low proactive assessment and high perceived relevance of reproductive factors. Psychotherapists acquired their knowledge through personal experience rather than clinical training or further education. Greater knowledge and perceived relevance increased the likelihood of proactively assessing reproductive factors.Conclusions: There is a clear need to incorporate a standardised, proactive assessment of reproductive factors into routine care. The responsibility to disclose them should not be left to the patients. Developing appropriate teaching content and tailored anamnestic instruments can help to overcome the neglect.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"28 1","pages":"157-165"},"PeriodicalIF":8.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13094238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solution-focused group counseling enhances attention control in Internet addiction: Behavioral and neural evidence. 以解决方案为中心的团体咨询可以增强网瘾患者的注意力控制：行为和神经证据。

IF 8.9 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2026-12-01 Epub Date: 2026-03-16 DOI: 10.1080/19585969.2026.2637718

Yawei Qi, Ziyou Yan, Yuting Liu, Ofir Turel, Xinhe Zhang, Haichao Zhao, Jiali Liu, Yingying Zhang, Qinghua He

{"title":"Solution-focused group counseling enhances attention control in Internet addiction: Behavioral and neural evidence.","authors":"Yawei Qi, Ziyou Yan, Yuting Liu, Ofir Turel, Xinhe Zhang, Haichao Zhao, Jiali Liu, Yingying Zhang, Qinghua He","doi":"10.1080/19585969.2026.2637718","DOIUrl":"10.1080/19585969.2026.2637718","url":null,"abstract":"Objective: Internet addiction (IA) is often associated with impaired attention control. Nevertheless, ways to improve this deficit are lacking, and so is the understanding of the mechanisms that such interventions might impact. To address this gap, this study seeks to examine the efficacy of Solution-Focused Group Counselling (SFGC) in enhancing attention networks among individuals with IA.Methods: A total of 32 college students with high IA scores were recruited, with 26 participants (16 females and 10 males; mean age 19.42 ± 1.10) completing a five-week SFGC intervention. Assessments conducted pre- and post-intervention included the Attention Network Test (ANT) and electroencephalogram (EEG).Results: Results demonstrated a significant reduction in executive network reaction times (RT) following the intervention. Neurophysiological analyses revealed an increase in P3 amplitude and a decrease in alpha-band event-related desynchronisation (ERD) in the central parietal lobe, suggesting altered executive control. Moreover, a novel event-related potential (ERP) component, termed the Executive Efficiency Difference Wave (EED), was identified. It negatively correlated with executive network RT post-intervention, but not pre-intervention.Conclusions: Preliminary findings in a small sample suggest that SFGC effectively enhances both behavioural performance and neural indices associated with attention in individuals with IA. We call for future research to examine the broader applicability and long-term efficacy of SFGC.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"28 1","pages":"119-130"},"PeriodicalIF":8.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating EEG and fMRI in naturalistic paradigms: Advances in understanding mental disorders-a decade study in review (2014-2024). 在自然主义范式中整合脑电图和功能磁共振成像：理解精神障碍的进展-十年研究回顾（2014-2024）。

IF 8.9 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2026-12-01 Epub Date: 2025-11-04 DOI: 10.1080/19585969.2025.2579280

Anam Mehmood, Shuyue Xu, Sultan Mehmood Siddiqi, Li Zhang, Gan Huang, Zhen Liang, Yongjie Zhou

{"title":"Integrating EEG and fMRI in naturalistic paradigms: Advances in understanding mental disorders-a decade study in review (2014-2024).","authors":"Anam Mehmood, Shuyue Xu, Sultan Mehmood Siddiqi, Li Zhang, Gan Huang, Zhen Liang, Yongjie Zhou","doi":"10.1080/19585969.2025.2579280","DOIUrl":"10.1080/19585969.2025.2579280","url":null,"abstract":"Background: Integrating electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) with naturalistic stimuli has advanced our understanding of the neural mechanisms underlying mental disorders. Naturalistic paradigms use dynamic, multimodal stimuli that capture complex emotional and cognitive processes more effectively than traditional experimental designs. Objective: This review synthesizes research from 2014 to 2024 exploring neural mechanisms of anxiety, depression, and schizophrenia within naturalistic paradigms. Methods: Recent EEG-fMRI studies employing naturalistic tasks were examined to identify common and disorder-specific neural alterations across affective and cognitive networks. Results: In anxiety, hyperactivity in the amygdala, prefrontal cortex, anterior cingulate cortex, and insula, together with changes in the dorsal attention, default mode, and frontoparietal networks, reflects excessive fear responses and impaired regulation. Depression is characterized by disruptions in default mode and frontoparietal connectivity and altered amygdala-prefrontal interactions, indicating maladaptive introspection and cognitive control. Schizophrenia shows abnormalities in motor and language processing, with aberrant activity in frontal, parietal, and temporal regions including the insula and temporoparietal junction. Conclusion: These findings highlight the shared involvement of the amygdala, prefrontal cortex, anterior cingulate cortex, and insula across disorders and demonstrate the potential of naturalistic paradigms for advancing personalized diagnostics and interventions in mental health.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"28 1","pages":"1-21"},"PeriodicalIF":8.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12590575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145446486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic effects of 40 Hz light stimulation on clinical and pathological features of Alzheimer's disease. 40hz光刺激对阿尔茨海默病临床和病理特征的治疗作用。

IF 8.9 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2026-12-01 Epub Date: 2026-04-26 DOI: 10.1080/19585969.2026.2658530

Ping-Song Chou, Ching-Fang Chien, Ling-Chun Huang, Yuan-Han Yang

{"title":"Therapeutic effects of 40 Hz light stimulation on clinical and pathological features of Alzheimer's disease.","authors":"Ping-Song Chou, Ching-Fang Chien, Ling-Chun Huang, Yuan-Han Yang","doi":"10.1080/19585969.2026.2658530","DOIUrl":"https://doi.org/10.1080/19585969.2026.2658530","url":null,"abstract":"Background: Current pharmacological treatments offer only limited benefits in altering the course of Alzheimer's disease (AD). Given these limitations, nonpharmacological interventions have emerged as potential therapeutic strategies. This study investigates the therapeutic effects of 40 Hz light stimulation in AD and analyzes blood biomarkers to explore its potential disease-modifying effects.Methods: This longitudinal study examined the effects of 40 Hz light stimulation on clinical symptoms and blood biomarkers in AD patients. Fourteen individuals were enrolled, with 11 completing the 3-month light stimulation, and 6 continuing to 6 months for the final blood biomarker analysis, including amyloid beta (Aβ) oligomers, Aβ-40, Aβ-42, tau phosphorylated at threonine 181 (p-tau181) and 217 (p-tau217), and neurofilament light chain.Results: At 3 months, cognitive function remained stable or improved in 63.6% of participants, depressive symptoms improved in 54.5%, caregiver burden decreased in 72.7%, and sleep quality improved in 90.9% (p = .014). At 6 months, cognitive function and neuropsychiatric symptoms remained stable or improved in 33.3% and 66.7% of participants, respectively. Biomarker analysis showed decreased Aβ oligomers, increased Aβ-42 and reduced p-tau, suggesting potential disease-modifying effects.Conclusions: 40 Hz light stimulation demonstrated short-term benefits in cognitive stability, caregiver burden relief, and sleep improvement, with biomarker findings indicating possible neuroprotective effects.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"28 1","pages":"177-187"},"PeriodicalIF":8.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13112872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amygdala-putamen connectivity links gratitude to greater well-being. 杏仁核-壳核连接将感恩与更大的幸福感联系起来。

IF 8.9 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2026-12-01 Epub Date: 2026-04-21 DOI: 10.1080/19585969.2026.2653597

Guanmin Liu, Ying Yang, Fei Wang, Feng Kong, Kaiping Peng, Jie Sui

{"title":"Amygdala-putamen connectivity links gratitude to greater well-being.","authors":"Guanmin Liu, Ying Yang, Fei Wang, Feng Kong, Kaiping Peng, Jie Sui","doi":"10.1080/19585969.2026.2653597","DOIUrl":"https://doi.org/10.1080/19585969.2026.2653597","url":null,"abstract":"Introduction: Gratitude plays a crucial role in promoting affective well-being, yet the neural mechanisms underlying their relationship remains unclear. Given the central role of the nucleus accumbens (NAcc) and amygdala in emotion and reward processing, this study investigated whether resting-state functional connectivity (RSFC) of these subcortical regions correlates with trait gratitude and mediates its association with affective well-being.Methods: Resting-state fMRI data were collected from 363 young adults. Seed-based connectivity analyses identified NAcc and amygdala connectivity patterns associated with trait gratitude. Mediation analyses tested whether these patterns explained the association between gratitude and affective well-being.Results: Trait gratitude was linked to stronger connectivity between the left NAcc and dorsomedial prefrontal cortex and left posterior superior temporal sulcus; between the right NAcc and left dorsolateral prefrontal cortex (DLPFC), right inferior temporal gyrus and bilateral fusiform; and between the right amygdala and right DLPFC, superior temporal gyrus, cerebellum, and putamen. Critically, the right amygdala-putamen connectivity mediated the relationship between gratitude and positive affective well-being.Conclusions: The right amygdala-putamen RSFC links gratitude to greater affective well-being. This finding identifies a specific subcortical pathway through which grateful dispositions translate into emotional benefit and suggests a potential target for interventions aimed at improving mental health.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"28 1","pages":"166-176"},"PeriodicalIF":8.9,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13101003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147789439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0