Dialogues in Clinical Neuroscience最新文献

Societal perspectives on psychedelics use in clinical context: Development of Concerns and Openness towards Psychedelic Scale (COPS).

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-03-06 DOI: 10.1080/19585969.2025.2470426

Paweł Holas, Justyna Kamińska, Marcin Zajenkowski

{"title":"Societal perspectives on psychedelics use in clinical context: Development of Concerns and Openness towards Psychedelic Scale (COPS).","authors":"Paweł Holas, Justyna Kamińska, Marcin Zajenkowski","doi":"10.1080/19585969.2025.2470426","DOIUrl":"10.1080/19585969.2025.2470426","url":null,"abstract":"Introduction: Psychedelics are gaining recognition for their therapeutic potential in mental health treatment, yet societal attitudes remain divided, influenced by both skepticism and curiosity. This study aimed to develop and validate a scale assessing attitudes toward psychedelics.Methods: Study 1 (n = 1000, convenience sample) explored the factor structure, identifying two dimensions: Openness toward Psychedelics and Concerns toward Psychedelics. Study 2 (n = 843, representative Polish sample) confirmed the scale's validity.Results: The Concerns factor negatively correlated with meaning in life, while the Openness factor was positively associated with openness to experience, agreeableness, conscientiousness, mindfulness, meaning in life, and nature-relatedness. These associations suggest that individuals with greater openness and psychological flexibility may hold more favorable views on psychedelics.Discussion: The Concerns and Openness towards Psychedelics Scale (COPS) is a psychometrically sound tool for assessing attitudes toward psychedelics. Its meaningful correlations with established psychological constructs underscore its utility in research and public health. By providing insight into societal perceptions, COPS may help inform discussions on psychedelic therapy, policy, and education, ultimately fostering a more nuanced understanding of their potential benefits and risks.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"11-21"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The flow cytometric analysis of depression focusing on modern-type depression and hikikomori: Exploring the link between subtypes of depression and immunological imbalances. 抑郁症的流式细胞分析聚焦于现代型抑郁症和隐蔽青年：探索抑郁症亚型与免疫失衡之间的联系。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-01-20 DOI: 10.1080/19585969.2025.2452842

Keitaro Matsuo, Mitsuru Watanabe, Shogo Inamine, Toshio Matsushima, Sota Kyuragi, Yasuhiro Maeda, Ryoko Katsuki, Masahiro Ohgidani, Ryo Yamasaki, Noriko Isobe, Tomohiro Nakao, Takahiro A Kato

{"title":"The flow cytometric analysis of depression focusing on modern-type depression and hikikomori: Exploring the link between subtypes of depression and immunological imbalances.","authors":"Keitaro Matsuo, Mitsuru Watanabe, Shogo Inamine, Toshio Matsushima, Sota Kyuragi, Yasuhiro Maeda, Ryoko Katsuki, Masahiro Ohgidani, Ryo Yamasaki, Noriko Isobe, Tomohiro Nakao, Takahiro A Kato","doi":"10.1080/19585969.2025.2452842","DOIUrl":"10.1080/19585969.2025.2452842","url":null,"abstract":"Introduction: Depression includes different phenotypes. Modern-type depression (MTD) is a gateway disorder to pathological social withdrawal, known as hikikomori. Adverse childhood experiences (ACEs) are also important aetiologies of depression. Recently, immune imbalance has been proposed as a biological basis of depression. We hypothesised that peripheral immunological characteristics may be involved in subtyping of depression.Methods: 21 patients with major depressive disorder (MDD) and 24 healthy controls (HC) were recruited. Peripheral blood mononuclear cells (PBMCs) were examined for surface antigens by flow cytometry. Participants were administered psychological scales such as Patient Health Questionnaire (PHQ)-9, Modern-Type Depression Trait Scale (TACS-22), Hikikomori Questionnaire (HQ-25), Child Abuse and Trauma Scale (CATS).Results: MDD group showed significantly higher percentage of B cells than HC group (p = 0.032). MDD group presented a negative correlation between: PHQ-9 and CD8 T effector memory cells (r= -0.639, p = 0.002), TACS-22 and monocytes (r= -0.459, p = 0.036), HQ-25 and NK T cells (r= -0.638, p = 0.004), CATS and Intermediate monocytes (r= -0.594, p = 0.009).Conclusions: MTD traits, hikikomori tendencies, and ACEs were correlated with specific characteristics of peripheral immune cells. Our results suggest that immune imbalance influences the diverse presentations of depression. Further validation is warranted by large-scale prospective studies.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"13-25"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of perceived side-effects of psychotropic treatments on quality of life in patients with severe mental illness.

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-02-11 DOI: 10.1080/19585969.2025.2463443

Théo Korchia, Mélanie Faugère, Vincent Achour, Eloïse Maakaron, Christelle Andrieu-Haller, Guillaume Fond, Christophe Lançon

{"title":"Impact of perceived side-effects of psychotropic treatments on quality of life in patients with severe mental illness.","authors":"Théo Korchia, Mélanie Faugère, Vincent Achour, Eloïse Maakaron, Christelle Andrieu-Haller, Guillaume Fond, Christophe Lançon","doi":"10.1080/19585969.2025.2463443","DOIUrl":"10.1080/19585969.2025.2463443","url":null,"abstract":"Background: Psychotropic medications are critical in managing severe mental illnesses (SMI) such as schizophrenia, major depressive disorder (MDD) and bipolar disorder. However, these treatments often lead to adverse side effects that can impair patients' quality of life (QoL) and affect treatment adherence.Objective: This study aims to investigate the specific side effects of psychotropic treatments that contribute to a decline in QoL among patients with SMI, independently of treatment adherence.Methods: We conducted a cross-sectional study with 1248 patients diagnosed with SMI, recruited from a university psychiatric unit in Marseille, France. QoL was assessed using the Schizophrenia Quality of Life Scale (SQoL-18), and side effects were measured using the UKU Side Effect Rating Scale. Treatment adherence was evaluated using the Medication Adherence Rating Scale (MARS). Statistical analyses included Pearson correlations and multiple linear regression models to identify predictors of QoL.Results: The study found that side effects, as identified by the UKU scores, could significantly predict a reduction in QoL across multiple domains, including multiple dimensions of QoL and the overall QoL index, independent of treatment adherence. Patients on antipsychotics and benzodiazepines reported higher levels of adverse side effects, which correlated with lower QoL scores. An increase in the number of psychotropic treatment classes was also associated with a significant decline in QoL (p < 0.001).Conclusion: Managing psychic side effects and minimising polypharmacy are critical to improving QoL in patients with SMI. Clinicians should consider these factors when developing personalised treatment strategies to enhance patient outcomes.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"10-19"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11816623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring novel therapeutic strategies: Could psychedelic perspectives offer promising solutions for Alzheimer's disease comorbidities?

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-03-19 DOI: 10.1080/19585969.2025.2480566

Michael Davidson, Gabriela-Dumitrita Stanciu, Jonathan Rabinowitz, Ilinca Untu, Romeo-Petru Dobrin, Bogdan-Ionel Tamba

{"title":"Exploring novel therapeutic strategies: Could psychedelic perspectives offer promising solutions for Alzheimer's disease comorbidities?","authors":"Michael Davidson, Gabriela-Dumitrita Stanciu, Jonathan Rabinowitz, Ilinca Untu, Romeo-Petru Dobrin, Bogdan-Ionel Tamba","doi":"10.1080/19585969.2025.2480566","DOIUrl":"https://doi.org/10.1080/19585969.2025.2480566","url":null,"abstract":"The increasing prevalence of dementia within an ageing global population, combined with prolonged life expectancy, accentuates Alzheimer's disease (AD) as a multifaceted healthcare challenge. This challenge is further compounded by the limited therapeutic options currently available. Addressing the intricacies of AD management, the mitigation of comorbidities has emerged as a pivotal facet of treatment. Comorbid conditions, such as neurobehavioral symptoms, play a role in shaping the clinical course, management, and outcomes of this pathology; highlighting the importance of comprehensive care approaches for affected individuals. Exploration of psychedelic compounds in psychiatric and palliative care settings has recently uncovered promising therapeutic potential, enhancing neuroplasticity, emotional processing and connection. These effects are particularly relevant in the context of AD, where psychedelic therapy offers hope not only for mitigating core symptoms but also for addressing the array of comorbidities associated with this condition. The integration of this comprehensive method offers a chance to significantly enhance the care provided to those navigating the intricate landscape of AD. Therefore, the current paper reviews the intricate link between more frequent additional health conditions that may coexist with dementia, particularly in the context of AD, and explores the therapeutic potential of psychedelic compounds in addressing these concurrent conditions.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"1-12"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antipsychotic off-label use in the 21st century: An enduring public health concern. 21世纪抗精神病药物的标签外使用：一个持久的公共卫生问题。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-01-10 DOI: 10.1080/19585969.2025.2449833

Hélène Verdoux

{"title":"Antipsychotic off-label use in the 21st century: An enduring public health concern.","authors":"Hélène Verdoux","doi":"10.1080/19585969.2025.2449833","DOIUrl":"10.1080/19585969.2025.2449833","url":null,"abstract":"Soon after the introduction of second-generation antipsychotics, antipsychotic off-label use (OLU) progressively became a common prescribing practice. This evolving practice should be regularly monitored considering the growing number of persons exposed to the adverse effects of antipsychotics. The aim of the present review was to synthesise the literature published over the last 15 years on antipsychotic OLU for mental health symptoms. Observational studies confirm the persisting high rate of antipsychotic OLU prescription in two out of three youths and 30-60% of adults using antipsychotics. Increasing rates of low-dose quetiapine prescriptions for anxiety or sleep symptoms are paradigmatic of the current public health concern regarding antipsychotic OLU. Such prescriptions receive impetus from industry-funded marketing strategies and prescribers' feeling of innocuousness, with a resulting underestimation of the risk of adverse drug reactions (ADR). However, antipsychotic OLU should be neither trivialised nor demonised since it may be the only therapeutic option in persons with resistant psychiatric disorders or serious ADR with labelled drugs. To reduce the populational impact of antipsychotic OLU, it is necessary to better control the influence of the pharmaceutical industry regarding newly marketed drugs and to better inform prescribers and users about the risks associated with OLU prescribing.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"1-12"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of causal relationships between genetic liability to inflammatory bowel disease and autism spectrum disorder by Mendelian randomization analysis.

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-02-03 DOI: 10.1080/19585969.2025.2460798

Ruijie Zeng, Rui Jiang, Wentao Huang, Huihuan Wu, Zewei Zhuo, Qi Yang, Jingwei Li, Felix W Leung, Weihong Sha, Hao Chen

{"title":"Evaluation of causal relationships between genetic liability to inflammatory bowel disease and autism spectrum disorder by Mendelian randomization analysis.","authors":"Ruijie Zeng, Rui Jiang, Wentao Huang, Huihuan Wu, Zewei Zhuo, Qi Yang, Jingwei Li, Felix W Leung, Weihong Sha, Hao Chen","doi":"10.1080/19585969.2025.2460798","DOIUrl":"10.1080/19585969.2025.2460798","url":null,"abstract":"Background: Emerging observational studies have indicated the association between autism spectrum disorder (ASD) and IBD, including Crohn's disease (CD) and ulcerative colitis (UC), whereas the causality remains unknown.Methods: Summary-level data from large-scale genome-wide association (GWAS) studies of IBD and ASD were retrieved. Mendelian randomisation analyses were performed with a series of sensitivity tests.Results: Genetic predisposition to ASD was not associated with the risk of IBD (odds ratio [OR] = 0.99, 95% confidence interval [CI = 0.91-1.06, p = 0.70; OR [95% CI]: 1.03 [0.93-1.13], p = 0.58 for CD; OR [95% CI]: 0.96 [0.87-1.05], p = 0.37 for UC) in the IIBDGC dataset. In the FinnGen dataset, their causal effects were unfounded (OR [95% CI]: 1.04 [0.94-1.15], p = 0.49 for IBD; OR [95% CI]: 1.08 [0.89-1.31], p = 0.42 for CD; OR [95% CI]: 1.00 [0.88-1.13], p = 0.95 for UC). In the meta-analysis of two datasets, the OR was 1.01 (95% CI 0.96-1.07, p = 0.45). For the risk of ASD under genetic liability to IBD, the OR from meta-analysis was 1.03 (95% CI 1.01-1.05, p = 0.01).Conclusion: Our findings indicate genetic predisposition to ASD might not increase the risk of IBD, whereas genetic liability to IBD is associated with an increased risk of ASD. Further investigations using more powerful datasets are warranted.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"26-34"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A global neuronal workspace model of functional neurological disorders. 功能性神经紊乱的全局神经元工作区模型。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2024-01-01 Epub Date: 2024-05-20 DOI: 10.1080/19585969.2024.2340131

Lionel Naccache, Esteban Munoz-Musat

引用次数: 0

Resting-state EEG microstate analysis of internet gaming disorder and alcohol use disorder. 网络游戏障碍和酒精使用障碍的静息态脑电图微状态分析。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2024-01-01 Epub Date: 2024-11-27 DOI: 10.1080/19585969.2024.2432913

Ji Sun Kim, Young Wook Song, Sungkean Kim, Ji-Yoon Lee, So Young Yoo, Joon Hwan Jang, Jung-Seok Choi

{"title":"Resting-state EEG microstate analysis of internet gaming disorder and alcohol use disorder.","authors":"Ji Sun Kim, Young Wook Song, Sungkean Kim, Ji-Yoon Lee, So Young Yoo, Joon Hwan Jang, Jung-Seok Choi","doi":"10.1080/19585969.2024.2432913","DOIUrl":"10.1080/19585969.2024.2432913","url":null,"abstract":"Introduction: To investigate the neurophysiological aspects of addiction, the microstate characteristics of internet gaming disorder (IGD), alcohol use disorder (AUD), and healthy control (HC) groups were compared using resting-state electroencephalography (EEG).Methods: In total, 199 young adults (75 patients with IGD, 57 patients with AUD, and 67 HCs) participated in this study. We conducted EEG microstate analysis among the groups and also compared the obtained parameters with the results of psychological assessments.Results: The global explained variance, occurrence, and coverage of microstate C were significantly lower in the AUD group than in the IGD group. Additionally, rates of transition from microstates A, B, and D to C were significantly lower in the AUD group than in the IGD group, whereas rates of transition from microstate A to B were lower in the IGD group compared to HCs. Furthermore, the occurrence of microstate C and transition from microstate B to C were negatively correlated with the Alcohol Use Disorder Identification and Behavioural Inhibition Scale score.Conclusion: There were significant differences in microstate characteristics among the groups, which correlated with the psychological scores. These findings suggest that microstate features can be used as neuromarkers in clinical settings to differentiate between addictive disorders and evaluate the pathophysiology of AUD and IGD.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"26 1","pages":"89-102"},"PeriodicalIF":8.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142734752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A profile of French clergymen who sexually assaulted victims and a review. 性侵犯受害者的法国神职人员简介及评论。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2024-01-01 Epub Date: 2024-11-22 DOI: 10.1080/19585969.2024.2429453

Bénédicte Aubet, Julia Marie, Philippe Portier, Florence Thibaut

{"title":"A profile of French clergymen who sexually assaulted victims and a review.","authors":"Bénédicte Aubet, Julia Marie, Philippe Portier, Florence Thibaut","doi":"10.1080/19585969.2024.2429453","DOIUrl":"10.1080/19585969.2024.2429453","url":null,"abstract":"Sexual abuse within the Catholic Church is a distressing concern. As part of the investigation conducted by the French Independent Commission on Sexual Abuse in the Church, we analysed available files of convicted sexual abusers between 1950 and 2020. We analysed the socio-demographic and clinical characteristics of French clergymen sex offenders. Thirty-five clergymen were included. Sexual assaults were documented for 176 individuals in total, including 153 minors (79.7% male) and 23 adults (52.2% female). No sex offender assaulted both juvenile and adult victims. Homosexuality was declared in 50% of the perpetrators. A past history of child sexual abuse was observed in 30% (N = 9) of juvenile offenders. The mean number of victims per offender was around 5, with the highest mean number in male or both sex juvenile offenders. More than 90% of the victims were known to the perpetrator. Both hands-on and hands-off sexual offences occurred in over 80% of male juvenile offenders compared to less than 6% of female juvenile offenders and less than 17% of adult offenders. Sex offenders within the Catholic Church present some specificities in comparison to non religious sex offenders, such as a higher number of male juvenile victims somewhat older and more often known. Personal, interpersonal and systemic factors, some of which being specific, interact to foster sexual offence. Prevention of sexual abuse within the Catholic Church is crucial.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"26 1","pages":"77-88"},"PeriodicalIF":8.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11587733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142689168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microcephaly type 22 and autism spectrum disorder: A case report and review of literature. 小头畸形 22 型和自闭症谱系障碍：病例报告和文献综述。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2024-01-01 Epub Date: 2024-06-03 DOI: 10.1080/19585969.2024.2359918

Jiqiang Ma, Yu'e Liu, Kaijun Zhao

{"title":"Microcephaly type 22 and autism spectrum disorder: A case report and review of literature.","authors":"Jiqiang Ma, Yu'e Liu, Kaijun Zhao","doi":"10.1080/19585969.2024.2359918","DOIUrl":"10.1080/19585969.2024.2359918","url":null,"abstract":"Introduction: Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder with a multifaceted etiology. This case report explores the ischemic cryptogenic vascular dissection as a potential underlying cause of ASD.Methods: A 9-year-old child presented with symptoms of ASD, including social interaction difficulties, repetitive behaviors, and cognitive challenges. Despite conventional ASD treatments, significant improvement was only observed after addressing an underlying ischemic cryptogenic vascular dissection identified through DCE-CT.Results: Following a reconstructive treatment approach to the vascular dissection, the patient showed marked improvement in cognitive functions, social abilities, and a reduction in ASD-related symptoms whether during the perioperative period or during approximately 5-month follow-up.Conclusion: This case suggests that ischemic cryptogenic vascular dissection may contribute to the symptoms of ASD. Identifying and treating underlying vascular anomalies may offer a new avenue for mitigating ASD symptoms, emphasizing the need for comprehensive diagnostic estimations in ASD management.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"26 1","pages":"24-27"},"PeriodicalIF":8.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11149562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141238829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0