Dialogues in Clinical Neuroscience最新文献

Societal perspectives on psychedelics use in clinical context: Development of Concerns and Openness towards Psychedelic Scale (COPS). 在临床环境中使用致幻剂的社会观点：对致幻剂量表（COPS）的关注和开放。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-03-06 DOI: 10.1080/19585969.2025.2470426

Paweł Holas, Justyna Kamińska, Marcin Zajenkowski

{"title":"Societal perspectives on psychedelics use in clinical context: Development of Concerns and Openness towards Psychedelic Scale (COPS).","authors":"Paweł Holas, Justyna Kamińska, Marcin Zajenkowski","doi":"10.1080/19585969.2025.2470426","DOIUrl":"10.1080/19585969.2025.2470426","url":null,"abstract":"Introduction: Psychedelics are gaining recognition for their therapeutic potential in mental health treatment, yet societal attitudes remain divided, influenced by both skepticism and curiosity. This study aimed to develop and validate a scale assessing attitudes toward psychedelics.Methods: Study 1 (n = 1000, convenience sample) explored the factor structure, identifying two dimensions: Openness toward Psychedelics and Concerns toward Psychedelics. Study 2 (n = 843, representative Polish sample) confirmed the scale's validity.Results: The Concerns factor negatively correlated with meaning in life, while the Openness factor was positively associated with openness to experience, agreeableness, conscientiousness, mindfulness, meaning in life, and nature-relatedness. These associations suggest that individuals with greater openness and psychological flexibility may hold more favorable views on psychedelics.Discussion: The Concerns and Openness towards Psychedelics Scale (COPS) is a psychometrically sound tool for assessing attitudes toward psychedelics. Its meaningful correlations with established psychological constructs underscore its utility in research and public health. By providing insight into societal perceptions, COPS may help inform discussions on psychedelic therapy, policy, and education, ultimately fostering a more nuanced understanding of their potential benefits and risks.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"11-21"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

5-HT6 receptors: Contemporary views on their neurobiological and pharmacological relevance in neuropsychiatric disorders. 5-HT6受体：其在神经精神疾病中的神经生物学和药理学相关性的当代观点

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-05-10 DOI: 10.1080/19585969.2025.2502028

Abdeslam Chagraoui, Florence Thibaut, Philippe De Deurwaerdère

{"title":"5-HT6 receptors: Contemporary views on their neurobiological and pharmacological relevance in neuropsychiatric disorders.","authors":"Abdeslam Chagraoui, Florence Thibaut, Philippe De Deurwaerdère","doi":"10.1080/19585969.2025.2502028","DOIUrl":"https://doi.org/10.1080/19585969.2025.2502028","url":null,"abstract":"Despite the relatively limited number of serotonergic neurons in humans, serotonin plays a key role in neurophysiological functions, including sleep, pain perception, learning, memory, cognition, emotion, reward, and mood regulation. Altered serotonergic neurotransmission is linked to conditions such as anxiety, depression, anorexia, migraine, insomnia, schizophrenia, Alzheimer's disease (AD), and cognitive impairments. The 5-HT6 receptor (5-HT6R), mainly found in brain regions involved in cognition, is a promising therapeutic target for cognitive deficits in neuropsychiatric disorders, particularly AD and schizophrenia. Preclinical studies have shown that 5-HT6R antagonists improve cognitive function. 5-HT6R interacts dynamically with an extensive intracellular protein network, regulating the localisation, trafficking, and signalling of these proteins. Proteomic and genetic studies have revealed interactions with mTOR kinase and neurofibromin, both of which are crucial for synaptic plasticity, learning, and memory. Fyn kinase is also associated with 5-HT6Rs, reinforcing receptor expression and G-protein coupling. Notably, the G protein-regulated inducer of neurite outgrowth 1 (GPRIN1) interacts with 5-HT6Rs independently of agonists, enhancing receptor activity. This review highlights the clinical testing of 5-HT6R ligands as regulators of these complex signalling properties, underscoring their therapeutic potential in addressing cognitive impairments associated with neuropsychiatric disorders.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"112-128"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An integrative model of perseverative thinking. 持续性思维的综合模式。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-05-23 DOI: 10.1080/19585969.2025.2481658

Lorenzo Mattioni, Ana V Nikčević, Francesca Ferri, Marcantonio M Spada, Carlo Sestieri

{"title":"An integrative model of perseverative thinking.","authors":"Lorenzo Mattioni, Ana V Nikčević, Francesca Ferri, Marcantonio M Spada, Carlo Sestieri","doi":"10.1080/19585969.2025.2481658","DOIUrl":"10.1080/19585969.2025.2481658","url":null,"abstract":"People spend most of their waking hours detached from external stimuli, remembering the past, foreseeing the future, imagining situations in which they did not attend or that have never existed, or, simply, thinking. Such a process is crucial for mental health. A common feature of many mental disorders is recurrent stress-related thoughts, the so-called 'perseverative thinking'. In this review, we describe how perseverative thinking represents a dysfunctional self-regulatory strategy that maintains and increases the effects of mental suffering and arises from the maladaptive interplay between discrepancy monitoring, strategy selection, executive regulation, and information representation. We further argue that perseverative thinking can change how the mind represents the world through memory updating, resulting in an increased perceived need for regulation of the external and internal inputs. Lastly, we propose a new integrated model incorporating the different features of perseverative thinking, offering a more unified perspective on psychopathology.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"34-54"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The flow cytometric analysis of depression focusing on modern-type depression and hikikomori: Exploring the link between subtypes of depression and immunological imbalances. 抑郁症的流式细胞分析聚焦于现代型抑郁症和隐蔽青年：探索抑郁症亚型与免疫失衡之间的联系。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-01-20 DOI: 10.1080/19585969.2025.2452842

Keitaro Matsuo, Mitsuru Watanabe, Shogo Inamine, Toshio Matsushima, Sota Kyuragi, Yasuhiro Maeda, Ryoko Katsuki, Masahiro Ohgidani, Ryo Yamasaki, Noriko Isobe, Tomohiro Nakao, Takahiro A Kato

{"title":"The flow cytometric analysis of depression focusing on modern-type depression and hikikomori: Exploring the link between subtypes of depression and immunological imbalances.","authors":"Keitaro Matsuo, Mitsuru Watanabe, Shogo Inamine, Toshio Matsushima, Sota Kyuragi, Yasuhiro Maeda, Ryoko Katsuki, Masahiro Ohgidani, Ryo Yamasaki, Noriko Isobe, Tomohiro Nakao, Takahiro A Kato","doi":"10.1080/19585969.2025.2452842","DOIUrl":"10.1080/19585969.2025.2452842","url":null,"abstract":"Introduction: Depression includes different phenotypes. Modern-type depression (MTD) is a gateway disorder to pathological social withdrawal, known as hikikomori. Adverse childhood experiences (ACEs) are also important aetiologies of depression. Recently, immune imbalance has been proposed as a biological basis of depression. We hypothesised that peripheral immunological characteristics may be involved in subtyping of depression.Methods: 21 patients with major depressive disorder (MDD) and 24 healthy controls (HC) were recruited. Peripheral blood mononuclear cells (PBMCs) were examined for surface antigens by flow cytometry. Participants were administered psychological scales such as Patient Health Questionnaire (PHQ)-9, Modern-Type Depression Trait Scale (TACS-22), Hikikomori Questionnaire (HQ-25), Child Abuse and Trauma Scale (CATS).Results: MDD group showed significantly higher percentage of B cells than HC group (p = 0.032). MDD group presented a negative correlation between: PHQ-9 and CD8 T effector memory cells (r= -0.639, p = 0.002), TACS-22 and monocytes (r= -0.459, p = 0.036), HQ-25 and NK T cells (r= -0.638, p = 0.004), CATS and Intermediate monocytes (r= -0.594, p = 0.009).Conclusions: MTD traits, hikikomori tendencies, and ACEs were correlated with specific characteristics of peripheral immune cells. Our results suggest that immune imbalance influences the diverse presentations of depression. Further validation is warranted by large-scale prospective studies.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"13-25"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cyberdelics: Virtual reality hallucinations modulate cognitive-affective processes. 网络幻觉：虚拟现实幻觉调节认知情感过程。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-05-23 DOI: 10.1080/19585969.2025.2499459

Giulia Brizzi, Chiara Pupillo, Clara Rastelli, Antonino Greco, Luca Bernardelli, Anna Flavia Di Natale, Silvia Francesca Maria Pizzoli, Elena Sajno, Fabio Frisone, Daniele Di Lernia, Giuseppe Riva

{"title":"Cyberdelics: Virtual reality hallucinations modulate cognitive-affective processes.","authors":"Giulia Brizzi, Chiara Pupillo, Clara Rastelli, Antonino Greco, Luca Bernardelli, Anna Flavia Di Natale, Silvia Francesca Maria Pizzoli, Elena Sajno, Fabio Frisone, Daniele Di Lernia, Giuseppe Riva","doi":"10.1080/19585969.2025.2499459","DOIUrl":"10.1080/19585969.2025.2499459","url":null,"abstract":"Introduction: Psychedelics were explored for their potential in the mental health field. However, research was delayed by concerns over short-term side effects and long-term consequences of substance use. Technological advances enabled the development of Hallucinatory Visual Virtual Experiences (HVVEs), namely psychedelic experiences simulations in immersive virtual reality. This study investigated HVVEs' impact on cognitive flexibility, affective response, and autonomic activity.Methods: 50 healthy participants underwent assessments of cognitive flexibility, control inhibition, emotional response, and autonomic activity at baseline. Participants were then exposed to two 10-minute immersive virtual reality (IVR) experiences: 'The Secret Garden' and its hallucinated counterpart created using Google DeepDream algorithm. All measures were presented after each video, in addition to the flow experience assessment.Results: Post-HVVE, participants demonstrated enhanced cognitive flexibility and inhibitory control. They reported increased flow-absorption and decreased flow-fluency. Both IVR experiences reduced positive affects and state anxiety compared to baseline; additionally, IVR reduced heart rate and sympathetic activity compared to baseline.Conclusions: HVVEs produced psychedelic positive effects on cognitive and emotional functioning. The complex emotional and autonomic profile mimicked awakened relaxation that, in conjunction with the cognitive flexibility enhancement, could offer the unique opportunity to exploit psychedelic advantages while mitigating risks, opening new avenues for therapeutic approaches.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"1-12"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12107671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of light therapy on amygdala connectivity and serotoninergic system in young adults with subthreshold depression.

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-06-01 DOI: 10.1080/19585969.2025.2503367

Pan Chen, Guanmao Chen, Guixian Tang, Zibin Yang, Wenhao Ma, Chao Chen, Shilin Sun, Yuan Zhang, Shu Zhang, Zhangzhang Qi, Wenjie Fang, Lijun Jiang, Li Huang, Junxian Ma, Qian Tao, Ying Wang

{"title":"Effects of light therapy on amygdala connectivity and serotoninergic system in young adults with subthreshold depression.","authors":"Pan Chen, Guanmao Chen, Guixian Tang, Zibin Yang, Wenhao Ma, Chao Chen, Shilin Sun, Yuan Zhang, Shu Zhang, Zhangzhang Qi, Wenjie Fang, Lijun Jiang, Li Huang, Junxian Ma, Qian Tao, Ying Wang","doi":"10.1080/19585969.2025.2503367","DOIUrl":"https://doi.org/10.1080/19585969.2025.2503367","url":null,"abstract":"Background: Bright light therapy (BLT) demonstrates efficacy in alleviating subthreshold depression (StD) among young adults. The amygdala plays a critical role in depression.Methods: StD subjects were divided into BLT group (N=47) and placebo group (N=42). Depression severity was assessed using HAM-D, Centre for Epidemiologic Studies Depression Scale (CES-D) and Beck Depression Inventory (BDI) pre-/post-8-week intervention. Structural/resting-state fMRI scan was conducted. Seed-based static FC (sFC) and dynamic FC (dFC) analyses of the bilateral amygdala and their subfields were conducted.Results: Compared to placebo, BLT showed reduced depression scale, and increased sFC of right basolateral amygdala (BLA)/superficial amygdala (SFA)-right middle temporal gyrus (MTG) and dFC of right centralmedial amygdala (CMA) and right inferior orbital frontal gyrus, and decreased sFC of right amygdalostriatal transition/CMA- left thalamus and dFC of right SFA- right medial prefrontal cortex after intervention; while the whole amygdala and its subnuclei volume did not change significantly after BLT. Right BLA-MTG sFC changes positively correlated with BDI improvement. Baseline amygdala sFC/dFC predicted post-BLT symptom changes. BLT-induced right BLA sFC alterations spatially correlated with 5-HT1A/5-HT2A receptor distributions, and right CMA dFC changes with 5-HT1A.Conclusions: Findings suggest BLT modulates amygdala-thalamocortical circuits and serotonergic pathways, highlighting FC biomarkers for treatment efficacy assessment.Trial registration clinicaltrials.gov identifier: ChiCTR2000032633.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"184-200"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of perceived side-effects of psychotropic treatments on quality of life in patients with severe mental illness. 精神药物治疗的副作用对严重精神疾病患者生活质量的影响

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-02-11 DOI: 10.1080/19585969.2025.2463443

Théo Korchia, Mélanie Faugère, Vincent Achour, Eloïse Maakaron, Christelle Andrieu-Haller, Guillaume Fond, Christophe Lançon

{"title":"Impact of perceived side-effects of psychotropic treatments on quality of life in patients with severe mental illness.","authors":"Théo Korchia, Mélanie Faugère, Vincent Achour, Eloïse Maakaron, Christelle Andrieu-Haller, Guillaume Fond, Christophe Lançon","doi":"10.1080/19585969.2025.2463443","DOIUrl":"10.1080/19585969.2025.2463443","url":null,"abstract":"Background: Psychotropic medications are critical in managing severe mental illnesses (SMI) such as schizophrenia, major depressive disorder (MDD) and bipolar disorder. However, these treatments often lead to adverse side effects that can impair patients' quality of life (QoL) and affect treatment adherence.Objective: This study aims to investigate the specific side effects of psychotropic treatments that contribute to a decline in QoL among patients with SMI, independently of treatment adherence.Methods: We conducted a cross-sectional study with 1248 patients diagnosed with SMI, recruited from a university psychiatric unit in Marseille, France. QoL was assessed using the Schizophrenia Quality of Life Scale (SQoL-18), and side effects were measured using the UKU Side Effect Rating Scale. Treatment adherence was evaluated using the Medication Adherence Rating Scale (MARS). Statistical analyses included Pearson correlations and multiple linear regression models to identify predictors of QoL.Results: The study found that side effects, as identified by the UKU scores, could significantly predict a reduction in QoL across multiple domains, including multiple dimensions of QoL and the overall QoL index, independent of treatment adherence. Patients on antipsychotics and benzodiazepines reported higher levels of adverse side effects, which correlated with lower QoL scores. An increase in the number of psychotropic treatment classes was also associated with a significant decline in QoL (p < 0.001).Conclusion: Managing psychic side effects and minimising polypharmacy are critical to improving QoL in patients with SMI. Clinicians should consider these factors when developing personalised treatment strategies to enhance patient outcomes.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"10-19"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11816623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analysis of emotional factors in patients with somatic symptom disorder and panic disorder. 躯体症状障碍与惊恐障碍患者情绪因素的比较分析。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-03-25 DOI: 10.1080/19585969.2025.2482123

Hye Youn Park, Yuna Jang, Arum Hong, EKyong Yoon, In-Young Yoon

{"title":"Comparative analysis of emotional factors in patients with somatic symptom disorder and panic disorder.","authors":"Hye Youn Park, Yuna Jang, Arum Hong, EKyong Yoon, In-Young Yoon","doi":"10.1080/19585969.2025.2482123","DOIUrl":"10.1080/19585969.2025.2482123","url":null,"abstract":"Objective: This study investigated the emotional symptom profiles and treatment responses in patients exhibiting overlapping physical symptoms to compare differences between Somatic Symptom Disorder (SSD) and Panic Disorder (PD).Methods: Pharmacotherapy outcomes were analysed in 208 outpatients with SSD (n = 94) and PD (n = 114). Stepwise multivariable logistic regression identified predictors of treatment response, considering variables such as the Clinical Global Impression-Severity (CGI-S), Beck Depression Inventory-II (BDI-II), State-Trait Anxiety Inventory, and State-Trait Anger Expression Inventory. Network analysis explored emotional patterns by estimating network structures for each group.Results: The overall response rate to pharmacotherapy was 23.6% (49/208), with no significant difference between groups. Baseline CGI-S and BDI-II scores were significant predictors of treatment response in both groups, while social phobia score was a significant predictor in PD. Depression and anxiety were related to physical symptoms in both groups, but anger was significantly associated only in SSD. Network analysis revealed that depression was central to other symptoms in SSD, while anxiety was the core symptom in PD, indicating different emotional drivers between the disorders.Conclusions: This study suggests the differences in emotional symptom profiles between SSD and PD. Findings suggest different mechanisms, considering the role of anger in SSD, highlighting the need for more personalised treatments for each disorder.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"56-67"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The complex interaction between oestrogen receptor genes, oestradiol, and perinatal mood. 雌激素受体基因、雌二醇和围产期情绪之间复杂的相互作用。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-03-21 DOI: 10.1080/19585969.2025.2482126

Gianna Zorzini, Alexandra Johann, Jelena Dukic, Ulrike Ehlert

{"title":"The complex interaction between oestrogen receptor genes, oestradiol, and perinatal mood.","authors":"Gianna Zorzini, Alexandra Johann, Jelena Dukic, Ulrike Ehlert","doi":"10.1080/19585969.2025.2482126","DOIUrl":"10.1080/19585969.2025.2482126","url":null,"abstract":"Introduction: Genetic variations in oestrogen receptor (ER) genes are associated with inter-individual differences in the sensitivity of ER-α, ER-β and G protein-coupled oestrogen receptor (GPER). These sensitivity differences may modulate susceptibility to mood changes during phases of endogenous oestrogen fluctuations, thereby explaining individual vulnerability. This study examined the association between ER gene variations, oestradiol and perinatal mood disturbances.Methods: A total of 159 women were observed during the perinatal period, providing saliva samples for oestradiol assessment and completing self-report measures of depressive and anxiety symptoms at five time points. Polymorphisms in ER genes were determined from dried blood spots. The associations were analysed using linear mixed models.Results: The ER-α gene haplotypes were associated with perinatal mood disturbances. The CG haplotype was associated with perinatal depressive (p = 0.0162, F-test) and anxiety symptoms (p = 2.396e-05, F-test), whereas the TA haplotype was associated with perinatal anxiety symptoms (p = 0.004, F-test). The interaction between ER gene variations, oestradiol and perinatal mood disturbances was not significant.Conclusions: ER-α gene variations are associated with an increased susceptibility to perinatal mood disturbances. Sensitivity differences in ER-α appear to play a more important role for emotional processes than those in ER-β and GPER, independently of oestradiol levels. This might be explained by ER-α's more dominant expression in the hypothalamus and amygdala.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"24-33"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychedelic interventions for major depressive disorder in the elderly: Exploring novel therapies, promise and potential. 致幻剂干预老年人重度抑郁症：探索新疗法，前景和潜力。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-05-06 DOI: 10.1080/19585969.2025.2499458

Ivona-Maria Tudorancea, Gabriela-Dumitrita Stanciu, Carla Torrent, Santiago Madero, Lucian Hritcu, Bogdan-Ionel Tamba

{"title":"Psychedelic interventions for major depressive disorder in the elderly: Exploring novel therapies, promise and potential.","authors":"Ivona-Maria Tudorancea, Gabriela-Dumitrita Stanciu, Carla Torrent, Santiago Madero, Lucian Hritcu, Bogdan-Ionel Tamba","doi":"10.1080/19585969.2025.2499458","DOIUrl":"https://doi.org/10.1080/19585969.2025.2499458","url":null,"abstract":"The global population is ageing rapidly, with the number of individuals aged 60 and older reaching 1 billion in 2019 and expected to double by 2050. As people age, neuropsychological health often deteriorates, leading to a higher prevalence of age-related depression. Symptoms may include anxiety, apathy, mood instability, sadness, and, in severe cases, suicidal thoughts. Depression in the elderly is a widespread concern, and conventional treatments such as antidepressants are often limited by side effects, reduced efficacy, and complications arising from polypharmacy. In response, novel therapeutic approaches are being explored, including psychedelic interventions. Recent clinical and preclinical studies suggest that psychedelics could offer a promising treatment for major depressive disorder (MDD) in older adults. These compounds, known for their profound neurobiological effects, have gained attention for their potential to address depression where traditional therapies fall short. This review aims to examine the therapeutic promise of psychedelic substances, focusing on those that show potential for treating MDD in the elderly. We also explore the underlying mechanisms through which psychedelics may exert their effects and highlight the preclinical models that support their use. Finally, we address safety considerations and propose strategies to enhance the effectiveness and safety of psychedelics in future clinical trials, offering new hope for treating age-related depressive disorders.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"98-111"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0