Effects of light therapy on amygdala connectivity and serotoninergic system in young adults with subthreshold depression.

IF 8.3 2区医学 Q1 Medicine

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-06-01 DOI:10.1080/19585969.2025.2503367

Pan Chen, Guanmao Chen, Guixian Tang, Zibin Yang, Wenhao Ma, Chao Chen, Shilin Sun, Yuan Zhang, Shu Zhang, Zhangzhang Qi, Wenjie Fang, Lijun Jiang, Li Huang, Junxian Ma, Qian Tao, Ying Wang

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Abstract

Background: Bright light therapy (BLT) demonstrates efficacy in alleviating subthreshold depression (StD) among young adults. The amygdala plays a critical role in depression.

Methods: StD subjects were divided into BLT group (N=47) and placebo group (N=42). Depression severity was assessed using HAM-D, Centre for Epidemiologic Studies Depression Scale (CES-D) and Beck Depression Inventory (BDI) pre-/post-8-week intervention. Structural/resting-state fMRI scan was conducted. Seed-based static FC (sFC) and dynamic FC (dFC) analyses of the bilateral amygdala and their subfields were conducted.

Results: Compared to placebo, BLT showed reduced depression scale, and increased sFC of right basolateral amygdala (BLA)/superficial amygdala (SFA)-right middle temporal gyrus (MTG) and dFC of right centralmedial amygdala (CMA) and right inferior orbital frontal gyrus, and decreased sFC of right amygdalostriatal transition/CMA- left thalamus and dFC of right SFA- right medial prefrontal cortex after intervention; while the whole amygdala and its subnuclei volume did not change significantly after BLT. Right BLA-MTG sFC changes positively correlated with BDI improvement. Baseline amygdala sFC/dFC predicted post-BLT symptom changes. BLT-induced right BLA sFC alterations spatially correlated with 5-HT1A/5-HT2A receptor distributions, and right CMA dFC changes with 5-HT1A.

Conclusions: Findings suggest BLT modulates amygdala-thalamocortical circuits and serotonergic pathways, highlighting FC biomarkers for treatment efficacy assessment.

Trial registration clinicaltrials.gov identifier: ChiCTR2000032633.

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光治疗对阈下抑郁症年轻人杏仁核连通性和血清素能系统的影响。

背景：光明疗法（BLT）在缓解年轻人的阈下抑郁症（StD）方面显示出疗效。杏仁核在抑郁症中起着关键作用。方法：将性病患者分为BLT组（N=47）和安慰剂组（N=42）。采用HAM-D、流行病学研究中心抑郁量表（CES-D）和贝克抑郁量表（BDI）评估干预前后8周的抑郁严重程度。进行结构/静息状态fMRI扫描。对双侧杏仁核及其子场进行了基于种子的静态FC （sFC）和动态FC （dFC）分析。结果：与安慰剂相比，BLT干预后抑郁量表降低，右侧基底外侧杏仁核(BLA)/浅表杏仁核(SFA)-右侧颞中回（MTG）的sFC升高，右侧中央内侧杏仁核（CMA）和右侧下眶额回的dFC升高，右侧杏仁核纹状体过渡/CMA-左侧丘脑的sFC降低，右侧SFA-右侧内侧前额叶皮层的dFC降低；而整个杏仁核及其亚核体积在BLT后无明显变化。右BLA-MTG sFC变化与BDI改善呈正相关。基线杏仁核sFC/dFC预测blt后症状变化。blt诱导右侧BLA sFC变化与5-HT1A/5-HT2A受体分布存在空间相关性，右侧CMA dFC变化与5-HT1A相关。结论：研究结果表明，BLT调节杏仁核-丘脑皮质回路和血清素能通路，突出FC生物标志物用于治疗疗效评估。试验注册clinicaltrials.gov识别码：ChiCTR2000032633。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dialogues in Clinical Neuroscience Medicine-Psychiatry and Mental Health

CiteScore

19.30

自引率

1.20%

发文量

期刊介绍： Dialogues in Clinical Neuroscience (DCNS) endeavors to bridge the gap between clinical neuropsychiatry and the neurosciences by offering state-of-the-art information and original insights into pertinent clinical, biological, and therapeutic aspects. As an open access journal, DCNS ensures accessibility to its content for all interested parties. Each issue is curated to include expert reviews, original articles, and brief reports, carefully selected to offer a comprehensive understanding of the evolving landscape in clinical neuroscience. Join us in advancing knowledge and fostering dialogue in this dynamic field.