Dialogues in Clinical Neuroscience最新文献_第2页

The complex interaction between oestrogen receptor genes, oestradiol, and perinatal mood. 雌激素受体基因、雌二醇和围产期情绪之间复杂的相互作用。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-03-21 DOI: 10.1080/19585969.2025.2482126

Gianna Zorzini, Alexandra Johann, Jelena Dukic, Ulrike Ehlert

{"title":"The complex interaction between oestrogen receptor genes, oestradiol, and perinatal mood.","authors":"Gianna Zorzini, Alexandra Johann, Jelena Dukic, Ulrike Ehlert","doi":"10.1080/19585969.2025.2482126","DOIUrl":"10.1080/19585969.2025.2482126","url":null,"abstract":"Introduction: Genetic variations in oestrogen receptor (ER) genes are associated with inter-individual differences in the sensitivity of ER-α, ER-β and G protein-coupled oestrogen receptor (GPER). These sensitivity differences may modulate susceptibility to mood changes during phases of endogenous oestrogen fluctuations, thereby explaining individual vulnerability. This study examined the association between ER gene variations, oestradiol and perinatal mood disturbances.Methods: A total of 159 women were observed during the perinatal period, providing saliva samples for oestradiol assessment and completing self-report measures of depressive and anxiety symptoms at five time points. Polymorphisms in ER genes were determined from dried blood spots. The associations were analysed using linear mixed models.Results: The ER-α gene haplotypes were associated with perinatal mood disturbances. The CG haplotype was associated with perinatal depressive (p = 0.0162, F-test) and anxiety symptoms (p = 2.396e-05, F-test), whereas the TA haplotype was associated with perinatal anxiety symptoms (p = 0.004, F-test). The interaction between ER gene variations, oestradiol and perinatal mood disturbances was not significant.Conclusions: ER-α gene variations are associated with an increased susceptibility to perinatal mood disturbances. Sensitivity differences in ER-α appear to play a more important role for emotional processes than those in ER-β and GPER, independently of oestradiol levels. This might be explained by ER-α's more dominant expression in the hypothalamus and amygdala.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"24-33"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychedelic interventions for major depressive disorder in the elderly: Exploring novel therapies, promise and potential. 致幻剂干预老年人重度抑郁症：探索新疗法，前景和潜力。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-05-06 DOI: 10.1080/19585969.2025.2499458

Ivona-Maria Tudorancea, Gabriela-Dumitrita Stanciu, Carla Torrent, Santiago Madero, Lucian Hritcu, Bogdan-Ionel Tamba

{"title":"Psychedelic interventions for major depressive disorder in the elderly: Exploring novel therapies, promise and potential.","authors":"Ivona-Maria Tudorancea, Gabriela-Dumitrita Stanciu, Carla Torrent, Santiago Madero, Lucian Hritcu, Bogdan-Ionel Tamba","doi":"10.1080/19585969.2025.2499458","DOIUrl":"https://doi.org/10.1080/19585969.2025.2499458","url":null,"abstract":"The global population is ageing rapidly, with the number of individuals aged 60 and older reaching 1 billion in 2019 and expected to double by 2050. As people age, neuropsychological health often deteriorates, leading to a higher prevalence of age-related depression. Symptoms may include anxiety, apathy, mood instability, sadness, and, in severe cases, suicidal thoughts. Depression in the elderly is a widespread concern, and conventional treatments such as antidepressants are often limited by side effects, reduced efficacy, and complications arising from polypharmacy. In response, novel therapeutic approaches are being explored, including psychedelic interventions. Recent clinical and preclinical studies suggest that psychedelics could offer a promising treatment for major depressive disorder (MDD) in older adults. These compounds, known for their profound neurobiological effects, have gained attention for their potential to address depression where traditional therapies fall short. This review aims to examine the therapeutic promise of psychedelic substances, focusing on those that show potential for treating MDD in the elderly. We also explore the underlying mechanisms through which psychedelics may exert their effects and highlight the preclinical models that support their use. Finally, we address safety considerations and propose strategies to enhance the effectiveness and safety of psychedelics in future clinical trials, offering new hope for treating age-related depressive disorders.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"98-111"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12057789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring novel therapeutic strategies: Could psychedelic perspectives offer promising solutions for Alzheimer's disease comorbidities? 探索新的治疗策略：迷幻视角能否为阿尔茨海默病合并症提供有希望的解决方案？

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-03-19 DOI: 10.1080/19585969.2025.2480566

Michael Davidson, Gabriela-Dumitrita Stanciu, Jonathan Rabinowitz, Ilinca Untu, Romeo-Petru Dobrin, Bogdan-Ionel Tamba

{"title":"Exploring novel therapeutic strategies: Could psychedelic perspectives offer promising solutions for Alzheimer's disease comorbidities?","authors":"Michael Davidson, Gabriela-Dumitrita Stanciu, Jonathan Rabinowitz, Ilinca Untu, Romeo-Petru Dobrin, Bogdan-Ionel Tamba","doi":"10.1080/19585969.2025.2480566","DOIUrl":"10.1080/19585969.2025.2480566","url":null,"abstract":"The increasing prevalence of dementia within an ageing global population, combined with prolonged life expectancy, accentuates Alzheimer's disease (AD) as a multifaceted healthcare challenge. This challenge is further compounded by the limited therapeutic options currently available. Addressing the intricacies of AD management, the mitigation of comorbidities has emerged as a pivotal facet of treatment. Comorbid conditions, such as neurobehavioral symptoms, play a role in shaping the clinical course, management, and outcomes of this pathology; highlighting the importance of comprehensive care approaches for affected individuals. Exploration of psychedelic compounds in psychiatric and palliative care settings has recently uncovered promising therapeutic potential, enhancing neuroplasticity, emotional processing and connection. These effects are particularly relevant in the context of AD, where psychedelic therapy offers hope not only for mitigating core symptoms but also for addressing the array of comorbidities associated with this condition. The integration of this comprehensive method offers a chance to significantly enhance the care provided to those navigating the intricate landscape of AD. Therefore, the current paper reviews the intricate link between more frequent additional health conditions that may coexist with dementia, particularly in the context of AD, and explores the therapeutic potential of psychedelic compounds in addressing these concurrent conditions.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"1-12"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of attention deficit hyperactivity disorder in homeless children and adolescents: A systematic review and meta-analysis. 流浪儿童和青少年中注意缺陷多动障碍的患病率：系统回顾和荟萃分析。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-04-02 DOI: 10.1080/19585969.2025.2486355

Charles Denis, Denis Boucaud-Maitre, Jérôme Brunelin, Lucie Jurek, William Vallet, Caroline Demily

{"title":"Prevalence of attention deficit hyperactivity disorder in homeless children and adolescents: A systematic review and meta-analysis.","authors":"Charles Denis, Denis Boucaud-Maitre, Jérôme Brunelin, Lucie Jurek, William Vallet, Caroline Demily","doi":"10.1080/19585969.2025.2486355","DOIUrl":"10.1080/19585969.2025.2486355","url":null,"abstract":"Introduction: This systematic review and meta-analysis aimed to examine the prevalence of Attention deficit hyperactivity disorder (ADHD) in homeless children and adolescents, and the factors that may influence its prevalence.Methods: Relevant publications in Medline, Web of Science, Scopus and PsycINFO were systematically searched to identify studies on the prevalence of ADHD in homeless children and adolescents (≤19 years). The extracted data were pooled using a random-effects model.Results: Thirteen studies involving 2878 homeless children and adolescents were included (mean age: 12.0 years, sex F/M: 0.43). The prevalence rates of ADHD vary considerably across studies, ranging from 1.6% to 64.5%. The pooled prevalence of ADHD was 22.8% (95% CI 12.9-34.4%, I2 =98%). Meta-regression analyses indicated that age (slope = 0.046; p = .042) significantly increased ADHD prevalence. The prevalence of ADHD in studies with a mean age ≥ 12 years (43.1%, 95% CI 26.5-60.4%) was higher than those with a mean age < 12 years (13.1%, 95%CI 4.3-25.6).Conclusion: Despite the high heterogeneity of the studies, we observed that ADHD could affect almost a quarter of homeless children and adolescents. Reintegrating them into care systems and ensuring access to public health interventions tailored for homeless families and youth is imperative for breaking the cycle of homelessness and improving long-term trajectories.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"86-97"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leveraging machine learning to uncover the hidden links between trusting behavior and biological markers. 利用机器学习来发现信任行为和生物标记之间的隐藏联系。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-06-20 DOI: 10.1080/19585969.2025.2513697

Zimu Cao, Daiki Setoyama, Monica Natsumi Daudelin, Toshio Matsushima, Yuichiro Yada, Motoki Watabe, Takatoshi Hikida, Takahiro A Kato, Honda Naoki

{"title":"Leveraging machine learning to uncover the hidden links between trusting behavior and biological markers.","authors":"Zimu Cao, Daiki Setoyama, Monica Natsumi Daudelin, Toshio Matsushima, Yuichiro Yada, Motoki Watabe, Takatoshi Hikida, Takahiro A Kato, Honda Naoki","doi":"10.1080/19585969.2025.2513697","DOIUrl":"10.1080/19585969.2025.2513697","url":null,"abstract":"Understanding the decision-making mechanisms underlying trust is essential, particularly for individuals with mental disorders who often experience difficulties in forming interpersonal trust. In this study, we aimed to explore biomarkers associated with trust-based decision-making through quantitative analysis. However, quantifying internal decision-making processes is challenging, as they are not directly observable. To address this, we developed a machine learning method based on a Bayesian hierarchical model to quantitatively infer latent decision-making parameters from behavioural data collected during a trust game. Applying this method to data from patients with major depressive disorder (MDD) and healthy controls (HCs), we estimated individualised model parameters that regulate trust-related decisions. The model successfully predicted participants' behaviours in the task. Although no significant group-level differences were observed in the estimated parameters between the MDD and HC groups, we uncovered hidden links between trust-related decision-making processes and specific blood biomarkers. Notably, metabolites such as 5-aminolevulinic acid, acetylcarnitine, and 2-aminobutyric acid were significantly associated with individual differences in trusting behaviour. These findings provide valuable insight into the biological basis of trust-based decision-making. They also offer a novel framework for integrating behavioural modelling with biomarker discovery, potentially informing the development of targeted interventions to enhance social functioning and overall well-being.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"201-215"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antipsychotic off-label use in the 21st century: An enduring public health concern. 21世纪抗精神病药物的标签外使用：一个持久的公共卫生问题。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-01-10 DOI: 10.1080/19585969.2025.2449833

Hélène Verdoux

{"title":"Antipsychotic off-label use in the 21st century: An enduring public health concern.","authors":"Hélène Verdoux","doi":"10.1080/19585969.2025.2449833","DOIUrl":"10.1080/19585969.2025.2449833","url":null,"abstract":"Soon after the introduction of second-generation antipsychotics, antipsychotic off-label use (OLU) progressively became a common prescribing practice. This evolving practice should be regularly monitored considering the growing number of persons exposed to the adverse effects of antipsychotics. The aim of the present review was to synthesise the literature published over the last 15 years on antipsychotic OLU for mental health symptoms. Observational studies confirm the persisting high rate of antipsychotic OLU prescription in two out of three youths and 30-60% of adults using antipsychotics. Increasing rates of low-dose quetiapine prescriptions for anxiety or sleep symptoms are paradigmatic of the current public health concern regarding antipsychotic OLU. Such prescriptions receive impetus from industry-funded marketing strategies and prescribers' feeling of innocuousness, with a resulting underestimation of the risk of adverse drug reactions (ADR). However, antipsychotic OLU should be neither trivialised nor demonised since it may be the only therapeutic option in persons with resistant psychiatric disorders or serious ADR with labelled drugs. To reduce the populational impact of antipsychotic OLU, it is necessary to better control the influence of the pharmaceutical industry regarding newly marketed drugs and to better inform prescribers and users about the risks associated with OLU prescribing.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"1-12"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of causal relationships between genetic liability to inflammatory bowel disease and autism spectrum disorder by Mendelian randomization analysis. 通过孟德尔随机化分析评估炎症性肠病和自闭症谱系障碍遗传易感性之间的因果关系。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-02-03 DOI: 10.1080/19585969.2025.2460798

Ruijie Zeng, Rui Jiang, Wentao Huang, Huihuan Wu, Zewei Zhuo, Qi Yang, Jingwei Li, Felix W Leung, Weihong Sha, Hao Chen

{"title":"Evaluation of causal relationships between genetic liability to inflammatory bowel disease and autism spectrum disorder by Mendelian randomization analysis.","authors":"Ruijie Zeng, Rui Jiang, Wentao Huang, Huihuan Wu, Zewei Zhuo, Qi Yang, Jingwei Li, Felix W Leung, Weihong Sha, Hao Chen","doi":"10.1080/19585969.2025.2460798","DOIUrl":"10.1080/19585969.2025.2460798","url":null,"abstract":"Background: Emerging observational studies have indicated the association between autism spectrum disorder (ASD) and IBD, including Crohn's disease (CD) and ulcerative colitis (UC), whereas the causality remains unknown.Methods: Summary-level data from large-scale genome-wide association (GWAS) studies of IBD and ASD were retrieved. Mendelian randomisation analyses were performed with a series of sensitivity tests.Results: Genetic predisposition to ASD was not associated with the risk of IBD (odds ratio [OR] = 0.99, 95% confidence interval [CI = 0.91-1.06, p = 0.70; OR [95% CI]: 1.03 [0.93-1.13], p = 0.58 for CD; OR [95% CI]: 0.96 [0.87-1.05], p = 0.37 for UC) in the IIBDGC dataset. In the FinnGen dataset, their causal effects were unfounded (OR [95% CI]: 1.04 [0.94-1.15], p = 0.49 for IBD; OR [95% CI]: 1.08 [0.89-1.31], p = 0.42 for CD; OR [95% CI]: 1.00 [0.88-1.13], p = 0.95 for UC). In the meta-analysis of two datasets, the OR was 1.01 (95% CI 0.96-1.07, p = 0.45). For the risk of ASD under genetic liability to IBD, the OR from meta-analysis was 1.03 (95% CI 1.01-1.05, p = 0.01).Conclusion: Our findings indicate genetic predisposition to ASD might not increase the risk of IBD, whereas genetic liability to IBD is associated with an increased risk of ASD. Further investigations using more powerful datasets are warranted.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"26-34"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11795766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143124013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gambling disorder comorbidity a narrative review. 赌博障碍共病的叙述回顾。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2025-12-01 Epub Date: 2025-04-03 DOI: 10.1080/19585969.2025.2484288

Rishi Sharma, Aviv Weinstein

{"title":"Gambling disorder comorbidity a narrative review.","authors":"Rishi Sharma, Aviv Weinstein","doi":"10.1080/19585969.2025.2484288","DOIUrl":"10.1080/19585969.2025.2484288","url":null,"abstract":"Introduction: Problematic and pathological gambling (PG) lead to major adverse consequences for individuals, their families, and society and is highly comorbid with numerous other mental health disorders.Methods: This narrative review summarized population-based, cross-sectional, treatment and prospective studies on gambling disorder and comorbidity over the past 14 years.Results: These studies show a high rate of comorbidity of PG and substance and alcohol use disorders, mood and anxiety disorders. Prospective studies indicate that, in some cases, gambling precedes the onset of the comorbid disorder, while in other instances, the temporal relationship is reversed. Women face greater psychiatric comorbidity and are more likely to have mood disorders, suicidality, mania, anxiety and alcohol dependence. Treatment of PG can be effective by improving the gambling and depressive symptoms of PG.Conclusions: Over the past 15 years, significant progress has been made in understanding and treating GD and its psychiatric comorbidities, with evidence highlighting the reciprocal relationships between GD and conditions like substance use, mood and anxiety disorders.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"27 1","pages":"1-18"},"PeriodicalIF":8.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A global neuronal workspace model of functional neurological disorders. 功能性神经紊乱的全局神经元工作区模型。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2024-01-01 Epub Date: 2024-05-20 DOI: 10.1080/19585969.2024.2340131

Lionel Naccache, Esteban Munoz-Musat

引用次数: 0

Resting-state EEG microstate analysis of internet gaming disorder and alcohol use disorder. 网络游戏障碍和酒精使用障碍的静息态脑电图微状态分析。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2024-01-01 Epub Date: 2024-11-27 DOI: 10.1080/19585969.2024.2432913

Ji Sun Kim, Young Wook Song, Sungkean Kim, Ji-Yoon Lee, So Young Yoo, Joon Hwan Jang, Jung-Seok Choi

{"title":"Resting-state EEG microstate analysis of internet gaming disorder and alcohol use disorder.","authors":"Ji Sun Kim, Young Wook Song, Sungkean Kim, Ji-Yoon Lee, So Young Yoo, Joon Hwan Jang, Jung-Seok Choi","doi":"10.1080/19585969.2024.2432913","DOIUrl":"10.1080/19585969.2024.2432913","url":null,"abstract":"Introduction: To investigate the neurophysiological aspects of addiction, the microstate characteristics of internet gaming disorder (IGD), alcohol use disorder (AUD), and healthy control (HC) groups were compared using resting-state electroencephalography (EEG).Methods: In total, 199 young adults (75 patients with IGD, 57 patients with AUD, and 67 HCs) participated in this study. We conducted EEG microstate analysis among the groups and also compared the obtained parameters with the results of psychological assessments.Results: The global explained variance, occurrence, and coverage of microstate C were significantly lower in the AUD group than in the IGD group. Additionally, rates of transition from microstates A, B, and D to C were significantly lower in the AUD group than in the IGD group, whereas rates of transition from microstate A to B were lower in the IGD group compared to HCs. Furthermore, the occurrence of microstate C and transition from microstate B to C were negatively correlated with the Alcohol Use Disorder Identification and Behavioural Inhibition Scale score.Conclusion: There were significant differences in microstate characteristics among the groups, which correlated with the psychological scores. These findings suggest that microstate features can be used as neuromarkers in clinical settings to differentiate between addictive disorders and evaluate the pathophysiology of AUD and IGD.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"26 1","pages":"89-102"},"PeriodicalIF":8.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142734752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0