Dialogues in Clinical Neuroscience最新文献_第10页

Diagnosis as dialogue: historical and current perspectives . 作为对话的诊断:历史和当前的观点 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2020-03-01 DOI: 10.31887/DCNS.2020.22.1/phoff

Paul Hoff, Anke Maatz, Johannes Simon Vetter

{"title":"Diagnosis as dialogue: historical and current perspectives\u2029.","authors":"Paul Hoff, Anke Maatz, Johannes Simon Vetter","doi":"10.31887/DCNS.2020.22.1/phoff","DOIUrl":"https://doi.org/10.31887/DCNS.2020.22.1/phoff","url":null,"abstract":"Ever since psychiatry emerged as a clinical discipline and field of scientific inquiry in the late 18th century, debates about diagnosis have been at its very heart. Considered by many a requirement for clinical communication as well as for systematic study, others have critiqued psychiatric diagnosis for being modeled on a medical conception of disease that is ill-suited to the specific nature of mental disorders. Based on a review of seminal positions in the conceptual history of psychiatry and an examination of their epistemological underpinnings, we propose to consider diagnosis as dialogue. Such understanding, we argue, can serve as a meta-framework that provides a conceptual and practical umbrella to encourage open-minded conversation across the diverse conceptual and experiential frameworks that are characteristic of psychiatry. In this perspective psychopathology will also reinforce the interpersonal realm as a necessary element of any clinical encounter, be it diagnostic in purpose or otherwise. Current challenges to traditional diagnostic systems like Research Domain Criteria (RDoC) and Hierarchical Taxonomy of Psychopathology (HiTOP) are discussed in light of these considerations.\u2029.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"22 1","pages":"27-35"},"PeriodicalIF":8.3,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8d/ba/DialoguesClinNeurosci-22-27.PMC7365291.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38189721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Do we need to rethink our current classifications of mental disorders? . 我们是否需要重新考虑我们目前的精神障碍分类? 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2020-03-01 DOI: 10.31887/DCNS.2020.22.1/fthibaut

Florence Thibaut

引用次数: 0

Wernicke-Kleist-Leonhard phenotypes  of endogenous psychoses: a review of their validity . 内源性精神病的wernickke - kleist - leonhard表型 :对其有效性的回顾 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2020-03-01 DOI: 10.31887/DCNS.2020.22.1/jfoucher

Jack R Foucher, Micha Gawlik, Julian N Roth, Clément de Crespin de Billy, Ludovic C Jeanjean, Alexandre Obrecht, Olivier Mainberger, Julie M E Clauss, Julien Elowe, Sébastien Weibel, Benoit Schorr, Marcelo Cetkovich, Carlos Morra, Federico Rebok, Thomas A Ban, Barbara Bollmann, Mathilde M Roser, Markus S Hanke, Burkhard E Jabs, Ernst J Franzek, Fabrice Berna, Bruno Pfuhlmann

{"title":"Wernicke-Kleist-Leonhard phenotypes \u2028of endogenous psychoses: a review of their validity\u2029.","authors":"Jack R Foucher, Micha Gawlik, Julian N Roth, Clément de Crespin de Billy, Ludovic C Jeanjean, Alexandre Obrecht, Olivier Mainberger, Julie M E Clauss, Julien Elowe, Sébastien Weibel, Benoit Schorr, Marcelo Cetkovich, Carlos Morra, Federico Rebok, Thomas A Ban, Barbara Bollmann, Mathilde M Roser, Markus S Hanke, Burkhard E Jabs, Ernst J Franzek, Fabrice Berna, Bruno Pfuhlmann","doi":"10.31887/DCNS.2020.22.1/jfoucher","DOIUrl":"10.31887/DCNS.2020.22.1/jfoucher","url":null,"abstract":"While the ICD-DSM paradigm has been a major advance in clinical psychiatry, its usefulness for biological psychiatry is debated. By defining consensus-based disorders rather than empirically driven phenotypes, consensus classifications were not an implementation of the biomedical paradigm. In the field of endogenous psychoses, the Wernicke-Kleist-Leonhard (WKL) pathway has optimized the descriptions of 35 major phenotypes using common medical heuristics on lifelong diachronic observations. Regarding their construct validity, WKL phenotypes have good reliability and predictive and face validity. WKL phenotypes come with remarkable evidence for differential validity on age of onset, familiality, pregnancy complications, precipitating factors, and treatment response. Most impressive is the replicated separation of high- and low-familiality phenotypes. Created in the purest tradition of the biomedical paradigm, the WKL phenotypes deserve to be contrasted as credible alternatives with other approaches currently under discussion.\u2029.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"22 1","pages":"37-49"},"PeriodicalIF":8.3,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/52/DialoguesClinNeurosci-22-37.PMC7365293.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38189723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Neurodevelopmental disorders-the history and future of a diagnostic concept . 神经发育障碍-诊断概念的历史和未来 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2020-03-01 DOI: 10.31887/DCNS.2020.22.1/macrocq

Deborah J Morris-Rosendahl, Marc-Antoine Crocq

{"title":"Neurodevelopmental disorders-the history and future of a diagnostic concept\u2029.","authors":"Deborah J Morris-Rosendahl, Marc-Antoine Crocq","doi":"10.31887/DCNS.2020.22.1/macrocq","DOIUrl":"10.31887/DCNS.2020.22.1/macrocq","url":null,"abstract":"This article describes the history of the diagnostic class of neurodevelopmental disorders (NDDs) up to DSM-5. We further analyze how the development of genetics will transform the classification and diagnosis of NDDs. In DSM-5, NDDs include intellectual disability (ID), autism spectrum disorder (ASD), and attention-deficit/hyperactivity disorder (ADHD). Physicians in German-, French- and English-speaking countries (eg, Weikard, Georget, Esquirol, Down, Asperger, and Kanner) contributed to the phenomenological definitions of these disorders throughout the 18th and 20th centuries. These diagnostic categories show considerable comorbidity and phenotypic overlap. NDDs are one of the chapters of psychiatric nosology most likely to benefit from the approach advocated by the National Institute of Mental Health's Research Domain Criteria project. Genetic research supports the hypothesis that ID, ASD, ADHD, schizophrenia, and bipolar disorder lie on a neurodevelopmental continuum. The identification of recurrently observed copy number variants and disruptive gene variants in ASD (eg, CDH8, 16p11.2, SCN2A) led to the adoption of the genotype-first approach to characterize individuals at the etiological level.\u2029.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"22 1","pages":"65-72"},"PeriodicalIF":8.3,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/78/ce/DialoguesClinNeurosci-22-65.PMC7365295.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38189724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 121

Changes from ICD-10 to ICD-11 and future directions in psychiatric classification . 从ICD-10到ICD-11的变化和精神病学分类的未来方向 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2020-03-01 DOI: 10.31887/DCNS.2020.22.1/wgaebel

Wolfgang Gaebel, Johannes Stricker, Ariane Kerst

{"title":"Changes from ICD-10 to ICD-11 and future directions in psychiatric classification\u2029.","authors":"Wolfgang Gaebel, Johannes Stricker, Ariane Kerst","doi":"10.31887/DCNS.2020.22.1/wgaebel","DOIUrl":"https://doi.org/10.31887/DCNS.2020.22.1/wgaebel","url":null,"abstract":"This article provides a brief overview of the changes from ICD-10 to ICD-11 regarding the classification of mental, behavioral, or neurodevelopmental disorders. These changes include a new chapter structure, new diagnostic categories, changes in diagnostic criteria, and steps towards dimensionality. Additionally, we review evaluative field studies of ICD-11, which provide preliminary evidence for higher reliability and clinical utility of ICD-11 compared with ICD-10. Despite the extensive revision process, changes from ICD-10 to ICD-11 were relatively modest in that both systems are categorical, classifying mental phenomena based on self-reported or clinically observable symptoms. Other recent approaches to psychiatric nosology and classification (eg, neurobiology-based or hierarchical) are discussed. To meet the needs of different user groups, we propose expanding the stepwise approach to diagnosis introduced for some diagnostic categories in ICD-11, which includes categorical and dimensional elements.\u2029.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"22 1","pages":"7-15"},"PeriodicalIF":8.3,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/87/9d/DialoguesClinNeurosci-22-7.PMC7365296.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38189720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Neurobiology and the Hierarchical Taxonomy of Psychopathology: progress toward ontogenetically informed and clinically useful nosology . 神经生物学和精神病理学的层次分类法:向个体遗传学和临床有用的病分学进展 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2020-03-01 DOI: 10.31887/DCNS.2020.22.1/eperkins

Emily R Perkins, Keanan J Joyner, Christopher J Patrick, Bruce D Bartholow, Robert D Latzman, Colin G DeYoung, Roman Kotov, Ulrich Reininghaus, Samuel E Cooper, Mohammad H Afzali, Anna R Docherty, Michael N Dretsch, Nicholas R Eaton, Vina M Goghari, John D Haltigan, Robert F Krueger, Elizabeth A Martin, Giorgia Michelini, Anthony C Ruocco, Jennifer L Tackett, Noah C Venables, Irwin D Waldman, David H Zald

{"title":"Neurobiology and the Hierarchical Taxonomy of Psychopathology: progress toward ontogenetically informed and clinically useful nosology\u2029.","authors":"Emily R Perkins, Keanan J Joyner, Christopher J Patrick, Bruce D Bartholow, Robert D Latzman, Colin G DeYoung, Roman Kotov, Ulrich Reininghaus, Samuel E Cooper, Mohammad H Afzali, Anna R Docherty, Michael N Dretsch, Nicholas R Eaton, Vina M Goghari, John D Haltigan, Robert F Krueger, Elizabeth A Martin, Giorgia Michelini, Anthony C Ruocco, Jennifer L Tackett, Noah C Venables, Irwin D Waldman, David H Zald","doi":"10.31887/DCNS.2020.22.1/eperkins","DOIUrl":"https://doi.org/10.31887/DCNS.2020.22.1/eperkins","url":null,"abstract":"The Hierarchical Taxonomy of Psychopathology (HiTOP) is an empirical structural model of psychological symptoms formulated to improve the reliability and validity of clinical assessment. Neurobiology can inform assessments of early risk and intervention strategies, and the HiTOP model has greater potential to interface with neurobiological measures than traditional categorical diagnoses given its enhanced reliability. However, one complication is that observed biological correlates of clinical symptoms can reflect various factors, ranging from dispositional risk to consequences of psychopathology. In this paper, we argue that the HiTOP model provides an optimized framework for conducting research on the biological correlates of psychopathology from an ontogenetic perspective that distinguishes among indicators of liability, current symptoms, and consequences of illness. Through this approach, neurobiological research can contribute more effectively to identifying individuals at high dispositional risk, indexing treatment-related gains, and monitoring the consequences of mental illness, consistent with the aims of the HiTOP framework.\u2029.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"22 1","pages":"51-63"},"PeriodicalIF":8.3,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/75/89/DialoguesClinNeurosci-22-51.PMC7365294.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38189725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Do DSM classifications help or hinder drug development? . DSM分类是帮助还是阻碍 药物开发? 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2020-03-01 DOI: 10.31887/DCNS.2020.22.1/mdavidson

Michael Davidson, Cristian Gabos-Grecu

引用次数: 4

Unraveling the epigenetic landscape of depression: focus on early life stress . 揭开抑郁症的表观遗传学面貌：关注早期生活压力 .

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2019-12-01 DOI: 10.31887/DCNS.2019.21.4/enestler

Angélica Torres-Berrío, Orna Issler, Eric M Parise, Eric J Nestler

{"title":"Unraveling the epigenetic landscape of depression: focus on early life stress\u2029.","authors":"Angélica Torres-Berrío, Orna Issler, Eric M Parise, Eric J Nestler","doi":"10.31887/DCNS.2019.21.4/enestler","DOIUrl":"10.31887/DCNS.2019.21.4/enestler","url":null,"abstract":"Depression is a devastating psychiatric disorder caused by a combination of genetic predisposition and life events, mainly exposure to stress. Early life stress (ELS) in particular is known to \"scar\" the brain, leading to an increased susceptibility to developing depression later in life via epigenetic mechanisms. Epigenetic processes lead to changes in gene expression that are not due to changes in DNA sequence, but achieved via modulation of chromatin modifications, DNA methylation, and noncoding RNAs. Here we review common epigenetic mechanisms including the enzymes that take part in reading, writing, and erasing specific epigenetic marks. We then describe recent developments in understanding how ELS leads to changes in the epigenome that are manifested in increased susceptibility to depression-like abnormalities in animal models. We conclude with highlighting the need for future studies that will potentially enable the utilisation of the understanding of epigenetic changes linked to ELS for the development of much-needed novel therapeutic strategies and biomarker discovery.\u2029.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"21 4","pages":"341-357"},"PeriodicalIF":8.3,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/68/e9/DialoguesClinNeurosci-21-341.PMC6952747.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37553665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of epigenetic contributions  to post-traumatic stress disorder . 回顾表观遗传学对创伤后应激障碍的影响 .

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2019-12-01 DOI: 10.31887/DCNS.2019.21.4/kressler

Hunter Howie, Chuda M Rijal, Kerry J Ressler

{"title":"A review of epigenetic contributions \u2028to post-traumatic stress disorder\u2029.","authors":"Hunter Howie, Chuda M Rijal, Kerry J Ressler","doi":"10.31887/DCNS.2019.21.4/kressler","DOIUrl":"10.31887/DCNS.2019.21.4/kressler","url":null,"abstract":"Post-traumatic stress disorder (PTSD) is a syndrome which serves as a classic example of psychiatric disorders that result from the intersection of nature and nurture, or gene and environment. By definition, PTSD requires the experience of a traumatic exposure, and yet data suggest that the risk for PTSD in the aftermath of trauma also has a heritable (genetic) component. Thus, PTSD appears to require both a biological (genetic) predisposition that differentially alters how the individual responds to or recovers from trauma exposure. Epigenetics is defined as the study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself, and more recently it has come to refer to direct alteration of DNA regulation, but without altering the primary sequence of DNA, or the genetic code. With regards to PTSD, epigenetics provides one way for environmental exposure to be \"written\" upon the genome, as a direct result of gene and environment (trauma) interactions. This review provides an overview of the main currently understood types of epigenetic regulation, including DNA methylation, histone regulation of chromatin, and noncoding RNA regulation of gene expression. Furthermore, we examine recent literature related to how these methods of epigenetic regulation may be involved in differential risk and resilience for PTSD in the aftermath of trauma.\u2029.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"21 4","pages":"417-428"},"PeriodicalIF":8.3,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/37/78/DialoguesClinNeurosci-21-417.PMC6952751.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37553057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptional mechanisms of drug addiction . 药物成瘾的转录机制 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2019-12-01 DOI: 10.31887/DCNS.2019.21.4/pkenny

Purva Bali, Paul J Kenny

引用次数: 7