Sabrina Mörkl, Andreas Oberascher, Josef M Tatschl, Sonja Lackner, Thomaz F S Bastiaanssen, Mary I Butler, Maximilian Moser, Matthias Frühwirth, Harald Mangge, John F Cryan, Timothy G Dinan, Sandra J Holasek
{"title":"Cardiac vagal activity is associated with gut-microbiome patterns in women-An exploratory pilot study.","authors":"Sabrina Mörkl, Andreas Oberascher, Josef M Tatschl, Sonja Lackner, Thomaz F S Bastiaanssen, Mary I Butler, Maximilian Moser, Matthias Frühwirth, Harald Mangge, John F Cryan, Timothy G Dinan, Sandra J Holasek","doi":"10.1080/19585969.2022.2128697","DOIUrl":"https://doi.org/10.1080/19585969.2022.2128697","url":null,"abstract":"<p><strong>Introduction: </strong>A functional reciprocity between the gut microbiome and vagal nerve activity has been suggested, however, human studies addressing this phenomenon are limited.</p><p><strong>Methods: </strong>Twenty-four-hour cardiac vagal activity (CVA) was assessed from 73 female participants (aged 24.5 ± 4.3 years). Additionally, stool samples were subjected to 16SrRNA gene analysis (V1-V2). Quantitative Insights Into Microbial Ecology (QIIME) was used to analyse microbiome data. Additionally, inflammatory parameters (such as CRP and IL-6) were derived from serum samples.</p><p><strong>Results: </strong>Daytime CVA correlated significantly with gut microbiota diversity (<i>r</i> <sub>sp</sub> = 0.254, <i>p</i> = 0.030), CRP (<i>r</i> <sub>sp</sub> = -0.348, <i>p</i> = 0.003), and IL-6 (<i>r</i> <sub>sp</sub> = -0.320, <i>p</i> = 0.006). When the group was divided at the median of 24 h CVA (Mdn = 1.322), the following features were more abundant in the high CVA group: <i>Clostridia</i> (Linear discriminant analysis effect size (LDA) = 4.195, <i>p</i> = 0.029), <i>Clostridiales</i> (LDA = 4.195, <i>p</i> = 0.029), <i>Lachnospira</i> (LDA = 3.489, <i>p</i> = 0.004), <i>Ruminococcaceae</i> (LDA = 4.073, <i>p</i> = 0.010), <i>Faecalibacterium</i> (LDA = 3.982, <i>p</i> = 0.042), <i>Lactobacillales</i> (LDA = 3.317, <i>p</i> = 0.029), <i>Bacilli</i> (LDA = 3.294, <i>p</i> = 0.0350), <i>Streptococcaceae</i> (LDA = 3.353, <i>p</i> = 0.006), <i>Streptococcus</i> (LDA = 3.332, <i>p</i> = 0.011). Based on Dirichlet multinomial mixtures two enterotypes could be detected, which differed significantly in CVA, age, BMI, CRP, IL-6, and diversity.</p><p><strong>Conclusions: </strong>As an indicator of gut-brain communication, gut microbiome analysis could be extended by measurements of CVA to enhance our understanding of signalling <i>via</i> microbiota-gut-brain-axis and its alterations through psychobiotics.</p>","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"24 1","pages":"1-9"},"PeriodicalIF":8.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9559470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10367778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lost Illusions, or From Intellectronics to Informatics","authors":"","doi":"10.7551/mitpress/13633.003.0013","DOIUrl":"https://doi.org/10.7551/mitpress/13633.003.0013","url":null,"abstract":"","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"14 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73650511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Ethics of Technology and the Technology of Ethics","authors":"","doi":"10.7551/mitpress/13633.003.0016","DOIUrl":"https://doi.org/10.7551/mitpress/13633.003.0016","url":null,"abstract":"","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"2 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72938712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Applied Cybernetics: An Example from Sociology","authors":"","doi":"10.7551/mitpress/13633.003.0014","DOIUrl":"https://doi.org/10.7551/mitpress/13633.003.0014","url":null,"abstract":"","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"44 1 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91230203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"I","authors":"D. Anggraini, E. Purnamasari","doi":"10.7551/mitpress/13633.003.0004","DOIUrl":"https://doi.org/10.7551/mitpress/13633.003.0004","url":null,"abstract":"This study aims to (1) describe the types of focalization used in Oka Rusmini’s Tempurung, (2) describe the relation between focalization and the other intrinsic elements, and (3) to describe the relevance of focalization in the novel to the study of literature in Senior High Schools (SMA)/Vocational Schools (SMK). This research is a qualitative research. The data were collected through the library research method by reading and note-taking techniques. The data were analyzed using the descriptive-analytical method. There are three research findings: (1) Oka Rusmini’s Tempurung tends to use internal focalization with the pronoun ”I”; (2) the focalization in the novel appears in various forms, namely direct speech, soliloquy, narrator’s commentary, and characters’ actions that can be directly related to character aspects and language style, and (3) focalization in Oka Rusmini’s Tempurung has relevance to the study of literature in SMA/SMK.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"9 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74232097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ilya Kabakov in Conversation with Ksenia Nouril","authors":"Ilya Kabakov, V. Pivovarov","doi":"10.36019/9781978814950-005","DOIUrl":"https://doi.org/10.36019/9781978814950-005","url":null,"abstract":"","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"43 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84236698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Catalogue of the Exhibition","authors":"Ilya Kabakov, V. Pivovarov","doi":"10.36019/9781978814950-010","DOIUrl":"https://doi.org/10.36019/9781978814950-010","url":null,"abstract":"","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"9 1","pages":""},"PeriodicalIF":8.3,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88392437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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