Dialogues in Clinical Neuroscience最新文献_第8页

Neurodevelopmental disorders-the history and future of a diagnostic concept . 神经发育障碍-诊断概念的历史和未来 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2020-03-01 DOI: 10.31887/DCNS.2020.22.1/macrocq

Deborah J Morris-Rosendahl, Marc-Antoine Crocq

{"title":"Neurodevelopmental disorders-the history and future of a diagnostic concept\u2029.","authors":"Deborah J Morris-Rosendahl, Marc-Antoine Crocq","doi":"10.31887/DCNS.2020.22.1/macrocq","DOIUrl":"10.31887/DCNS.2020.22.1/macrocq","url":null,"abstract":"This article describes the history of the diagnostic class of neurodevelopmental disorders (NDDs) up to DSM-5. We further analyze how the development of genetics will transform the classification and diagnosis of NDDs. In DSM-5, NDDs include intellectual disability (ID), autism spectrum disorder (ASD), and attention-deficit/hyperactivity disorder (ADHD). Physicians in German-, French- and English-speaking countries (eg, Weikard, Georget, Esquirol, Down, Asperger, and Kanner) contributed to the phenomenological definitions of these disorders throughout the 18th and 20th centuries. These diagnostic categories show considerable comorbidity and phenotypic overlap. NDDs are one of the chapters of psychiatric nosology most likely to benefit from the approach advocated by the National Institute of Mental Health's Research Domain Criteria project. Genetic research supports the hypothesis that ID, ASD, ADHD, schizophrenia, and bipolar disorder lie on a neurodevelopmental continuum. The identification of recurrently observed copy number variants and disruptive gene variants in ASD (eg, CDH8, 16p11.2, SCN2A) led to the adoption of the genotype-first approach to characterize individuals at the etiological level.\u2029.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"22 1","pages":"65-72"},"PeriodicalIF":8.3,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/78/ce/DialoguesClinNeurosci-22-65.PMC7365295.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38189724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 121

Changes from ICD-10 to ICD-11 and future directions in psychiatric classification . 从ICD-10到ICD-11的变化和精神病学分类的未来方向 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2020-03-01 DOI: 10.31887/DCNS.2020.22.1/wgaebel

Wolfgang Gaebel, Johannes Stricker, Ariane Kerst

{"title":"Changes from ICD-10 to ICD-11 and future directions in psychiatric classification\u2029.","authors":"Wolfgang Gaebel, Johannes Stricker, Ariane Kerst","doi":"10.31887/DCNS.2020.22.1/wgaebel","DOIUrl":"https://doi.org/10.31887/DCNS.2020.22.1/wgaebel","url":null,"abstract":"This article provides a brief overview of the changes from ICD-10 to ICD-11 regarding the classification of mental, behavioral, or neurodevelopmental disorders. These changes include a new chapter structure, new diagnostic categories, changes in diagnostic criteria, and steps towards dimensionality. Additionally, we review evaluative field studies of ICD-11, which provide preliminary evidence for higher reliability and clinical utility of ICD-11 compared with ICD-10. Despite the extensive revision process, changes from ICD-10 to ICD-11 were relatively modest in that both systems are categorical, classifying mental phenomena based on self-reported or clinically observable symptoms. Other recent approaches to psychiatric nosology and classification (eg, neurobiology-based or hierarchical) are discussed. To meet the needs of different user groups, we propose expanding the stepwise approach to diagnosis introduced for some diagnostic categories in ICD-11, which includes categorical and dimensional elements.\u2029.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"22 1","pages":"7-15"},"PeriodicalIF":8.3,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/87/9d/DialoguesClinNeurosci-22-7.PMC7365296.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38189720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 35

Neurobiology and the Hierarchical Taxonomy of Psychopathology: progress toward ontogenetically informed and clinically useful nosology . 神经生物学和精神病理学的层次分类法:向个体遗传学和临床有用的病分学进展 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2020-03-01 DOI: 10.31887/DCNS.2020.22.1/eperkins

Emily R Perkins, Keanan J Joyner, Christopher J Patrick, Bruce D Bartholow, Robert D Latzman, Colin G DeYoung, Roman Kotov, Ulrich Reininghaus, Samuel E Cooper, Mohammad H Afzali, Anna R Docherty, Michael N Dretsch, Nicholas R Eaton, Vina M Goghari, John D Haltigan, Robert F Krueger, Elizabeth A Martin, Giorgia Michelini, Anthony C Ruocco, Jennifer L Tackett, Noah C Venables, Irwin D Waldman, David H Zald

{"title":"Neurobiology and the Hierarchical Taxonomy of Psychopathology: progress toward ontogenetically informed and clinically useful nosology\u2029.","authors":"Emily R Perkins, Keanan J Joyner, Christopher J Patrick, Bruce D Bartholow, Robert D Latzman, Colin G DeYoung, Roman Kotov, Ulrich Reininghaus, Samuel E Cooper, Mohammad H Afzali, Anna R Docherty, Michael N Dretsch, Nicholas R Eaton, Vina M Goghari, John D Haltigan, Robert F Krueger, Elizabeth A Martin, Giorgia Michelini, Anthony C Ruocco, Jennifer L Tackett, Noah C Venables, Irwin D Waldman, David H Zald","doi":"10.31887/DCNS.2020.22.1/eperkins","DOIUrl":"https://doi.org/10.31887/DCNS.2020.22.1/eperkins","url":null,"abstract":"The Hierarchical Taxonomy of Psychopathology (HiTOP) is an empirical structural model of psychological symptoms formulated to improve the reliability and validity of clinical assessment. Neurobiology can inform assessments of early risk and intervention strategies, and the HiTOP model has greater potential to interface with neurobiological measures than traditional categorical diagnoses given its enhanced reliability. However, one complication is that observed biological correlates of clinical symptoms can reflect various factors, ranging from dispositional risk to consequences of psychopathology. In this paper, we argue that the HiTOP model provides an optimized framework for conducting research on the biological correlates of psychopathology from an ontogenetic perspective that distinguishes among indicators of liability, current symptoms, and consequences of illness. Through this approach, neurobiological research can contribute more effectively to identifying individuals at high dispositional risk, indexing treatment-related gains, and monitoring the consequences of mental illness, consistent with the aims of the HiTOP framework.\u2029.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"22 1","pages":"51-63"},"PeriodicalIF":8.3,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/75/89/DialoguesClinNeurosci-22-51.PMC7365294.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38189725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Do DSM classifications help or hinder drug development? . DSM分类是帮助还是阻碍 药物开发? 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2020-03-01 DOI: 10.31887/DCNS.2020.22.1/mdavidson

Michael Davidson, Cristian Gabos-Grecu

引用次数: 4

Unraveling the epigenetic landscape of depression: focus on early life stress . 揭开抑郁症的表观遗传学面貌：关注早期生活压力 .

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2019-12-01 DOI: 10.31887/DCNS.2019.21.4/enestler

Angélica Torres-Berrío, Orna Issler, Eric M Parise, Eric J Nestler

{"title":"Unraveling the epigenetic landscape of depression: focus on early life stress\u2029.","authors":"Angélica Torres-Berrío, Orna Issler, Eric M Parise, Eric J Nestler","doi":"10.31887/DCNS.2019.21.4/enestler","DOIUrl":"10.31887/DCNS.2019.21.4/enestler","url":null,"abstract":"Depression is a devastating psychiatric disorder caused by a combination of genetic predisposition and life events, mainly exposure to stress. Early life stress (ELS) in particular is known to \"scar\" the brain, leading to an increased susceptibility to developing depression later in life via epigenetic mechanisms. Epigenetic processes lead to changes in gene expression that are not due to changes in DNA sequence, but achieved via modulation of chromatin modifications, DNA methylation, and noncoding RNAs. Here we review common epigenetic mechanisms including the enzymes that take part in reading, writing, and erasing specific epigenetic marks. We then describe recent developments in understanding how ELS leads to changes in the epigenome that are manifested in increased susceptibility to depression-like abnormalities in animal models. We conclude with highlighting the need for future studies that will potentially enable the utilisation of the understanding of epigenetic changes linked to ELS for the development of much-needed novel therapeutic strategies and biomarker discovery.\u2029.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"21 4","pages":"341-357"},"PeriodicalIF":8.3,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/68/e9/DialoguesClinNeurosci-21-341.PMC6952747.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37553665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of epigenetic contributions  to post-traumatic stress disorder . 回顾表观遗传学对创伤后应激障碍的影响 .

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2019-12-01 DOI: 10.31887/DCNS.2019.21.4/kressler

Hunter Howie, Chuda M Rijal, Kerry J Ressler

{"title":"A review of epigenetic contributions \u2028to post-traumatic stress disorder\u2029.","authors":"Hunter Howie, Chuda M Rijal, Kerry J Ressler","doi":"10.31887/DCNS.2019.21.4/kressler","DOIUrl":"10.31887/DCNS.2019.21.4/kressler","url":null,"abstract":"Post-traumatic stress disorder (PTSD) is a syndrome which serves as a classic example of psychiatric disorders that result from the intersection of nature and nurture, or gene and environment. By definition, PTSD requires the experience of a traumatic exposure, and yet data suggest that the risk for PTSD in the aftermath of trauma also has a heritable (genetic) component. Thus, PTSD appears to require both a biological (genetic) predisposition that differentially alters how the individual responds to or recovers from trauma exposure. Epigenetics is defined as the study of changes in organisms caused by modification of gene expression rather than alteration of the genetic code itself, and more recently it has come to refer to direct alteration of DNA regulation, but without altering the primary sequence of DNA, or the genetic code. With regards to PTSD, epigenetics provides one way for environmental exposure to be \"written\" upon the genome, as a direct result of gene and environment (trauma) interactions. This review provides an overview of the main currently understood types of epigenetic regulation, including DNA methylation, histone regulation of chromatin, and noncoding RNA regulation of gene expression. Furthermore, we examine recent literature related to how these methods of epigenetic regulation may be involved in differential risk and resilience for PTSD in the aftermath of trauma.\u2029.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"21 4","pages":"417-428"},"PeriodicalIF":8.3,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/37/78/DialoguesClinNeurosci-21-417.PMC6952751.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37553057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptional mechanisms of drug addiction . 药物成瘾的转录机制 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2019-12-01 DOI: 10.31887/DCNS.2019.21.4/pkenny

Purva Bali, Paul J Kenny

引用次数: 7

Epigenetics: the missing link between genes and psychiatric disorders? . 表观遗传学:基因与精神疾病之间缺失的一环? 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2019-12-01 DOI: 10.31887/DCNS.2019.21.4/fthibaut

Florence Thibaut

引用次数: 1

Genetic and epigenetic editing in nervous system . 神经系统 的遗传和表观遗传编辑。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2019-12-01 DOI: 10.31887/DCNS.2019.21.4/jday

Jeremy J Day

{"title":"Genetic and epigenetic editing in\u2028nervous system\u2029.","authors":"Jeremy J Day","doi":"10.31887/DCNS.2019.21.4/jday","DOIUrl":"https://doi.org/10.31887/DCNS.2019.21.4/jday","url":null,"abstract":"Numerous neuronal functions depend on the precise spatiotemporal regulation of gene expression, and the cellular machinery that contributes to this regulation is frequently disrupted in neurodevelopmental, neuropsychiatric, and neurological disease states. Recent advances in gene editing technology have enabled increasingly rapid understanding of gene sequence variation and gene regulatory function in the central nervous system. Moreover, these tools have provided new insights into the locus-specific functions of epigenetic modifications and enabled epigenetic editing at specific gene loci in disease contexts. Continued development of clustered regularly interspaced short palindromic repeats (CRISPR)-based tools has provided not only cell-specific modulation, but also rapid induction profiles that permit sophisticated interrogation of the temporal dynamics that contribute to brain health and disease. This review summarizes recent advances in genetic editing, transcriptional modulation, and epigenetic reorganization, with a focus on applications to neuronal systems and potential uses in brain disorders characterized by genetic sequence variation or transcriptional dysregulation.\u2029.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"21 4","pages":"359-368"},"PeriodicalIF":8.3,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/29/d5/DialoguesClinNeurosci-21-359.PMC6952749.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37553666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The epigenetics of perinatal stress . 围产期应激的表观遗传学 。

IF 8.3 2区医学

Dialogues in Clinical Neuroscience Pub Date : 2019-12-01 DOI: 10.31887/DCNS.2019.21.4/mszyf

Moshe Szyf

{"title":"The epigenetics of perinatal stress\u2029.","authors":"Moshe Szyf","doi":"10.31887/DCNS.2019.21.4/mszyf","DOIUrl":"https://doi.org/10.31887/DCNS.2019.21.4/mszyf","url":null,"abstract":"Early life adversity is associated with long-term effects on physical and mental health later in life, but the mechanisms are yet unclear. Epigenetic mechanisms program cell-type-specific gene expression during development, enabling one genome to be programmed in many ways, resulting in diverse stable profiles of gene expression in different cells and organs in the body. DNA methylation, an enzymatic covalent modification of DNA, has been one of the principal epigenetic mechanisms investigated. Emerging evidence is consistent with the idea that epigenetic processes are involved in embedding the impact of early-life experience in the genome and mediating between social environments and later behavioral phenotypes. Whereas there is evidence supporting this hypothesis in animal studies, human studies have been less conclusive. A major problem is the fact that the brain is inaccessible to epigenetic studies in humans and the relevance of DNA methylation in peripheral tissues to behavioral phenotypes has been questioned. In addition, human studies are usually confounded with genetic and environmental heterogeneity and it is very difficult to derive causality. The idea that epigenetic mechanisms mediate the life-long effects of perinatal adversity has attractive potential implications for early detection, prevention, and intervention in mental health disorders will be discussed.\u2029.","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":"21 4","pages":"369-378"},"PeriodicalIF":8.3,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f3/03/DialoguesClinNeurosci-21-369.PMC6952743.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37553667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26