Jack R Foucher, Micha Gawlik, Julian N Roth, Clément de Crespin de Billy, Ludovic C Jeanjean, Alexandre Obrecht, Olivier Mainberger, Julie M E Clauss, Julien Elowe, Sébastien Weibel, Benoit Schorr, Marcelo Cetkovich, Carlos Morra, Federico Rebok, Thomas A Ban, Barbara Bollmann, Mathilde M Roser, Markus S Hanke, Burkhard E Jabs, Ernst J Franzek, Fabrice Berna, Bruno Pfuhlmann
{"title":"内源性精神病的wernickke - kleist - leonhard表型\u2028:对其有效性的回顾\u2029。","authors":"Jack R Foucher, Micha Gawlik, Julian N Roth, Clément de Crespin de Billy, Ludovic C Jeanjean, Alexandre Obrecht, Olivier Mainberger, Julie M E Clauss, Julien Elowe, Sébastien Weibel, Benoit Schorr, Marcelo Cetkovich, Carlos Morra, Federico Rebok, Thomas A Ban, Barbara Bollmann, Mathilde M Roser, Markus S Hanke, Burkhard E Jabs, Ernst J Franzek, Fabrice Berna, Bruno Pfuhlmann","doi":"10.31887/DCNS.2020.22.1/jfoucher","DOIUrl":null,"url":null,"abstract":"<p><p>While the ICD-DSM paradigm has been a major advance in clinical psychiatry, its usefulness for biological psychiatry is debated. By defining consensus-based disorders rather than empirically driven phenotypes, consensus classifications were not an implementation of the biomedical paradigm. In the field of endogenous psychoses, the Wernicke-Kleist-Leonhard (WKL) pathway has optimized the descriptions of 35 major phenotypes using common medical heuristics on lifelong diachronic observations. Regarding their construct validity, WKL phenotypes have good reliability and predictive and face validity. WKL phenotypes come with remarkable evidence for differential validity on age of onset, familiality, pregnancy complications, precipitating factors, and treatment response. Most impressive is the replicated separation of high- and low-familiality phenotypes. Created in the purest tradition of the biomedical paradigm, the WKL phenotypes deserve to be contrasted as credible alternatives with other approaches currently under discussion.\u2029.</p>","PeriodicalId":54343,"journal":{"name":"Dialogues in Clinical Neuroscience","volume":null,"pages":null},"PeriodicalIF":8.3000,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/52/DialoguesClinNeurosci-22-37.PMC7365293.pdf","citationCount":"26","resultStr":"{\"title\":\"Wernicke-Kleist-Leonhard phenotypes \\u2028of endogenous psychoses: a review of their validity\\u2029.\",\"authors\":\"Jack R Foucher, Micha Gawlik, Julian N Roth, Clément de Crespin de Billy, Ludovic C Jeanjean, Alexandre Obrecht, Olivier Mainberger, Julie M E Clauss, Julien Elowe, Sébastien Weibel, Benoit Schorr, Marcelo Cetkovich, Carlos Morra, Federico Rebok, Thomas A Ban, Barbara Bollmann, Mathilde M Roser, Markus S Hanke, Burkhard E Jabs, Ernst J Franzek, Fabrice Berna, Bruno Pfuhlmann\",\"doi\":\"10.31887/DCNS.2020.22.1/jfoucher\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>While the ICD-DSM paradigm has been a major advance in clinical psychiatry, its usefulness for biological psychiatry is debated. By defining consensus-based disorders rather than empirically driven phenotypes, consensus classifications were not an implementation of the biomedical paradigm. In the field of endogenous psychoses, the Wernicke-Kleist-Leonhard (WKL) pathway has optimized the descriptions of 35 major phenotypes using common medical heuristics on lifelong diachronic observations. Regarding their construct validity, WKL phenotypes have good reliability and predictive and face validity. WKL phenotypes come with remarkable evidence for differential validity on age of onset, familiality, pregnancy complications, precipitating factors, and treatment response. Most impressive is the replicated separation of high- and low-familiality phenotypes. Created in the purest tradition of the biomedical paradigm, the WKL phenotypes deserve to be contrasted as credible alternatives with other approaches currently under discussion.\\u2029.</p>\",\"PeriodicalId\":54343,\"journal\":{\"name\":\"Dialogues in Clinical Neuroscience\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":8.3000,\"publicationDate\":\"2020-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/52/DialoguesClinNeurosci-22-37.PMC7365293.pdf\",\"citationCount\":\"26\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Dialogues in Clinical Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.31887/DCNS.2020.22.1/jfoucher\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dialogues in Clinical Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.31887/DCNS.2020.22.1/jfoucher","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Medicine","Score":null,"Total":0}
Wernicke-Kleist-Leonhard phenotypes of endogenous psychoses: a review of their validity .
While the ICD-DSM paradigm has been a major advance in clinical psychiatry, its usefulness for biological psychiatry is debated. By defining consensus-based disorders rather than empirically driven phenotypes, consensus classifications were not an implementation of the biomedical paradigm. In the field of endogenous psychoses, the Wernicke-Kleist-Leonhard (WKL) pathway has optimized the descriptions of 35 major phenotypes using common medical heuristics on lifelong diachronic observations. Regarding their construct validity, WKL phenotypes have good reliability and predictive and face validity. WKL phenotypes come with remarkable evidence for differential validity on age of onset, familiality, pregnancy complications, precipitating factors, and treatment response. Most impressive is the replicated separation of high- and low-familiality phenotypes. Created in the purest tradition of the biomedical paradigm, the WKL phenotypes deserve to be contrasted as credible alternatives with other approaches currently under discussion. .
期刊介绍：
Dialogues in Clinical Neuroscience (DCNS) endeavors to bridge the gap between clinical neuropsychiatry and the neurosciences by offering state-of-the-art information and original insights into pertinent clinical, biological, and therapeutic aspects. As an open access journal, DCNS ensures accessibility to its content for all interested parties. Each issue is curated to include expert reviews, original articles, and brief reports, carefully selected to offer a comprehensive understanding of the evolving landscape in clinical neuroscience. Join us in advancing knowledge and fostering dialogue in this dynamic field.
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