Cardiovascular Engineering and Technology最新文献

{"title":"A Novel Transcatheter Posterior Ventricular Anchoring Neochordoplasty Mitral Valve Repair Device.","authors":"Matthew H Park, Annabel M Imbrie-Moore, Michael J Paulsen, Yuanjia Zhu, John W MacArthur, Y Joseph Woo","doi":"10.1007/s13239-024-00764-9","DOIUrl":"10.1007/s13239-024-00764-9","url":null,"abstract":"<p><strong>Purpose: </strong>Advancements in minimally invasive technologies to decrease postoperative morbidity and recovery times represent a large opportunity for mitral valve repair operations. However, current technologies are unable to replicate gold standard surgical neochord implantation.</p><p><strong>Methods: </strong>We developed a novel neochordal repair device, Minimally Invasive Ventricular Anchoring Neochordoplasty (MIVAN), which operates via transcatheter, trans-septal anchoring to the posterior ventricular wall. We evaluated MIVAN in an ex vivo heart simulator and compared it with surgical neochordal repair and MitraClip using a prolapse model.</p><p><strong>Results: </strong>Upon MIVAN repair of the model (n = 5), regurgitant fraction was reduced from 19.46 ± 1.77% to 7.30 ± 0.99% (p = 0.01). Surgical neochordal repair reduced regurgitant fraction to 5.65 ± 0.66%, but there was no significant difference between MIVAN and surgical repair (p = 0.22). Unpaired MitraClip repair had significantly higher regurgitant fraction of 11.9 ± 1.40%, compared with those of neochord (p < 0.01) and MIVAN (p = 0.03) repairs.</p><p><strong>Conclusions: </strong>MIVAN represents a high-value opportunity for minimally invasive mitral valve repair. The benefits of the percutaneous, trans-septal approach for implantation on the posterior ventricular wall necessitate the expanded exploration of this device as a treatment alternative.</p>","PeriodicalId":54322,"journal":{"name":"Cardiovascular Engineering and Technology","volume":" ","pages":"251-257"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Shortcomings of the Flow Convergence Method for Quantification of Mitral Regurgitation in a Pulsatile In-Vitro Environment and with Computational Fluid Dynamics.","authors":"Robin Leister, Roger Karl, Lubov Stroh, Derliz Mereles, Matthias Eden, Luis Neff, Raffaele de Simone, Gabriele Romano, Jochen Kriegseis, Matthias Karck, Christoph Lichtenstern, Norbert Frey, Bettina Frohnapfel, Alexander Stroh, Sandy Engelhardt","doi":"10.1007/s13239-024-00763-w","DOIUrl":"10.1007/s13239-024-00763-w","url":null,"abstract":"<p><p>The flow convergence method includes calculation of the proximal isovelocity surface area (PISA) and is widely used to classify mitral regurgitation (MR) with echocardiography. It constitutes a primary decision factor for determination of treatment and should therefore be a robust quantification method. However, it is known for its tendency to underestimate MR and its dependence on user expertise. The present work systematically compares different pulsatile flow profiles arising from different regurgitation orifices using transesophageal echocardiographic (TEE) probe and particle image velocimetry (PIV) as a reference in an in-vitro environment. It is found that the inter-observer variability using echocardiography is small compared to the systematic underestimation of the regurgitation volume for large orifice areas (up to 52%) where a violation of the flow convergence method assumptions occurs. From a flow perspective, a starting vortex was found as a dominant flow pattern in the regurgant jet for all orifice shapes and sizes. A series of simplified computational fluid dynamics (CFD) simulations indicate that selecting a suboptimal aliasing velocity during echocardiography measurements might be a primary source of potential underestimation in MR characterization via the PISA-based method, reaching up to 40%. In this study, it has been noted in clinical observations that physicians often select an aliasing velocity higher than necessary for optimal estimation in diagnostic procedures.</p>","PeriodicalId":54322,"journal":{"name":"Cardiovascular Engineering and Technology","volume":"16 2","pages":"155-170"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and Prototyping of a Novel Triple Lumen Photo-Angioplasty Device: Lumi-Solve-T.","authors":"Aldous Tria, Anak Dharma, Loren Spiegel, Andrew E Rodda, Asvini Allada, Pavel Sluka, Amarnath Sangeetha Menon, Ethan Prabaharan, Pulasthi V Wettesinghe, Justin W Adams, Manfred Spanger, Anthony E Dear","doi":"10.1007/s13239-024-00768-5","DOIUrl":"10.1007/s13239-024-00768-5","url":null,"abstract":"<p><strong>Purpose: </strong>A triple lumen iteration of the novel photo-angioplasty drug eluting balloon catheter (DEBc) Lumi-Solve may be compromised by guidewire shadow (GWS)-mediated attenuation of balloon surface drug activation. The current study aimed to design and evaluate a novel triple lumen prototype, designated Lumi-Solve-T, to circumvent these issues.</p><p><strong>Methods: </strong>Effects of guidewire shadowing (GWS) on vascular smooth muscle cell (VSMC) proliferation was evaluated using the MTT assay. In-silico modelling of GWS in the novel triple lumen design was conducted. Computer-aided design (CAD) and finite element analysis (FEA) contributed to development of a novel triple lumen catheter. 3D printing of rudimentary and refined prototypes of the catheter together with assembly of a novel fibre-optic (FO) complex and ex-vivo evaluation of the triple lumen device, Lumi-Solve T, was also performed.</p><p><strong>Results: </strong>GW insertion in a parallel triple lumen FO: GW port orientation demonstrated significantly reduced inhibition of VSMC proliferation after 7 days confirming the need for an alternative triple lumen design. In-silico analysis identified a multi-fibre FO sleeve design supported uniform, radial and uninterrupted UV365nm light transmission to the angioplasty balloon surface. FEA confirmed a multi-fibre FO ribbon design afforded a practical method of FO sleeve generation and facilitated a novel hub configuration able to afford a FO ribbon to sleeve transition. 3D printed prototypes demonstrated the utility of the novel design.</p><p><strong>Conclusions: </strong>A dedicated third port and lumen for the Lumi-Solve FO is required for optimal balloon surface photo-activation. A novel triple lumen design, Lumi-Solve-T, incorporating a ribbon to sleeve FO transition and novel hub design offers a realistic solution to current device limitations.</p>","PeriodicalId":54322,"journal":{"name":"Cardiovascular Engineering and Technology","volume":" ","pages":"211-221"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flow-Based Coronary Artery Bypass Graft Patency Metrics: Uncertainty Quantification Simulations to Guide Development.","authors":"Sita Drost, Cornelis J Drost","doi":"10.1007/s13239-024-00765-8","DOIUrl":"10.1007/s13239-024-00765-8","url":null,"abstract":"<p><strong>Purpose: </strong>Over time, transit time flow measurement (TTFM) has proven itself as a simple and effective tool for intra-operative evaluation of coronary artery bypass grafts (CABGs). However, metrics used to screen for possible technical error show considerable spread, preventing the definition of sharp cut-off values to distinguish between patent, questionable, and failed grafts. The simulation study presented in this paper aims to quantify this uncertainty for commonly used patency metrics, and to identify the most important physiological parameters influencing it.</p><p><strong>Methods: </strong>Uncertainty quantification was performed on a realistic multiscale numerical model of the coronary circulation, guided by Morris screening sensitivity analysis of a simpler, lumped-parameter model. Simulation results were qualitatively verified against results of a recent clinical study.</p><p><strong>Results: </strong>Correspondence with clinical study data is reasonable, especially considering that the model was not fitted in any way. Stenosis severity was confirmed to be an influential parameter. However, also cardiac period and graft diameter were observed to be important, particularly for mean flow rate and pulsatility index.</p><p><strong>Conclusion: </strong>Metrics quantifying the flow waveform's diastolic dominance show the highest sensitivity to graft stenosis, and seem to be least affected by autoregulation. Among these, the novel diastolic resistance index shows the strongest sensitivity to stenosis severity.</p><p><strong>Significance: </strong>The approach used in this study is expected to benefit the development of improved patency metrics, by allowing medical engineers to include sensitivity and uncertainty in assessing, in-silico, the potential of novel metrics, thus enabling them to provide better guidance in the design of clinical studies.</p>","PeriodicalId":54322,"journal":{"name":"Cardiovascular Engineering and Technology","volume":" ","pages":"171-189"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computer-generated Clinical Decision-making in the Treatment of Pulmonary Atresia with Intact Ventricular Septum.","authors":"Canberk Yıldırım, Berk Ural, Ender Odemis, Samir Donmazov, Kerem Pekkan","doi":"10.1007/s13239-024-00769-4","DOIUrl":"10.1007/s13239-024-00769-4","url":null,"abstract":"<p><strong>Purpose: </strong>Pulmonary atresia with intact ventricular septum is a multifactorial disease requiring complex surgeries. The treatment route is determined based on the right ventricle (RV) size, tricuspid annulus size and coronary circulation dependency of RV. Since multiple parameters influence the post-operative success, a personalized decision-making based on computed hemodynamics is hypothesized to improve the treatment efficacy.</p><p><strong>Methods: </strong>A lumped parameter cardiovascular model is developed to calculate the hemodynamics of virtual patients which are generated by statistical distribution of circulation parameters. Four cohorts each with 30 digital patients are grouped based on RV size. For each patient, biventricular and one-and-half ventricle (1.5 V) repair were applied in silico and assessed via pressure, flow and saturations computed for every organ bed.</p><p><strong>Results: </strong>Biventricular and 1.5 V repair yield significant increase in the pulmonary flow and oxygen saturation for all patients compared to the pre-operative state (p-values < 0.001). Approximately 30% of generated patients failed to meet the sufficient saturation and flow following biventricular repair and were directed to 1.5 V repair. However, 14% of these 1.5 V repair patients failed post-operatively, requiring Fontan completion. Based on the pre-determined hemodynamics criteria, this study implies that patients having RV sizes larger than 22 ml/m² are likely to undergo successful biventricular repair.</p><p><strong>Conclusion: </strong>Pending further clinical trials, computational pre-interventional planning has the potential to screen patients that would not optimally fit to the traditional pathway prior to in vivo execution by providing personalized hemodynamic outcome. Statistical approach allows in silico clinical trials, useful for diseases with low patient numbers.</p>","PeriodicalId":54322,"journal":{"name":"Cardiovascular Engineering and Technology","volume":" ","pages":"222-237"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing the Radiopacity of an Injectable Polymer on Fluoroscopy used for Treatment of Type II Endoleak After Endovascular Aneurysm Repair.","authors":"Jeffrey R Nagel, Erik Groot Jebbink, Stefan P M Smorenburg, Arjan W J Hoksbergen, Rutger J Lely, Michel Versluis, Michel M P J Reijnen","doi":"10.1007/s13239-025-00779-w","DOIUrl":"https://doi.org/10.1007/s13239-025-00779-w","url":null,"abstract":"<p><strong>Purpose: </strong>Type II endoleaks (T2EL) are a common complication after endovascular aneurysm repair. AneuFix is a newly designed elastic polymer for T2EL. AneuFix contains tantalum for visualization during fluoroscopy, which is crucial for monitoring the polymer in the side branches. The purpose of this study was to find the lowest concentration tantalum that is sufficient for safe injection in the aneurysmal sac.</p><p><strong>Methods: </strong>AneuFix polymer with tantalum concentrations between 0 and 30% was injected into endoleak phantoms, connected to a pulsatile flow setup and with a realistic background for fluoroscopy. Furthermore, the radiopacity was investigated on fluoroscopic systems from three different vendors, using static phantoms. Results from both the dynamic and static phantoms were qualitatively evaluated by 10 clinical experts.</p><p><strong>Results: </strong>Concentrations of ≥ 20% tantalum were consistently detected within the first 5 mm after entering the side branch, with a corresponding contrast-to-noise ratio of 2.23 ± 0.21. Furthermore, sufficient detectability scores (of at least 3 out of 5) were given to ≥ 15% tantalum. Significant differences were found in detectability scores on different fluoroscopic systems, using the default lowest-radiation-dose scan protocol for each system.</p><p><strong>Conclusions: </strong>This study showed that tantalum concentrations ≥ 20% are consistently detected on fluoroscopy in the specified region. Compared to the original 30%, this would reduce imaging artifacts from high attenuation and scattering on follow-up imaging, while retaining sufficient detectability during injection. However, because of differences in fluoroscopic systems and scan protocols between hospitals, the combination of tantalum concentration and scan protocol should be optimized for each clinical setting.</p>","PeriodicalId":54322,"journal":{"name":"Cardiovascular Engineering and Technology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finite Element Simulation of Opening Angle Response of Porcine Aortas Using Layer Specific GAG Distributions in One and Two Layered Solid Matrices.","authors":"Noor M Ghadie, Jean-Philippe St-Pierre, Michel R Labrosse","doi":"10.1007/s13239-024-00754-x","DOIUrl":"10.1007/s13239-024-00754-x","url":null,"abstract":"<p><strong>Purpose: </strong>Recent studies have identified an effect of glycosaminoglycans (GAG) on residual stresses in the aorta, underscoring the need to better understand their biomechanical roles.</p><p><strong>Methods: </strong>Aortic ring models for each of the ascending, arch and descending thoracic regions of the porcine thoracic aorta were created in FEBioStudio, using a framework that incorporates the Donnan osmotic swelling in a porous solid matrix. The distribution of fixed charge densities (FCD) through the thickness of the tissue was prescribed as calculated from experimentally quantified sulfated GAG mural distributions. Material parameters for the solid matrix, modeled using a Holmes-Mow constitutive law, were optimized using data from biaxial tensile tests. In addition to modelling the solid matrix as one layer, two layers were considered to capture the differences between the intima-media and the adventitia, for which various stiffness ratios were explored.</p><p><strong>Results: </strong>As the stiffness of the adventitia with respect to that of the media increased, the simulated opening angle increased. The opening angle also decreased from the ascending to the descending thoracic region in both one- and two-layered solid matrices models. The simulated results were compared against the experimental contribution of GAG to the opening angle, as previously quantified via enzymatic GAG-depletion. When using one layer for the solid matrix, the errors between the simulated opening angles and the experimental contribution of GAG to the opening angle were respectively 28%, 15% and 23% in the ascending, arch and descending thoracic regions. When using two layers for the solid matrix, the smallest errors in the ascending and arch regions were 21% and 5% when the intima-media was modelled as 10 times stiffer, and as twice stiffer than the adventitia, respectively, and 23% in the descending thoracic regions when the intima-media and adventitia shared similar mechanical properties.</p><p><strong>Conclusions: </strong>Overall, this study demonstrates that GAG partially contribute to circumferential residual stress, and that GAG swelling is one of several regulators of the opening angle. The minor discrepancies between simulated and experimental opening angles imply that the contribution of GAG extends beyond mere swelling, aligning with previous experimental indications of their interaction with ECM fibers in determining the opening angle.</p>","PeriodicalId":54322,"journal":{"name":"Cardiovascular Engineering and Technology","volume":" ","pages":"20-33"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11821734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluid Dynamic and in Vitro Blood Study to Understand Catheter-Related Thrombosis.","authors":"Hannah Palahnuk, Boyang Su, Thaddeus Harbaugh, Cleo Gesenberg, Shouhao Zhou, Elias Rizk, Jonathan Bernstein, S Will Hazard, Keefe B Manning","doi":"10.1007/s13239-024-00761-y","DOIUrl":"10.1007/s13239-024-00761-y","url":null,"abstract":"<p><strong>Purpose: </strong>Central venous catheters (CVCs) provide a direct route to the venous circulation but are prone to catheter-related thrombosis (CRT). A known CRT risk factor is a high catheter-to-vein ratio (CVR), or a large catheter diameter with respect to the indwelling vein size. In this study, the CVR's effect on CVC hemodynamics and its impact on CRT is investigated with in vitro and in silico experiments.</p><p><strong>Methods: </strong>An in vitro flow loop is used to characterize the hemodynamics around CVCs using particle image velocimetry. In addition, CRT is investigated using an in vitro flow loop with human blood and clinical catheters. The wall shear rate of flow around the CVC is computed numerically. CVRs of 0.20, 0.33, and 0.49 and Reynolds numbers of 200, 800, and 1300 are evaluated. No flow is used through CVC lumens to model chronic indwelling catheters.</p><p><strong>Results: </strong>Results show CVR ≥ 0.33 promotes platelet-rich clot growth at the device tip and at an increased rate compared to lower CVR cases. A high wall shear rate gradient on the CVC tip and an extended wake distal to the tip exists for higher CVR cases, promoting the aggregation of platelets and subsequent stagnation for clot formation. Further, the combination of the CVR and Reynolds number are crucial to CRT potential, not the CVR alone. Specifically, thrombosis risk is increased with low (stasis driven) and/or high (platelet activation driven) flow conditions, with the CVR and CVC's geometry playing an additional role in promoting fluid mechanic driven thrombus development. A high CVR (≥ 0.33) and high flow condition (≥ 1300) results in the highest risk for clot growth at the tip of the device; other locations of the device are at risk for thrombus development in lower flow conditions, regardless of the CVR. The importance of the device geometry and flow in promoting thrombus and fibrin sheath formation is also shown for the device investigated.</p><p><strong>Conclusions: </strong>This work demonstrates that the CVR, flow, and device geometry affect CRT. For clinical cases with CVR ≥ 0.33 and/or Re ≥ 1300, the device tip may be monitored more consistently for clot formation. Thrombosis risks remain on the entire catheter, regardless of the flow condition, for a CVR = 0.49. Device placement should be chosen carefully with respect to the combination of the Reynolds number and CVR. Further study is needed on the effect of catheterization to confirm these findings.</p>","PeriodicalId":54322,"journal":{"name":"Cardiovascular Engineering and Technology","volume":" ","pages":"116-137"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Impact of Cardiac Output and Valve Orientation on Bioprosthetic Pulmonary Valve Hemodynamics Using In Vitro 4D-Flow MRI and High-Speed Imaging.","authors":"Nicole K Schiavone, Priya J Nair, Christopher J Elkins, Doff B McElhinney, Daniel B Ennis, John K Eaton, Alison L Marsden","doi":"10.1007/s13239-024-00762-x","DOIUrl":"10.1007/s13239-024-00762-x","url":null,"abstract":"<p><strong>Purpose: </strong>Pulmonary valve replacement (PVR) using bioprosthetic valves is a common procedure performed in patients with repaired Tetralogy of Fallot and other conditions, but these valves frequently become dysfunctional within 15 years of implantation. The causes for early valve failure are not clearly understood. The purpose of this study was to explore the impact of changing cardiac output (CO) and valve orientation on local hemodynamics and valve performance.</p><p><strong>Methods: </strong>A 25 mm bioprosthetic valve was implanted in an idealized 3D-printed model of the right ventricular outflow tract (RVOT). The local hemodynamics at three COs and two valve orientations were assessed using 4D-Flow MRI and high-speed camera imaging.</p><p><strong>Results: </strong>Noticeable differences in jet asymmetry, the amount of recirculation, leaflet opening patterns, as well as the size and location of reversed flow regions were observed with varying CO. Rotation of the valve resulted in drastic differences in reversed flow regions, but not forward flow.</p><p><strong>Conclusion: </strong>Flow features observed in the valve with low CO in this study have previously been correlated with calcification, hemolysis, and leaflet fatigue, indicating their potential negative impact on local hemodynamics and leaflet performance.</p>","PeriodicalId":54322,"journal":{"name":"Cardiovascular Engineering and Technology","volume":" ","pages":"138-153"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Efficacy of Cardiac Contractility Modulation for Treating Patients with Heart Failure.","authors":"NingNing Zheng, YongBing Fu, MingZhu Xu, Lin Ling, TingBo Jiang, Feng Xue","doi":"10.1007/s13239-024-00760-z","DOIUrl":"10.1007/s13239-024-00760-z","url":null,"abstract":"<p><strong>Purpose: </strong>Heart failure (HF) is still a leading cause of mortality and morbidity despite considerable advances in therapy. This study aimed to evaluate the efficacy of cardiac contractility modulation (CCM) for treating Chinese patients with HF.</p><p><strong>Methods: </strong>This retrospective study included six HF patients who had New York Heart Association (NYHA) class II or III and received CCM implantation at the First Affiliated Hospital of Soochow University from May 2022 to May 2023. Assessments were conducted before and after 12 months of CCM treatment to evaluate the left ventricular ejection fraction (LVEF), the left ventricular end-diastolic dimension (LVEDD), the left atrium diameter (LAD), and cardiac function.</p><p><strong>Results: </strong>After the 12-month follow-up, all outcome measures showed improvement: the LVEF increased from (27 ± 4.73) % to (39.67 ± 7.06) %, the LVEDD decreased from (70.33 ± 1.97) mm to (64.83 ± 3.71) mm, and the LAD decreased from (52.83 ± 7.14) mm to (47.00 ± 7.48) mm. All patients reached NYHA functional class II.</p><p><strong>Conclusions: </strong>The findings from this small study suggest that CCM therapy can enhance the cardiac functional status, improve LVEF, and reverse ventricular remodeling.</p>","PeriodicalId":54322,"journal":{"name":"Cardiovascular Engineering and Technology","volume":" ","pages":"108-115"},"PeriodicalIF":1.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}