Cardiovascular Engineering and Technology最新文献

Theoretical and Practical Aspects of the Nonlinear Dynamics' Methods of Heart Rate Variability Analyses in Tachyarrhythmia Patients Underwent Radiofrequency Catheter Ablation.

IF 1.6 4区医学

Cardiovascular Engineering and Technology Pub Date : 2025-04-01 Epub Date: 2025-01-06 DOI: 10.1007/s13239-024-00766-7

Andrey Ardashev, Alexander Loskutov, Rod Passman, Evgeny Zhelyakov, Eric Rytkin, Igor Efimov

{"title":"Theoretical and Practical Aspects of the Nonlinear Dynamics' Methods of Heart Rate Variability Analyses in Tachyarrhythmia Patients Underwent Radiofrequency Catheter Ablation.","authors":"Andrey Ardashev, Alexander Loskutov, Rod Passman, Evgeny Zhelyakov, Eric Rytkin, Igor Efimov","doi":"10.1007/s13239-024-00766-7","DOIUrl":"10.1007/s13239-024-00766-7","url":null,"abstract":"Purpose: This study explores the use of heart rate variability (HRV) analysis, a noninvasive technique for assessing the autonomic nervous system, by applying nonlinear dynamics and chaos theory to detect chaotic behavior in RR intervals and assess cardiovascular health.Methods: Employing the \"System Analysis of Heart Rate Dynamics\" (SADR) program, this research combines chaos analysis with the short-time Fourier transform to assess nonlinear dynamic parameters in HRV. It includes constructing phase portraits in Takens space and calculating measures of chaos to identify deterministic chaos indicators.Results: The analysis identifies distinct chaos indicators in the cardiac rhythm of healthy volunteers compared to tachyarrhythmia patients, both before and after catheter treatment. Post-radiofrequency ablation (RFA) analysis shows promise as a predictive tool for arrhythmia recurrence.Conclusions: The findings suggest that HRV analysis, through nonlinear dynamics, can be an effective noninvasive method for predicting arrhythmia recurrence following treatments like catheter ablation. This approach has the potential for early and precise detection of arrhythmia, pending further validation.","PeriodicalId":54322,"journal":{"name":"Cardiovascular Engineering and Technology","volume":"16 2","pages":"190-201"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Performance Comparison of Centered and Tilted Blunt and Lighthouse Tip Cannulae for Drainage in Extracorporeal Life Support.

IF 1.6 4区医学

Cardiovascular Engineering and Technology Pub Date : 2025-04-01 Epub Date: 2025-02-10 DOI: 10.1007/s13239-024-00770-x

Federico Rorro, Lars Mikael Broman, Lisa Prahl Wittberg

{"title":"Performance Comparison of Centered and Tilted Blunt and Lighthouse Tip Cannulae for Drainage in Extracorporeal Life Support.","authors":"Federico Rorro, Lars Mikael Broman, Lisa Prahl Wittberg","doi":"10.1007/s13239-024-00770-x","DOIUrl":"10.1007/s13239-024-00770-x","url":null,"abstract":"Introduction: Extracorporeal membrane oxygenation is a lifesaving treatment for patients with refractory acute respiratory, circulatory, or combined cardiopulmonary failure. The patient is cannulated with one or two cannulae for drainage and reinfusion of blood. Blood is drained from the patient, pumped through a membrane lung for oxygenation and returned to the patient. Treatment efficiency depends on correct cannula positioning and interactions between drainage and reinfusion cannula.Methods: An experimental setup was built to study the isolated drainage performance of 24 Fr rigid models of a blunt and lighthouse tip cannula, both when centered and when tilted towards the vessel wall. Planar particle image velocimetry was used to investigate the flow field with water as the fluid medium.Results: For similar flow configuration, higher shear stresses were recorded in the blunt tip rather than lighthouse tip cannula. Moreover, in the lighthouse tip cannula, side-holes furthest from the tip (proximal side-holes) had the highest drainage. Results did not change substantially when the cannula was tilted towards the vessel wall.Conclusions: The effective drainage point of the lighthouse tip cannula was located near the proximal side-holes. Lower shear stresses were recorded in the lighthouse tip cannula when compared with the blunt tip cannula, for all considered flow rate ratios and cannula positions.","PeriodicalId":54322,"journal":{"name":"Cardiovascular Engineering and Technology","volume":" ","pages":"238-250"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric Cardiovascular Multiscale Modeling using a Functional Mock-up Interface.

IF 1.6 4区医学

Cardiovascular Engineering and Technology Pub Date : 2025-04-01 Epub Date: 2025-01-06 DOI: 10.1007/s13239-024-00767-6

Ellen E Garven, Ethan Kung, Randy M Stevens, Amy L Throckmorton

{"title":"Pediatric Cardiovascular Multiscale Modeling using a Functional Mock-up Interface.","authors":"Ellen E Garven, Ethan Kung, Randy M Stevens, Amy L Throckmorton","doi":"10.1007/s13239-024-00767-6","DOIUrl":"10.1007/s13239-024-00767-6","url":null,"abstract":"Purpose: Computational models of the cardiovascular system continue to increase in complexity. As more elements of the physiology are captured in multiscale models, there is a need to efficiently integrate subsystems. The objective of this study is to demonstrate the effectiveness of a coupling methodology, called functional mock-up interface (FMI), as applied to multiscale cardiovascular modeling.Methods: The multiscale model is composed of two subsystems: a computational fluid dynamics (CFD) model coupled to a lumped parameter model (LPM). The LPM is packaged using the FMI standard and imported into the CFD subsystem using an FMI co-simulation architecture. The functionality of an FMI coupling was demonstrated in a univentricular parallel circulation by means of compatible tools, including ANSYS CFX and Python. Predicted pressures and flows were evaluated in comparison with clinical data and a previously developed computational model.Results: The two models exchanged pressure and flow data between their boundaries at each timestep, demonstrating sufficient inter-subsystem communication. The models recreated pressures and flows from clinical measurements and a patient-specific model previously published.Conclusion: FMI integrated with ANSYS CFX is an effective approach for interfacing cardiovascular multiscale models as demonstrated by the presented univentricular circulatory model. FMI offers a modular approach towards tool integration and is an advantageous strategy for modeling complex systems.","PeriodicalId":54322,"journal":{"name":"Cardiovascular Engineering and Technology","volume":"16 2","pages":"202-210"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Transcatheter Posterior Ventricular Anchoring Neochordoplasty Mitral Valve Repair Device. 一种新型经导管后心室锚定新脊索成形术二尖瓣修复装置。

IF 1.6 4区医学

Cardiovascular Engineering and Technology Pub Date : 2025-04-01 Epub Date: 2024-12-26 DOI: 10.1007/s13239-024-00764-9

Matthew H Park, Annabel M Imbrie-Moore, Michael J Paulsen, Yuanjia Zhu, John W MacArthur, Y Joseph Woo

{"title":"A Novel Transcatheter Posterior Ventricular Anchoring Neochordoplasty Mitral Valve Repair Device.","authors":"Matthew H Park, Annabel M Imbrie-Moore, Michael J Paulsen, Yuanjia Zhu, John W MacArthur, Y Joseph Woo","doi":"10.1007/s13239-024-00764-9","DOIUrl":"10.1007/s13239-024-00764-9","url":null,"abstract":"Purpose: Advancements in minimally invasive technologies to decrease postoperative morbidity and recovery times represent a large opportunity for mitral valve repair operations. However, current technologies are unable to replicate gold standard surgical neochord implantation.Methods: We developed a novel neochordal repair device, Minimally Invasive Ventricular Anchoring Neochordoplasty (MIVAN), which operates via transcatheter, trans-septal anchoring to the posterior ventricular wall. We evaluated MIVAN in an ex vivo heart simulator and compared it with surgical neochordal repair and MitraClip using a prolapse model.Results: Upon MIVAN repair of the model (n = 5), regurgitant fraction was reduced from 19.46 ± 1.77% to 7.30 ± 0.99% (p = 0.01). Surgical neochordal repair reduced regurgitant fraction to 5.65 ± 0.66%, but there was no significant difference between MIVAN and surgical repair (p = 0.22). Unpaired MitraClip repair had significantly higher regurgitant fraction of 11.9 ± 1.40%, compared with those of neochord (p < 0.01) and MIVAN (p = 0.03) repairs.Conclusions: MIVAN represents a high-value opportunity for minimally invasive mitral valve repair. The benefits of the percutaneous, trans-septal approach for implantation on the posterior ventricular wall necessitate the expanded exploration of this device as a treatment alternative.","PeriodicalId":54322,"journal":{"name":"Cardiovascular Engineering and Technology","volume":" ","pages":"251-257"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Shortcomings of the Flow Convergence Method for Quantification of Mitral Regurgitation in a Pulsatile In-Vitro Environment and with Computational Fluid Dynamics.

IF 1.6 4区医学

Cardiovascular Engineering and Technology Pub Date : 2025-04-01 Epub Date: 2025-01-06 DOI: 10.1007/s13239-024-00763-w

Robin Leister, Roger Karl, Lubov Stroh, Derliz Mereles, Matthias Eden, Luis Neff, Raffaele de Simone, Gabriele Romano, Jochen Kriegseis, Matthias Karck, Christoph Lichtenstern, Norbert Frey, Bettina Frohnapfel, Alexander Stroh, Sandy Engelhardt

{"title":"Investigating the Shortcomings of the Flow Convergence Method for Quantification of Mitral Regurgitation in a Pulsatile In-Vitro Environment and with Computational Fluid Dynamics.","authors":"Robin Leister, Roger Karl, Lubov Stroh, Derliz Mereles, Matthias Eden, Luis Neff, Raffaele de Simone, Gabriele Romano, Jochen Kriegseis, Matthias Karck, Christoph Lichtenstern, Norbert Frey, Bettina Frohnapfel, Alexander Stroh, Sandy Engelhardt","doi":"10.1007/s13239-024-00763-w","DOIUrl":"10.1007/s13239-024-00763-w","url":null,"abstract":"The flow convergence method includes calculation of the proximal isovelocity surface area (PISA) and is widely used to classify mitral regurgitation (MR) with echocardiography. It constitutes a primary decision factor for determination of treatment and should therefore be a robust quantification method. However, it is known for its tendency to underestimate MR and its dependence on user expertise. The present work systematically compares different pulsatile flow profiles arising from different regurgitation orifices using transesophageal echocardiographic (TEE) probe and particle image velocimetry (PIV) as a reference in an in-vitro environment. It is found that the inter-observer variability using echocardiography is small compared to the systematic underestimation of the regurgitation volume for large orifice areas (up to 52%) where a violation of the flow convergence method assumptions occurs. From a flow perspective, a starting vortex was found as a dominant flow pattern in the regurgant jet for all orifice shapes and sizes. A series of simplified computational fluid dynamics (CFD) simulations indicate that selecting a suboptimal aliasing velocity during echocardiography measurements might be a primary source of potential underestimation in MR characterization via the PISA-based method, reaching up to 40%. In this study, it has been noted in clinical observations that physicians often select an aliasing velocity higher than necessary for optimal estimation in diagnostic procedures.","PeriodicalId":54322,"journal":{"name":"Cardiovascular Engineering and Technology","volume":"16 2","pages":"155-170"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and Prototyping of a Novel Triple Lumen Photo-Angioplasty Device: Lumi-Solve-T. 一种新型三腔光血管成形术装置的设计与原型：Lumi-Solve-T。

IF 1.6 4区医学

Cardiovascular Engineering and Technology Pub Date : 2025-04-01 Epub Date: 2024-12-20 DOI: 10.1007/s13239-024-00768-5

Aldous Tria, Anak Dharma, Loren Spiegel, Andrew E Rodda, Asvini Allada, Pavel Sluka, Amarnath Sangeetha Menon, Ethan Prabaharan, Pulasthi V Wettesinghe, Justin W Adams, Manfred Spanger, Anthony E Dear

{"title":"Design and Prototyping of a Novel Triple Lumen Photo-Angioplasty Device: Lumi-Solve-T.","authors":"Aldous Tria, Anak Dharma, Loren Spiegel, Andrew E Rodda, Asvini Allada, Pavel Sluka, Amarnath Sangeetha Menon, Ethan Prabaharan, Pulasthi V Wettesinghe, Justin W Adams, Manfred Spanger, Anthony E Dear","doi":"10.1007/s13239-024-00768-5","DOIUrl":"10.1007/s13239-024-00768-5","url":null,"abstract":"Purpose: A triple lumen iteration of the novel photo-angioplasty drug eluting balloon catheter (DEBc) Lumi-Solve may be compromised by guidewire shadow (GWS)-mediated attenuation of balloon surface drug activation. The current study aimed to design and evaluate a novel triple lumen prototype, designated Lumi-Solve-T, to circumvent these issues.Methods: Effects of guidewire shadowing (GWS) on vascular smooth muscle cell (VSMC) proliferation was evaluated using the MTT assay. In-silico modelling of GWS in the novel triple lumen design was conducted. Computer-aided design (CAD) and finite element analysis (FEA) contributed to development of a novel triple lumen catheter. 3D printing of rudimentary and refined prototypes of the catheter together with assembly of a novel fibre-optic (FO) complex and ex-vivo evaluation of the triple lumen device, Lumi-Solve T, was also performed.Results: GW insertion in a parallel triple lumen FO: GW port orientation demonstrated significantly reduced inhibition of VSMC proliferation after 7 days confirming the need for an alternative triple lumen design. In-silico analysis identified a multi-fibre FO sleeve design supported uniform, radial and uninterrupted UV365nm light transmission to the angioplasty balloon surface. FEA confirmed a multi-fibre FO ribbon design afforded a practical method of FO sleeve generation and facilitated a novel hub configuration able to afford a FO ribbon to sleeve transition. 3D printed prototypes demonstrated the utility of the novel design.Conclusions: A dedicated third port and lumen for the Lumi-Solve FO is required for optimal balloon surface photo-activation. A novel triple lumen design, Lumi-Solve-T, incorporating a ribbon to sleeve FO transition and novel hub design offers a realistic solution to current device limitations.","PeriodicalId":54322,"journal":{"name":"Cardiovascular Engineering and Technology","volume":" ","pages":"211-221"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flow-Based Coronary Artery Bypass Graft Patency Metrics: Uncertainty Quantification Simulations to Guide Development. 基于血流的冠状动脉旁路移植术通畅指标：不确定性量化模拟以指导发展。

IF 1.6 4区医学

Cardiovascular Engineering and Technology Pub Date : 2025-04-01 Epub Date: 2025-01-03 DOI: 10.1007/s13239-024-00765-8

Sita Drost, Cornelis J Drost

{"title":"Flow-Based Coronary Artery Bypass Graft Patency Metrics: Uncertainty Quantification Simulations to Guide Development.","authors":"Sita Drost, Cornelis J Drost","doi":"10.1007/s13239-024-00765-8","DOIUrl":"10.1007/s13239-024-00765-8","url":null,"abstract":"Purpose: Over time, transit time flow measurement (TTFM) has proven itself as a simple and effective tool for intra-operative evaluation of coronary artery bypass grafts (CABGs). However, metrics used to screen for possible technical error show considerable spread, preventing the definition of sharp cut-off values to distinguish between patent, questionable, and failed grafts. The simulation study presented in this paper aims to quantify this uncertainty for commonly used patency metrics, and to identify the most important physiological parameters influencing it.Methods: Uncertainty quantification was performed on a realistic multiscale numerical model of the coronary circulation, guided by Morris screening sensitivity analysis of a simpler, lumped-parameter model. Simulation results were qualitatively verified against results of a recent clinical study.Results: Correspondence with clinical study data is reasonable, especially considering that the model was not fitted in any way. Stenosis severity was confirmed to be an influential parameter. However, also cardiac period and graft diameter were observed to be important, particularly for mean flow rate and pulsatility index.Conclusion: Metrics quantifying the flow waveform's diastolic dominance show the highest sensitivity to graft stenosis, and seem to be least affected by autoregulation. Among these, the novel diastolic resistance index shows the strongest sensitivity to stenosis severity.Significance: The approach used in this study is expected to benefit the development of improved patency metrics, by allowing medical engineers to include sensitivity and uncertainty in assessing, in-silico, the potential of novel metrics, thus enabling them to provide better guidance in the design of clinical studies.","PeriodicalId":54322,"journal":{"name":"Cardiovascular Engineering and Technology","volume":" ","pages":"171-189"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computer-generated Clinical Decision-making in the Treatment of Pulmonary Atresia with Intact Ventricular Septum. 计算机生成的临床决策在完全性室间隔肺闭锁治疗中的应用。

IF 1.6 4区医学

Cardiovascular Engineering and Technology Pub Date : 2025-04-01 Epub Date: 2024-12-20 DOI: 10.1007/s13239-024-00769-4

Canberk Yıldırım, Berk Ural, Ender Odemis, Samir Donmazov, Kerem Pekkan

{"title":"Computer-generated Clinical Decision-making in the Treatment of Pulmonary Atresia with Intact Ventricular Septum.","authors":"Canberk Yıldırım, Berk Ural, Ender Odemis, Samir Donmazov, Kerem Pekkan","doi":"10.1007/s13239-024-00769-4","DOIUrl":"10.1007/s13239-024-00769-4","url":null,"abstract":"Purpose: Pulmonary atresia with intact ventricular septum is a multifactorial disease requiring complex surgeries. The treatment route is determined based on the right ventricle (RV) size, tricuspid annulus size and coronary circulation dependency of RV. Since multiple parameters influence the post-operative success, a personalized decision-making based on computed hemodynamics is hypothesized to improve the treatment efficacy.Methods: A lumped parameter cardiovascular model is developed to calculate the hemodynamics of virtual patients which are generated by statistical distribution of circulation parameters. Four cohorts each with 30 digital patients are grouped based on RV size. For each patient, biventricular and one-and-half ventricle (1.5 V) repair were applied in silico and assessed via pressure, flow and saturations computed for every organ bed.Results: Biventricular and 1.5 V repair yield significant increase in the pulmonary flow and oxygen saturation for all patients compared to the pre-operative state (p-values < 0.001). Approximately 30% of generated patients failed to meet the sufficient saturation and flow following biventricular repair and were directed to 1.5 V repair. However, 14% of these 1.5 V repair patients failed post-operatively, requiring Fontan completion. Based on the pre-determined hemodynamics criteria, this study implies that patients having RV sizes larger than 22 ml/m2 are likely to undergo successful biventricular repair.Conclusion: Pending further clinical trials, computational pre-interventional planning has the potential to screen patients that would not optimally fit to the traditional pathway prior to in vivo execution by providing personalized hemodynamic outcome. Statistical approach allows in silico clinical trials, useful for diseases with low patient numbers.","PeriodicalId":54322,"journal":{"name":"Cardiovascular Engineering and Technology","volume":" ","pages":"222-237"},"PeriodicalIF":1.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing the Radiopacity of an Injectable Polymer on Fluoroscopy used for Treatment of Type II Endoleak After Endovascular Aneurysm Repair.

IF 1.6 4区医学

Cardiovascular Engineering and Technology Pub Date : 2025-03-24 DOI: 10.1007/s13239-025-00779-w

Jeffrey R Nagel, Erik Groot Jebbink, Stefan P M Smorenburg, Arjan W J Hoksbergen, Rutger J Lely, Michel Versluis, Michel M P J Reijnen

{"title":"Optimizing the Radiopacity of an Injectable Polymer on Fluoroscopy used for Treatment of Type II Endoleak After Endovascular Aneurysm Repair.","authors":"Jeffrey R Nagel, Erik Groot Jebbink, Stefan P M Smorenburg, Arjan W J Hoksbergen, Rutger J Lely, Michel Versluis, Michel M P J Reijnen","doi":"10.1007/s13239-025-00779-w","DOIUrl":"https://doi.org/10.1007/s13239-025-00779-w","url":null,"abstract":"Purpose: Type II endoleaks (T2EL) are a common complication after endovascular aneurysm repair. AneuFix is a newly designed elastic polymer for T2EL. AneuFix contains tantalum for visualization during fluoroscopy, which is crucial for monitoring the polymer in the side branches. The purpose of this study was to find the lowest concentration tantalum that is sufficient for safe injection in the aneurysmal sac.Methods: AneuFix polymer with tantalum concentrations between 0 and 30% was injected into endoleak phantoms, connected to a pulsatile flow setup and with a realistic background for fluoroscopy. Furthermore, the radiopacity was investigated on fluoroscopic systems from three different vendors, using static phantoms. Results from both the dynamic and static phantoms were qualitatively evaluated by 10 clinical experts.Results: Concentrations of ≥ 20% tantalum were consistently detected within the first 5 mm after entering the side branch, with a corresponding contrast-to-noise ratio of 2.23 ± 0.21. Furthermore, sufficient detectability scores (of at least 3 out of 5) were given to ≥ 15% tantalum. Significant differences were found in detectability scores on different fluoroscopic systems, using the default lowest-radiation-dose scan protocol for each system.Conclusions: This study showed that tantalum concentrations ≥ 20% are consistently detected on fluoroscopy in the specified region. Compared to the original 30%, this would reduce imaging artifacts from high attenuation and scattering on follow-up imaging, while retaining sufficient detectability during injection. However, because of differences in fluoroscopic systems and scan protocols between hospitals, the combination of tantalum concentration and scan protocol should be optimized for each clinical setting.","PeriodicalId":54322,"journal":{"name":"Cardiovascular Engineering and Technology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of Inter-Patient, Intra-Patient, and Patient-Specific Based Training in Deep Learning for Classification of Heartbeat Arrhythmia.

IF 1.6 4区医学

Cardiovascular Engineering and Technology Pub Date : 2025-02-26 DOI: 10.1007/s13239-025-00777-y

Reza Bahrami, Ali Mohammad Fotouhi

{"title":"Investigation of Inter-Patient, Intra-Patient, and Patient-Specific Based Training in Deep Learning for Classification of Heartbeat Arrhythmia.","authors":"Reza Bahrami, Ali Mohammad Fotouhi","doi":"10.1007/s13239-025-00777-y","DOIUrl":"https://doi.org/10.1007/s13239-025-00777-y","url":null,"abstract":"Effective diagnosis of electrocardiogram (ECG) is one of the simplest and fastest ways to assess the heart's function. In the recent decade, various attempts have been made to automate the classification of electrocardiogram signals to detect heartbeat arrhythmias based on deep learning. However, due to the lack of a comprehensive standard for how to divide the database into the train and test datasets and the variety of methods used for this purpose, it is not possible to make a fair comparison between many of these studies. One of the main criteria for creating train and test datasets that have a great impact on the final results is their distribution paradigm. There are three paradigms for this purpose, including Inter-Patient, Intra-Patient, and Patient-Specific. In this research, we have conducted a detailed study of the impact of these three paradigms on the final results obtained from a CNN-based deep learning model for the classification of heartbeat arrhythmia into five classes. The experimental results on the standard arrhythmia dataset show that the Patient-Specific reached the best average performance in all of the metrics. Also, this training pattern is more practical and can be employed to create patient customized devices for the classification of ECG arrhythmia.","PeriodicalId":54322,"journal":{"name":"Cardiovascular Engineering and Technology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0