Validation of a Mathematical Model of Arterial Wall Mechanics with Drug Induced Vasoconstriction Against Ex Vivo Measurements.

IF 1.8 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Engineering and Technology Pub Date : 2025-09-30 DOI:10.1007/s13239-025-00796-9

Sara Costa Faya, Callan Wesley, Marina Vidrascu, Miguel A Fernández, Pieter-Jan Guns, Damiano Lombardi

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引用次数: 0

Abstract

Purpose: In this work we investigate a mathematical model in order to reproduce experimental data of arterial compliance under the action of vasoconstrictors and vasodilators related to pharmacological studies.

Methods: The considered model is a 3D-shell with active fibers. Model parameters are identified by means of an optimization procedure.

Results: The resulting model was able to reproduce the experimental data and predict the system behavior in scenarios other than those used for the parameter estimation. This enables the assessment of different scenarios concerning the impact of the molecules on the active or passive contributions of the arterial wall.

Conclusion: The results suggest that smooth muscle cell contraction modulates stiffness through direct fiber-induced regulation of vascular tone, while parameters related to the passive arterial wall component remain relatively stable across different vasoactive scenarios.

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药物诱导血管收缩的动脉壁力学数学模型在离体测量中的验证。

目的：在这项工作中，我们研究了一个数学模型，以便重现与药理学研究相关的血管收缩剂和血管舒张剂作用下动脉顺应性的实验数据。方法：考虑的模型是一个具有活性纤维的3d外壳。通过优化程序确定了模型参数。结果：所得到的模型能够再现实验数据，并预测系统在不同情况下的行为，而不是用于参数估计的情况。这样就可以评估不同情况下分子对动脉壁主动或被动贡献的影响。结论：平滑肌细胞收缩通过直接纤维诱导的血管张力调节僵硬度，而被动动脉壁成分相关参数在不同血管活性情况下保持相对稳定。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular Engineering and Technology Engineering-Biomedical Engineering

CiteScore

4.00

自引率

0.00%

发文量

期刊介绍： Cardiovascular Engineering and Technology is a journal publishing the spectrum of basic to translational research in all aspects of cardiovascular physiology and medical treatment. It is the forum for academic and industrial investigators to disseminate research that utilizes engineering principles and methods to advance fundamental knowledge and technological solutions related to the cardiovascular system. Manuscripts spanning from subcellular to systems level topics are invited, including but not limited to implantable medical devices, hemodynamics and tissue biomechanics, functional imaging, surgical devices, electrophysiology, tissue engineering and regenerative medicine, diagnostic instruments, transport and delivery of biologics, and sensors. In addition to manuscripts describing the original publication of research, manuscripts reviewing developments in these topics or their state-of-art are also invited.