Gm Crops & Food-Biotechnology in Agriculture and the Food Chain最新文献_第3页

Risk assessment of homologous variants of biotech trait proteins using a bridging approach. 采用桥接法对生物技术性状蛋白的同源变体进行风险评估。

IF 4.5 2区农林科学

Gm Crops & Food-Biotechnology in Agriculture and the Food Chain Pub Date : 2024-12-31 Epub Date: 2024-11-09 DOI: 10.1080/21645698.2024.2420412

Cunxi Wang, Jennifer Calcaterra, Beverly Anderson, Timothy Rydel, Rong Wang, Lieselot Bertho, Scott A Saracco, Kimberly Hodge-Bell, Luis Burzio, Tommi White, Bin Li

{"title":"Risk assessment of homologous variants of biotech trait proteins using a bridging approach.","authors":"Cunxi Wang, Jennifer Calcaterra, Beverly Anderson, Timothy Rydel, Rong Wang, Lieselot Bertho, Scott A Saracco, Kimberly Hodge-Bell, Luis Burzio, Tommi White, Bin Li","doi":"10.1080/21645698.2024.2420412","DOIUrl":"10.1080/21645698.2024.2420412","url":null,"abstract":"A transgenic protein is frequently expressed as different homologous variants in genetically modified crops due to differential processing of targeting peptides or optimization of activity and specificity. The aim of this study was to develop a science-based approach for risk assessment of homologous protein variants using dicamba mono-oxygenase (DMO) as a case study. In this study, DMO expressed in the next-generation dicamba-tolerant maize, sugar beet and soybean crops exhibited up to 27 amino acid sequence differences in the N-terminus. Structure modeling using AlphaFold, ESMFold and OpenFold demonstrates that these small N-terminal extensions lack an ordered secondary structure and do not disrupt the DMO functional structure. Three DMO variants were demonstrated to have equivalent immunoreactivity and functional activity ranging from 214 to 331 nmol/min/mg. Repeated toxicity studies using each DMO variant found no test substance-related adverse effects. These results support that homologous protein variants, which have demonstrated physicochemical and functional equivalence, can leverage existing safety data from one variant without requiring additional de novo safety assessments.","PeriodicalId":54282,"journal":{"name":"Gm Crops & Food-Biotechnology in Agriculture and the Food Chain","volume":"15 1","pages":"336-351"},"PeriodicalIF":4.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biotechnology executive order opens door for regulatory reform and social acceptance of genetically engineered microbes in agriculture. 生物技术行政命令为农业转基因微生物的监管改革和社会接受打开了大门。

IF 4.5 2区农林科学

Gm Crops & Food-Biotechnology in Agriculture and the Food Chain Pub Date : 2024-12-31 Epub Date: 2024-07-27 DOI: 10.1080/21645698.2024.2381294

Jabeen Ahmad, Amy Grunden, Jennifer Kuzma

引用次数: 0

Risk-appropriate regulations for gene-editing technologies. 基因编辑技术的风险适当监管。

IF 3.9 2区农林科学

Gm Crops & Food-Biotechnology in Agriculture and the Food Chain Pub Date : 2024-12-31 Epub Date: 2024-01-12 DOI: 10.1080/21645698.2023.2293510

Graham Brookes, Stuart J Smyth

引用次数: 0

Regulatory framework for genetically modified organisms in the Kingdom of Eswatini. 埃斯瓦提尼王国转基因生物监管框架。

IF 4.5 2区农林科学

Gm Crops & Food-Biotechnology in Agriculture and the Food Chain Pub Date : 2024-12-31 Epub Date: 2024-07-04 DOI: 10.1080/21645698.2024.2375664

Bongani Z Nkhabindze, Cebisile N Magagula, Diana Earnshaw, Calsile F Mhlanga, Sipho N Matsebula, Isaac G Dladla

引用次数: 0

Twenty-eight years of GM Food and feed without harm: why not accept them? 转基因食品和饲料二十八年无危害：为什么不接受它们？

IF 3.9 2区农林科学

Gm Crops & Food-Biotechnology in Agriculture and the Food Chain Pub Date : 2024-12-31 Epub Date: 2024-03-12 DOI: 10.1080/21645698.2024.2305944

Richard E Goodman

{"title":"Twenty-eight years of GM Food and feed without harm: why not accept them?","authors":"Richard E Goodman","doi":"10.1080/21645698.2024.2305944","DOIUrl":"10.1080/21645698.2024.2305944","url":null,"abstract":"Since the first genetically engineered or modified crops or organisms (GMO) were approved for commercial production in 1995, no new GMO has been proven to be a hazard or cause harm to human consumers. These modifications have improved crop efficiency, reduced losses to insect pests, reduced losses to viral and microbial plant pathogens and improved drought tolerance. A few have focused on nutritional improvements producing beta carotene in Golden Rice. Regulators in the United States and countries signing the CODEX Alimentarius and Cartagena Biosafety agreements have evaluated human and animal food safety considering potential risks of allergenicity, toxicity, nutritional and anti-nutritional risks. They consider risks for non-target organisms and the environment. There are no cases where post-market surveillance has uncovered harm to consumers or the environment including potential transfer of DNA from the GMO to non-target organisms. In fact, many GMOs have helped improve production, yield and reduced risks from chemical insecticides or fungicides. Yet there are generic calls to label foods containing any genetic modification as a GMO and refusing to allow GM events to be labeled as organic. Many African countries have accepted the Cartagena Protocol as a tool to keep GM events out of their countries while facing food insecurity. The rationale for those restrictions are not rational. Other issues related to genetic diversity, seed production and environmental safety must be addressed. What can be done to increase acceptance of safe and nutritious foods as the population increases, land for cultivation is reduced and energy costs soar?","PeriodicalId":54282,"journal":{"name":"Gm Crops & Food-Biotechnology in Agriculture and the Food Chain","volume":"15 1","pages":"40-50"},"PeriodicalIF":3.9,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10939142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140112193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Growing knowledge impact of gene-editing technology on public acceptance: a longitudinal analysis in Japan.

IF 4.5 2区农林科学

Gm Crops & Food-Biotechnology in Agriculture and the Food Chain Pub Date : 2024-12-31 Epub Date: 2024-12-06 DOI: 10.1080/21645698.2024.2435709

Atsushi Sato, Daiki Watanabe, Yoko Saito

{"title":"Growing knowledge impact of gene-editing technology on public acceptance: a longitudinal analysis in Japan.","authors":"Atsushi Sato, Daiki Watanabe, Yoko Saito","doi":"10.1080/21645698.2024.2435709","DOIUrl":"10.1080/21645698.2024.2435709","url":null,"abstract":"Genome editing (GE) technology holds significant promise for advancements in crop development and medical applications. However, public acceptance of GE in Japan remains uncertain. This study aimed to examine how knowledge impacts public acceptance of GE technology, focusing on differences across diffusion stages and application purposes. Using ordinary least squares regression on repeated survey data collected from 2018 to 2023 in Japan (n = 6,234), we investigated the influence of knowledge on support for GE in consumer benefits, producer benefits, and medical technology. Our findings revealed that the effect of knowledge on technology acceptance has strengthened over time. Consumers with greater knowledge of GE are increasingly supportive of its advancement, emphasizing the growing importance of information as the technology becomes more widespread. This research highlights the role of transparent policy discussions in fostering public trust and support, thereby promoting the successful integration of new technologies into society.","PeriodicalId":54282,"journal":{"name":"Gm Crops & Food-Biotechnology in Agriculture and the Food Chain","volume":"15 1","pages":"411-428"},"PeriodicalIF":4.5,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene editing achieves consistently higher favorability in social and traditional media than GMOs. 与转基因生物相比，基因编辑在社交媒体和传统媒体中获得的好感度一直较高。

IF 3.9 2区农林科学

Gm Crops & Food-Biotechnology in Agriculture and the Food Chain Pub Date : 2023-12-31 Epub Date: 2023-06-21 DOI: 10.1080/21645698.2023.2226889

Mark Lynas, Selene Adams, Karen Stockert

{"title":"Gene editing achieves consistently higher favorability in social and traditional media than GMOs.","authors":"Mark Lynas, Selene Adams, Karen Stockert","doi":"10.1080/21645698.2023.2226889","DOIUrl":"10.1080/21645698.2023.2226889","url":null,"abstract":"While GMOs have been the subject of negative discourse over a long time period, it is possible that newer breeding technologies like gene editing are viewed more favorably. We present data for a 5-year period between January 2018 and December 2022, showing that in content specific to agricultural biotechnology, gene editing achieves consistently higher favorability ratings than GMOs in both social and traditional English-language media. Our sentiment analysis shows that favorability is especially positive in social media, with close to 100% favorability achieved in numerous monthly values throughout our 5 years of analysis. We believe that the scientific community can therefore be cautiously optimistic based on current trends that gene editing will be accepted by the public and be able to achieve its promise of making a substantial contribution to future food security and environmental sustainability worldwide. However, there are some recent indications of more sustained downward trends, which may be a cause for concern.","PeriodicalId":54282,"journal":{"name":"Gm Crops & Food-Biotechnology in Agriculture and the Food Chain","volume":" ","pages":"1-8"},"PeriodicalIF":3.9,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10761093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10042924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modification of Fatty Acid Profile and Oil Contents Using Gene Editing in Oilseed Crops for a Changing Climate. 利用基因编辑技术改变油料作物的脂肪酸组成和含油量，以适应不断变化的气候。

IF 3.9 2区农林科学

Gm Crops & Food-Biotechnology in Agriculture and the Food Chain Pub Date : 2023-12-31 Epub Date: 2023-08-08 DOI: 10.1080/21645698.2023.2243041

Saeed Rauf, Seerat Fatima, Rodomiro Ortiz

引用次数: 0

Genetically modified DP915635 maize is agronomically and compositionally comparable to non-genetically modified maize. 转基因DP915635玉米在农艺和成分上与非转基因玉米相当。

IF 4.5 2区农林科学

Gm Crops & Food-Biotechnology in Agriculture and the Food Chain Pub Date : 2023-12-31 DOI: 10.1080/21645698.2023.2208997

Jennifer A Anderson, James Mickelson, Brandon J Fast, Nathan Smith, Robert C Pauli, Carl Walker

{"title":"Genetically modified DP915635 maize is agronomically and compositionally comparable to non-genetically modified maize.","authors":"Jennifer A Anderson, James Mickelson, Brandon J Fast, Nathan Smith, Robert C Pauli, Carl Walker","doi":"10.1080/21645698.2023.2208997","DOIUrl":"10.1080/21645698.2023.2208997","url":null,"abstract":"DP915635 maize was genetically modified (GM) to express the IPD079Ea protein for corn rootworm (Diabrotica spp.) control. DP915635 maize also expresses the phosphinothricin acetyltransferase (PAT) protein for tolerance to glufosinate herbicide and the phosphomannose isomerase (PMI) protein that was used as a selectable marker. A field study was conducted at ten sites in the United States and Canada during the 2019 growing season. Of the 11 agronomic endpoints that were evaluated, two of them (early stand count and days to flowering) were statistically significant compared with the control maize based on unadjusted p-values; however, these differences were not significant after FDR-adjustment of p-values. Composition analytes from DP915635 maize grain and forage (proximates, fiber, minerals, amino acids, fatty acids, vitamins, anti-nutrients, and secondary metabolites) were compared to non-GM near-isoline control maize (control maize) and non-GM commercial maize (reference maize). Statistically significant differences were observed for 7 of the 79 compositional analytes (16:1 palmitoleic acid, 18:0 stearic acid, 18:1 oleic acid, 18:2 linoleic acid, 24:0 lignoceric acid, methionine, and α-tocopherol); however, these differences were not significant after FDR-adjustment. Additionally, all of the values for composition analytes fell within the range of natural variation established from the in-study reference range, literature range, and/or tolerance interval. These results demonstrate that DP915635 is agronomically and compositionally comparable to non-GM maize represented by non-GM near-isoline control maize and non-GM commercial maize.","PeriodicalId":54282,"journal":{"name":"Gm Crops & Food-Biotechnology in Agriculture and the Food Chain","volume":"14 1","pages":"1-8"},"PeriodicalIF":4.5,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10161957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9792625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deconstruction of science hegemony: discursive strategies of Chinese science communication on genetically modified foods. 解构科学霸权：中国转基因食品科学传播的话语策略》。

IF 3.9 2区农林科学

Gm Crops & Food-Biotechnology in Agriculture and the Food Chain Pub Date : 2023-12-31 Epub Date: 2023-08-20 DOI: 10.1080/21645698.2023.2247133

Jinrong Lin

引用次数: 0