Bulletin of the Korean Chemical Society最新文献

{"title":"Structural and energetic insights into SARS-CoV-2 nucleocapsid protein inhibitors from molecular dynamics and MM-PBSA analyses","authors":"Srimai Vuppala,&nbsp;Jaeyoung Kim,&nbsp;Mengdi Zhao,&nbsp;Joonkyung Jang","doi":"10.1002/bkcs.70207","DOIUrl":"https://doi.org/10.1002/bkcs.70207","url":null,"abstract":"<p>The SARS-CoV-2 nucleocapsid (N) protein is a key regulator of viral genome packaging and replication, making it an attractive antiviral target. Here, we provide structural and energetic insights into N-protein inhibition using molecular docking, pharmacophore screening, molecular dynamics (MD) simulations, and MM-PBSA analyses. Experimentally known inhibitors Onalespib, JQ-1, and Zotatifin were used to construct pharmacophores that screened the ZINC database, yielding 927 hits. Three top candidates, ZINC37602048, ZINC06246181, and ZINC12077824, underwent 150 ns MD simulations to assess their long-term dynamic stability within the N-protein binding pocket. MM-PBSA calculations over the 150 ns trajectories revealed strong binding for ZINC37602048 (−27.24 kcal/mol) and ZINC06246181 (−22.81 kcal/mol), driven mainly by van der Waals contributions, whereas ZINC12077824 showed comparatively weaker, though still favorable, affinity (−18.91 kcal/mol) owing to a large unfavorable electrostatic contribution partially offset by polar solvation. These results highlight promising scaffolds for further optimization and underscore the utility of MD and free energy-based methods in guiding antiviral drug discovery targeting the SARS-CoV-2 N protein.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"47 9","pages":"1162-1176"},"PeriodicalIF":2.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functionalization of fused N-heterocyclic frameworks using organometallic reagents: Reactivity, selectivity, and biological application","authors":"Jenu Navyatha,&nbsp;Selvam Vasanth,&nbsp;Palanisamy Sowntharya,&nbsp;Pitchamuthu Amaladass,&nbsp;Vasudevan Dhayalan","doi":"10.1002/bkcs.70203","DOIUrl":"https://doi.org/10.1002/bkcs.70203","url":null,"abstract":"<p>Benzo-fused <i>N</i>-heterocycles, such as quinoline, isoquinoline, phthalazine, quinoxaline, cinnoline, and quinazoline derivatives, are pivotal scaffolds in pharmaceuticals, medicinal chemistry, agrochemicals, and materials science. Over the past three decades, organometallic reagent-mediated strategies have transformed the highly regioselective functionalization of arenes and heteroarenes, enabling efficient carbon–carbon, carbon–heteroatom, and carbon–halogen bond formation under sustainable conditions. Transition metal-catalyzed cross-coupling, C<span></span>H activation, photochemical, electrochemical, flow reaction, and 2,2,6,6-tetramethylpiperidine (TMP)–bases-involved directed metalation strategies offer versatile access to structurally diverse benzo-fused bicyclic <i>N</i>-heteroaromatics and their related scaffolds. This review highlights recent advances in the functionalization of benzo-fused pyridine scaffolds using a variety of organometallic reagents (Li, Mg, Zn, B, Al, etc.) between 2010 and 2025, emphasizing reaction scope, tolerance of sensitive functional groups, regioselectivity, enantioselectivity, and sustainable approaches for the development of biologically relevant <i>N</i>-heterobicyclic compounds. Furthermore, the review paper describes the biological, pharmaceutical, medicinal, and other relevant applications of benzo-fused <i>N</i>-heterocyclic compounds.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"47 9","pages":"1063-1114"},"PeriodicalIF":2.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular filming: A director's grammar for visualizing chemistry in motion","authors":"Hyotcherl Ihee","doi":"10.1002/bkcs.70206","DOIUrl":"https://doi.org/10.1002/bkcs.70206","url":null,"abstract":"<p>Time-resolved x-ray and electron scattering now follow the changing structures of molecules directly, on femtosecond timescales and sub-ångström length scales. The community has long captured this achievement in one evocative phrase: the molecular movie. Yet that phrase names a product, the movie one obtains, rather than the practice that produces it. Drawing an explicit analogy to molecular editing in organic synthesis, where an action-oriented reframing helped reorganize and reinvigorate a broad area of synthesis, I propose <i>molecular filming</i> as a complementary, action-oriented paradigm in which the experimentalist is the director of an atomic-scale movie. Building on more than two decades of my own group's molecular filming, spanning ultrafast electron diffraction, time-resolved x-ray liquidography, and time-resolved serial femtosecond crystallography, I survey the field as a set of directorial choices: which trigger to call “Action!”, which imaging modality to use, which phase of matter to study, what temporal and structural information to capture, and how to reconstruct molecular structure from the resulting data. These choices encompass x-ray and electron scattering, complementary structural probes, and increasingly automated, machine-learning-assisted analysis. I then make this logic explicit as a grammar of molecular filming that mirrors the cut-and-paste logic of molecular editing while describing motion rather than connectivity. Naming the practice, I argue, does for structural dynamics what naming molecular editing did for synthesis: it organizes a heterogeneous field, re-values what a product-focused view overlooks, and turns “we made a movie of X” into the sharper question “which scene can we not yet shoot?” I close by identifying the field's defining frontier: extending molecular filming from photoinduced unimolecular reactions to the thermal bimolecular reactions that dominate synthesis, and advancing from the structures of intermediates to those of transition states and conical intersections, and thus to the reaction coordinate itself.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"47 9","pages":"1042-1057"},"PeriodicalIF":2.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.70206","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poly(lactic-co-glycolic acid) microsphere loaded dissolving microneedles for sustained and coordinated transdermal delivery of desogestrel and ethinyl estradiol","authors":"Young-Jin Kim,&nbsp;Byeongsu Kim,&nbsp;Sokyoung Joo,&nbsp;So-Jeong Jeong,&nbsp;Chang-Soo Han,&nbsp;Chun-Woong Park","doi":"10.1002/bkcs.70194","DOIUrl":"https://doi.org/10.1002/bkcs.70194","url":null,"abstract":"<p>Minimally invasive drug delivery systems that improve patient compliance have gained increasing attention. Dissolving microneedles (MN) incorporating PLGA microspheres offer a promising platform for sustained transdermal delivery of hormones. We developed PLGA microspheres encapsulating desogestrel (DS) and ethinyl estradiol (EE) and fabricated dissolving microneedles incorporating these microspheres. Their physicochemical properties, drug release profiles, permeability through STRAT-M® membranes, and skin irritation potential were evaluated. Although differences in dissolution profiles were observed between DS-P753H MN and EE-P753H MN, with cumulative releases of approximately 76.6% and 55.7% at 120 h, respectively, both formulations exhibited comparable permeation behavior in Franz diffusion cell studies, indicating consistent transdermal delivery performance. Reproducibility of microsphere and microneedle fabrication was confirmed through independent batch preparation, showing low variability and comparable release profiles (f₂ &gt;60). Slight skin irritation observed with the drug-loaded microneedles was attributed to the incorporated drugs rather than the microneedle matrix itself. Notably, irritation scores decreased gradually. Therefore, the dissolving microneedle system demonstrates strong potential as a minimally invasive, long-acting contraceptive platform.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"47 8","pages":"1007-1019"},"PeriodicalIF":2.2,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.70194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148783518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anticancer potential of 1H-naphth[2,3-d]imidazolium salts through structural, DNA binding, and tumor necrosis factor alpha (TNF-α) modulation studies","authors":"Nguyen Thi Ngoc Vinh,&nbsp;Sondavid Nandanwar,&nbsp;Van Thong Pham,&nbsp;Ngoc Dung Tran,&nbsp;Hang Yen Thi Bui,&nbsp;Thi Minh Nguyen,&nbsp;Hak Jun Kim,&nbsp;Luc Van Meervelt,&nbsp;Dongwon Kim,&nbsp;Ok-Sang Jung,&nbsp;Minh Tho Nguyen,&nbsp;Thanh Chung Pham,&nbsp;Songyi Lee","doi":"10.1002/bkcs.70198","DOIUrl":"https://doi.org/10.1002/bkcs.70198","url":null,"abstract":"<p>A structurally diverse series of <i>1H</i>-naphth[2,3-d]imidazolium salts was prepared by N-alkylation/quaternization and isolated in high yields. Structural assignment by ¹H NMR spectroscopy confirmed successful quaternization, while single-crystal x-ray diffraction analyses of <b>BIM</b>, <b>CIM</b>, and <b>CIC</b> revealed that the fused naphthimidazolium core remains essentially planar and that peripheral substituents, counterions and solvent molecules govern torsion and supramolecular packing. Interaction of the salts with calf thymus DNA was investigated by UV–vis absorption titration and agarose gel electrophoresis. All compounds showed measurable but substituent-dependent DNA affinity, with intrinsic binding constants in the range 0.08 × 10⁶–1.37 × 10⁶ M⁻¹, consistent with mixed binding involving π-stacking together with groove and/or electrostatic contributions. In vitro anticancer evaluation against MCF-7 and A549 cells revealed a pronounced structure–activity relationship: sulfonate-containing analogues were inactive, whereas bromobenzyl- and carbazolyl-containing halide salts displayed low-micromolar cytotoxicity, with <b>BIC</b> and <b>CIC</b> among the most active members of the series. Because cytotoxic potency did not correlate directly with DNA binding strength, TNF-<i>α</i> was examined by docking, 300 ns molecular dynamics simulations, and cellular ELISA. Docking/MD suggested favorable interactions of the active salts within the Tyr-rich hydrophobic cavity of TNF-<i>α</i>, while ELISA assays showed that <b>BIB</b> and <b>CIC</b> suppressed LPS-induced TNF-<i>α</i> production in HeLa cells by up to 47.2% and 52.8%, respectively, at 2 μM. Overall, hydrophobic and π-extended substitution around the naphthimidazolium core is a major determinant of cytotoxic activity and TNF-α modulation, but further optimization is required to improve selectivity and establish direct target engagement.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"47 8","pages":"1028-1038"},"PeriodicalIF":2.2,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148783755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-pot synthesis of PtNi/carbon composites derived from polytetrahydrofuran for bifunctional alkaline HER and ORR","authors":"Jinho Kim,&nbsp;Eejin Jang,&nbsp;Hyewon Heo,&nbsp;Bobin Kang,&nbsp;Intek Song,&nbsp;Myung-Gil Kim,&nbsp;Seok Min Yoon","doi":"10.1002/bkcs.70190","DOIUrl":"https://doi.org/10.1002/bkcs.70190","url":null,"abstract":"<p>Developing robust carbon-supported electrocatalysts through simplified synthesis is crucial for scalable hydrogen-energy technologies. Herein, we report a one-pot, poly(tetrahydrofuran) (PTHF)-derived PtNi/C architecture in which PTHF serves as a carbon precursor/support and enables in situ carbonization of PTHF to a carbon-bridged nanoparticle network during Pt–Ni nucleation and alloying in a single thermal step. The resulting catalyst delivers efficient alkaline HER and, importantly, sustains hydrogen evolution deep into the high-current-density regime with strong operational durability, addressing a key limitation of many PtNi-based catalysts commonly evaluated only at low currents. Impedance and surface-accessibility analyses indicate that the integrated carbon framework lowers interfacial resistive losses and stabilizes electrode connectivity, thereby reducing voltage penalties under high-rate operation. Beyond HER, the same junction-engineered PtNi/C also shows promising alkaline ORR activity with a predominantly near four-electron pathway, highlighting the broader utility of this carbon-integration concept.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"47 8","pages":"999-1006"},"PeriodicalIF":2.2,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148784082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-performance tetrahedral palladium nanocatalyst for microwave-assisted organic synthesis","authors":"Dicky Annas,&nbsp;Kyung Hee Oh,&nbsp;Muthuchamy Nallal,&nbsp;Hack-Keun Lee,&nbsp;Shin Wook Kang,&nbsp;Kwonho Jang,&nbsp;Jun-Hyun Kim,&nbsp;Hyun Sung Kim,&nbsp;Ji Chan Park,&nbsp;Kang Hyun Park","doi":"10.1002/bkcs.70189","DOIUrl":"https://doi.org/10.1002/bkcs.70189","url":null,"abstract":"<p>Palladium is widely recognized for its effectiveness in catalyzing various organic transformations. In this study, we synthesized tetrahedral palladium (Pd) nanoparticles anchored on graphene sheets (T-Pd/graphene) through a solvent-free process involving thermal decomposition in an environment rich in carbon monoxide at elevated temperatures. The produced Pd nanoparticles, with an average size of 18 nm, were found to be evenly dispersed across the graphene substrate. Leveraging microwave irradiation, the T-Pd/graphene nanocatalyst demonstrated exceptional catalytic performance, marked by high conversion rates and selectivity in key reactions such as the Suzuki-Miyaura cross-coupling and the semi-hydrogenation of phenylacetylene. Notably, the nanocatalyst exhibited remarkable durability, retaining its catalytic efficiency over five successive recycling rounds without significant loss of activity.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"47 8","pages":"988-998"},"PeriodicalIF":2.2,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.70189","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148783497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BODIPY-based J-aggregates: From supramolecular chemistry to NIR bioimaging and phototherapies","authors":"Pooja Sharma,&nbsp;Yeonkyeong Lee,&nbsp;Youngmi Kim","doi":"10.1002/bkcs.70196","DOIUrl":"https://doi.org/10.1002/bkcs.70196","url":null,"abstract":"<p>Boron-dipyrromethene (BODIPY) dyes have attracted sustained interest owing to their exceptional photophysical properties, including high fluorescence quantum yields, tunable absorption and emission wavelengths, and excellent photostability. Beyond their molecular-level attributes, the supramolecular organization of BODIPY derivatives provides a powerful means of modulating their optical and electronic properties. In particular, J-aggregation has emerged as a key self-assembly mode that gives rise to narrow, red-shifted spectral bands, small Stokes shift, and enhanced radiative constants. The formation of BODIPY J-aggregates is governed by a delicate balance of non-covalent interactions, including π–π stacking, hydrogen bonding, van der Waals interactions, hydrophobic effects, and, in selected systems, halogen bonding. These interactions can be systematically regulated through molecular geometry, substitution pattern, amphiphilicity, solvent environment, and external stimuli, thereby enabling access to diverse supramolecular architectures with tailored functions. This review provides a comprehensive overview of the fundamental principles underlying J-aggregate formation in BODIPY-based systems, with particular emphasis on molecular design strategies, aggregation mechanisms, solvent and environmental effects, and structure–property relationships. Recent advances in the application of self-assembled BODIPY J-aggregates are surveyed across diverse fields, including fluorescence sensing, bioimaging, and photodynamic and photothermal therapy.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"47 8","pages":"951-982"},"PeriodicalIF":2.2,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.70196","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148783538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover Picture: High-Performance Tetrahedral Palladium Nanocatalyst for Microwave-Assisted Organic Synthesis (BKCS 8/2026) by Hyun Sung Kim, Ji Chan Park, and Kang Hyun Park","authors":"","doi":"10.1002/bkcs.70152","DOIUrl":"https://doi.org/10.1002/bkcs.70152","url":null,"abstract":"<p>The cover image depicts tetrahedral palladium nanoparticles anchored on graphene sheets (T-Pd/graphene) driving catalytic reactions under a shower of microwave irradiation, envisioned as comets streaking through space bathed in intense light. Synthesized via a solvent-free thermal decomposition in a CO-rich atmosphere, the nanocatalyst delivers high conversion and selectivity in Suzuki–Miyaura cross-coupling and phenylacetylene semi-hydrogenation, with excellent recyclability. Details are in the article by Dicky Annas, Kyung Hee Oh, Muthuchamy Nallal, Hack-Keun Lee, Shin Wook Kang, Kwonho Jang, Jun-Hyun Kim, Hyun Sung Kim, Ji Chan Park, and Kang Hyun Park.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"47 8","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.70152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148784440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solvent vapor annealing effect on organic solar cells based on a nonfullerene acceptor","authors":"Da Young Kim,&nbsp;Kyoungheon Park,&nbsp;Chang Eun Song,&nbsp;Eunhee Lim","doi":"10.1002/bkcs.70195","DOIUrl":"https://doi.org/10.1002/bkcs.70195","url":null,"abstract":"<p>A nonfullerene acceptor, FBTT-BORH, was synthesized based on a central core consisting of a monofluorinated benzothiadiazole unit flanked by thiophene groups with rhodanine (RH) end groups functionalized with octyl chains for use as an electron acceptor in organic solar cells (OSCs). The UV–vis absorption spectra showed that solvent vapor annealing (SVA) effectively enhanced the molecular aggregation of FBTT-BORH compared with that of the as-cast film. This improvement led to higher short-circuit current densities and fill factors in OSCs fabricated using PTB7-Th as the polymer donor and FBTT-BORH as the acceptor. The SVA-treated FBTT-BORH-based device achieved a power conversion efficiency of 6.73% and an open-circuit voltage close to 1.0 V. To further understand the efficiency enhancement induced by SVA, the charge recombination behavior, hole and electron mobilities, and film morphologies were examined. AFM, TEM, GIWAXS, and UV–vis analyses revealed suppressed recombination, higher charge mobility, improved molecular ordering, and enhanced crystallinity relative to the as-cast condition, providing direct evidence that SVA treatment effectively regulates molecular arrangement and promotes superior device performance.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"47 8","pages":"1020-1027"},"PeriodicalIF":2.2,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.70195","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148783566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}