Bulletin of the Korean Chemical Society最新文献

{"title":"2,6-Diarylbenzo[d]oxazoles as MAO-B inhibitors for the treatment of Parkinson's disease","authors":"Haeun Lee,&nbsp;Vikram Shahaji Sawant,&nbsp;Uhyeok Kim,&nbsp;Jinhyeok Kim,&nbsp;Soo Yeon Baek,&nbsp;Sanghee Lee,&nbsp;Hyunah Choo,&nbsp;Taek Kang,&nbsp;Byungsun Jeon","doi":"10.1002/bkcs.70010","DOIUrl":"https://doi.org/10.1002/bkcs.70010","url":null,"abstract":"<p>Parkinson's disease (PD) is a progressive neurodegenerative disease caused by a loss of dopaminergic neurons in the substantia nigra. Monoamine oxidase-B (MAO-B) inhibition is a promising strategy for disease modification. Here, we synthesized a series of 2,6-diarylbenzo[<i>d</i>]oxazoles and identified two potent and selective hMAO-B inhibitors: 4,4′-(benzo[<i>d</i>]oxazole-2,6-diyl)diphenol <b>4a</b> (IC₅₀ = 0.182 μM) and 4-(2-(3-fluorophenyl)benzo[<i>d</i>]oxazol-6-yl)phenol <b>4f</b> (IC₅₀ = 0.184 μM). Molecular modeling indicated that the benzoxazole core interacts hydrophobically within the active site, contributing to their inhibitory potency. Both compounds demonstrated reversible or partially reversible inhibition of hMAO-B and neuroprotective effects in the MPP⁺-induced neurotoxicity assay using human neuroblastoma cells. Additionally, both compounds exhibited good microsomal stability and lacked significant perturbation of hERG channel activity. While <b>4a</b> showed CYP inhibition against some isozymes, <b>4f</b> had minimal effects on CYP isozyme activities, suggesting a more favorable pharmacokinetic profile. Based on these findings, <b>4f</b> presents a promising therapeutic candidate for the treatment of PD.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 4","pages":"422-428"},"PeriodicalIF":1.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced photocatalytic CO2 reduction of covalent triazine-based photocatalyst: Mechanistic insights from time-resolved spectroscopy","authors":"Rajesh K. Yadav,&nbsp;Seung Yeon Choi,&nbsp;Satyam Singh,&nbsp;Tae Wu Kim","doi":"10.1002/bkcs.70013","DOIUrl":"https://doi.org/10.1002/bkcs.70013","url":null,"abstract":"<p>Photocatalytic conversion of waste carbon dioxide (CO₂) into fine chemicals is crucial for solar energy utilization and mitigating the global climate crisis. Artificial photocatalysis based on the integrated biocatalyst offers a promising approach for converting CO₂ into high-value chemicals. The development of metal-free heterogeneous photocatalysts has gained significant attention as a sustainable platform for practical artificial photocatalytic systems. In this study, we report a one-pot synthesis of covalent triazine-based photocatalysts (CTPs) and their photocatalytic applications. The as-synthesized CTPs exhibit excellent photocatalytic performance, achieving the generation of HCOOH from CO₂ with a yield of 224.85 μM. The underlying photo-physical properties of CTPs were investigated by using systematic time-resolved laser spectroscopies. These measurements reveal that the formation of a long-lived charge transfer state in CTPs at the late time window is strongly correlated with the enhanced photocatalytic efficiency by delaying the ultrafast charge recombination. This study will serve as a benchmark example of heterogeneous photocatalysts and their wide applications for CO₂ fixation and solar chemical production.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 4","pages":"441-447"},"PeriodicalIF":1.7,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances and protocol summaries for degradation of polyethylene microplastics using TiO2-based photocatalysts","authors":"Yu Jin Jung,&nbsp;In Young Kim","doi":"10.1002/bkcs.70004","DOIUrl":"https://doi.org/10.1002/bkcs.70004","url":null,"abstract":"<p>The amount of plastic waste is increasing exponentially worldwide, and the environmental impact of microplastics (MPs) is correspondingly significant. Developing photocatalysts capable of degrading MPs is a critical area of research. However, the wide variation in experimental conditions for photocatalytic MPs degradation poses challenges for conducting comparative studies and advancing efficient photocatalyst design. Since polyethylene (PE) and TiO₂ are among the most extensively studied materials for MPs and photocatalysts, respectively, this review focuses on recent advances in the degradation of PE MPs using TiO₂-based photocatalysts. The review examines the mechanisms of photocatalytic degradation of PE MPs and summarizes protocols for the preparation of PE MPs, TiO₂-based photocatalysts, and photocatalytic assessment systems. Additionally, it introduces methods for quantifying degraded PE MPs and compares recently reported PE MPs degradation efficiencies, accounting for variations in photocatalytic assessment parameters. This review aims to contribute to the establishment of a standardized laboratory-scale protocol for photocatalytic PE MPs degradation research.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 3","pages":"198-210"},"PeriodicalIF":1.7,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.70004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Through-space electronic coupling in π-stacked organic mixed-valence systems: A quantitative comparison of cationic and anionic states","authors":"Dohoon Jeon,&nbsp;Kyu Cheol Cho,&nbsp;Youn K. Kang","doi":"10.1002/bkcs.70007","DOIUrl":"https://doi.org/10.1002/bkcs.70007","url":null,"abstract":"<p>This work investigates the structural characteristics, redox behavior, intervalence charge transfer (IVCT) transition, and electronic coupling of a mixed-valence (MV) system featuring quinoidal redox centers in 4′,4″′-(naphthalene-1,8-diyl)bis(4-methyl-[1,1′-biphenyl]-2,5-dione) (<b>2</b>). The three-dimensional structures of two conformers, [<b>2_<i>syn</i></b>]^•− and [<b>2_<i>anti</i></b>]^•−, were determined using density functional theory calculations. The centroid-to-centroid distances between the two redox centers were 3.69 Å for [<b>2_<i>syn</i></b>]^•− and 3.41 Å for [<b>2_<i>anti</i></b>]^•−, with a weighted average distance of 3.59 Å. Electrochemical methods that include cyclic voltammetry and differential pulse voltammetry revealed two closely spaced reduction potentials (−1.04 and − 1.13 V vs. Fc⁺/Fc). The electronic coupling between the redox centers was evaluated using two complementary approaches: the Mulliken–Hush analysis of the IVCT band obtained through the spectroelectrochemical method and partial charge resonance analysis derived from geometrical bond length variations. The results demonstrate a significant disparity in electronic coupling, with the anion radical MV system (<b>2</b>^•−, 413 cm⁻¹) exhibiting electronic coupling approximately one-third weaker than the previously reported cation radical MV system (<b>1</b>^•+, 2055 cm⁻¹). Charge transfer rate constants (<i>k</i>_ET) between two redox centers, calculated using parameters from spectroelectrochemical measurement, revealed that charge transfer in <b>2</b>^•− (5.8 × 10¹³ s⁻¹) is 180 times slower than in <b>1</b>^•+ (3.2 × 10¹¹ s⁻¹). These findings underscore the critical role of electronic coupling in determining charge transfer rates and highlight the pronounced advantage of hole-type charge carriers over electron-type carriers. The study provides valuable insights for the rational design of advanced materials in organic electronics.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 3","pages":"281-292"},"PeriodicalIF":1.7,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-toxicity metal–organic frameworks: Sustainable solutions for versatile applications","authors":"Juan L. Obeso,&nbsp;Catalina V. Flores,&nbsp;Aldo G. Gutiérrez,&nbsp;Carolina Leyva,&nbsp;Juan Carlos Valdivia-Corona,&nbsp;Leonardo D. Herrera-Zúñiga,&nbsp;José Antonio de los Reyes,&nbsp;Ricardo A. Peralta,&nbsp;Ilich A. Ibarra","doi":"10.1002/bkcs.70005","DOIUrl":"https://doi.org/10.1002/bkcs.70005","url":null,"abstract":"<p>The conventional synthesis of metal-organic framework (MOF) materials generates high amounts of waste solvents, which are directly associated with human and environmental issues. Developing green and affordable MOF materials is necessary since this strategy is based on methods that prioritize sustainability and minimize environmental impact. In this scenario, less toxic metals such as Zn, Zr, Al, and Fe can be applied in addition to linkers from renewable sources. This review discusses eco-friendly synthesis pathways, such as hydrothermal, mechanochemical, at room temperature, ionic liquid, and renewable resources. The current methodologies from specific low-toxicity MOF materials are highlighted. Applications include water treatment, sensing, drug delivery, catalysis, and gas storage, which are mentioned and examined. Interestingly, developing low-impact MOF materials as eco-friendly platforms for diverse applications can be a remarkable opportunity to achieve a sustainable future in the quality of the planet.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 3","pages":"265-280"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.70005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ephedrannin A: A potent dual inhibitor of FAK and Src with anticancer effects","authors":"Hien Thi My Ong,&nbsp;Eda Ates,&nbsp;Min-Jung Kang","doi":"10.1002/bkcs.70002","DOIUrl":"https://doi.org/10.1002/bkcs.70002","url":null,"abstract":"<p>Cancer is the leading cause of death worldwide, and the development of effective treatments remains an important challenge. Here, we present ephedrannin A, a compound that exhibits strong anticancer activity against various types of cancer including lung, liver, colon, and kidney cancer. The compound has demonstrated its remarkable ability to inhibit cell proliferation and invasion similar to conferone and Y15, known focal adhesion kinase (FAK) inhibitors. Treatment with 10 μM ephedrannin A significantly reduced the expression of FAK, and phosphorylated FAK and proto-oncogene tyrosine-protein kinase Src, two major signaling proteins involved in cancer progression in colon, kidney, and lung cancer cell lines. Furthermore, knockdown experiments targeting Src found no effect on FAK expression and phosphorylation, suggesting that FAK/Src complex inhibition is the main mechanism of action of ephedrannin A. Co-targeting of FAK and Src is a promising therapeutic strategy because these proteins play important roles in promoting cell proliferation, migration, and invasion. By disrupting these pathways, ephedrannin A could effectively inhibit the growth and metastasis of cancer cells. Further investigation is necessary to elucidate the exact molecular mechanisms underlying the anticancer effects of ephedrannin A and to explore the possibility of clinical development.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 3","pages":"317-325"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and properties of Zn5(OH)8Cl2 as an inorganic filler in poly(vinylidene fluoride) based electrolytes for dye-sensitized solar cells","authors":"Mi-Ra Kim,&nbsp;Sung Soo Park,&nbsp;Wontae Oh,&nbsp;Seongman Lee,&nbsp;Gahyun Kim,&nbsp;Minseok Yoo,&nbsp;Hu Ying,&nbsp;Pilgun Oh,&nbsp;Songyi Lee","doi":"10.1002/bkcs.70006","DOIUrl":"https://doi.org/10.1002/bkcs.70006","url":null,"abstract":"<p>The integration of inorganic fillers into polymer materials has garnered considerable attention for the development of advanced electrolyte materials, particularly in dye-sensitized solar cells (DSSCs). Among various potential fillers, zinc hydroxide chloride (Zn₅(OH)₈Cl₂) emerged as a promising inorganic filler owing to its unique structural and electrochemical properties. This study focuses on developing a preparation method for Zn₅(OH)₈Cl₂ as an inorganic filler, investigating its effects on the properties of poly(vinylidene fluoride) (PVDF)-based electrolytes, and evaluating the performance of the resulting electrolyte in DSSCs. When Zn₅(OH)₈Cl₂ was used as a filler, significant enhancements were observed in ionic conductivity and the overall cell performance. By harnessing the interactions between Zn₅(OH)₈Cl₂ and PVDF, we optimized the PVDF-based electrolytes for improved energy conversion efficiency of DSSCs. Notably, a DSSC device with a PVDF-based electrolyte containing 15 wt% of Zn₅(OH)₈Cl₂ in PVDF exhibited an overall efficiency of 7.52%.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 3","pages":"211-220"},"PeriodicalIF":1.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover Picture: Enhancing electrochemical xanthine detection: a two-step incubation strategy to minimize interference from ascorbic acid (BKCS 2/2025) Taeyeon Yoo, Seonhwa Park, Hyoeun Lee, Subin Park, Youngsuk Kim, Haesik Yang","authors":"","doi":"10.1002/bkcs.12858","DOIUrl":"https://doi.org/10.1002/bkcs.12858","url":null,"abstract":"<p>This cover image illustrates the selective electrochemical detection of xanthine in serum with interfering species such as ascorbic acid and uric acid. It features crystals formed in the fingers by gout, depicted with glitter effects to enhance their visual impact. The image also demonstrates the electron transfer from xanthine to an electrode, facilitated by Os(bpy)2Cl2+ and xanthine dehydrogenase. This research contributes to the early diagnosis of purine-related metabolic disorders. More details are available in the article by Taeyeon Yoo, Seonhwa Park, Hyoeun Lee, Subin Park, Youngsuk Kim, Haesik Yang\u0000 \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 2","pages":"93"},"PeriodicalIF":1.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.12858","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing selectivity challenges in seawater splitting: Catalyst design for oxygen and chlorine evolution reactions","authors":"Gisang Park,&nbsp;Minjeong Kim,&nbsp;Joon Yong Park,&nbsp;Ki Min Nam","doi":"10.1002/bkcs.70003","DOIUrl":"https://doi.org/10.1002/bkcs.70003","url":null,"abstract":"<p>Direct seawater splitting is a promising pathway for sustainable hydrogen (H₂) production. However, significant challenges persist, particularly at the anode, where the high concentration of chloride ions induces competitive reactions between the chlorine evolution reaction (CER) and the oxygen evolution reaction (OER). Although chlorine gas (Cl₂) has a higher commercial value than oxygen (O₂), selective oxygen generation is often more advantageous for large-scale hydrogen production. Compared with freshwater splitting, seawater splitting introduces additional complexities, including material degradation caused by chlorine corrosion. Therefore, the development of robust electrocatalysts is essential to enhance long-term system stability and overall efficiency, as well as to enable selective Cl₂ or O₂ production. These challenges make seawater splitting inherently more complex than freshwater splitting. This review provides a comprehensive overview of recent advancements in electrocatalysts for seawater splitting, delving into the fundamental mechanisms governing anode reactions, particularly OER and CER. In addition, we critically examine strategies to control reaction selectivity, focusing on designing electrocatalysts that favor one reaction over the other, considering factors such as catalyst composition and structure. Finally, we outline significant opportunities, challenges, and design approaches to guide future research and technological advancements in seawater splitting.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 3","pages":"253-264"},"PeriodicalIF":1.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Highly active cobalt(II) and copper(II) complexes supported by aminomethylquinoline mediating stereoselective ring-opening polymerization of rac-lactide”","authors":"","doi":"10.1002/bkcs.70001","DOIUrl":"https://doi.org/10.1002/bkcs.70001","url":null,"abstract":"<p>\u0000 <span>J. Lee</span>, <span>S. Nayab</span>, <span>A. Kumar</span>, <span>D. Kim</span>, <span>H. Jung</span>, <span>S. H. Lee</span>, <span>H. Lee</span>, <span>Highly active cobalt(II) and copper(II) complexes supported by aminomethylquinoline mediating stereoselective ring-opening polymerization of <i>rac</i>-lactide</span>, <i>Bull. Korean Chem. Soc.</i> <span>2024</span>, <span>45</span>(<span>4</span>), <span>317</span>–<span>321</span>.</p><p>In the author list, author “Ameet Kumar²” was incorrect. This should be “Ameet Kumar¹”. The author Ameet Kumar has the affiliation of ¹Department of Chemistry and Green-Nano Materials Research Center, Kyungpook National University, Daegu, Republic of Korea, but in the article, it is mistakenly written ²Department of Chemistry, Shaheed Benazir Bhutto University (SBBU), Khyber Pakhtunkhwa, Pakistan.</p><p>We apologize for this error.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 2","pages":"193"},"PeriodicalIF":1.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.70001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}