EpCAM and CD24 specific EVRNA analysis for ovarian cancer diagnosis

IF 2.2 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2025-06-23 DOI:10.1002/bkcs.70041

Yejin Kim, Da Han Hyun, Yoon Hee Lee, Woojeong Lim, Hoyeon Lee, Soyeon Lee, Hyeon-Ki Jang, Joohyun Lim, Dae Gy Hong, Jun Seok Park, Soo Yeun Park, Jongmin Park

引用次数: 0

Abstract

Extracellular vesicles (EVs) are recently emerged as biomarkers for cancer diagnosis. RNA in EV specifically has drawn attention for its high stability and accuracy for early cancer diagnosis. However, analysis of EV RNA in plasma for cancer diagnosis often can be limited by a low population of cancer-derived EVs in the plasma samples. Herein, we developed a sensitive EV RNA analysis technique with protein-specific EV enrichment for accurate ovarian cancer diagnosis.

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EpCAM和CD24特异性EVRNA分析在卵巢癌诊断中的应用

细胞外囊泡（EVs）最近成为癌症诊断的生物标志物。特别是在EV中，RNA因其在早期癌症诊断中的高稳定性和准确性而受到关注。然而，分析血浆中EV RNA用于癌症诊断往往会受到血浆样本中癌症源性EV数量较少的限制。在此，我们开发了一种具有蛋白质特异性EV富集的灵敏EV RNA分析技术，用于准确诊断卵巢癌。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of the Korean Chemical Society Chemistry-General Chemistry

自引率

23.50%

发文量

182

期刊介绍： The Bulletin of the Korean Chemical Society is an official research journal of the Korean Chemical Society. It was founded in 1980 and reaches out to the chemical community worldwide. It is strictly peer-reviewed and welcomes Accounts, Communications, Articles, and Notes written in English. The scope of the journal covers all major areas of chemistry: analytical chemistry, electrochemistry, industrial chemistry, inorganic chemistry, life-science chemistry, macromolecular chemistry, organic synthesis, non-synthetic organic chemistry, physical chemistry, and materials chemistry.