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Bulletin of the Korean Chemical Society最新文献

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Droplet microfluidics for single-molecule and single-cell analysis in research, diagnosis, and therapy 用于研究、诊断和治疗中单分子和单细胞分析的液滴微流控技术
IF 1.7 4区 化学
Bulletin of the Korean Chemical Society Pub Date : 2024-05-16 DOI: 10.1002/bkcs.12848
Joel Sanchez Barea, Dong-Ku Kang
{"title":"Droplet microfluidics for single-molecule and single-cell analysis in research, diagnosis, and therapy","authors":"Joel Sanchez Barea,&nbsp;Dong-Ku Kang","doi":"10.1002/bkcs.12848","DOIUrl":"10.1002/bkcs.12848","url":null,"abstract":"<p>During the last decade, molecular diagnostics has become increasingly important, especially during the SARS-CoV-2 pandemic. Advances in droplet-based microfluidics, which divides samples into thousands of microdroplets, are responsible for high-throughput data provision, increased analysis sensitivity, and improved performance to overcome challenges in controlling diseases and early diagnosis. Different targets, such as nucleic acids, proteins, or single cells, can be detected and analyzed in terms of their characteristics in a much more extensive and precise manner with the integration of droplet microfluidics into various molecular diagnostic techniques. In this review, we explore recent advances in the development of droplet microfluidics-based molecular diagnostic techniques and future perspectives in the field.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"45 6","pages":"495-502"},"PeriodicalIF":1.7,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.12848","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141127628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Narrowing the photoluminescence bandwidth of InP-based colloidal quantum dots through photon-triggered isolation 通过光子触发隔离缩小 InP 基胶体量子点的光致发光带宽
IF 1.7 4区 化学
Bulletin of the Korean Chemical Society Pub Date : 2024-05-10 DOI: 10.1002/bkcs.12847
Hyekyeong Kwon, Byeong-Seo Cheong, Jiwon Bang
{"title":"Narrowing the photoluminescence bandwidth of InP-based colloidal quantum dots through photon-triggered isolation","authors":"Hyekyeong Kwon,&nbsp;Byeong-Seo Cheong,&nbsp;Jiwon Bang","doi":"10.1002/bkcs.12847","DOIUrl":"10.1002/bkcs.12847","url":null,"abstract":"<p>The optimization of photoluminescence (PL) spectral bandwidths in InP-based colloidal quantum dots (QDs) faces limitations with traditional synthetic methods. This study introduces a novel approach utilizing light-induced thiolate ligand detachment to selectively precipitate QDs within an ensemble, triggered by photons whose energy matches the red tail of the band-edge absorption peak. We demonstrate that incorporating benzoquinone as an electron acceptor under inert conditions crucially enhances the efficiency of photoexcited hole-induced ligand detachment. Through careful optimization of laser exposure conditions, we successfully narrowed the PL bandwidth of InP/ZnSe/ZnS QDs from 39 to 35 nm. Our findings offer significant insights into the development of high-performance QD-based displays, promising advancements in color purity.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"45 6","pages":"530-534"},"PeriodicalIF":1.7,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140990627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NOE analysis using dual injection DNP-NMR for studies of solvent–solute interactions at low concentrations 利用双注入 DNP-NMR 进行 NOE 分析，研究低浓度溶剂与溶质之间的相互作用
IF 1.7 4区 化学
Bulletin of the Korean Chemical Society Pub Date : 2024-05-09 DOI: 10.1002/bkcs.12852
Jihyun Kim
{"title":"NOE analysis using dual injection DNP-NMR for studies of solvent–solute interactions at low concentrations","authors":"Jihyun Kim","doi":"10.1002/bkcs.12852","DOIUrl":"10.1002/bkcs.12852","url":null,"abstract":"<p>Dynamic nuclear polarization (DNP) offers significant signal enhancement compared to conventional nuclear magnetic resonance (NMR) in measuring the nuclear Overhauser effect. Owing to this enhancement, DNP enables the quantitative analysis of solvent–solute interactions, which are typically challenging to assess using standard NMR techniques. However, current experimental setups generally require the use of samples with relatively high solute concentrations because of large dilution factors. This limits the studies on solvent–solute interactions for bio-related molecules, particularly those with low solubility. In such cases, the concentration of solute post-dilution often falls below the detection limits. Herein, we introduce a novel dual injection system designed to considerably increase the dilution factor, thereby enabling the use of samples with lower solute concentrations while maintaining detectable signal levels. The effectiveness of this system was demonstrated in experiments using trifluoroacetic acid at concentrations 50 times lower than those used in the conventional method.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"45 6","pages":"560-566"},"PeriodicalIF":1.7,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140994630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combinatorial entropy determines the early stages of nucleation 组合熵决定成核的早期阶段
IF 1.7 4区 化学
Bulletin of the Korean Chemical Society Pub Date : 2024-05-09 DOI: 10.1002/bkcs.12849
Da-Hyun Koo, Ho Jun Park, Jeong-Mo Choi
{"title":"Combinatorial entropy determines the early stages of nucleation","authors":"Da-Hyun Koo,&nbsp;Ho Jun Park,&nbsp;Jeong-Mo Choi","doi":"10.1002/bkcs.12849","DOIUrl":"10.1002/bkcs.12849","url":null,"abstract":"<p>Biomolecular phase separation, a complex phenomenon within living systems, has garnered significant interest due to its diverse roles in cellular organization and function. Despite its importance, studying phase separation dynamics experimentally, particularly in the early stages, poses challenges. Our study investigates the dynamics of biomolecular phase separation using a graph-based simulation module, particularly emphasizing its early stages. Through a simplified model, we dissect the influences of various factors on collective behavior, highlighting the crucial role of combinatorial entropy in percolation dynamics. This study offers valuable insights into the fundamental principles governing biomolecular phase separation, with implications for understanding cellular processes and disease mechanisms.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"45 6","pages":"526-529"},"PeriodicalIF":1.7,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.12849","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140994501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A single-step synthesis of 5,6-dihydropyrrolo[2,1-a]isoquinolines and evaluation of their anti-leukemic activity 5,6-二氢吡咯并[2,1-a]异喹啉的一步合成及其抗白血病活性的评估
IF 1.7 4区 化学
Bulletin of the Korean Chemical Society Pub Date : 2024-05-08 DOI: 10.1002/bkcs.12846
Hoyeong Park, Santosh Shivanand Raikar, Min Jeong Ahn, Seong Hwan Kim, Pilho Kim
{"title":"A single-step synthesis of 5,6-dihydropyrrolo[2,1-a]isoquinolines and evaluation of their anti-leukemic activity","authors":"Hoyeong Park,&nbsp;Santosh Shivanand Raikar,&nbsp;Min Jeong Ahn,&nbsp;Seong Hwan Kim,&nbsp;Pilho Kim","doi":"10.1002/bkcs.12846","DOIUrl":"10.1002/bkcs.12846","url":null,"abstract":"<p>While a pharmaceutically intriguing scaffold, 5,6-dihydropyrrolo[2,1-<i>a</i>]isoquinoline (DHPIQ), has precedently been prepared from diverse tetrahydroisoquinolines (THIQs) using elaborate conditions, convenient metal-free methods were discovered from condensation of cyanomethylene-THIQ (<b>1</b>) and α-halo-ketones or aldehydes (<b>1a</b>) to afford 15 DHPIQs (<b>2</b>–<b>16</b>) in moderate yields by employing unique reactivities of the secondary amine and α-carbon to the nitrile of <b>1</b>. Preliminary biological studies with chronic myelogenous leukemia K562 and adriamycin-resistant K562 (K562/ADM) cells exhibited some of the DHPIQs tested were active in the both cell lines. In particular, cyclohexyl-fused DHPIQ (<b>10</b>) showed GI<sub>50</sub> values of 9.79 and 13.60 μM in K562 and K562/ADM cells, respectively. Based on the flow cytometry analysis of <b>10</b>, the anti-cancer activity could be from apoptosis-related mechanisms. Overall, this DHPIQ scaffold may be further optimized to discover clinically meaningful anti-leukemic agents overcoming adriamycin resistance.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"45 6","pages":"551-559"},"PeriodicalIF":1.7,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.12846","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140998883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of interstellar synthesis of glycine, alanine, and serine from aminonitriles, OH, and H2O 从氨基腈、OH 和 H2O 星际合成甘氨酸、丙氨酸和丝氨酸的机制
IF 1.7 4区 化学
Bulletin of the Korean Chemical Society Pub Date : 2024-05-04 DOI: 10.1002/bkcs.12844
Joong Chul Choe
{"title":"Mechanisms of interstellar synthesis of glycine, alanine, and serine from aminonitriles, OH, and H2O","authors":"Joong Chul Choe","doi":"10.1002/bkcs.12844","DOIUrl":"10.1002/bkcs.12844","url":null,"abstract":"<p>A new potential energy surface for forming glycine in the gas phase, starting from association of aminoacetonitrile (NH<sub>2</sub>CH<sub>2</sub>CN) with OH followed by subsequent hydrolysis, was determined using CBS-QB3 calculation. The overall activation energy was 90 kJ mol<sup>−1</sup> or 0 without or with catalytic H<sub>2</sub>O, respectively. Alanine or serine was formed from 2-aminopropionitrile (CH<sub>3</sub>CH(NH<sub>2</sub>)CN) or 2-amino-3-hydrxypropionitrile (HOCH<sub>2</sub>CH(NH<sub>2</sub>)CN) instead of aminoacetonitrile with the overall activation energies of 89 or 49 kJ mol<sup>−1</sup>, respectively. When an additional H<sub>2</sub>O was involved in each reaction as a catalyst, barrierless reaction pathways were obtained. These results suggest that it is possible for investigated reactions to occur in interstellar ices along the proposed pathways, taking kinetic aspects into account.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"45 6","pages":"520-525"},"PeriodicalIF":1.7,"publicationDate":"2024-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.12844","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141014023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organometallic ruthenium complexes derived from anthracene and pyrene chromophores: Synthesis and photophysical properties 源自蒽和芘发色团的有机金属钌配合物：合成与光物理性质
IF 1.7 4区 化学
Bulletin of the Korean Chemical Society Pub Date : 2024-05-02 DOI: 10.1002/bkcs.12841
Gajendra Gupta, Yena Choe, Suhyun Kim, Junseong Lee, Jiwon Bang, Chang Yeon Lee
{"title":"Organometallic ruthenium complexes derived from anthracene and pyrene chromophores: Synthesis and photophysical properties","authors":"Gajendra Gupta,&nbsp;Yena Choe,&nbsp;Suhyun Kim,&nbsp;Junseong Lee,&nbsp;Jiwon Bang,&nbsp;Chang Yeon Lee","doi":"10.1002/bkcs.12841","DOIUrl":"10.1002/bkcs.12841","url":null,"abstract":"<p>Two new monopyridyl-based Anthracene and Pyrene ligands were synthesized and employed to design Ruthenium-coordinated organometallic complexes, <b>RuAnthra</b> and <b>RuPyrene</b>, respectively. The ligands and their metal complexes were fully characterized by different analytical techniques, including multinuclear 1D- and 2D-NMR, electrospray ionization-mass spectrometry, UV–Vis, fluorescence spectroscopy, and elemental analysis. Furthermore, their photophysical properties were studied in different solvents with increasing polarity using UV–Vis and fluorescence spectroscopy, showing less or no significant solvolysis effect. The average emission lifetimes of the complexes were further determined using time-resolved emission spectroscopy. Additionally, the ligands and their metal complexes showed excellent ability to generate singlet oxygen and can be useful for several important potential applications.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"45 5","pages":"398-403"},"PeriodicalIF":1.7,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141020014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gold nanoshells with varying morphologies through templated surfactant-assisted seed-growth method 通过模板表面活性剂辅助种子生长法获得形态各异的金纳米壳
IF 1.7 4区 化学
Bulletin of the Korean Chemical Society Pub Date : 2024-04-30 DOI: 10.1002/bkcs.12845
Sunghee Lee, Soyun Lee, Soojin Hwang, So-Jung Park
{"title":"Gold nanoshells with varying morphologies through templated surfactant-assisted seed-growth method","authors":"Sunghee Lee,&nbsp;Soyun Lee,&nbsp;Soojin Hwang,&nbsp;So-Jung Park","doi":"10.1002/bkcs.12845","DOIUrl":"https://doi.org/10.1002/bkcs.12845","url":null,"abstract":"<p>Plasmonic nanoparticles exhibit dramatic changes in optical properties depending on their spatial organization. Therefore, the ability to precisely control their assembly structure is important for both fundamental understanding and practical applications. In this personal account, we describe a templated surfactant-assisted seed-growth method to synthesize core–shell-type gold nanoparticle assemblies with controllable surface morphologies and optical properties. This approach provides a simple procedure for simultaneous growth and assembly of metal nanoparticles on polymer templates, producing well-defined nanostructures such as spiky nanoshells and raspberry-like metamolecules with useful and interesting optical properties, such as strong and uniform surface-enhanced Raman scattering and metamaterial properties. We discuss the factors that control the morphology and collective properties, describe the design rules acquired from the system, and suggest future directions of this research area.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"45 6","pages":"486-494"},"PeriodicalIF":1.7,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.12845","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141430324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computational basis of TEAD-3 protein noncovalent inhibition: 3D-QSAR modeling and molecular dynamics simulation TEAD-3 蛋白非共价抑制的计算基础：3D-QSAR 建模和分子动力学模拟
IF 1.7 4区 化学
Bulletin of the Korean Chemical Society Pub Date : 2024-04-17 DOI: 10.1002/bkcs.12843
Bita Kaviani, Marzieh Ghani Dehkordi, Hamed Haghshenas
{"title":"Computational basis of TEAD-3 protein noncovalent inhibition: 3D-QSAR modeling and molecular dynamics simulation","authors":"Bita Kaviani,&nbsp;Marzieh Ghani Dehkordi,&nbsp;Hamed Haghshenas","doi":"10.1002/bkcs.12843","DOIUrl":"10.1002/bkcs.12843","url":null,"abstract":"<p>The tumor-suppressing phosphorylation cascade is primarily regulated by transcriptional enhanced associate domain (TEAD) transcription factors, and the overexpression of these factors is associated with tumorigenesis and cancer progression. The central pocket of TEAD protein can be targeted by noncovalent inhibitors, and therefore, investigating the interaction patterns for TEAD and its available inhibitors seems essential. In this regard, molecular dynamics simulations were conducted to identify the most potent TEAD3 noncovalent inhibitors and to study TEAD3–inhibitor interaction patterns. We developed a 3D-quantitative structure–activity relationship model to investigate the structure–activity correlation for the available TEAD3 inhibitors. Our results indicated the role of Tyr230, Val317, Thr333, Met367, Cys368, Met371, Phe394, Ile396, Gln398, and Phe416 residues in TEAD3–inhibitor interactions. Dihydropyrazolo pyrimidines and compound 2 were identified as the most potent TEAD3 noncovalent inhibitors. The Comparative Molecular Field Analysis model analysis identified the hydrophobic-favored regions around the pyrazolo[1,5-a]pyrimidin-7(4H)-one ring and the unfavored steric regions around cyclohexane and phenyl groups of dihydropyrazolo pyrimidines.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"45 6","pages":"535-550"},"PeriodicalIF":1.7,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140690420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cover Picture: Metal-Organic Frameworks as a Fluorescent Probe for Detection of Pathogenic Biomarkers in Human Urine (BKCS 4/2024) Seyeon Jeong, Hoi Ri Moon 封面图片：金属有机框架作为荧光探针检测人类尿液中的致病性生物标记物（BKCS 4/2024 Seyeon Jeong, Hoi Ri Moon
IF 1.7 4区 化学
Bulletin of the Korean Chemical Society Pub Date : 2024-04-15 DOI: 10.1002/bkcs.12732
{"title":"Cover Picture: Metal-Organic Frameworks as a Fluorescent Probe for Detection of Pathogenic Biomarkers in Human Urine (BKCS 4/2024) Seyeon Jeong, Hoi Ri Moon","authors":"","doi":"10.1002/bkcs.12732","DOIUrl":"https://doi.org/10.1002/bkcs.12732","url":null,"abstract":"<p>The cover picture illustrates metal-organic frameworks (MOFs) being used as fluorescent probes to detect biomarkers in human urine. MOF-based fluorescent probes facilitate the diagnosis of diseases, including pheochromocytoma, toluene exposure, vitamin deficiencies, gout, hyperuricemia, cancers, various body disorders, and teratogenic effects, with low detection limits. Unlike conventional disease diagnosis methods such as biopsies or blood collection, detecting pathogenic biomarkers in human urine is non-invasive and carries less risk. More details are available in the article by Seyeon Jeong and Hoi Ri Moon.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"45 4","pages":"293"},"PeriodicalIF":1.7,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.12732","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140556295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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