Bulletin of the Korean Chemical Society最新文献_第10页

Insights to develop tau-directed therapeutics to protect the synaptic integrity for tauopathies 开发以牛磺酸为导向的治疗药物以保护牛磺酸病突触完整性的启示

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2023-10-20 DOI: 10.1002/bkcs.12792

Eunji Cha, Hak Joong Kim, Sang Min Lim

引用次数: 0

A biodegradable drug-controlled delivery system based on mesoporous manganese dioxide and poly(dopamine) 基于介孔二氧化锰和聚多巴胺的生物可降解药物控制输送系统

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2023-10-18 DOI: 10.1002/bkcs.12788

Miaomiao Li, Wenrong Cai, Lihua Jiang, Junyao Li, Shan Li, Tongtong Tang, Yong Kong

引用次数: 0

A facile route for highly enantioenriched six-membered 1,4-N,N- and N,O-heterocycles from L-serinate-derived α-bromoacetates 从L-丝氨酸衍生的α-溴乙酸酯制备高对映体富集的六元 1,4-N,N-和 N,O-杂环的简便路线

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2023-10-14 DOI: 10.1002/bkcs.12787

So Jeong Lee, Min Ji Park, Seyeon Kim, Yong Sun Park

引用次数: 0

Cover Picture: Recent progress in poly(ethylene oxide)-based solid-state electrolytes for lithium-ion batteries (BKCS 10/2023) Jiyoung Lee, Byeong-Su Kim 封面图片：锂离子电池用聚环氧乙烷基固态电解质的最新进展（BKCS 10/2023）Jiyoung Lee，Byeong Su Kim

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2023-10-13 DOI: 10.1002/bkcs.12567

引用次数: 0

Mono o-nitrobenzyl dihydrofluorescein as a photoactivatable ROS sensor for oxidative stress in live cells 单邻硝基苄基二氢荧光素作为活细胞氧化应激的光活化 ROS 传感器

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2023-09-25 DOI: 10.1002/bkcs.12784

Hye-Ryeong Jo, Seo Jin Kim, Yingyu Zheng, Seok-Hyun Cho, Sang un Nam, Seungwon Moon, Chulhun Kang, Tae Woo Kim

{"title":"Mono o-nitrobenzyl dihydrofluorescein as a photoactivatable ROS sensor for oxidative stress in live cells","authors":"Hye-Ryeong Jo, Seo Jin Kim, Yingyu Zheng, Seok-Hyun Cho, Sang un Nam, Seungwon Moon, Chulhun Kang, Tae Woo Kim","doi":"10.1002/bkcs.12784","DOIUrl":"10.1002/bkcs.12784","url":null,"abstract":"The confocal interpretation of organelle-selective fluorogenic chemosensors can be ambiguous because of inconsistency between the sensor localization and reaction site. To overcome this limitation, we implemented the photoactivation strategy which refers to light-controlled probe activation within cells at the desired time. In this study, we synthesized a photoactivatable dihydrofluorescein probe (1) and its cell-permeable derivative (3, acetoxymethyl ester of 1). We confirmed their reactivity to reactive oxygen species (ROS) and photoactivation in both solution and cells. The photoactivation of probe 3 facilitated temporal control between probe treatment and the occurrence of fluorogenic events. We conducted organelle colocalization studies and cellular ROS imaging, clearly showing that the probe primarily localized to early/late endosomes and reacted with intracellular ROS at these endosomes. These findings highlight the effectiveness of the photoactivation strategy for fluorogenic ROS probes in mitigating ambiguities associated with conventional fluorogenic ROS sensing approaches.","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135770767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanochemical activation of NHC–CS2 adducts for the generation of N-heterocyclic carbenes 通过机械化学活化 NHC-CS2 加合物生成 N-杂环碳烯

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2023-09-19 DOI: 10.1002/bkcs.12782

Subin Park, Youngsuk Kim

引用次数: 0

Cover Picture: KHC2O4·B(OH)3: A nonlinear optical crystal with large birefringence in the short-wavelength ultraviolet region (BKCS 9/2023) Yang Li, Jihyun Lee, Kang Min Ok 封面图片：KHC2O4·B（OH）3：短波长紫外区域大双折射非线性光学晶体（BKCS 9/2023）杨丽，李继云，Ok Kang Min

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2023-09-18 DOI: 10.1002/bkcs.12565

引用次数: 0

Investigation of the photovoltaic effect in dye-sensitized solar cells based on poly(ethylene glycol)-nanofiber electrolytes 基于聚乙二醇-纳米纤维电解质的染料敏化太阳能电池的光伏效应研究

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2023-09-11 DOI: 10.1002/bkcs.12781

Mi-Ra Kim, Sung Soo Park, Jeonghye Han, Thanh Chung Pham, Minkyung Kang, Songyi Lee

{"title":"Investigation of the photovoltaic effect in dye-sensitized solar cells based on poly(ethylene glycol)-nanofiber electrolytes","authors":"Mi-Ra Kim, Sung Soo Park, Jeonghye Han, Thanh Chung Pham, Minkyung Kang, Songyi Lee","doi":"10.1002/bkcs.12781","DOIUrl":"10.1002/bkcs.12781","url":null,"abstract":"In this study, the effectiveness of electrospun poly(ethylene glycol) (PEG) nanofibers as polymer electrolytes for dye-sensitized solar cells (DSSCs) is evaluated. Regular PEG nanofibers are electrospun at an applied voltage of 15 kV, using a polymer concentration of 13 wt% and tip-to-collector distance of 20 cm. Subsequently, the photovoltaic effect in DSSCs containing PEG-nanofiber electrolytes with different I2 concentrations is analyzed. On reducing the concentration of I2 in the PEG-nanofiber electrolyte, the short-circuit photocurrent density (Jsc) of the corresponding DSSC increases significantly. A high power-conversion efficiency of 5.93% is recorded (by a solar simulator under AM 1.5 illumination) for a PEG-nanofiber-based DSSC containing an I2/tetrabuthylammonium iodide (TBAI) molar ratio of 0.25. Additionally, electrochemical impedance spectroscopy is used to analyze the charge-transfer resistance of the TiO2/PEG-nanofiber electrolyte interface in the fabricated DSSCs; the electrolyte uptake, ionic conductivity, and charge-transfer resistance values are investigated as a function of the molar ratio of I2/TBAI.","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135981378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improvement of the metabolic stability of pan-RAF/VEGFR2 dual inhibitors pan - RAF/VEGFR2双抑制剂代谢稳定性的改善

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2023-09-03 DOI: 10.1002/bkcs.12779

Santanu Maiti, Jeong Hee Kwon, Sung Pyo Hong, Ho-Seok Kwon, Jinho Kim, Soon Kil Ahn

{"title":"Improvement of the metabolic stability of pan-RAF/VEGFR2 dual inhibitors","authors":"Santanu Maiti, Jeong Hee Kwon, Sung Pyo Hong, Ho-Seok Kwon, Jinho Kim, Soon Kil Ahn","doi":"10.1002/bkcs.12779","DOIUrl":"10.1002/bkcs.12779","url":null,"abstract":"Development of dual inhibitors of pan-RAF/VEGFR2 is important for the treatment of K-Ras mutated colorectal cancer, which is one of the most common and lethal malignancies. Building upon our studies in dual inhibitors of pan-RAF/VEGFR2, we designed and synthesized new dual inhibitor candidates by installing a urea or guanidine moiety to the previously reported dual inhibitors in order to enhance both metabolic stability and solubility. Various 1-(5-((3-(9H-purin-6-yl)pyridin-2-yl)amino)-2-fluorophenyl)-3-phenylurea and 1-(5-((3-(9H-purin-6-yl)pyridin-2-yl)amino)-2-fluorophenyl)-3-phenylguanidine derivatives were synthesized, and their antiproliferative activities against LS513 cell (K-RasG12D) and VEGFR2 were evaluated. Among the tested compounds, 1-(5-((3-(9H-purin-6-yl)pyridin-2-yl)amino)-2-fluorophenyl)-3-(3-fluorophenyl)urea (7b) and 1-(5-((3-(9H-purin-6-yl)pyridin-2-yl)amino)-2-fluorophenyl)-3-(4-chloro-3-trifluoromethyl)phenyl)urea (7e) are the most potent dual inhibitors against LS513 (GI50 = 0.1 and 0.06 μM, respectively) and VEGFR2 (IC50 = 0.03 and 0.06 μM, respectively). The preclinical study with these compounds are currently underway.","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80634494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reactions of 2,4-dinitrophenyl 5-substituted-2-thiophenecarboxylate promoted by 4-ZC6H4O−/4-ZC6H4OH in 20 mol% DMSO(aq). Effects of leaving group and nucleophile on the acyl transfer reactions 4 - ZC6H4O−/4 - ZC6H4OH促进2,4 -二硝基苯- 5 -取代- 2 -噻吩羧酸盐在20 mol% DMSO(aq)中的反应。离去基和亲核试剂对酰基转移反应的影响

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2023-09-01 DOI: 10.1002/bkcs.12780

Sang Yong Pyun, Kyu Cheol Paik, Man So Han, Seung Taek Hong, Bong Rae Cho

{"title":"Reactions of 2,4-dinitrophenyl 5-substituted-2-thiophenecarboxylate promoted by 4-ZC6H4O−/4-ZC6H4OH in 20 mol% DMSO(aq). Effects of leaving group and nucleophile on the acyl transfer reactions","authors":"Sang Yong Pyun, Kyu Cheol Paik, Man So Han, Seung Taek Hong, Bong Rae Cho","doi":"10.1002/bkcs.12780","DOIUrl":"10.1002/bkcs.12780","url":null,"abstract":"The kinetics of nucleophilic substitution reactions involving 2,4-dinitrophenyl 5-substituted-2-thiophenecarboxylate were studied kinetically with 4-Z-C6H4O−/4-Z-C6H4OH, which facilitated the reactions, in 20 mol% DMSO(aq). The reactions followed second-order kinetics and exhibited βacyl = −2.34 to −2.92, ρ(Y) = 2.71–3.39, βnuc = 0.74–0.83, and |βlg| = 0.40–0.57. Based on the interpretation of the results, we have concluded that the reaction follows an addition–elimination mechanism in which the first step is the rate-determining step (rds). The transition state structures for the 4-ZC6H4O−-promoted reactions remained nearly the same with a change in the leaving group from 4-nitrophenoxide to 2,4-dinitrophenoxide. The mechanism of the 4-ZC6H4O−-promoted reaction was similar to that of R2NH-promoted reactions, except that the former proceeded with the 1st step being the rds and the latter proceeded with a change in the rds from the second to the first step with a stronger nucleophile.","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90414289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0