Bulletin of the Korean Chemical Society最新文献_第9页

A biothiols and H2O2 responsive fluorescence probe for selective cancer imaging 用于选择性癌症成像的生物硫醇和 H2O2 响应型荧光探针

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2023-12-26 DOI: 10.1002/bkcs.12811

Nan Yin, Guixin Qin, Yuting Wang, Jiali Tang, Xin Yao, Qingling Xu

{"title":"A biothiols and H2O2 responsive fluorescence probe for selective cancer imaging","authors":"Nan Yin, Guixin Qin, Yuting Wang, Jiali Tang, Xin Yao, Qingling Xu","doi":"10.1002/bkcs.12811","DOIUrl":"10.1002/bkcs.12811","url":null,"abstract":"Identification of cancer from normal tissues is important for early diagnosis of cancer. Combined detection of multiple tumor markers is important for accurate diagnosis. It is urgent to develop fluorescent probes that are responsive to multiple cancer characterizations for selective cancer imaging. Herein, we designed a novel near-infrared (NIR) fluorescent probe (IRAPA) using a hemi-cyanine skeleton as fluorophore and 3-acrylamidopropanoic ester as recognizing unit that is responsive to both oxidative and reductive molecules. IRAPA has faint fluorescence emission as the intramolecular charge transfer (ICT) process is blocked. H2O2, glutathione (GSH) and cysteine (Cys) can individually induce the hydrolysis of ester bond and give fluorescent NIR IROH. IRAPA shows low cytotoxicity and produces strong fluorescence specifically in cancer cells/tissues. While the normal cells/tissues showed very weak fluorescence. Moreover, IRAPA shows higher differences between cancer and normal cells compared to probes that only response to biothiols or ROS.","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"45 3","pages":"252-258"},"PeriodicalIF":1.7,"publicationDate":"2023-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139055802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of co-substitution on complex thermoelectric compounds: The Zintl phase Ba1-xSrxZn2-yCuySb2 system 共取代对复杂热电化合物的影响：Zintl 相 Ba1-xSrxZn2-yCuySb2 系统

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2023-12-23 DOI: 10.1002/bkcs.12806

Jiwon Jeong, Daewon Shim, Myung-Ho Choi, Kang Min Ok, Tae-Soo You

{"title":"Effect of co-substitution on complex thermoelectric compounds: The Zintl phase Ba1-xSrxZn2-yCuySb2 system","authors":"Jiwon Jeong, Daewon Shim, Myung-Ho Choi, Kang Min Ok, Tae-Soo You","doi":"10.1002/bkcs.12806","DOIUrl":"10.1002/bkcs.12806","url":null,"abstract":"Three co-substituted quaternary and quinary Zintl phases belonging to the Ba1-xSrxZn2-yCuySb2 (x = 0, 0.09; 0.24 ≤ y ≤ 0.42) system were prepared by the molten Pb metal-flux method. Co-substitution using the cationic Sr and anionic Cu for Ba and Zn was initially applied to lower the thermal conductivities and to improve the electric conductivities of these title compounds simultaneously. The homogeneities of single-phase products were verified by powder x-ray diffraction analysis, and the BaCu2S2-type orthorhombic crystal structures with the Ba/Sr and the Zn/Cu mixed-sites were refined by single crystal x-ray diffraction analysis. Structural selectivity for the observed BaCu2S2-type phase was rationalized by the radius ratio of cationic and anionic elements, where r+/r− > 1. DFT calculations using the three structural models revealed that the Sr and Cu substitutions can increase the structural stability and the hole carrier concentration. A series of temperature-dependent electrical transport property measurements for BaZn1.76Cu0.24Sb2 and Ba0.91Sr0.09Zn1.70Cu0.30Sb2 successfully proved that the co-substitution using Sr and Cu enhanced electrical conductivities, but reduced the Seebeck coefficients resulting in the slight change in power factor.","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"45 2","pages":"165-170"},"PeriodicalIF":1.7,"publicationDate":"2023-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139031380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cover Picture: Optimized Stereoselective and Scalable Synthesis of Five-Membered Cyclic trans-β-Amino Acid Building Blocks via Reductive Amination (BKCS 12/2023) Jungwoo Hong, Wonchul Lee, Hee-Seung Lee 封面图片：通过还原胺化优化立体选择性和可扩展合成五元环反式-β-氨基酸构筑物 (BKCS 12/2023) Jungwoo Hong, Wonchul Lee, Hee-Seung Lee

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2023-12-20 DOI: 10.1002/bkcs.12571

引用次数: 0

Molecular structural descriptor-assisted machine learning for organic photovoltaics with perylenediimide acceptors 利用分子结构描述符辅助机器学习过二亚胺受体的有机光伏技术

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2023-12-15 DOI: 10.1002/bkcs.12810

Gyu-Hee Kim, Keonho Yoon, Chihyung Lee, Minwoo Nam, Doo-Hyun Ko

{"title":"Molecular structural descriptor-assisted machine learning for organic photovoltaics with perylenediimide acceptors","authors":"Gyu-Hee Kim, Keonho Yoon, Chihyung Lee, Minwoo Nam, Doo-Hyun Ko","doi":"10.1002/bkcs.12810","DOIUrl":"10.1002/bkcs.12810","url":null,"abstract":"Although organic photovoltaics (OPVs) have evolved over the last two decades, the discovery of new materials and optimization of numerous considerations for high-performance devices remain challenging. To reduce these laborious processes and expedite the advancement of OPVs, we constructed machine learning (ML) models that predict photovoltaic parameters. We designed a unique descriptor that divides the molecular structure into smaller units and translates them into a concise matrix. This allows the ML model to easily track structural units and understand which units are important for predicting target performance, enabling the ML model to prioritize crucial units. Therefore, without requiring additional data from measurements or calculations, the ML models can extract chemical properties from molecular structural information and accurately predict the photovoltaic parameters. The ML models that predict the photovoltaic parameters, including the open-circuit voltage, short-circuit current density, fill factor, and power conversion efficiency, all show remarkably superior prediction performance, with Pearson correlation coefficients exceeding 0.68. Consequently, in this article, we propose a highly precise and reliable predictive OPV-ML platform that can robustly screen for unnecessary experiments and accelerate OPV development.","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"45 2","pages":"125-130"},"PeriodicalIF":1.7,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138714802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photoluminescence properties of Eu2+-activated thiogallate phosphors Eu2+ 激活的硫代镓酸盐荧光粉的光致发光特性

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2023-12-12 DOI: 10.1002/bkcs.12805

Young-Sik Cho, Moon-Su Bok, Young-Duk Huh

引用次数: 0

Tandem annulation and dipolar cycloaddition of azomethine imines in catalytic C(sp2)–H functionalization 催化 C(sp2)-H官能团化中偶氮亚胺的串联环化和双极环加成反应

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2023-12-12 DOI: 10.1002/bkcs.12809

Neeraj Kumar Mishra, Amitava Rakshit, Kyeongwon Moon, Pargat Singh, In Su Kim

引用次数: 0

Dimensionality reduction in diffusion–reaction systems 降低扩散反应系统的维度

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2023-12-12 DOI: 10.1002/bkcs.12808

Kihyun Park, Taejun Kim, Hyojoon Kim

引用次数: 0

A geometric key for enhancing the radiative efficiency of ortho-carboranyl luminophores: Indolocarbazole- and m-terphenyl-ortho-carboranes 提高正硼烷基发光体辐射效率的几何关键：吲哚咔唑和间三联苯正硼烷

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2023-12-09 DOI: 10.1002/bkcs.12804

Mingi Kim, Kanghee Cho, Yung Ju Seo, Junhyeok Choi, Namkyun Kim, Ilsup Shin, Kang Mun Lee

{"title":"A geometric key for enhancing the radiative efficiency of ortho-carboranyl luminophores: Indolocarbazole- and m-terphenyl-ortho-carboranes","authors":"Mingi Kim, Kanghee Cho, Yung Ju Seo, Junhyeok Choi, Namkyun Kim, Ilsup Shin, Kang Mun Lee","doi":"10.1002/bkcs.12804","DOIUrl":"10.1002/bkcs.12804","url":null,"abstract":"In this study, we introduce two ortho-carboranyl compounds, namely ICzCB and mTPCB, which exhibit different planarity in their appended π-conjugated aromatic groups, to investigate the influence of geometric effects on the regulation of the radiative efficiency. Both the compounds are fully characterized, revealing distinct geometric differences (planarity) in their single-crystal structures. While ICzCB presents strong ICT-based emission in the solid (film) state, mTPCB displays dual emission in the high- and low-energy regions that originates from locally excited (LE)- and ICT-based processes, respectively. Quantitative analysis of the photophysical characteristics of the compounds shows that the ICT-based radiative efficiency in ICzCB is higher than that in mTPCB. Consequently, these findings demonstrate that the planarity of the π-conjugated aryl group appended on o-carborane, which is represented by planar ICzCB and distorted mTPCB, is an important key to control the ICT-based radiative decay efficiency.","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"45 2","pages":"101-109"},"PeriodicalIF":1.7,"publicationDate":"2023-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138562109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Li-ion hopping conduction enabled by associative Li-salt in acetonitrile solutions 结合锂盐在乙腈溶液中实现锂离子跳变传导

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2023-12-06 DOI: 10.1002/bkcs.12802

Bonhyeop Koo, Hyejin Lee, Kisung Park, Sunwook Hwang, Hochun Lee

{"title":"Li-ion hopping conduction enabled by associative Li-salt in acetonitrile solutions","authors":"Bonhyeop Koo, Hyejin Lee, Kisung Park, Sunwook Hwang, Hochun Lee","doi":"10.1002/bkcs.12802","DOIUrl":"10.1002/bkcs.12802","url":null,"abstract":"To date, ionic conduction in nonaqueous electrolytes has been explained through the vehicle-type migration mechanism. Yet, new research hints at another conduction mode: ion-hopping, seen in highly concentrated solutions with multi-coordinating solvents. Our research uncovers that Li-ion hopping conduction also occurs in monodentate acetonitrile (AN) electrolytes, enabled by a highly associative Li-salt. Using techniques like pulse-field gradient NMR, Raman spectroscopy, and dielectric relaxation spectroscopy, we examined AN solutions with lithium trifluoroacetate (LiTFA) and lithium bis(fluorosulfonyl)imide (LiFSI). Results showed that Li-ion diffusion in LiTFA-AN was faster due to an anion-bridge structure formed by the associative nature of LiTFA. In contrast, the LiFSI-AN solution demonstrated slower Li-ion movement. In practical applications, like LiFePO4 symmetric cells, 4 M LiTFA-AN outperformed 1 M LiTFA-AN in rate performance, despite its lower ionic conductivity. This challenges the belief that associative Li-salts are unsuitable for battery electrolytes and prompts reconsideration of other associative Li-salts.","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"45 2","pages":"92-100"},"PeriodicalIF":1.7,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138526713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and biological evaluation of (2-aminosulfonylpyridin-6-yl)pyrazolopyrimidinone derivatives as Wee1 inhibitors for cancer treatment (2-氨基磺酰基吡啶-6-酰基)吡唑嘧啶衍生物作为Wee1肿瘤抑制剂的合成及生物学评价

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2023-12-06 DOI: 10.1002/bkcs.12791

Yeon Ju Kim, Myoung Eun Jung, Ju Yeong Lee, Yun-Han Lee, Gildon Choi, Moon-Kook Jeon

{"title":"Synthesis and biological evaluation of (2-aminosulfonylpyridin-6-yl)pyrazolopyrimidinone derivatives as Wee1 inhibitors for cancer treatment","authors":"Yeon Ju Kim, Myoung Eun Jung, Ju Yeong Lee, Yun-Han Lee, Gildon Choi, Moon-Kook Jeon","doi":"10.1002/bkcs.12791","DOIUrl":"10.1002/bkcs.12791","url":null,"abstract":"For an analog-based design of novel Wee1 inhibitors, we profiled in vitro ADMET and in vivo PK properties of adavosertib. Based on the properties of adavosertib, we aimed to improve its metabolic stability by designing a novel target compound 1a with an aminosulfonyl group instead of the 2-hydroxypropan-2-yl moiety in adavosertib. Derivatives of target compound 1a were synthesized and evaluated for Wee1 enzyme inhibition and liver microsomal phase I stability. We identified compound 1a as a sub-nanomolar Wee1 inhibitor and 10 additional compounds with one-digit nanomolar Wee1 inhibitory activity, among which seven compounds including 1a exhibited improved metabolic stabilities compared with adavosertib. However, MDA-MB-231 cell growth inhibitory activities of all synthesized compounds and Wee1 substrate phosphorylation inhibitory activities of selected compounds were inferior to adavosertib overall. Moreover, the representative compound 1a exhibited low permeability, which may be the reason for the low cellular activities of compound 1a.","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"45 1","pages":"60-66"},"PeriodicalIF":1.7,"publicationDate":"2023-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.12791","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138526778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0