Jun Yong Oh, Gyeongseok Yang, Eunshil Choi, Ja-Hyoung Ryu
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引用次数: 0
Abstract
For the construction of a nanoparticle (NP)-supported drug delivery system (DDS), loading efficiency, stable encapsulation, and targeted delivery are considered crucial to achieve a high therapeutic outcome of the resulting system. Conventionally, NPs are functionalized with desired molecules via covalent interactions, which do not only limit the intraparticle space for drug loading but also cause significant loss of the preloaded drug through the multistep chemical reactions. Furthermore, NPs with covalently modified surface are easily surrounded with biomolecules during blood circulation, and their accumulation in a target site becomes considerably hampered. Keeping these issues in mind, we herein summarize the recently reported unconventional strategies to prepare a more powerful DDS with enhanced loading and targeting ability, by installing a noncovalent polymeric gatekeeper or surface-protective biomolecular layer on the NP surface.
期刊介绍：
The Bulletin of the Korean Chemical Society is an official research journal of the Korean Chemical Society. It was founded in 1980 and reaches out to the chemical community worldwide. It is strictly peer-reviewed and welcomes Accounts, Communications, Articles, and Notes written in English. The scope of the journal covers all major areas of chemistry: analytical chemistry, electrochemistry, industrial chemistry, inorganic chemistry, life-science chemistry, macromolecular chemistry, organic synthesis, non-synthetic organic chemistry, physical chemistry, and materials chemistry.
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