Bulletin of the Korean Chemical Society最新文献_第2页

Electrocatalytic activity of nickel and cobalt cinnamate for oxygen evolution reaction with reduced graphene oxide or carbon nanotube 肉桂酸镍和钴与还原氧化石墨烯或碳纳米管的析氧反应的电催化活性

IF 2.2 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2025-07-31 DOI: 10.1002/bkcs.70052

Jimin Lee, Sunwoo Geum, Jiehye Shin, Hyewon Shin, Sun Jun Jin, Jaedo Na, Minkyun Shin, Junghwan Do, Seong Jung Kwon, Sumin Lee

{"title":"Electrocatalytic activity of nickel and cobalt cinnamate for oxygen evolution reaction with reduced graphene oxide or carbon nanotube","authors":"Jimin Lee, Sunwoo Geum, Jiehye Shin, Hyewon Shin, Sun Jun Jin, Jaedo Na, Minkyun Shin, Junghwan Do, Seong Jung Kwon, Sumin Lee","doi":"10.1002/bkcs.70052","DOIUrl":"https://doi.org/10.1002/bkcs.70052","url":null,"abstract":"The stability and catalytic properties of coordination polymers (CPs) in electrochemical reactions can be improved by incorporating supporting materials. In this study, the enhancement of the electrocatalytic performance of two isostructural CP electrocatalysts, Ni and Co trans-cinnamate (t-ca), was investigated using three carbon-based supports: reduced graphene oxide (rGO), multi-walled carbon nanotubes (MWCNT), and carboxylic acid-functionalized MWCNT (MWCNT-COOH). The objective was to improve the catalytic performance in the oxygen evolution reaction (OER). Investigation of the OER characteristics of each catalyst/support combination, Ni t-ca/MWCNT-COOH and Co t-ca/rGO combinations, exhibited overpotential reductions of approximately 20 and 35 mV, respectively, compared to the unsupported catalyst. The enhanced electrocatalytic properties can be attributed to chemical interactions such as π–π interactions and hydrogen bonding between the supports and the π-conjugated hydrocarbon and carboxylate groups present in the t-ca ligand.","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 8","pages":"813-820"},"PeriodicalIF":2.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ACE2-rich cells-targeted fluorescence imaging using newly discovered peptides from SARS-CoV-2 epitopes and neutralizing antibodies 利用新发现的SARS-CoV-2表位肽和中和抗体的富ace2细胞靶向荧光成像

IF 2.2 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2025-07-27 DOI: 10.1002/bkcs.70050

Jaehui Lee, Do-Yeon Kim, Ju Hyeon Park, Nam Cheol Hwang, Jong Min An, Dokyoung Kim

{"title":"ACE2-rich cells-targeted fluorescence imaging using newly discovered peptides from SARS-CoV-2 epitopes and neutralizing antibodies","authors":"Jaehui Lee, Do-Yeon Kim, Ju Hyeon Park, Nam Cheol Hwang, Jong Min An, Dokyoung Kim","doi":"10.1002/bkcs.70050","DOIUrl":"https://doi.org/10.1002/bkcs.70050","url":null,"abstract":"The discovery of new targeting peptides for specific cells, tissues, or disease sites has gained significant attention in both basic research and translational medicine, particularly for the development of drug delivery platforms. This study identified a targeting peptide for ACE2-rich cells, which play a crucial role in maintaining blood–brain barrier integrity and neurovascular function, and applied the peptides for the fluorescence imaging of ACE2-rich cells. By analyzing the epitope sequences of the SARS-CoV-2 spike protein and the binding sites of neutralizing antibodies, we identified a hit peptide sequence, GFQPTNGVGYQ. In vitro and in vivo experiments demonstrated the peptide's selective binding to ACE2-rich cells and its accumulation in brain tumor tissue in a glioblastoma mouse model. These findings provide valuable insights into the development of peptide-based therapeutics and hold potential for treating brain-related neurovascular diseases.","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 8","pages":"803-812"},"PeriodicalIF":2.2,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.70050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and evaluation of hydroxypropyl methylcellulose-based film incorporated with aspirin-loaded solid lipid nanoparticles to treat skin cancer 羟丙基甲基纤维素复合载阿司匹林固体脂质纳米颗粒治疗皮肤癌的制备及评价

IF 2.2 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2025-07-21 DOI: 10.1002/bkcs.70053

Sooho Yeo, Min Je Kim, Bomin Kim, Il Yoon, Woo Kyoung Lee

{"title":"Preparation and evaluation of hydroxypropyl methylcellulose-based film incorporated with aspirin-loaded solid lipid nanoparticles to treat skin cancer","authors":"Sooho Yeo, Min Je Kim, Bomin Kim, Il Yoon, Woo Kyoung Lee","doi":"10.1002/bkcs.70053","DOIUrl":"https://doi.org/10.1002/bkcs.70053","url":null,"abstract":"The purpose of this study was to develop a hydroxypropyl methylcellulose (HPMC)-based thin film incorporating aspirin (ASP)-loaded solid lipid nanoparticles (SLNs) for skin cancer therapy. SLNs are allowed to effectively interact with the intercellular lipids in the stratum corneum, leading to a continuous release of ASP. Thin films based on HPMC, a mucoadhesive polymer, can improve the skin residence time of SLN. ASP, a biopharmaceutics classification system (BCS) class I drug, was encapsulated into SLNs using the water-in-oil-in-water (W/O/W) emulsion method. Among tested SLN formulations, the one utilizing stearic acid, Span 80, and poloxamer 188 exhibited the smallest particle size (111.80 nm) and highest loading efficiency (67.40%). The HPMC-thin film with 10% SLNs showed sustained ASP release and significant anti-cancer effects. In cytotoxicity studies on skin cancer cells, the half maximal inhibitory concentration (IC50) values for ASP solution, SLNs, and the HPMC-thin film with SLNs were 0.23, 0.15, and 0.18 mM, respectively. This means that the anti-cancer effect of ASP was enhanced by approximately 1.55 times (SLNs) and 1.28 times (HPMC-thin film with SLNs) compared to the ASP solution. These results indicate that the HPMC-based thin film with ASP-loaded SLNs could be useful as a skin cancer treatment agent.","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 8","pages":"821-829"},"PeriodicalIF":2.2,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A theoretical study on the acid-catalyzed disproportionation reaction of a Mn(IV)-oxo porphyrin complex 锰(IV)-氧卟啉配合物酸催化歧化反应的理论研究

IF 2.2 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2025-07-21 DOI: 10.1002/bkcs.70049

Steiny Russelisaac Premakumari, Yunhee Choi, Maggie Ng, Vandana Kardam, Wonwoo Nam, Kyung-Bin Cho

{"title":"A theoretical study on the acid-catalyzed disproportionation reaction of a Mn(IV)-oxo porphyrin complex","authors":"Steiny Russelisaac Premakumari, Yunhee Choi, Maggie Ng, Vandana Kardam, Wonwoo Nam, Kyung-Bin Cho","doi":"10.1002/bkcs.70049","DOIUrl":"https://doi.org/10.1002/bkcs.70049","url":null,"abstract":"Density functional theory (DFT) calculation were performed to study the disproportionation reaction of high-valent Mn(IV)(O) species, such as 2[MnIV(O)(Porp)] → [MnIV(O)(Porp•+)] + [MnIII(O)(Porp)] (Porp = porphine2−), which experimentally occurs (only) in the presence of acid. Energy calculations of all possible derivatives of the above species with regard to protonation and Cl− and OTf− axial ligation enabled us to calculate the approximate thermodynamics of all the possible reactions and pinpoint the most probable disproportionation reaction occurring for more detailed studies. Thus, we predict that the real disprotonation reaction occurs in four steps, such as (i) reactant protonation, (ii) axial ligand exchange, (iii) proton-coupled electron transfer mediated disproportionation, and finally (iv) product protonation. The conditions for the disproportionation reaction to occur in this system may be applicable for similar systems, such as other high-valent metal-oxo systems. Furthermore, the current study is an example where relatively rudimentary calculations can give surprisingly deep insights into a biochemically relevant reaction.","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 8","pages":"784-790"},"PeriodicalIF":2.2,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.70049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design principles of protein–protein interfaces 蛋白质-蛋白质界面的设计原则

IF 2.2 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2025-07-21 DOI: 10.1002/bkcs.70051

Chan-Gyu Kim, Tae Hwan Kim, Jeong-Mo Choi

引用次数: 0

Cover Picture: Fast and Stable Cycling of 2,6-Diaminoanthraquinone as a Redox-Active Organic Cathode for Sodium-Ion Batteries (BKCS 7/2025) Honggyu Seong, Youngseok Chang, Jaewon Choi 封面图：2,6-二氨基蒽醌作为钠离子电池氧化还原活性有机阴极的快速稳定循环(BKCS 7/2025

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2025-07-21 DOI: 10.1002/bkcs.12868

引用次数: 0

Protease-associated enzyme-linked immunosorbent assay for detecting matrix metalloproteinase-9 蛋白酶相关酶联免疫吸附法检测基质金属蛋白酶-9

IF 2.2 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2025-07-19 DOI: 10.1002/bkcs.70046

Saodat Nurulloeva, Yeon-Ju Lee, Hana Cho, Dong-Sik Shin

{"title":"Protease-associated enzyme-linked immunosorbent assay for detecting matrix metalloproteinase-9","authors":"Saodat Nurulloeva, Yeon-Ju Lee, Hana Cho, Dong-Sik Shin","doi":"10.1002/bkcs.70046","DOIUrl":"https://doi.org/10.1002/bkcs.70046","url":null,"abstract":"Matrix metalloproteinase-9 (MMP-9) plays a key role in extracellular matrix remodeling and is implicated in various physiological and pathological processes, including tissue regeneration and cancer progression. Accurate quantification of MMP-9 is essential for diagnostic and therapeutic applications. In this study, we developed a protease-based fluorescence enzyme-linked immunosorbent assay (ELISA) platform utilizing biotinylated α-chymotrypsin (α-CTB) as an alternative enzymatic reporter to conventional horseradish peroxidase (HRP). α-CT was conjugated with biotin using biotinamidohexanoic acid 3-sulfo-N-hydroxysuccinimide ester, achieving a labeling ratio of approximately 6.5:1 without significantly compromising enzymatic activity. The biotinylation efficiency was verified using the 2-(4-hydroxyphenylazo)benzoic acid (HABA)–avidin assay, and proteolytic activity was assessed with the fluorogenic substrate. Comparative kinetic analysis revealed that α-CTB retained substantial activity, including when immobilized on streptavidin-coated surfaces, validating its use in solid-phase immunoassays. The α-CTB-based ELISA was applied to quantify MMP-9 and compared with a conventional HRP-based ELISA. The α-CTB assay exhibited a concentration-dependent increase in fluorescence across a broad dynamic range, achieving a lower limit of quantification (LOQ) of 1.49 ng/mL, whereas the traditional ELISA showed reduced sensitivity at low concentrations with an LOQ of 3.19 ng/mL. This improved sensitivity demonstrates the suitability of α-CTB as an alternative enzymatic reporter for accurate biomarker quantification.","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 8","pages":"796-802"},"PeriodicalIF":2.2,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of phenoxyartemisinin derivatives on the inhibition of colorectal cancer and cancer stem cells 苯氧青蒿素衍生物对结直肠癌和肿瘤干细胞的抑制作用

IF 2.2 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2025-07-19 DOI: 10.1002/bkcs.70047

Nam Hyun Kim, Seokjoon Lee, Woon-seob Shin, Sangtae Oh

{"title":"Effects of phenoxyartemisinin derivatives on the inhibition of colorectal cancer and cancer stem cells","authors":"Nam Hyun Kim, Seokjoon Lee, Woon-seob Shin, Sangtae Oh","doi":"10.1002/bkcs.70047","DOIUrl":"https://doi.org/10.1002/bkcs.70047","url":null,"abstract":"As the aging population grows, the incidence of colorectal cancer (CRC) is increasing, making it a significant global health concern. Despite advancements in surgical and chemotherapeutic treatments, the five-year survival rate for CRC remains around 65%, largely due to the presence of chemotherapy-resistant cancer stem cells (CSCs). Artemisinin derivatives, known for their antimalarial properties, have shown potential anticancer activity. This study focuses on phenoxyartemisinin compounds and their effects on colon cancer cells and CSCs. We synthesized C-10 substituted phenoxyartemisinins and evaluated their efficacy using in vitro and in vivo models. The results demonstrated that phenoxyartemisinins, particularly compound 4a, significantly inhibited the growth of colon CSCs and reduced sphere formation, an indicator of stem cell activity. Additionally, in a mouse tumor xenograft model, 4a showed substantial tumor reduction with minimal toxicity. These findings suggest that phenoxyartemisinin compounds could offer a novel therapeutic approach for CRC, targeting both cancer cells and CSCs to potentially prevent recurrence and improve patient outcomes.","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 8","pages":"778-783"},"PeriodicalIF":2.2,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.70047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Quantitative analysis of disaggregation properties of aggregation-induced emission luminogens (AIEgens) and off-the-shelf dyes” 对“聚集致发射发光物质（AIEgens）和现成染料分解特性的定量分析”的修正

IF 2.2 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2025-07-17 DOI: 10.1002/bkcs.70048

引用次数: 0

Excited-state proton transfer of weak and medium-strength photoacids in confined methanol-in-oil reverse micelles 弱和中等强度光酸在受限油中甲醇反胶束中的激发态质子转移

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2025-07-08 DOI: 10.1002/bkcs.70034

Taehyung Jang, Yoonsoo Pang

引用次数: 0