Bulletin of the Korean Chemical Society最新文献_第2页

Cp*Co(III)-catalyzed C–H functionalization of bioactive heterocyclic motifs Cp*Co（III）催化的C-H功能化生物活性杂环基序

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2025-06-05 DOI: 10.1002/bkcs.70031

Yeongmi Park, Junbeom Park, Yong Ho Lee, Jongwoo Son

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Bovine-serum-albumin-stabilized Au nanocluster/porous layered double hydroxide hybrid catalyst with enhanced efficiency and reusability 牛血清白蛋白稳定金纳米团簇/多孔层状双氢氧化物杂化催化剂，提高效率和可重复使用性

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2025-06-05 DOI: 10.1002/bkcs.70033

Soo Yeon Kim, Hankyeol Bae, Sunglun Kwon, Jong Hyeon Lee

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α-Azaaryl carbonyl derivatives in stereodivergent catalytic reactions 立体发散催化反应中的α-氮杂芳羰基衍生物

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2025-06-04 DOI: 10.1002/bkcs.70029

Ilwoo Song, Byungjun Kim, Hooseung Lee, Sarah Yunmi Lee

{"title":"α-Azaaryl carbonyl derivatives in stereodivergent catalytic reactions","authors":"Ilwoo Song, Byungjun Kim, Hooseung Lee, Sarah Yunmi Lee","doi":"10.1002/bkcs.70029","DOIUrl":"https://doi.org/10.1002/bkcs.70029","url":null,"abstract":"The catalytic synthesis of chiral azaarenes has become a focal point of research due to their signifi`1cant applications across various fields, including medicinal chemistry and materials science. α-Azaaryl carbonyl compounds, featuring both an electron-withdrawing C=N moiety within an azaarene core and a carbonyl functional group, have proven to be versatile precursors in the synthesis of stereochemically intricate azaaryl molecules. In particular, the generation of chiral α-azaaryl enolate intermediates, catalyzed by chiral Lewis acids, has enabled the precise construction of α-stereogenic chiral azaarenes. This review explores recent advances in the stereodivergent transformations of α-azaaryl carbonyl derivatives with an array of carbon electrophiles, emphasizing the efficiency of catalytic systems involving chiral copper Lewis acids combined with Ir, Pd, Ni, amine, or Ru catalysts. These strategies offer precise control over the stereochemical outcome, facilitating access to all stereoisomers of multi-stereogenic chiral azaarenes. Additionally, we discuss a sequence-dependent approach that allows for controlled stereodivergence in reactions with α-azaaryl carbonyl derivatives. Through a detailed exploration of recent advancements, mechanistic insights, and practical applications, this review underscores the potential of stereodivergent catalytic reactions to unlock new avenues in the synthesis of azaaryl compounds. By presenting diverse strategies and expanding opportunities for controlling stereochemistry, it fosters further development in the design of structurally and stereochemically complex azaarene-based frameworks.","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 6","pages":"602-621"},"PeriodicalIF":1.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.70029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Zn-MOFs incorporating 1,2-bis(4-pyridyl)ethylene and 4,4′-azopyridine: Unlocking new frontiers in antifungal research 含1,2-双（4-吡啶基）乙烯和4,4 ' -偶氮吡啶的zn - mof：开启抗真菌研究的新领域

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2025-06-04 DOI: 10.1002/bkcs.70037

Seo Yeon Heo, Dae Yong Kim, Young Sok Yun, Tae Keun Kwon, Inhong Jung, Young Jae Lee, Youngmee Kim, Suk Joong Lee

{"title":"Zn-MOFs incorporating 1,2-bis(4-pyridyl)ethylene and 4,4′-azopyridine: Unlocking new frontiers in antifungal research","authors":"Seo Yeon Heo, Dae Yong Kim, Young Sok Yun, Tae Keun Kwon, Inhong Jung, Young Jae Lee, Youngmee Kim, Suk Joong Lee","doi":"10.1002/bkcs.70037","DOIUrl":"https://doi.org/10.1002/bkcs.70037","url":null,"abstract":"Metal–organic frameworks (MOFs) have gained significant attention for their antimicrobial properties due to their structural versatility and functional tunability. In this study, two Zn-MOFs, namely, 1-bpe and 2-AZPY, were synthesized using bpe and AZPY ligands, respectively, via solvothermal reactions. These MOFs were systematically evaluated for their antifungal activities against C. cladosporioides, A. niger, and C. albicans. Structural characterization confirmed both MOFs as two-fold interpenetrated frameworks with thermal stability up to 300 °C. Antifungal tests demonstrated that 2-AZPY exhibited superior antifungal efficacy compared to 1-bpe. At a concentration of 2 mg/mL, 2-AZPY achieved 95% inactivation of A. niger and 61% inactivation of C. cladosporioides, while 1-bpe showed relatively weaker antifungal performance. The enhanced antifungal activity of 2-AZPY is attributed to the release of AZPY ligands, which promote thiol oxidation in fungal proteins, leading to cellular inactivation. Further improvement was achieved by incorporating 2-AZPY into a polyvinyl alcohol (PVA) nanofiber matrix, forming 2-AZPY@PVA. This composite significantly enhanced antifungal performance, achieving nearly complete inactivation of all tested fungal species. These findings underscore the potential of AZPY-functionalized MOFs for targeted antifungal applications, particularly when integrated into nanofiber materials for enhanced bioavailability and stability. The results highlight the promising role of MOFs in developing effective antifungal agents for environmental and medical applications.","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 7","pages":"743-753"},"PeriodicalIF":1.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic protein interactions probed by NMR spectroscopy 核磁共振波谱探测动态蛋白质相互作用

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2025-06-04 DOI: 10.1002/bkcs.70036

Jaeseok Lee, Jung Ho Lee

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Non-targeted metabolite profiling reveals biochemical diversity of three East Asian mosses 非靶向代谢物分析揭示了三种东亚苔藓生物化学多样性

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2025-05-29 DOI: 10.1002/bkcs.70032

Fatima Tuz Zahra, Kyungwon Min, Jungeun Lee, Maeng-Joon Jung, Hyoungseok Lee, Sunghwan Kim

{"title":"Non-targeted metabolite profiling reveals biochemical diversity of three East Asian mosses","authors":"Fatima Tuz Zahra, Kyungwon Min, Jungeun Lee, Maeng-Joon Jung, Hyoungseok Lee, Sunghwan Kim","doi":"10.1002/bkcs.70032","DOIUrl":"https://doi.org/10.1002/bkcs.70032","url":null,"abstract":"Mosses are known for their rich diversity in bioactive compounds and their essential role in maintaining ecosystems. While genetic and metabolomics studies have been conducted on some model species, research on comprehensive metabolomics of common mosses in East Asia remains limited. In this study, we conducted an untargeted analysis of three East Asian moss species, Niphotrichum japonicum, Calohypnum plumiforme, and Polytrichum formosum, by ultrasonic-assisted extraction and liquid chromatography coupled with high-resolution mass spectrometry. This approach facilitated the detailed profiling and compound classification through reference databases. Tandem mass spectrometry with positive mode tentatively identified 188, 183, and 186 metabolites, respectively, with lipids and terpenoids as the predominant class. Among these, 25 potential biomarkers were identified to differentiate between species. Multivariate analysis, including principal component analysis, revealed distinct metabolic profiles for each species, representing taxonomical differences, confirming data reproducibility, and clear species differentiation. Enrichment analysis further highlighted the upregulation of unsaturated fatty acid biosynthesis across all moss species. This is the first report utilizing an untargeted metabolomics approach with chemometrics to differentiate moss species cultivated in the same location, offering a new foundation for studying the metabolic responses of East Asian mosses.","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 6","pages":"641-653"},"PeriodicalIF":1.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.70032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cover Picture: Frontier Femtosecond Mid-Infrared Pump-Probe and 2DIR Techniques: Advances in Experimental Methodologies (BKCS 5/2025) Joongwon Shim, Kwanghee Park, Minhyuk Lee, Minharng Cho, JunWoo Kim, Kyungwon Kwak 封面图片：前沿飞秒中红外泵浦探针和2DIR技术：实验方法的进展(BKCS 5/2025

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2025-05-26 DOI: 10.1002/bkcs.12864

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BL2D-SMC: The versatile chemical crystallography beamline at PLS-II, Korea BL2D-SMC：韩国PLS-II的多功能化学晶体学光束线

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2025-05-22 DOI: 10.1002/bkcs.70021

Jong Won Shin, Dae-Woong Kim, Dongwon Kim, Dohyun Moon

{"title":"BL2D-SMC: The versatile chemical crystallography beamline at PLS-II, Korea","authors":"Jong Won Shin, Dae-Woong Kim, Dongwon Kim, Dohyun Moon","doi":"10.1002/bkcs.70021","DOIUrl":"https://doi.org/10.1002/bkcs.70021","url":null,"abstract":"BL2D-SMC is a bending magnet beamline dedicated to chemical crystallography at the 3 GeV PLS-II in Korea. The beamline features tunable energy in the range from 8.3 to 21.8 keV to support single wavelength experiments. At the standard supporting energy of 17.7142 keV (0.70000 Å), the monochromatic X-ray beam is focused to a full width at a half-maximum of 100 μm (horizontal) × 85 μm (vertical) at the sample position, with a measured photon flux of 6.2 × 1011 photons/s. The experimental hutch is equipped with a Rayonix MX225HS detector and a PH6 (Crystal Logics Inc.) goniometer, which can be configured for both single-axis and multi-axis setups. This beamline is particularly suitable for studying weakly diffracting crystalline materials such as micrometer-sized crystals, highly porous metal–organic frameworks, and disordered coordination polymers. To date, support for various experiments has been extended, encompassing structural studies involving variable temperature crystallography, investigations into photo-excitation phenomena, and research on gas sorption in porous materials. This article offers detailed descriptions of the current beamline design, technical information for users, and highlights recent scientific findings.","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 6","pages":"594-601"},"PeriodicalIF":1.7,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-atom catalyst design for efficient hydrazine oxidation reaction: A density functional theory study 高效肼氧化反应的双原子催化剂设计：密度泛函理论研究

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2025-05-19 DOI: 10.1002/bkcs.70026

Hyeonwoo Kim, Hanna Jeon, Hyeyoung Shin

{"title":"Dual-atom catalyst design for efficient hydrazine oxidation reaction: A density functional theory study","authors":"Hyeonwoo Kim, Hanna Jeon, Hyeyoung Shin","doi":"10.1002/bkcs.70026","DOIUrl":"https://doi.org/10.1002/bkcs.70026","url":null,"abstract":"As climate change accelerates due to the continued use of fossil fuels, hydrogen production technologies that offer both high efficiency and environmental sustainability are urgently needed for the global energy transition. However, conventional water electrolysis is limited by the oxygen evolution reaction (OER), which suffers from sluggish kinetics and high overpotentials, significantly reducing overall energy efficiency. To address this challenge, the hydrazine oxidation reaction (HzOR) has emerged as a promising alternative, featuring more favorable reaction kinetics and lower overpotentials. Despite its advantages, the practical implementation of HzOR remains limited due to its reliance on noble metal-based catalysts, which are costly and scarce. In this study, we propose a dual-atom catalyst (DAC) design strategy for efficient HzOR, using combinations of noble and non-noble metals (NiCo, CoPt, and NiIr). Density functional theory (DFT) calculations were performed to evaluate their structural stability, electronic structures, and catalytic performance. The results reveal that heterometallic DACs can enhance HzOR activity by optimizing intermediate adsorption and lowering activation energy. Among the studied systems, NiCo Type-I demonstrates the most favorable balance of catalytic efficiency and electronic conductivity. This work highlights the potential of DACs as cost-effective and efficient HzOR catalysts and provides design insights for next-generation hydrogen production technologies aligned with global decarbonization goals.","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 5","pages":"554-561"},"PeriodicalIF":1.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in methodologies for quantifying protein–protein interactions in living cells 活细胞中蛋白质-蛋白质相互作用定量方法的进展

IF 1.7 4区化学

Bulletin of the Korean Chemical Society Pub Date : 2025-05-15 DOI: 10.1002/bkcs.70028

Soojung Yi, Yejin Ahn, Nam Ki Lee

{"title":"Advances in methodologies for quantifying protein–protein interactions in living cells","authors":"Soojung Yi, Yejin Ahn, Nam Ki Lee","doi":"10.1002/bkcs.70028","DOIUrl":"https://doi.org/10.1002/bkcs.70028","url":null,"abstract":"Protein–protein interactions (PPIs) occur in most cellular processes, and characterizing PPIs is essential for understanding biological function and regulation. One of the most important parameters is the dissociation constant (Kd), which reflects the strength of PPIs. A range of in vitro methods, including isothermal titration calorimetry, fluorescence resonance energy transfer (FRET), surface plasmon resonance, and single-molecule fluorescence assays, have been developed to determine Kd values under controlled conditions. However, the living cell environment differs markedly from dilute buffer systems due to macromolecular crowding, compartmentalization, and regulatory complexity, often leading to discrepancies between in vitro and in-cell Kd values. In mammalian cells, advances in fluorescence-based techniques, including fluorescence lifetime imaging microscopy-FRET and fluorescence cross-correlation spectroscopy, have enabled quantitative measurements of PPI affinity in living systems. In contrast, accurately measuring Kd in bacterial cells has remained a challenge. Recently, in-cell NMR and quantitative FRET approaches have been developed for measuring Kd in bacterial cells. This review highlights the principles, capabilities, and limitations of representative in-cell Kd measurement techniques and provides guidance for selecting appropriate approaches to quantitatively characterize PPIs in physiologically relevant contexts.","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 6","pages":"574-586"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/bkcs.70028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0