Nano Letters最新文献_第7页

Magnetic-Field-Induced Large OER Enhancement in Co-Based Ferrimagnetic Thin Films 钴基铁磁薄膜中磁场诱导的大OER增强

IF 9.1 1区材料科学

Nano Letters Pub Date : 2026-10-14 Epub Date: 2026-09-29 DOI: 10.1021/acs.nanolett.6c03575

Li Liu, Ziang Meng, Guojian Zhao, Zhiyuan Duan, Jingyu Li, Sixu Jiang, Xiaoyang Tan, Shiheng Bu, Chen Liang, Xiaoning Wang, Peixin Qin, Zhiqi Liu

{"title":"Magnetic-Field-Induced Large OER Enhancement in Co-Based Ferrimagnetic Thin Films","authors":"Li Liu, Ziang Meng, Guojian Zhao, Zhiyuan Duan, Jingyu Li, Sixu Jiang, Xiaoyang Tan, Shiheng Bu, Chen Liang, Xiaoning Wang, Peixin Qin, Zhiqi Liu","doi":"10.1021/acs.nanolett.6c03575","DOIUrl":"https://doi.org/10.1021/acs.nanolett.6c03575","url":null,"abstract":"Electrochemical water splitting offers a promising routeto sustainablehydrogen production, yet the oxygen evolution reaction (OER) remainskinetically sluggish and subject to spin-selection constraints associatedwith triplet O2. Here, CoTb ferrimagnetic thin films withstrong perpendicular magnetic anisotropy (PMA) are used to investigatethe relationship between magnetic ordering and OER kinetics. Undera 300 mT magnetic field, the onset potential decreases by ∼96mV and the Tafel slope by ∼15.1 mV·dec–1, accompanied by reduced charge-transfer resistance. The enhancedOER activity is strongly correlated with magnetic-state regulationand largely retained after field removal. Tb-mediated 3d–4f exchange and strong PMA contribute toregulating and retaining the Co magnetic state, which may influenceinteractions between Co active sites and oxygen intermediates. Thisnonvolatile magnetic state may eliminate the need for continuous fieldapplication, potentially reducing energy consumption. These findingsprovide a new perspective for magnetically regulated electrocatalysts.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"26 40","pages":"13962–13970"},"PeriodicalIF":9.1,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Buoyancy-Mediated in Situ Phase-TransitionMicrobubbles Enable Efficient Aqueous Humor Drug Delivery for AcceleratedCorneal Endothelial Regeneration 浮力介导的原位相变微泡使房水药物有效递送加速角膜内皮再生

IF 10.8 1区材料科学

Nano Letters Pub Date : 2026-10-14 DOI: 10.1021/acs.nanolett.6c03143

Shundong Cai,Mengdie Li,Jingbin Zhuang,Meiqin Zhong,Mingyou Zhang,Xu Hu,Jinfa Ye,Yun Han,Min Su,Wei Li,Gang Liu,Chengchao Chu

{"title":"Buoyancy-Mediated\u0000 in Situ\u0000 Phase-Transition\u0000Microbubbles Enable Efficient Aqueous Humor Drug Delivery for Accelerated\u0000Corneal Endothelial Regeneration","authors":"Shundong Cai,Mengdie Li,Jingbin Zhuang,Meiqin Zhong,Mingyou Zhang,Xu Hu,Jinfa Ye,Yun Han,Min Su,Wei Li,Gang Liu,Chengchao Chu","doi":"10.1021/acs.nanolett.6c03143","DOIUrl":"https://doi.org/10.1021/acs.nanolett.6c03143","url":null,"abstract":"Abstract The corneal endothelium plays a pivotal role in maintaining corneal clarity, and its damage leads to a hydration dysfunction and secondary glaucoma. We previously identified XMU-MP-1, a Hippo pathway inhibitor, as a potent stimulator of corneal endothelial cell proliferation in nonhuman primate models. However, its therapeutic potential is limited by poor intraocular permeability and low bioavailability. Herein, we report an engineered perfluoropentane (PFP)-cored lipid microbubble (MB) platform for the buoyancy-mediated targeted delivery of XMU-MP-1. Post intracameral injection, drug-loaded microbubbles (D@MB) undergo spontaneous in situ liquid-to-gas phase transition at physiological temperature, which grants them buoyancy-driven upward movement in aqueous humor to maintain continuous direct contact with the endothelial layer, achieving an extended retention of over 72 h in the anterior chamber. Finally, the D@MB drug delivery platform accelerates regenerative processes and restores both the corneal ultrastructure and physiological function. This study highlights a minimally invasive approach that bypasses traditional surgical interventions to stimulate the repair of the damaged corneal endothelium.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"12 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GCLC Deficiency Enhances Cellular Uptake of BNCT Agents via Oxidative Stress-Induced Macropinocytosis GCLC缺陷通过氧化应激诱导的巨噬细胞增多症增强细胞对BNCT药物的摄取

IF 9.1 1区材料科学

Nano Letters Pub Date : 2026-10-14 Epub Date: 2026-09-17 DOI: 10.1021/acs.nanolett.6c01862

Qing Zhang, Yujiao Wang, Junhui Zhang, Zhenwei Liang, Linwen Lv, Chuan Du, Quegula Bamutijiang, Jiayi Wang, Dingkang Ren, Xian Gong, Kui Chen, Minghua Shen, Yuan Ma

{"title":"GCLC Deficiency Enhances Cellular Uptake of BNCT Agents via Oxidative Stress-Induced Macropinocytosis","authors":"Qing Zhang, Yujiao Wang, Junhui Zhang, Zhenwei Liang, Linwen Lv, Chuan Du, Quegula Bamutijiang, Jiayi Wang, Dingkang Ren, Xian Gong, Kui Chen, Minghua Shen, Yuan Ma","doi":"10.1021/acs.nanolett.6c01862","DOIUrl":"10.1021/acs.nanolett.6c01862","url":null,"abstract":"Boronneutron capture therapy (BNCT) is a promising targeted radiotherapyfor osteosarcoma, offering selective tumor cytotoxicity and localizedenergy deposition, but its efficacy is limited by heterogeneous intratumoralboron distribution. Using a genome-wide CRISPR-Cas9 screen in U2OSosteosarcoma cells, we identified genetic regulators of boron uptake. GCLC deficiency markedly enhanced internalization of boron-containingagents. Mechanistically, GCLC loss depleted glutathione,triggered oxidative stress, and potentiated macropinocytosis, therebyboosting boron compound uptake. This effect was preferentially observedin tumor cells, as GCLC deficiency profoundly enhancedthe uptake of boron delivery agents in tumor cells (such as U2OS andMDA-MB-231), far exceeding its impact on normal osteoblasts (HOB-SV40).In U2OS xenografts, GCLC silencing significantlyenhanced preferential boron accumulation in tumors without alteringnormal tissue biodistribution. Our findings nominate GCLC as a druggable target to overcome boron delivery barriers in BNCT,providing a translatable strategy to improve efficacy for osteosarcoma,especially refractory cases.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"26 40","pages":"13737–13745"},"PeriodicalIF":9.1,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148974053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reconfigurable Photodetection and Neuromorphic Synapse of GaSb Nanowire Heterojunctions for Visual Perception 用于视觉感知的GaSb纳米线异质结的可重构光检测和神经形态突触

IF 9.1 1区材料科学

Nano Letters Pub Date : 2026-10-14 Epub Date: 2026-10-05 DOI: 10.1021/acs.nanolett.6c03377

Yanxue Yin, Pengsheng Li, Zixu Sa, Shuxian Wang, Fei Liang, Sukjoon Hong, Zai-xing Yang, Haohai Yu, Huaijin Zhang

{"title":"Reconfigurable Photodetection and Neuromorphic Synapse of GaSb Nanowire Heterojunctions for Visual Perception","authors":"Yanxue Yin, Pengsheng Li, Zixu Sa, Shuxian Wang, Fei Liang, Sukjoon Hong, Zai-xing Yang, Haohai Yu, Huaijin Zhang","doi":"10.1021/acs.nanolett.6c03377","DOIUrl":"10.1021/acs.nanolett.6c03377","url":null,"abstract":"In this work, the wavelength-selective reconfigurableoptoelectronicdevices capable of autonomously switching between photodetection andneuromorphic synapse are demonstrated by constructing GaSb nanowire(NW) heterojunctions for adaptive visual perception. With an optimalgrowth time, the NW heterojunctions achieve stable photodetectionperformance at illumination wavelengths of ≥1310 nm, enablingthe desirable stable near-infrared imaging. At illumination wavelengthsof ≤850 nm, the obvious synaptic behaviors are observed, suchas synaptic weight increases from 15.5% to 50.6% with an increaseof the pulse number, thereby facilitating robust adaptive visual perceptionwith recognition accuracy exceeding 85% under a noise level of 0.9.This wavelength-selective reconfiguration behavior originates fromthe distinct photoresponse bandwidth of the heterojunction, togetherwith heterojunction-mediated carrier trapping dynamics. In the end,a conceptual autonomous-driving scenario under noisy conditions isdemonstrated, achieving over 90% recognition accuracy. This work pavesthe way of Group III–V NWs in the coming intelligent visionsystems.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"26 40","pages":"13921–13927"},"PeriodicalIF":9.1,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct-Write Defects for Bias-Free Two-Dimensional Optical Synapses Towards In-Sensor Motion Detection 面向传感器内运动检测的无偏置二维光学突触的直接写入缺陷

IF 9.1 1区材料科学

Nano Letters Pub Date : 2026-10-14 Epub Date: 2026-10-05 DOI: 10.1021/acs.nanolett.6c03873

Tsz Wing Tang, Yunxia Hu, Yuxiang Li, Mohsen Tamtaji, Md Saif Hasan, Jiawen You, Jinghan Shen, Sheng Pei, Jun Wang, Yaxuan Li, GuanHua Chen, Zhaoli Gao, Nan Zhang, Zhengtang Luo

{"title":"Direct-Write Defects for Bias-Free Two-Dimensional Optical Synapses Towards In-Sensor Motion Detection","authors":"Tsz Wing Tang, Yunxia Hu, Yuxiang Li, Mohsen Tamtaji, Md Saif Hasan, Jiawen You, Jinghan Shen, Sheng Pei, Jun Wang, Yaxuan Li, GuanHua Chen, Zhaoli Gao, Nan Zhang, Zhengtang Luo","doi":"10.1021/acs.nanolett.6c03873","DOIUrl":"10.1021/acs.nanolett.6c03873","url":null,"abstract":"Optoelectronic synaptic devices, particularly those basedon two-dimensional(2D) transition metal dichalcogenides (TMDs), emulate biological synapticfunctions, promising in neuromorphic computing. However, most TMD-basedsynapses rely on external gate or bias control, leading to complicateddevice architecture and high-power consumption. Here, we demonstratea gate-free and bias-free optical synapses, based on monolayer molybdenumdisulfide (MoS2) homojunction with its counterpart madeof spatially controlled sulfur (S) vacancies, obtained through laserpatterning. By precisely controlling the defect density from 0.15nm–2 to 0.78 nm–2, we effectivelymodify the synaptic memory from a short retention time (∼125s) to a long retention time (>450 s). We further demonstrate neuromorphiccomputing from image denoising and recognition to motion trajectoryprediction for autonomous driving, highlighting the device’sapplicability in on-chip visual preprocessing. This work shows greatpromise for neuromorphic computing by offering a scalable platformfor energy-efficient optoelectronic neuromorphic technology.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"26 40","pages":"14030–14039"},"PeriodicalIF":9.1,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149088195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programmable Multisite Recognition Enables Amplification-Free Nanopore Detection of Mycobacterium tuberculosis in Sputum and Plasma 可编程多位点识别使痰和血浆中结核分枝杆菌的无扩增纳米孔检测成为可能

IF 9.1 1区材料科学

Nano Letters Pub Date : 2026-10-14 Epub Date: 2026-10-01 DOI: 10.1021/acs.nanolett.6c03484

Zhan Wang, Yexiang Liu, Yanrong Chen, Ke Jiao, Lin Sun, Wenjuan Nie, Siwei Wang, Jing Wei, Kaikai Chen, Weiwei Jiao, Rui Hu, Qing Zhao

{"title":"Programmable Multisite Recognition Enables Amplification-Free Nanopore Detection of Mycobacterium tuberculosis in Sputum and Plasma","authors":"Zhan Wang, Yexiang Liu, Yanrong Chen, Ke Jiao, Lin Sun, Wenjuan Nie, Siwei Wang, Jing Wei, Kaikai Chen, Weiwei Jiao, Rui Hu, Qing Zhao","doi":"10.1021/acs.nanolett.6c03484","DOIUrl":"https://doi.org/10.1021/acs.nanolett.6c03484","url":null,"abstract":"Tuberculosisdiagnostics remain challenged by low target abundance,strain diversity, and the need for reliable testing in difficult clinicalspecimens. Here, we develop an amplification-free nanopore sensingplatform based on programmable linear DNA nanohook arrays for directdetection of Mycobacterium tuberculosis (Mtb) DNA. This work presents a dual-target, multisiterecognition strategy that simultaneously captures two conserved insertionsequences, IS6110 and IS1081, and converts their binding events intoresolvable nanopore electrical signatures. This design improves targetrecovery and reduces dependence on any single genomic locus, enablingrobust detection across diverse Mtb strains. Usingthis approach, we achieved a limit of detection of 9.5 copies/μLand demonstrated accurate identification of Mtb inboth sputum and plasma samples without nucleic acid amplification.Our results show that programmable multisite recognition combinedwith nanopore readout provides a powerful route toward sensitive,sample-flexible tuberculosis diagnostics.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"26 40","pages":"13938–13947"},"PeriodicalIF":9.1,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling Plasmon-Enhanced Localized Fields of Titanium Nitride via Complementary Electron Microscopy Techniques 利用互补电子显微镜技术揭示等离子体增强的氮化钛局域场

IF 9.1 1区材料科学

Nano Letters Pub Date : 2026-10-14 Epub Date: 2026-09-28 DOI: 10.1021/acs.nanolett.6c03589

Wanting He, Isobel C. Bicket, Yong Wang, Oscar Ávalos-Ovando, Andrei I. Pastukhov, Andrei V. Kabashin, Gianluigi A. Botton, Alexander O. Govorov, Dongling Ma

{"title":"Unveiling Plasmon-Enhanced Localized Fields of Titanium Nitride via Complementary Electron Microscopy Techniques","authors":"Wanting He, Isobel C. Bicket, Yong Wang, Oscar Ávalos-Ovando, Andrei I. Pastukhov, Andrei V. Kabashin, Gianluigi A. Botton, Alexander O. Govorov, Dongling Ma","doi":"10.1021/acs.nanolett.6c03589","DOIUrl":"https://doi.org/10.1021/acs.nanolett.6c03589","url":null,"abstract":"Titanium nitride nanoparticles (TiNNPs) are promisingalternativesto noble metals for visible-range plasmonic applications, yet theirstructure–property relationships remain insufficiently understood.Here, we combine ultrafast transmission electron microscopy (UTEM)and monochromated TEM to investigate plasmon-enhanced localized fieldsin TiN NPs. Photon-induced near-field electron microscopy (PINEM)enables the visualization and quantification of near fields in individualNPs while also serving as a tool to fuse smaller NPs with an ultrafastpulsed laser, creating larger NPs to explore the maximum near-fieldenhancement under a specific excitation wavelength. Our findings alsoreveal that the surface oxidation of TiN NPs, induced by initial high-energylaser synthesis in water, could contribute to a red-shift of theirplasmon resonance toward the near-infrared region. By correlatingnanoparticle size and composition with plasmonic response, this studyprovides new insights into light–TiN interactions and highlightsthe potential of tunable-laser-integrated TEM for investigating plasmonicallyand photothermally responsive nanomaterials.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"26 40","pages":"13993–14001"},"PeriodicalIF":9.1,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface-Periodicity-Guided Structure Mapping for Automated Scanning Tunneling Microscopy 自动扫描隧道显微镜的表面周期导向结构映射

IF 9.1 1区材料科学

Nano Letters Pub Date : 2026-10-14 Epub Date: 2026-09-28 DOI: 10.1021/acs.nanolett.6c03145

Shujun Li, Bingrui Li, Shiyang Chen, Xuefeng Wu, Kedong Wang, Fangfei Ming, Shaozhi Deng

{"title":"Surface-Periodicity-Guided Structure Mapping for Automated Scanning Tunneling Microscopy","authors":"Shujun Li, Bingrui Li, Shiyang Chen, Xuefeng Wu, Kedong Wang, Fangfei Ming, Shaozhi Deng","doi":"10.1021/acs.nanolett.6c03145","DOIUrl":"https://doi.org/10.1021/acs.nanolett.6c03145","url":null,"abstract":"Automatingscanning tunneling microscopy (STM) is essential forscaling atomically precise characterization and, ultimately, fabricationof next-generation materials and devices. A key challenge is to maintainatomic precision across extended surface regions, where local structuresmust be aligned, identified, and revisited in a common lattice frame.Here we use surface periodicity as an intrinsic reference frame totransform lattice-resolved STM images into lattice-registered unit-cellmaps. Using Ag/Si(111)-(7×7) as a model system, the frameworkpreserves lattice indices and neighborhood relationships while standardizinglocal structural units. This representation enables data-efficientsupervised recognition of Ag adsorption configurations from one ora few reference images and supports environment-aware target-siteselection. We further implement the framework in a continuous automatedSTM workflow, demonstrating autonomous scanning, target identification,and structure-specific characterization. Our results show that crystallinesurface periodicity can provide a transferable basis for automatedSTM operations on lattice-resolved surfaces.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"26 40","pages":"13879–13886"},"PeriodicalIF":9.1,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to “Sheddable Prodrug Vesicles Combating Adaptive Immune Resistance for Improved Photodynamic Immunotherapy of Cancer” 修正“可脱落的前药囊泡对抗适应性免疫抵抗，改进癌症光动力免疫治疗”

IF 9.1 1区材料科学

Nano Letters Pub Date : 2026-10-14 Epub Date: 2026-09-29 DOI: 10.1021/acs.nanolett.6c04642

Ang Gao, Binfan Chen, Jing Gao, Fengqi Zhou, Madiha Saeed, Bo Hou, Yaping Li, Haijun Yu

引用次数: 0

Correction to “The Electric Field Morphology of Plasmonic Picocavities” 修正“等离子体微空腔的电场形态”

IF 9.1 1区材料科学

Nano Letters Pub Date : 2026-10-14 Epub Date: 2026-09-28 DOI: 10.1021/acs.nanolett.6c04064

Tommaso Giovannini, Luca Nicoli, Stefano Corni, Chiara Cappelli

引用次数: 0