Jazmine Prana, Luana Zagami, Kelly Yan, Daniel Hernangómez-Pérez*, María Camarasa-Gómez* and Michael S. Inkpen*,
{"title":"","authors":"Jazmine Prana, Luana Zagami, Kelly Yan, Daniel Hernangómez-Pérez*, María Camarasa-Gómez* and Michael S. Inkpen*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"25 26","pages":"XXX-XXX 962–968"},"PeriodicalIF":9.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.nanolett.5c01893","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144521915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hazem Abdelsalam*, Domenico Corona*, Renebeth B. Payod*, Mahmoud A. S. Sakr*, Omar H. Abd-Elkader*, Qinfang Zhang* and Vasil A. Saroka*,
{"title":"","authors":"Hazem Abdelsalam*, Domenico Corona*, Renebeth B. Payod*, Mahmoud A. S. Sakr*, Omar H. Abd-Elkader*, Qinfang Zhang* and Vasil A. Saroka*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"25 26","pages":"XXX-XXX 962–968"},"PeriodicalIF":9.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.nanolett.5c02355","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144521929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano LettersPub Date : 2025-07-02Epub Date: 2025-06-10DOI: 10.1021/acs.nanolett.5c01840
Yannan Hou, Meizi Chen, Letao Yang, Ki-Bum Lee
{"title":"Real-Time Intracellular Monitoring of miRNA Dynamics during Induced Pluripotent Stem Cell Neuronal Differentiation via Plasmon-Enhanced Nanobiosensing.","authors":"Yannan Hou, Meizi Chen, Letao Yang, Ki-Bum Lee","doi":"10.1021/acs.nanolett.5c01840","DOIUrl":"10.1021/acs.nanolett.5c01840","url":null,"abstract":"<p><p>Induced pluripotent stem cells (iPSCs) offer immense potential for treating central nervous system (CNS) disorders and injuries. However, the lack of highly sensitive, selective, and noninvasive biosensors for real-time monitoring of iPSC neuronal differentiation remains a critical barrier. In this work, we introduce a gold nanorod-based metal-enhanced molecular beacon (MEMB) nanobiosensor for the noninvasive, real-time detection of intracellular miRNA-124, a key biomarker for neuronal differentiation in human iPSC-derived neural stem cells. Designed through finite-difference time-domain (FDTD) simulations and experimentally validated for optimized localized surface plasmon resonance (LSPR) properties, MEMB nanobiosensors achieved picomolar-level sensitivity and single-mismatch selectivity toward miRNA-124 detection, along with great biocompatibility demonstrated by live-cell assays. Collectively, the MEMB platform provides a robust analytical tool for in-depth investigations of molecular and genetic regulatory networks during iPSC neuronal differentiation in a nondestructive manner, paving the way toward safer, more efficient, and better-characterized iPSC-derived cell therapies for CNS diseases and injuries.</p>","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":" ","pages":"10402-10411"},"PeriodicalIF":9.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano LettersPub Date : 2025-07-02Epub Date: 2025-06-16DOI: 10.1021/acs.nanolett.5c02539
Verda Saygin, Yihong Xu, Sean B Andersson, Keith A Brown
{"title":"Quantitative Mixing of Fluids Using Dip-Pen Nanolithography for Combinatorial Materials Science.","authors":"Verda Saygin, Yihong Xu, Sean B Andersson, Keith A Brown","doi":"10.1021/acs.nanolett.5c02539","DOIUrl":"10.1021/acs.nanolett.5c02539","url":null,"abstract":"<p><p>Dip-pen nanolithography (DPN) represents a versatile approach for depositing nanoscale quantities of fluids onto surfaces. Here, we show that overwriting─or patterning fluids onto previously deposited features─results in patterns with predictable size and composition that are useful for combinatorial materials experiments. We combine fluorescence microscopy and inertial sensing to show that multiple fluid reservoirs can be mixed together to realize combinatorial libraries of nanoscale features with known mass and composition. As an example of the utility of this approach from a materials discovery perspective, we employ this process to study the mechanics and swelling behavior of polyethylene glycol hydrogels with different compositions. Given that this approach allows one to prepare compositional gradients using less than a microgram of material and functionality to evaluate these using the versatility of the atomic force microscope, it has tremendous potential for the discovery and optimization of performance materials for catalysis, mechanics, photonics, and electronics.</p>","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":" ","pages":"10666-10672"},"PeriodicalIF":9.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano LettersPub Date : 2025-07-02Epub Date: 2025-06-16DOI: 10.1021/acs.nanolett.5c02383
Hongyang Xu, Xi Xie, Chuangye Zhang, Yuquan Zhang, Xiaocong Yuan, Yijie Shen, Changjun Min
{"title":"Topological Magnetic Lattices for On-Chip Nanoparticle Trapping and Sorting.","authors":"Hongyang Xu, Xi Xie, Chuangye Zhang, Yuquan Zhang, Xiaocong Yuan, Yijie Shen, Changjun Min","doi":"10.1021/acs.nanolett.5c02383","DOIUrl":"10.1021/acs.nanolett.5c02383","url":null,"abstract":"<p><p>On-chip optical lattices based on surface plasmon polariton (SPP) fields have been shown to generate diverse novel topologies and potential for sorting nanoparticles. However, the reliance on metallic excitation in SPP systems suffers from heavy ohmic loss and heat buildup. In this work, we propose a magnetic topological lattice based on Bloch surface waves (BSWs) excited on transparent dielectric multilayers, offering ultralong propagation ranges and markedly reduced thermal effects. In contrast to the conventional SPPs, rich topologies appear in the magnetic field and spin vector. Furthermore, large-scale dynamic manipulation as well as size-dependent sorting of nanoparticles is feasible by leveraging the ability to reconfigure lattice topologies via polarization and phase adjustments, which further expands its functional versatility. Our results provide new insight into optical topologies governed by magnetic fields and hold promise for application in other wave systems, including elastic and water waves.</p>","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":" ","pages":"10611-10618"},"PeriodicalIF":9.6,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}