Nano Letters最新文献_第4页

Near-Infrared Light Driven Reversible Photoelectrochemical Bioassay by S-Scheme All-Polymer Blends for Acetylcholinesterase Activity Monitoring

IF 10.8 1区材料科学

Nano Letters Pub Date : 2024-12-19 DOI: 10.1021/acs.nanolett.4c05417

Ying Qin, Runshi Xiao, Wentao Xu, Han Yu, Mingwang Liu, Wenhong Yang, Rong Tan, Yuanxing Chen, Jing Wen, Xiang Peng, Wenling Gu, Chengzhou Zhu, Liuyong Hu

{"title":"Near-Infrared Light Driven Reversible Photoelectrochemical Bioassay by S-Scheme All-Polymer Blends for Acetylcholinesterase Activity Monitoring","authors":"Ying Qin, Runshi Xiao, Wentao Xu, Han Yu, Mingwang Liu, Wenhong Yang, Rong Tan, Yuanxing Chen, Jing Wen, Xiang Peng, Wenling Gu, Chengzhou Zhu, Liuyong Hu","doi":"10.1021/acs.nanolett.4c05417","DOIUrl":"https://doi.org/10.1021/acs.nanolett.4c05417","url":null,"abstract":"Photoelectrochemical (PEC) biosensing, recognized for its heightened sensitivity, faces limitations in its application for in vivo diagnosis due to the inefficiency of UV–visible light-driven photoactive materials in nontransparent biological samples. In this study, we investigate the potential of an S-scheme all-polymer heterojunction comprising a prototype nonfullerene polymeric acceptor (PYIT) and carbon nitride to develop a near-infrared (NIR) light-driven PEC biosensor for monitoring acetylcholinesterase activity in nontransparent human whole blood. The distinct molecular structure of PYIT enables efficient light absorption in the NIR region, enhancing sensitivity in nontransparent biological samples. The biosensor functions via a proton-dependent conversion mechanism between PYIT-OH and PYIT, leveraging the selective and reversible chemical reactivity of the moieties in backbone, eliminating the need for traditional and intricate integration of a biorecognition unit. Our findings demonstrate a direct correlation between variations in photoelectric performance and acetylcholinesterase concentration, showcasing exceptional sensitivity, selectivity, and reversibility.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"1 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrathin BIC Metasurfaces Based on Ultra-Low-Loss Sb2Se3 Phase-Change Material

IF 10.8 1区材料科学

Nano Letters Pub Date : 2024-12-19 DOI: 10.1021/acs.nanolett.4c04904

Zhaoyang Xie, Chi Li, Krishna Murali, Haoyi Yu, Changxu Liu, Yiqing Lu, Stefan A. Maier, Madhu Bhaskaran, Haoran Ren

{"title":"Ultrathin BIC Metasurfaces Based on Ultra-Low-Loss Sb2Se3 Phase-Change Material","authors":"Zhaoyang Xie, Chi Li, Krishna Murali, Haoyi Yu, Changxu Liu, Yiqing Lu, Stefan A. Maier, Madhu Bhaskaran, Haoran Ren","doi":"10.1021/acs.nanolett.4c04904","DOIUrl":"https://doi.org/10.1021/acs.nanolett.4c04904","url":null,"abstract":"Ultrathin and low-loss phase-change materials (PCMs) are highly valued for their fast and effective phase transitions and applications in reconfigurable photonic chips, metasurfaces, optical modulators, sensors, photonic memories, and neuromorphic computing. However, conventional PCMs mostly suffer from high intrinsic losses in the near-infrared (NIR) region, limiting their potential for high quality factor (Q-factor) resonant metasurfaces. Here we present the design and fabrication of tunable bound states in the continuum (BIC) metasurfaces using the ultra-low-loss PCM Sb2Se3. Our BIC metasurfaces, only 25 nm thick, achieve high modulation depth and broad resonance tuning in the NIR with high Q-factors up to 130. Experimentally, we employ these BIC metasurfaces to modulate photoluminescence in rare earth-doped upconversion nanoparticles, reducing the excitation power for multiphoton photoluminescence and enabling emission polarization manipulation. This work offers a promising platform for developing active resonant metasurfaces, with broad applications including optical modulation, ultrafast switches, color filtering, and optical sensing.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"94 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Highly Efficient and Linearly Polarized Light Emission of Micro-LED Integrated with Double-Functional Meta-Grating

IF 10.8 1区材料科学

Nano Letters Pub Date : 2024-12-18 DOI: 10.1021/acs.nanolett.4c04914

Xuzheng Wang, Zhenhuan Tian, Shuheng Pei, Chuangcheng Xu, Qinyue Sun, Jiadong Zhang, Jieming Wei, Feng Li, Feng Yun

引用次数: 0

Real-Time Structural Dynamics at the 3D/2D Perovskite Interface in CsPbBr3/PEA2PbBr4 Nano-heterostructures CsPbBr3/PEA2PbBr4 纳米异质结构中三维/二维过氧化物界面的实时结构动态变化

IF 10.8 1区材料科学

Nano Letters Pub Date : 2024-12-18 DOI: 10.1021/acs.nanolett.4c05021

Xiayan Wu, Nithin Pathoor, Xin Xu, Shun Omagari, Toranosuke Takagi, Martin Vacha

{"title":"Real-Time Structural Dynamics at the 3D/2D Perovskite Interface in CsPbBr3/PEA2PbBr4 Nano-heterostructures","authors":"Xiayan Wu, Nithin Pathoor, Xin Xu, Shun Omagari, Toranosuke Takagi, Martin Vacha","doi":"10.1021/acs.nanolett.4c05021","DOIUrl":"https://doi.org/10.1021/acs.nanolett.4c05021","url":null,"abstract":"Three-dimensional (3D) and two-dimensional (2D) perovskite hybrid systems, known for their exceptional optoelectronic properties and stability, are revolutionizing optoelectronic materials research. However, fundamental physics of the 3D/2D interfaces and their dynamics remain poorly understood. We use fluorescence microspectroscopy to study the photoluminescence (PL) properties of 3D/2D nano-heterostructures of CsPbBr3/PEA2PbBr4 formed by postgrowth self-assembly. The in situ PL spectra uncover the presence of new structural phases, quasi-2D PEA2Csn–1PbnBr3n+1 layers of varying n, at the 3D/2D interface and demonstrate their reversible restructuring under light excitation at room temperature. The restructuring is a result of layer-by-layer cation diffusion at the epitaxial interfaces, manifested as reversible spectral shifts occurring on a time scale of seconds. Such dynamics ultimately leads to optimized distribution of the quasi-2D phases in the system for efficient energy transfer from the 2D to the 3D phases. Our findings provide new insights into controlling energy flow in 3D/2D perovskites for next-generation optoelectronic devices.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"256 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infrared Spectroscopy for Diagnosing Superlattice Minibands in Twisted Bilayer Graphene near the Magic Angle.

IF 9.6 1区材料科学

Nano Letters Pub Date : 2024-12-18 Epub Date: 2024-12-05 DOI: 10.1021/acs.nanolett.4c02853

Geng Li, Roshan Krishna Kumar, Petr Stepanov, Pierre A Pantaleón, Zhen Zhan, Hitesh Agarwal, Adrien Bercher, Julien Barrier, Kenji Watanabe, Takashi Taniguchi, Alexey B Kuzmenko, Francisco Guinea, Iacopo Torre, Frank H L Koppens

{"title":"Infrared Spectroscopy for Diagnosing Superlattice Minibands in Twisted Bilayer Graphene near the Magic Angle.","authors":"Geng Li, Roshan Krishna Kumar, Petr Stepanov, Pierre A Pantaleón, Zhen Zhan, Hitesh Agarwal, Adrien Bercher, Julien Barrier, Kenji Watanabe, Takashi Taniguchi, Alexey B Kuzmenko, Francisco Guinea, Iacopo Torre, Frank H L Koppens","doi":"10.1021/acs.nanolett.4c02853","DOIUrl":"10.1021/acs.nanolett.4c02853","url":null,"abstract":"Twisted bilayer graphene (TBG) represents a highly tunable, strongly correlated electron system. However, understanding the single-particle band structure alone has been challenging due to a lack of spectroscopic measurements over a broad energy range. Here, we probe the band structure of TBG around the magic angle using infrared spectroscopy and reveal spectral features that originate from interband transitions. In combination with quantum transport, we connect spectral features over a broad energy range (10-700 meV) and track their evolution with the twist angle. We compare our data with calculations of the band structures obtained via the continuum model and find good agreement only when considering a variation of interlayer/intralayer tunneling parameters with the twist angle. Our analysis suggests that the magic angle also shifts due to lattice relaxation and is better defined for a wide angular range of 0.9-1.1°. Additionally, our measurements offer an optical fingerprint of the magic angle for screening heterostructures before nanofabrication.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":" ","pages":"15956-15963"},"PeriodicalIF":9.6,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142783352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-Targeted Drug Delivery to Myeloid Leukemia Cells via Complement- and Transferrin-Based Protein Corona

IF 10.8 1区材料科学

Nano Letters Pub Date : 2024-12-18 DOI: 10.1021/acs.nanolett.4c04429

Wen Wu, Yuanyuan Li, Qihui Liu, Tao Liu, Yanan Zhao, Hui Shao, Ping Ren, Yueyang Tang, Jiayi Feng, Yihan Wang, Guodong Sun, Haiyan Liu, Yuansong Bai, Fangfang Chen

{"title":"Dual-Targeted Drug Delivery to Myeloid Leukemia Cells via Complement- and Transferrin-Based Protein Corona","authors":"Wen Wu, Yuanyuan Li, Qihui Liu, Tao Liu, Yanan Zhao, Hui Shao, Ping Ren, Yueyang Tang, Jiayi Feng, Yihan Wang, Guodong Sun, Haiyan Liu, Yuansong Bai, Fangfang Chen","doi":"10.1021/acs.nanolett.4c04429","DOIUrl":"https://doi.org/10.1021/acs.nanolett.4c04429","url":null,"abstract":"Although traditionally regarded as an impediment, the protein corona can facilitate the advancement of targeted drug delivery systems. This study presents an innovative approach for targeting acute myeloid leukemia (AML) using nanoparticles with agglutinated protein (NAPs). Agglutinated transferrin and C3b in NAPs selectively bind to CD71 and CD11b, receptors that are overexpressed on myeloid leukemic cells compared to nonmalignant cells. In vitro, NAPs achieved a 73.9% doxorubicin (DOX) uptake in leukemic cells, compared to 6.19% for the free drug, while significantly reducing off-target accumulation in normal cells from 42.9% to 5.76%. In vivo, the distribution of NAPs correlated to the organ infiltration pattern of leukemic cells. NAPs demonstrated antileukemic activity in both in vitro and in vivo NSG mouse models, inducing cell death via apoptosis and ferroptosis. In conclusion, NAP-mediated targeted drug delivery represents a promising therapeutic strategy for AML, enhancing treatment efficacy and minimizing off-target effects.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"52 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intrinsically Slow Cooling of Hot Electrons in CdSe Nanocrystals Compared to CdS 与 CdS 相比，CdSe 纳米晶体中热电子的本征冷却速度较慢

IF 10.8 1区材料科学

Nano Letters Pub Date : 2024-12-18 DOI: 10.1021/acs.nanolett.4c04912

Matthew J. Coley-O’Rourke, Bokang Hou, Skylar J. Sherman, Gordana Dukovic, Eran Rabani

引用次数: 0

Piezostrain-Driven Bidirectional Enhancement of Optical Synaptic Plasticity in Wafer-Scale Co-Phased Tin Selenide Layers

IF 10.8 1区材料科学

Nano Letters Pub Date : 2024-12-18 DOI: 10.1021/acs.nanolett.4c04371

Changhyeon Yoo, Sang Sub Han, Chung Won Lee, Jebadiah Pond, Yu-Jin Song, Jung Han Kim, Yeonwoong Jung

{"title":"Piezostrain-Driven Bidirectional Enhancement of Optical Synaptic Plasticity in Wafer-Scale Co-Phased Tin Selenide Layers","authors":"Changhyeon Yoo, Sang Sub Han, Chung Won Lee, Jebadiah Pond, Yu-Jin Song, Jung Han Kim, Yeonwoong Jung","doi":"10.1021/acs.nanolett.4c04371","DOIUrl":"https://doi.org/10.1021/acs.nanolett.4c04371","url":null,"abstract":"Tin (Sn)-based two-dimensional (2D) materials exhibit intriguing mechanical and optoelectrical properties owing to their non-centrosymmetric crystallinity and tunable band structures. A judicious integration of these individually decoupled properties is projected to introduce unparalleled functionalities into them, which remain largely unexplored. Herein, we develop wafer-scale tin selenide (SnSe2–x, 0 < x < 1) 2D layers composed of thermodynamically stable coexisting phases of SnSe and SnSe2 with distinct functionalities and identify a strong interplay between their mechanical and optoelectrical characteristics. Mechanically, they display a strain-dependent piezoelectricity upon an anisotropic deformation of convex vs concave bending. Optoelectrically, they present an optical pulse-induced potentiation and synaptic plasticity accompanying a wavelength-tunable photoconduction upon visible to near-infrared (IR) illuminations. Harnessing these two independent features in a coupled manner enables a drastic enhancement of their synaptic responsiveness by >40% with a piezostrain of <1%. These findings suggest opportunities for atomically thin semiconductors in mechano-optical neuromorphic device applications.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"31 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Operando Observation of Electrically Triggered Phase Transition in Thin Cu2S Crystal 运算观测薄 Cu2S 晶体中的电触发相变

IF 10.8 1区材料科学

Nano Letters Pub Date : 2024-12-18 DOI: 10.1021/acs.nanolett.4c05293

Meiyan Wang, Yimeng Yu, Lin Liao, Zukang Zhu, Mingqi Zhang, Dongwang Yang, Xianli Su, Qingjie Zhang, Xinfeng Tang, Jinsong Wu

{"title":"Operando Observation of Electrically Triggered Phase Transition in Thin Cu2S Crystal","authors":"Meiyan Wang, Yimeng Yu, Lin Liao, Zukang Zhu, Mingqi Zhang, Dongwang Yang, Xianli Su, Qingjie Zhang, Xinfeng Tang, Jinsong Wu","doi":"10.1021/acs.nanolett.4c05293","DOIUrl":"https://doi.org/10.1021/acs.nanolett.4c05293","url":null,"abstract":"Cu2S has been identified as a functional material of memristors with multilevel resistance switching. However, as the migration of Cu ions under the electric field is tangled with defect evolution and phase transition, the electroresistance mechanism of Cu2S remains largely unclear. Here, the electrically triggered phase transition was studied by in situ transmission electron microscopy. It is found that the γ(L)-Cu2S phase is transformed into β-Cu2S accompanied by the change in resistance, when a voltage lower than 1 V is applied at room temperature. The electrically triggered phase transition is also observed at −150 °C. Precipitation of metal Cu nanoparticles is observed when the applied voltage is further increased after the complete formation of β-Cu2S. These findings indicate that Cu2S can achieve fast and controllable phase switching through electrical tuning when the energy consumption is appropriately controlled, offering the potential for low-power electronic devices such as memory and sensors.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"86 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142841924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peptide-Functionalized Lipid Nanoparticles for Targeted Systemic mRNA Delivery to the Brain 肽功能化脂质纳米颗粒用于向大脑定向系统性递送 mRNA

IF 10.8 1区材料科学

Nano Letters Pub Date : 2024-12-17 DOI: 10.1021/acs.nanolett.4c05186

Emily L. Han, Sophia Tang, Dongyoon Kim, Amanda M. Murray, Kelsey L. Swingle, Alex G. Hamilton, Kaitlin Mrksich, Marshall S. Padilla, Rohan Palanki, Jacqueline J. Li, Michael J. Mitchell

{"title":"Peptide-Functionalized Lipid Nanoparticles for Targeted Systemic mRNA Delivery to the Brain","authors":"Emily L. Han, Sophia Tang, Dongyoon Kim, Amanda M. Murray, Kelsey L. Swingle, Alex G. Hamilton, Kaitlin Mrksich, Marshall S. Padilla, Rohan Palanki, Jacqueline J. Li, Michael J. Mitchell","doi":"10.1021/acs.nanolett.4c05186","DOIUrl":"https://doi.org/10.1021/acs.nanolett.4c05186","url":null,"abstract":"Systemic delivery of large nucleic acids, such as mRNA, to the brain remains challenging in part due to the blood-brain barrier (BBB) and the tendency of delivery vehicles to accumulate in the liver. Here, we design a peptide-functionalized lipid nanoparticle (LNP) platform for targeted mRNA delivery to the brain. We utilize click chemistry to functionalize LNPs with peptides that target receptors overexpressed on brain endothelial cells and neurons, namely the RVG29, T7, AP2, and mApoE peptides. We evaluate the effect of LNP targeting on brain endothelial and neuronal cell transfection in vitro, investigating factors such as serum protein adsorption, intracellular trafficking, endothelial transcytosis, and exosome secretion. Finally, we show that LNP peptide functionalization enhances mRNA transfection in the mouse brain and reduces hepatic delivery after systemic administration. Specifically, RVG29 LNPs improved neuronal transfection in vivo, establishing its potential as a nonviral platform for delivering mRNA to the brain.","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":"48 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142832808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0