Revista Peruana de Medicina de Experimental y Salud Publica最新文献_第4页

Multidrug-resistant enterobacterales carrying the acc(6')-Ian gene. 携带acc（6’）-Ian基因的多重耐药肠杆菌。

IF 1.1

Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2026-06-22 DOI: 10.17843/rpmesp.2026.432.15661

Kristel G Soto-Flores, Jimena R Cisneros-Aguilar, Maricecy K Rueda-Vicente, Edgar Gonzales-Escalante, Arturo O Gonzales-Rodríguez, Juan C Gomez de La Torre-Prettel, Luis A Alvarado Ríos

{"title":"Multidrug-resistant enterobacterales carrying the acc(6')-Ian gene.","authors":"Kristel G Soto-Flores, Jimena R Cisneros-Aguilar, Maricecy K Rueda-Vicente, Edgar Gonzales-Escalante, Arturo O Gonzales-Rodríguez, Juan C Gomez de La Torre-Prettel, Luis A Alvarado Ríos","doi":"10.17843/rpmesp.2026.432.15661","DOIUrl":"10.17843/rpmesp.2026.432.15661","url":null,"abstract":"This study describes carbapenemase-producing enterobacterales isolates obtained from urine samples collected at a private laboratory in Lima, Peru. Eighty-four carbapenem-resistant strains of Klebsiella pneumoniae and Escherichia coli were analyzed, among which 13 carried the aac(6')-Ian gene. These isolates showed resistance to amikacin and other aminoglycosides. Furthermore, all isolates carried the blaNDM, blaPER-2, and qnrVC1 genes, associated with IncC2-type plasmids, suggesting a genetic environment with high horizontal transfer potential. Through conjugation assays, we confirmed plasmid transfer to recipient strains, and through genomic analyses, we verified the co-occurrence of resistance genes and mobile genetic elements, highlighting the role of plasmids in the dissemination of these determinants in clinical settings. These findings highlight the need to implement surveillance measures to reduce the risk of infections by multidrug-resistant bacteria in the hospital setting.","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"43 2","pages":"238-243"},"PeriodicalIF":1.1,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequency of nasal carriers of methicillin-resistant Staphylococcus aureus among health personnel in Ayacucho, Peru. 秘鲁阿亚库乔卫生人员中耐甲氧西林金黄色葡萄球菌鼻腔携带者的频率

IF 1.1

Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2026-06-16 DOI: 10.17843/rpmesp.2026.432.15609

Alexandra A Urrutia, Nilda A Apayco, Sayda L Cancho, Liz V Muñoz, Máximo R Sosa

{"title":"Frequency of nasal carriers of methicillin-resistant Staphylococcus aureus among health personnel in Ayacucho, Peru.","authors":"Alexandra A Urrutia, Nilda A Apayco, Sayda L Cancho, Liz V Muñoz, Máximo R Sosa","doi":"10.17843/rpmesp.2026.432.15609","DOIUrl":"10.17843/rpmesp.2026.432.15609","url":null,"abstract":"Objectives: To estimate the frequency of nasal carriers of Methicillin-Resistant Staphylococcus aureus(MRSA) among healthcare personnel of the Red de Salud Huamanga (Ayacucho, Peru) between October and November 2024.Materials and methods: Descriptive cross-sectional study in 265 healthcare workers, recruited by convenience sampling. Nasal swabs were cultured on mannitol salt agar, MRSA was confirmed by cefoxitin disk diffusion (EUCAST v14.0 2024: diameter <22 mm). Antimicrobial susceptibility was evaluated by Kirby-Bauer. The use of personal protective equipment (PPE) was recorded by structured questionnaire. Absolute and relative frequencies were calculated.Results: Staphylococcus aureus was detected in 14.0% (37/265) of the participants. Of these isolates, 64.9% (24/37) were MRSA, representing a frequency of 9.1% (24/265). Of the total Staphylococcus aureus carriers, MRSA isolates were more frequent in interns/trainees (18.9%; 7/37) and nurses (16.2%; 6/37). Outpatient clinics (27.0%; 10/37) and emergency (13.5%; 5/37) concentrated the highest number of carriers. High resistance to erythromycin was observed in MRSA (70.8%) and in methicillin-susceptible Staphylococcus aureus (84.6%).Conclusions: In the studied sample, approximately one in ten healthcare workers was a nasal carrier of MRSA. Given the convenience sampling, the findings should not be extrapolated as population prevalence. Strengthening the use of PPE, hand hy-giene, and microbiological surveillance are priority measures to reduce transmission.","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"43 2","pages":"197-206"},"PeriodicalIF":1.1,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13456926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148632858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous botryomycosis in sequelae lesions of cutaneous leishmaniasis: case report in Peru. 皮肤利什曼病后遗症病变中的皮肤孢杆菌病：秘鲁一例报告。

IF 1.1

Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2026-06-10 DOI: 10.17843/rpmesp.2026.432.15488

Jossy Elena García-Ubillús, Josué M Flores-Espejo, Rafael Alarco Herrera, Roger Sernaque Mechato

引用次数: 0

Aedes taeniorhynchus in urban areas of northern Peru: a concerning finding in the context of the Coastal El Niño Phenomenon 2026. 秘鲁北部城市地区的带喙伊蚊：沿海El Niño现象2026背景下的一个有关发现。

IF 1.1

Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2026-06-04 DOI: 10.17843/rpmesp.2026.432.15787

Alfredo Julian Sandoval-Norabuena, Ricky Alonso Chumacero-Correa, Raul David Izquierdo-Ramos, Sararosa Victoria Martinez-Alvarado, Cristian Alejandro Lopez-Dominguez, Archi Alejandro Ruiz-Polo

引用次数: 0

Facial protection of hats and caps against ultraviolet radiation: experimental study in Ica, Peru. 在秘鲁伊卡的实验研究中，帽子和帽子对紫外线辐射的面部保护。

IF 1.1

Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2026-06-04 DOI: 10.17843/rpmesp.2026.432.15080

Ubaldo Miranda-Soberón, Stefanie Guerrero-Jhong, Yovanny Buleje-Mendoza, Hugo Arroyo-Hernández

引用次数: 0

Clinical and microbiological characteristics of neonates with bacteremia by NDM-producing Klebsiella pneumoniae in a Peruvian referral hospital. 秘鲁一家转诊医院产ndm肺炎克雷伯菌菌血症新生儿的临床和微生物学特征

IF 1.1

Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2026-06-04 DOI: 10.17843/rpmesp.2026.432.15600

Flavia Lara-Herrera, Ana Amable-Castilla, Daniela Mori-Rodriguez, Giancarlo Pérez-Lazo

引用次数: 0

Bacteremia due to Sphingomonas paucimobilis in pediatric and adult patients at a reference hospital in Peru 2020-2024. 2020-2024年秘鲁某参考医院儿科和成人患者因少动鞘氨单胞菌引起菌血症

IF 1.1

Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2026-03-31 DOI: 10.17843/rpmesp.2026.431.14786

Stalin Vilcarromero, Olguita Del Águila, Mario Agramonte-Vilca, Norka Luarte-Saldaña

{"title":"Bacteremia due to Sphingomonas paucimobilis in pediatric and adult patients at a reference hospital in Peru 2020-2024.","authors":"Stalin Vilcarromero, Olguita Del Águila, Mario Agramonte-Vilca, Norka Luarte-Saldaña","doi":"10.17843/rpmesp.2026.431.14786","DOIUrl":"10.17843/rpmesp.2026.431.14786","url":null,"abstract":"Sphingomonas paucimobilis is a ubiquitous bacterium of low virulence that can cause bacteremia, especially in immunocompromised patients. Given the absence of recent reports on this pathogen and its resistance profile in Peru, this series evaluated its clinical and microbiological characteristics in a reference hospital. Six cases confirmed by blood culture between January 2020 and September 2024 were analyzed (4 pe-diatric, 2 adults). All patients presented multiple risk factors or comorbidities, with the majority using a central venous catheter. The mortality observed in the series was 50%. Regarding sensitivity, two isolates showed resistance to third- and fourth-generation cephalosporins and ciprofloxacin, all being sensitive to aminoglycosides and another quinolone such as levofloxacin. S. paucimobilis represents an emerging pathogen, with variable resistance patterns that highlight the need for continuous surveillance and individualized therapeutic management guided by an antibiogram.","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"43 1","pages":"132-137"},"PeriodicalIF":1.1,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13245978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148426276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Years of life lost due to external causes in Honduras, 2013 - 2023. 2013 - 2023年洪都拉斯因外部原因造成的生命损失年数。

IF 1.1

Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2026-03-31 DOI: 10.17843/rpmesp.2026.431.15420

Augusto A Rosales-Meléndez

{"title":"Years of life lost due to external causes in Honduras, 2013 - 2023.","authors":"Augusto A Rosales-Meléndez","doi":"10.17843/rpmesp.2026.431.15420","DOIUrl":"10.17843/rpmesp.2026.431.15420","url":null,"abstract":"Objectives: To estimate the years of life lost (YLL) for deaths due to external causes in Honduras during the 2013-2023 period.Materials and methods: A descriptive-ecological study based on mortality records for external causes from the National Observatory on Violence of Honduras (2013-2023). YLL were estimated, and a stratified analysis by sex, age, and type of cause was performed. Additionally, a trend analysis using the Mann-Kendall test was conducted, stratified by sex and type of cause.Results: During the analyzed period, 1.9 million YLL due to external causes were estimated, 86% of which corresponded to men. Homi-cides were the main cause of YLL in both sexes (62.4% in men and 43.5% in women), followed by traffic accidents (18.3% and 25%, respectively). Between 2013 and 2023, YLL showed a steady increase. In men, increases were observed in unintentional causes (110.5%), suicide (100.1%), and traffic accidents (98.7%); in women, in unintentional causes (146.2%), suicide (62.6%), and traffic accidents (40.4%).Conclusions: Deaths due to external causes, which are mostly preventable, disproportionately affect the young adult population and show an increasing trend. It is essential to implement interventions differentiated by age and sex that contribute to reducing their impact on premature mortality.","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"43 1","pages":"69-76"},"PeriodicalIF":1.1,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13245990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148426430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tocolytic activity of the hydroalcoholic extract of Peperomia galioides Kunth (congona) leaves in non-pregnant rat uterus. 红椒叶水醇提取物在未孕大鼠子宫内的溶胎活性。

IF 1.1

Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2026-03-31 DOI: 10.17843/rpmesp.2026.431.15504

Withney Quinto-Aylas, Luz Poma-Aquino, Daisy Flores-Cortez, Eduardo Villalobos-Pacheco, Cecilia Ignacio-Punin

{"title":"Tocolytic activity of the hydroalcoholic extract of Peperomia galioides Kunth (congona) leaves in non-pregnant rat uterus.","authors":"Withney Quinto-Aylas, Luz Poma-Aquino, Daisy Flores-Cortez, Eduardo Villalobos-Pacheco, Cecilia Ignacio-Punin","doi":"10.17843/rpmesp.2026.431.15504","DOIUrl":"10.17843/rpmesp.2026.431.15504","url":null,"abstract":"Objectives: To evaluate the effect of the hydroalcoholic extract of Peperomia galioides Kunth (congona) leaves on uterine contractility in an isolated non-pregnant rat uterus model.Materials and methods: An in vitro experimental study was conducted with 15 female rats pretreated with estrogen 48 hours prior to the experiment. Uterine horns were sectioned into 10 mm segments and mounted in an isolated organ bath under a basal tension of 1 g. The tissue was stimulated with oxytocin (10-⁶ M) and subsequently exposed to the hydroalcoholic extract of P. galioides (0.1%, 1%, and 10%) and the control. The frequency, duration, and intensity of uterine contractions were evaluated, and the percentage of inhibition was calculated. Ad-ditionally, a preliminary phytochemical screening of the extract was performed.Results: All evaluated concentrations of P. galioides significantly reduced the frequency of oxytocin-induced uterine contractions compared to basal values and the control group (p < 0.001). Regarding intensity and duration, only the 1% and 10% concentrations produced a significant decrease relative to basal values (p < 0.05). However, only the 10% extract significantly inhibited intensity and duration compared to the control group. Phytochemical analysis revealed a high content of phenolic compounds and flavonoids.Conclusions: The hydroalcoholic extract of P. galioides Kunth leaves exerts an inhibitory effect on uterine contractility in the isolated rat uterus, supporting its potential tocolytic action.","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"43 1","pages":"61-68"},"PeriodicalIF":1.1,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13245984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148426332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nicotine e-cigarettes in Peru: analysis of law 32159 against international evidence and gaps for adolescent protection. 秘鲁的尼古丁电子烟：针对国际证据和青少年保护差距的32159号法律分析。

IF 1.1

Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2026-03-31 DOI: 10.17843/rpmesp.2026.431.15979

Jesus Chirinos-Caceres, Eva Chanamé-Ampuero, Abel Zavaleta-Martínez-Vargas, Alfonso Zúñiga

{"title":"Nicotine e-cigarettes in Peru: analysis of law 32159 against international evidence and gaps for adolescent protection.","authors":"Jesus Chirinos-Caceres, Eva Chanamé-Ampuero, Abel Zavaleta-Martínez-Vargas, Alfonso Zúñiga","doi":"10.17843/rpmesp.2026.431.15979","DOIUrl":"10.17843/rpmesp.2026.431.15979","url":null,"abstract":"The article analyzes the regulation of nicotine electronic cigarettes (EC) in Peru, with an emphasis on Law 32159 and its capacity to protect the health of adolescents in light of international evidence. Although they are often perceived as less harmful than combustible cigarettes, studies link their use to cardiovascular and respiratory risks, as well as a higher probability of transitioning to combustible tobacco use in adolescents. The evolution of the Peruvian regulatory framework for tobacco control is reviewed, and it is recognized that Law 32159 constitutes an advance by explicitly incorporating electronic nicotine delivery systems within a comprehensive regulatory approach. In this sense, the law addresses 100% smoke- and vape-free environments, the prohibition of advertising, promotion, and sponsorship, health warnings, marketing restrictions, multisectoral oversight, and incorporates Art. 5.3 of the Framework Convention on Tobacco Control regarding industry interference in control policies for the consumption of tobacco products, nicotine, and substitutes for both. However, gaps persist between the law and its implementation: insufficient definitions of flavorings, lower requirements for health warnings, and limited capacity to control indirect and digital advertising in a context of informal markets and online trade. The absence of fiscal measures weakens public policy. In conclusion, the impact of the law will depend on precise regulations, effective oversight, and complementary instruments such as price and tax policies.","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"43 1","pages":"119-125"},"PeriodicalIF":1.1,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13245993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148426340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0