Revista Peruana de Medicina de Experimental y Salud Publica最新文献

Epidemiology and treatment in patients with HIV in a secondary-level hospital in Mexico. 墨西哥一家二级医院艾滋病毒患者的流行病学和治疗。

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Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2026-02-02 DOI: 10.17843/rpmesp.2025.424.14693

María Fernanda Aguilar-Etchegaray, Hector Martinez-Troncoso, Lilia Susana Gallardo-Vidal, Brenda Michelle Pérez-García, Jacqueline Jiménez-Avila

引用次数: 0

Prostate cancer survival according to socioeconomic and tumor characteristics in Manizales, Colombia. 根据社会经济和肿瘤特征在哥伦比亚马尼萨莱斯的前列腺癌生存率。

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Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2026-02-02 DOI: 10.17843/rpmesp.2025.424.14721

Alexandra Giraldo-Osorio, Juan David Ladino, Miguel Ángel Giraldo Restrepo, Luisa Fernanda Vargas Dussan, Nelson Arias-Ortiz

{"title":"Prostate cancer survival according to socioeconomic and tumor characteristics in Manizales, Colombia.","authors":"Alexandra Giraldo-Osorio, Juan David Ladino, Miguel Ángel Giraldo Restrepo, Luisa Fernanda Vargas Dussan, Nelson Arias-Ortiz","doi":"10.17843/rpmesp.2025.424.14721","DOIUrl":"10.17843/rpmesp.2025.424.14721","url":null,"abstract":"Objective.: To estimate prostate cancer survival according to socioeconomic and tumor characteristics in the municipality of Manizales, Colombia, during the 2008-2018 period, based on population-based data.Materials and methods.: A population-based retrospective cohort study was conducted, including all incident cases of primary prostate cancer diagnosed in Manizales between 2008 and 2018, recorded in the Manizales Population-Based Cancer Registry. Overall survival was estimated using the Kaplan-Meier method, both for the total cohort and according to health insurance regimen, area of residence, socioeconomic position, age groups, histological type, essential Tumor-Node-Metastasis (TNM) classification, and risk according to Gleason score. The association between the variables of interest and survival was evaluated using Cox regression models.Results.: The overall five-year survival was 76.5%. Significant differences in survival were identified according to the health insurance regimen, with the risk of death before five years being approximately twice as high in patients from the subsidized and non-affiliated regimen compared to those from the contributory, special, and exception regimen.Conclusions.: Prostate cancer survival in Manizales is lower than that reported in populations with higher levels of development. Significant gaps in survival persist according to the health insurance regimen, disadvantaging the most socioeconomically vulnerable population, possibly mediated by late diagnoses due to barriers in timely access to treatment.","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"42 4","pages":"349-360"},"PeriodicalIF":1.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12879986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T-cell exhaustion and antibody response in SARS-CoV-2 vaccine recipients. SARS-CoV-2疫苗接种者的t细胞耗竭和抗体反应

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Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2026-02-02 DOI: 10.17843/rpmesp.2025.424.14687

Iván Lozada-Requena, Camila A Arones-Santayana, Angela Vidal Riva, Joel de León, Arturo Pareja Cruz

{"title":"T-cell exhaustion and antibody response in SARS-CoV-2 vaccine recipients.","authors":"Iván Lozada-Requena, Camila A Arones-Santayana, Angela Vidal Riva, Joel de León, Arturo Pareja Cruz","doi":"10.17843/rpmesp.2025.424.14687","DOIUrl":"10.17843/rpmesp.2025.424.14687","url":null,"abstract":"Objectives.: To evaluate the percentage variations of the total lymphocyte population, T cells (TC), and their subpopulations; to characterize the cellular exhaustion profiles in CD4+ and CD8+ T cells; and to quantify anti-spike IgG antibody levels in individuals who received different vaccination schedules.Materials and methods.: We isolated PBMCs (peripheral blood mononuclear cells) from 45 vaccinated and 15 unvaccinated participants to measure TC percentages and MFI (mean fluorescence intensity) by flow cytometry. Additionally, we obtained serum from 42 vaccinated participants, 9 unvaccinated participants, and 20 pre-pandemic controls to measure the concentration of specific IgG antibodies against the SARS-CoV-2 spike protein, respectively.Results.: Vaccination with 3P+1M+1P induced a lower %CD3+ than 3P+1M; a lower %CD8+ than 3P and 3P+1M, but a higher %CD4+ than 3P+1M. All groups, whether vaccinated or not, presented a negative correlation in which a higher %CD8+ corresponded to a lower %CD4+. Cellular exhaustion in CD4+PD1+ of the 3P+1M group was higher than in all CD8+PD1+ of all vaccination platforms including the unvaccinated, except for 3P and the vaccinated or unvaccinated platforms in CD4+PD1+. No significant differences were found in IgG (anti-spike) production across vaccination platforms.Conclusions.: Homologous or heterologous vaccination platforms from three doses onwards do not modify IgG (anti-spike) antibody production; however, they improve CD8+ T cell values, which constitute the most important subpopulation for the antiviral response against SARS-CoV-2.","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"42 4","pages":"370-378"},"PeriodicalIF":1.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12879979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characteristics of Parkinson's disease in the outpatient clinic of a regional hospital in Peru. 秘鲁一家地区医院门诊帕金森病的临床特征

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Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2026-02-02 DOI: 10.17843/rpmesp.2025.424.15105

José J Centeno-Arispe, Carlos A Hurtado-González, Alan P Murillo-Salas, Isabel P Camargo-Salazar, Karlo J Lizarraga-Mendoza

{"title":"Clinical characteristics of Parkinson's disease in the outpatient clinic of a regional hospital in Peru.","authors":"José J Centeno-Arispe, Carlos A Hurtado-González, Alan P Murillo-Salas, Isabel P Camargo-Salazar, Karlo J Lizarraga-Mendoza","doi":"10.17843/rpmesp.2025.424.15105","DOIUrl":"10.17843/rpmesp.2025.424.15105","url":null,"abstract":"Parkinson's Disease (PD) is the fastest-growing neurodegenerative disorder worldwide. The clinical characteristics of adults with PD in a regional referral hospital in Arequipa were determined through a descriptive and cross-sectional study conducted between June 2023 and January 2025. Sixty adults with PD were included (20 women), and the average age was 64.4 years. The most frequent motor phenotype was the tremor-dominant type (73.3%). All received tablets with 250 mg of levodopa and 25 mg of carbidopa. Half took between 250 and 750 mg of levodopa daily, and 21% presented with dyskinesias. The most frequent non-motor symptoms were anxiety (93.2%), depression (88.6%), and mild cognitive impairment (>60%). These findings highlight the opportunity to optimize the treatment of motor and non-motor symptoms with pharmacological and non-pharmacological therapies focused on improving the quality of life of PD patients residing in the Arequipa region.","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"42 4","pages":"430-435"},"PeriodicalIF":1.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12879983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Territory-rooted curiosity and public service: the legacy of dr. Paul Pachas. 扎根于地域的好奇心和公共服务：保罗·帕卡斯博士的遗产。

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Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2026-02-02 DOI: 10.17843/rpmesp.2025.424.15711

César Cabezas

引用次数: 0

Need for standardization in norepinephrine dosage in the management of septic shock. 脓毒性休克治疗中去甲肾上腺素用量标准化的必要性。

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Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2026-02-02 DOI: 10.17843/rpmesp.2025.424.15450

Jorge Cerna, Liz Aliaga, José Amado, Daisy Torres, Patricia Martínez, Rosa Lisson, Consuelo Cornejo, Arturo Ota

引用次数: 0

Distribution of serotypes, biotype, and antibiotic sensitivity of Haemophilus influenzae in nasopharyngeal carrier children in Lima, Peru. 秘鲁利马鼻咽带菌者儿童流感嗜血杆菌血清型、生物型和抗生素敏感性分布

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Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2026-02-02 DOI: 10.17843/rpmesp.2025.424.14767

Brayan E Gonzales, Maria Pinedo-Bardales, Marcela Lopez-Briceño, Edison A Rivera-Fernandez, David Durand, Erik H Mercado, Faviola Valdivia, Theresa J Ochoa

{"title":"Distribution of serotypes, biotype, and antibiotic sensitivity of Haemophilus influenzae in nasopharyngeal carrier children in Lima, Peru.","authors":"Brayan E Gonzales, Maria Pinedo-Bardales, Marcela Lopez-Briceño, Edison A Rivera-Fernandez, David Durand, Erik H Mercado, Faviola Valdivia, Theresa J Ochoa","doi":"10.17843/rpmesp.2025.424.14767","DOIUrl":"10.17843/rpmesp.2025.424.14767","url":null,"abstract":"After the introduction of the Hib (Haemophilus influenzae type b) vaccine, invasive infection caused by this bacterium markedly decreased; however, concern increased regarding the other typable and non-typable strains (NTHi). Prior colonization with this pathogen can become a source of invasive infection. This study aimed to determine colonization by H. influenzae in 888 healthy children under 24 months of age. Colonization was 4.1% (37 samples) using molecular methods (all NTHi) and 1.1% (10 isolates) by culture (8/10 biotype I and 2/10 biotype IV). A history of prematurity was associated with higher colonization in multivariate analysis. Of the isolates, 9/10 were resistant to sulfamethoxazole/trimethoprim, 3/10 to ampicillin and cefuroxime, 2/10 to azithromycin, and no resistance to ceftriaxone was observed. Understanding the carriage status of H. influenzae and local resistance patterns is useful for empirical antibiotic therapy in invasive infections where this bacterium is suspected.","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"42 4","pages":"416-423"},"PeriodicalIF":1.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12879982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herpes simplex virus esophagitis in an immunocompromised patient: case report of an atypical presentation. 免疫功能低下患者的单纯疱疹病毒性食管炎：非典型表现的病例报告。

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Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2026-02-02 DOI: 10.17843/rpmesp.2025.424.14674

Gonzalo David Layza-Reyes, Camila Milagros León-Mejía, Eloy Maier Valencia Reyes, José Luis Villalva Luna, Gustavo Quispe-Villegas, Álvaro Bellido-Caparó

{"title":"Herpes simplex virus esophagitis in an immunocompromised patient: case report of an atypical presentation.","authors":"Gonzalo David Layza-Reyes, Camila Milagros León-Mejía, Eloy Maier Valencia Reyes, José Luis Villalva Luna, Gustavo Quispe-Villegas, Álvaro Bellido-Caparó","doi":"10.17843/rpmesp.2025.424.14674","DOIUrl":"10.17843/rpmesp.2025.424.14674","url":null,"abstract":"We present the case of a 28-year-old male with diarrhea, headache, and significant weight loss. He was diagnosed with HIV in the AIDS stage (CD4: 3 cells/μL), Cryptococcus neoformans meningoencephalitis, and multisystemic tuberculosis. Given the persistence of diarrhea and negative coproparasitological studies, endoscopic studies were performed. Upper digestive endoscopy incidentally showed esophageal erosions coated with fibrin and punched-out ulcers; these findings were identified as herpetic esophagitis by histopathological and immunohistochemical analysis. Treatment with intravenous acyclovir was initiated, followed by oral administration for 14 days. This case highlights the importance of considering herpetic esophagitis in immunosuppressed patients, even in the absence of esophageal symptoms, and emphasizes the value of upper digestive endoscopy with biopsy in the comprehensive diagnosis of HIV/AIDS.","PeriodicalId":53651,"journal":{"name":"Revista Peruana de Medicina de Experimental y Salud Publica","volume":"42 4","pages":"436-441"},"PeriodicalIF":1.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12879978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146159064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chilean physicians and the study of Peruvian wart: a critical review. 智利医生和秘鲁疣的研究：一个重要的回顾。

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Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2026-02-02 DOI: 10.17843/rpmesp.2025.424.15401

Oscar G Pamo Reyna

引用次数: 0

Fulminant myocarditis associated with severe dengue in a young patient from the Peruvian Amazon: case report and literature review. 秘鲁亚马逊地区1例年轻患者伴重症登革热的暴发性心肌炎：病例报告及文献回顾

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Revista Peruana de Medicina de Experimental y Salud Publica Pub Date : 2026-02-02 DOI: 10.17843/rpmesp.2025.424.14881

Edgar A Ramirez-García, María José V Canchanya-Olimar, Gian F Montenegro-Matute, Eliana E Varela-Meza, Vicente Mesones-Ramirez, Christian Paucar-Gonzales, Dayanna Reyes-Correa, Alex G Ramirez-Fernández, Juan C Celis-Salinas, Martín Casapía-Morales

引用次数: 0