Retinal Cases and Brief Reports最新文献_第3页

THE RETINAL DEEP CAPILLARY PLEXUS AS A VENOUS OUTFLOW SYSTEM: INSIGHTS FROM STURGE-WEBER SYNDROME. 视网膜深层毛细血管丛作为静脉流出系统：从斯特鲁格-韦伯综合征中获得的启示。

Retinal Cases and Brief Reports Pub Date : 2024-09-01 DOI: 10.1097/ICB.0000000000001460

Aristomenis Thanos, Jonathan Young, Brad Fortune, Stephen J Tang

{"title":"THE RETINAL DEEP CAPILLARY PLEXUS AS A VENOUS OUTFLOW SYSTEM: INSIGHTS FROM STURGE-WEBER SYNDROME.","authors":"Aristomenis Thanos, Jonathan Young, Brad Fortune, Stephen J Tang","doi":"10.1097/ICB.0000000000001460","DOIUrl":"10.1097/ICB.0000000000001460","url":null,"abstract":"Purpose: To report on the venous abnormalities of a patient with Sturge-Weber syndrome.Method: Case report.Patient: A 29-year-old woman with a history of Sturge-Weber syndrome since infancy was referred for evaluation of possible diffuse choroidal hemangioma. Multimodal imaging, including ultra-widefield fluorescein, indocyanine green, and optical coherence tomography angiography, was performed.Results: Dilated fundus examination was remarkable for increased cupping of the optic disk in the right eye, venous tortuosity, and marked dilation of the choroidal vessels. Ultra-widefield fluorescein angiography confirmed marked venous tortuosity and dilation, as well as anastomoses of the retinal veins ipsilateral to the port wine stain. Indocyanine green angiography revealed marked engorgement of the vortex veins and choroidal vasculature. Optical coherence tomography angiography revealed dilated vascular channels in the deep capillary plexus that were directly anastomosing to the superficial capillary plexus, but not the intermediate capillary plexus. Engorgement of the ampullae of the deep capillary plexus vortex system was also observed. The normal contralateral eye was used as comparison for all imaging studies.Conclusion: These findings support the notion of generalized venous hypertension state in adult eyes with Sturge-Weber syndrome and corroborate previous evidence that the deep capillary plexus acts as a venous outflow system.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9870882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TELANGIECTATIC CAPILLARIES CAUSING PERSISTENT DIABETIC MACULAR EDEMA SUCCESSFULLY TREATED BY PHOTODYNAMIC THERAPY. 光动力疗法成功治疗了导致持续性糖尿病黄斑水肿的毛细血管扩张。

Retinal Cases and Brief Reports Pub Date : 2024-09-01 DOI: 10.1097/ICB.0000000000001446

Marion Schaeffer, Léa Dormegny, Claude Speeg-Schatz, Arnaud Sauer, Tristan Bourcier, David Gaucher

{"title":"TELANGIECTATIC CAPILLARIES CAUSING PERSISTENT DIABETIC MACULAR EDEMA SUCCESSFULLY TREATED BY PHOTODYNAMIC THERAPY.","authors":"Marion Schaeffer, Léa Dormegny, Claude Speeg-Schatz, Arnaud Sauer, Tristan Bourcier, David Gaucher","doi":"10.1097/ICB.0000000000001446","DOIUrl":"10.1097/ICB.0000000000001446","url":null,"abstract":"Purpose: To report two cases of persistent macular edema caused by the exudation of diabetic telangiectatic capillaries (TelCaps), which have been successfully treated with photodynamic therapy (PDT).Methods: Review of data from two patients suffering from persistent macular edema caused by parafoveolar TelCaps. In both cases, conventional laser was impossible because TelCaps were to close from foveal center.Results: The use of focal PDT on perifoveolar TelCaps permitted to reduce persistent macular edema and to avoid inefficient intravitreal anti-vascular epithelial growth factor or steroid injections. In both cases, visual acuity was fully restored four to six months after PDT. Central macular thickness was also normalized in the first case and significantly reduced in the second case. In both cases, visual gain was sustained throughout the whole follow-up period (2 and 1 year, respectively).Conclusion: Photodynamic therapy can be helpful to treat diabetic macular edema caused by TelCaps nonresponding to approved intravitreal therapy or for which conventional laser is contraindicated.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10029309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BILATERAL RETINAL HEMORRHAGES AFTER SEQUENTIAL ENDOVASCULAR TREATMENT OF BILATERAL UNRUPTURED CEREBRAL ANEURYSMS. 双侧未破裂脑动脉瘤序贯血管内治疗后双侧视网膜出血。

Retinal Cases and Brief Reports Pub Date : 2024-09-01 DOI: 10.1097/ICB.0000000000001448

Tianyu Liu, Jonathan C Tsui, Omar A Choudhri, Benjamin J Kim, Alexander J Brucker

{"title":"BILATERAL RETINAL HEMORRHAGES AFTER SEQUENTIAL ENDOVASCULAR TREATMENT OF BILATERAL UNRUPTURED CEREBRAL ANEURYSMS.","authors":"Tianyu Liu, Jonathan C Tsui, Omar A Choudhri, Benjamin J Kim, Alexander J Brucker","doi":"10.1097/ICB.0000000000001448","DOIUrl":"10.1097/ICB.0000000000001448","url":null,"abstract":"Purpose: To report a case of bilateral retinal hemorrhages in a patient undergoing two separate endovascular interventions for bilateral cerebral aneurysms.Methods: A comprehensive ophthalmic examination was performed after the patient underwent each of two separate endovascular interventions for bilateral cerebral aneurysms. Multimodal imaging including widefield pseudocolor fundus photography, optical coherence tomography, and widefield fluorescein angiography was obtained. A systemic workup including genetic testing and hypercoagulability studies was performed.Results: Dilated fundus examination revealed new visually significant ipsilateral retinal hemorrhages after each endovascular procedure. Fluorescein angiography showed evidence of a peripheral retinal microangiopathy present in both eyes before the patient underwent her second endovascular procedure. Systemic workup revealed persistently elevated serum anticardiolipin IgM antibody levels at >99th percentile.Conclusion: Retinal complications after endovascular intracranial interventions are uncommon. This patient who developed bilateral retinal complications was found to have persistently elevated anticardiolipin antibody levels, a risk factor for thrombosis. Patients who develop retinal complications after endovascular intracranial intervention may benefit from systemic workup for hypercoagulable conditions.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9831414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MACULAR NEOVASCULARIZATION IN A CASE OF LATE-ONSET RETINAL DEGENERATION TREATED WITH AFLIBERCEPT. 用 aflibercept 治疗晚发性视网膜变性病例中的黄斑新生血管。

Retinal Cases and Brief Reports Pub Date : 2024-09-01 DOI: 10.1097/ICB.0000000000001439

Durga Ganesh, Giulia Corradetti, Srinivas R Sadda

{"title":"MACULAR NEOVASCULARIZATION IN A CASE OF LATE-ONSET RETINAL DEGENERATION TREATED WITH AFLIBERCEPT.","authors":"Durga Ganesh, Giulia Corradetti, Srinivas R Sadda","doi":"10.1097/ICB.0000000000001439","DOIUrl":"10.1097/ICB.0000000000001439","url":null,"abstract":"Purpose: To describe the outcomes from treatment of macular neovascularization in an eye affected by late-onset retinal degeneration.Methods: A 72-year-old female patient presented with a history of decreased vision since several years. The patient was previously diagnosed with age-related macular degeneration and treated with anti-vascular endothelial growth factors.Results: Clinical examination of the retina and ultra-widefield color fundus photographs showed extensive atrophy in both eyes. The left eye showed macular neovascularization on fluorescein angiography, subretinal fluid on optical coherence tomography, and correspondent hemorrhages on the color fundus photography. Aflibercept anti-vascular endothelial factor treatment was used to treat the macular neovascularization in the left eye.Conclusion: We report a case of genetically confirmed late-onset retinal degeneration (heterozygous pathogenic mutation p.Ser163Arg in one C1QTN5 allele) with advanced degeneration of the retina complicated by macular neovascularization, which responded well to treatment with a single aflibercept injection.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9570457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Panuveitis after ultraviolet light treatments for light adjustable intraocular lens. 光调节眼内透镜紫外线治疗后的泛光炎。

Retinal Cases and Brief Reports Pub Date : 2024-08-28 DOI: 10.1097/ICB.0000000000001653

Jay C Wang, Jose Ramirez, Rahul N Khurana

引用次数: 0

Pre-term Familial Exudative Vitreoretinopathy: A Novel Nonsense LRP5 Mutation. 先期家族性渗出性玻璃体视网膜病变：一种新的无义 LRP5 基因突变

Retinal Cases and Brief Reports Pub Date : 2024-08-26 DOI: 10.1097/ICB.0000000000001652

Parnian Arjmand, Michael Balas, Jovi C Y Wong, Mariana Flores Pimentel, Nasrin Tehrani, Kamiar Mireskandari, Peter J Kertes

{"title":"Pre-term Familial Exudative Vitreoretinopathy: A Novel Nonsense LRP5 Mutation.","authors":"Parnian Arjmand, Michael Balas, Jovi C Y Wong, Mariana Flores Pimentel, Nasrin Tehrani, Kamiar Mireskandari, Peter J Kertes","doi":"10.1097/ICB.0000000000001652","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001652","url":null,"abstract":"Purpose: This case report details the diagnosis and management of a pre-term infant with aggressive bilateral retinal pathology.Methods: A 4-week-old preterm baby girl, born at 28 weeks and 6 days to consanguineous parents, was referred for suspected aggressive posterior retinopathy of prematurity (ROP). She had a family history of bilateral retinal detachments and intellectual disability in an older sister. Clinical assessment included retinal examination, fluorescein angiography, optical coherence tomography, dual-energy X-ray absorptiometry (DEXA), and genetic testing. The genetic testing involved sequence analysis and copy number variation analysis of 25 genes related to vitreoretinopathy.Results: Retinal examination and fluorescein angiography revealed extensive non-perfusion and telangiectatic vessels in both eyes, and a macula-involving tractional retinal detachment in the left eye. Despite treatment with intravitreal bevacizumab and laser photocoagulation, they progressed to total retinal detachment and no light perception in both eyes. Genetic testing revealed a pathogenic homozygous nonsense mutation in the LRP5 gene (c.3259C>T, p.(Gln1087*)), a mutation not previously reported in association with familial exudative vitreoretinopathy (FEVR). At 10 months of age, DEXA demonstrated normal bone density, diverging from the typical presentation of osteoporosis pseudoglioma syndrome associated with LRP5 mutations.Conclusion: This case describes a novel mutation in a complex retinal disease and underscores the necessity of considering pre-term FEVR in the differential diagnosis of atypical or aggressive ROP in preterm infants. The overlap in clinical features between ROP and FEVR highlights the complexity of diagnosis and management and the importance of genetic testing in preterm infants with retinal vascular abnormalities.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142086400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central retinal artery and Common Carotid artery occlusions following COVID-19 infection: A case report. COVID-19感染后视网膜中央动脉和颈总动脉闭塞：病例报告。

Retinal Cases and Brief Reports Pub Date : 2024-08-19 DOI: 10.1097/ICB.0000000000001651

Mohamed Eldakkak, Dimitrios Kalogeropoulos, Andrew J Lotery

引用次数: 0

Long Term Follow Up of a Family with A3243G Mitochondrial Syndrome. 一个 A3243G 线粒体综合征家庭的长期随访。

Retinal Cases and Brief Reports Pub Date : 2024-08-14 DOI: 10.1097/ICB.0000000000001647

Alessandro Feo, Claudia Fossataro, Néda Abraham, Shilo Voichanski, Jack D Lemon, David Sarraf

{"title":"Long Term Follow Up of a Family with A3243G Mitochondrial Syndrome.","authors":"Alessandro Feo, Claudia Fossataro, Néda Abraham, Shilo Voichanski, Jack D Lemon, David Sarraf","doi":"10.1097/ICB.0000000000001647","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001647","url":null,"abstract":"Purpose: To describe the clinical and multimodal imaging (MMI) features of a family (proband, sister and mother) with A3243G mitochondrial retinopathy and long-term follow up.Methods: Medical and imaging records were retrospectively evaluated. Multimodal imaging included ultra-widefield color fundus photography, fundus autofluorescence, and spectral-domain optical coherence tomography. Long-term MMI follow up ranged from 6 to 15 years and was available for each member.Results: The proband (Case 1) exhibited rapidly progressive bilateral macular atrophy, corneal endothelial polymegathism, and an A3243G mutation in the mitochondrial DNA. The proband also endorsed a history of early-onset myocardial infarction (MI) ten years prior at the age of 42. The proband's sister (Case 2) only exhibited unilateral focal macular atrophy but admitted to a history of severe multiorgan systemic disease, including multiple sclerosis and major depression disorder. The proband's mother (Case 3), the only one with diabetes mellitus and hearing loss, originally presented with branch retinal vein occlusion in the right eye and pattern dystrophy in the left eye which evolved to geographic atrophy, OD > OS, 15 years later.Conclusion: A3243G mitochondrial syndrome can exhibit heterogenous ocular and systemic features, even within members of the same family. The development of the characteristic maculopathy with early-onset MI warrants genetic testing. Early cardiac and systemic screening may be recommended in individuals with characteristic retinal findings and genetic confirmation.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141992498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serous Choroidal Detachment Associated with Suspected Contralateral Cavernous Sinus Thrombosis. 疑似对侧海绵窦血栓形成导致的浆液性脉络膜脱离

Retinal Cases and Brief Reports Pub Date : 2024-08-09 DOI: 10.1097/ICB.0000000000001650

Dominic M Choo, Arjun G Merchant, Angeline L Wang

{"title":"Serous Choroidal Detachment Associated with Suspected Contralateral Cavernous Sinus Thrombosis.","authors":"Dominic M Choo, Arjun G Merchant, Angeline L Wang","doi":"10.1097/ICB.0000000000001650","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001650","url":null,"abstract":"Purpose: To describe a case of choroidal detachment (CD) secondary to cavernous sinus thrombosis (CST).Methods: Case report.Results: A 73-year-old male with a history of primary open angle glaucoma and pseudophakia presented with retrobulbar pain, blurred vision, and diplopia of the right eye. Exam revealed severe non-hemorrhagic bullous chemosis, tortuous retinal vessels, and elevated intraocular pressure (IOP) in the right eye. Although computed tomography venography findings initially raised suspicion of a carotid-cavernous fistula (CCF), the diagnostic angiogram showed no such evidence, instead raising concern for cavernous sinus thrombosis (CST). Dilated fundus exam and MRI were notable for multiple serous choroidal detachments in the right eye, which resolved with systemic management of CST and topical steroids.Conclusion: The possibility of choroidal detachment during the clinical course of a CST should be recognized. CST may be related to impaired venous drainage that forces transudate into perivascular spaces and results in choroidal effusion.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141910177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paenibacillus lautus: A new foe in endogenous endophthalmitis. 猪链球菌：内源性眼内炎的新敌人。

Retinal Cases and Brief Reports Pub Date : 2024-08-06 DOI: 10.1097/ICB.0000000000001636

Aditi Joshi, Chetan Rao, Parthopratim Dutta Majumder, A R Anand

{"title":"Paenibacillus lautus: A new foe in endogenous endophthalmitis.","authors":"Aditi Joshi, Chetan Rao, Parthopratim Dutta Majumder, A R Anand","doi":"10.1097/ICB.0000000000001636","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001636","url":null,"abstract":"Purpose: To discuss the diagnosis and management of a rare case of endogenous endophthalmitis (EE) caused by Paenibacillus lautus mimicking granulomatous uveitis in a child, highlighting the use of 16S rRNA gene amplicon sequencing as an accurate method to identify rare pathogens.Method: A retrospective chart review of the clinical presentation, microbiologic workup-including microscopy, culture, antibiotic susceptibility, and polymerase chain reaction for pathogen DNA of clinical samples-and the clinical management of the case were recorded.Result: A 13-year-old boy presented with decreased vision in the right eye for one month. On examination, he had uveitis with hypopyon and complicated cataract. The case underwent an anterior chamber tap followed by vitrectomy and lensectomy. The culture of the vitreous aspirate grew Gram-variable bacilli that could not be identified by conventional microbiological techniques. However, PCR-based sequencing of the 16S rRNA gene was performed, and the bacterium was identified as P. lautus. The patient subsequently developed rhegmatogenous retinal detachment, for which he underwent endo laser photocoagulation and oil tamponade. Four months later, silicone oil was removed, and an intraocular lens was implanted. At six weeks follow-up, the retina remained well attached, and intraocular pressure was maintained.Conclusion: P. lautus can cause EE and mimic granulomatous uveitis. Techniques such as 16S rRNA gene sequencing can significantly facilitate aetiological diagnosis in cases where conventional methods fail.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141910176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0