Retinal Cases and Brief Reports最新文献_第2页

A NOVEL FINDING IN THE DIAGNOSIS OF PRIMARY VITREORETINAL LYMPHOMA: A CASE REPORT. 诊断原发性玻璃体视网膜淋巴瘤的新发现：一例报告。

Retinal Cases and Brief Reports Pub Date : 2025-01-01 Epub Date: 2023-10-09 DOI: 10.1097/ICB.0000000000001489

Arash Maleki

{"title":"A NOVEL FINDING IN THE DIAGNOSIS OF PRIMARY VITREORETINAL LYMPHOMA: A CASE REPORT.","authors":"Arash Maleki","doi":"10.1097/ICB.0000000000001489","DOIUrl":"10.1097/ICB.0000000000001489","url":null,"abstract":"Purpose: Introduce a unique case of primary vitreoretinal lymphoma with a new optical coherence tomography finding.Methods: A case report. A 67-year-old healthy man with complaints of blurry vision in his right eye.Results: The patient's visual acuity was 20/60 and 20/20 in the right and left eyes, respectively. Anterior segment examination of the right eye demonstrated mild inflammation. Dilated fundoscopy revealed 2+ vitreous haze and 4+ disk edema. Optical coherence tomography of the macula in the right eye revealed optic nerve head swelling and thickening of the retina. Fluorescein angiography demonstrated mild leakage and staining of vessels along the inferotemporal arcade in the right eye. Labs were within normal limits except positive Herpes simplex virus 1 IgG. Initially, the patient was treated for herpetic panuveitis for 3 weeks with a favorable response. However, the clinical condition deteriorated as a new abnormality was identified in the macular region of the right eye through optical coherence tomography. Considering intraocular lymphoma as a potential diagnosis, the patient underwent a diagnostic vitrectomy. The vitreous sample analysis confirmed primary vitreoretinal lymphoma through immunohistochemistry and flow cytometry. The patient exhibited a rapid response after the initiation of intravenous and intravitreal methotrexate treatment.Conclusion: The presence of subretinal fluid accompanied by suspended hyperreflective lesions originating from the roof of the subretinal fluid pocket on the optical coherence tomography of macula \"stalactite sign\" may serve as a characteristic sign indicative of primary vitreoretinal lymphoma; however, further investigation using robust studies is necessary to examine this hypothesis.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"28-33"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41219920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FAMILIAL EXUDATIVE VITREORETINOPATHY WITH NASAL RETINAL INVOLVEMENT: A RARE PRESENTATION. 家族性渗出性玻璃体视网膜病变（FEVR）伴鼻视网膜受累：罕见表现。

Retinal Cases and Brief Reports Pub Date : 2025-01-01 Epub Date: 2024-12-13 DOI: 10.1097/ICB.0000000000001511

Amelia Cooper, Henry Stevens, Ivan Batlle

{"title":"FAMILIAL EXUDATIVE VITREORETINOPATHY WITH NASAL RETINAL INVOLVEMENT: A RARE PRESENTATION.","authors":"Amelia Cooper, Henry Stevens, Ivan Batlle","doi":"10.1097/ICB.0000000000001511","DOIUrl":"10.1097/ICB.0000000000001511","url":null,"abstract":"Purpose: To present a case of familial exudative vitreoretinopathy with nasal retinal involvement and aim to describe the clinical presentation, diagnostic findings, management strategies, and genetic testing.Methods: An evaluation of a 31-year-old female patient with familial exudative vitreoretinopathy presenting with predominate nasal retinal involvement. Diagnostic tests-including fundus examination, optical coherence tomography, fluorescein angiography, and genetic testing-were performed. The patient's management involved intravitreal injection of 1.25 mg/0.05 mL of bevacizumab in the left eye and sectoral panretinal photocoagulation in both eyes.Results: The patient exhibited discrete neovascularization and tortuosity predominantly localized to the nasal retinal blood vessels. Optical coherence tomography imaging showed macular schisis and vitreomacular traction without retinal detachment. Genetic testing identified a likely pathogenic variant associated with autosomal dominant and recessive exudative vitreoretinopathy. Treatment with bevacizumab and panretinal photocoagulation resulted in regression of neovascularization and improvement in macular schisis. Conclusion: This case report highlights an atypical presentation of familial exudative vitreoretinopathy with nasal retinal involvement. Early recognition and genetic testing aids in diagnosis and management.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"107-111"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11649170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71488881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BELZUTIFAN FOR TREATMENT OF GIANT RETINAL HEMANGIOBLASTOMA WITH EXTRASCLERAL EXTENSION ASSOCIATED WITH VON HIPPEL-LINDAU SYNDROME. 贝尔祖替芬治疗伴希佩尔-林道综合征的巨大视网膜血管母细胞瘤。

Retinal Cases and Brief Reports Pub Date : 2025-01-01 Epub Date: 2024-12-13 DOI: 10.1097/ICB.0000000000001516

Caroline C Cotton, Anirudha S Chandrabhatla, Patrick H Andrews, Benjamin W Purrow, Yevgeniy Eugene Shildkrot

{"title":"BELZUTIFAN FOR TREATMENT OF GIANT RETINAL HEMANGIOBLASTOMA WITH EXTRASCLERAL EXTENSION ASSOCIATED WITH VON HIPPEL-LINDAU SYNDROME.","authors":"Caroline C Cotton, Anirudha S Chandrabhatla, Patrick H Andrews, Benjamin W Purrow, Yevgeniy Eugene Shildkrot","doi":"10.1097/ICB.0000000000001516","DOIUrl":"10.1097/ICB.0000000000001516","url":null,"abstract":"Purpose: To describe the clinical response and safety profile of the novel HIF-2ɑ inhibitor belzutifan in treating a giant retinal hemangioblastoma with extrascleral extension associated with von Hippel-Lindau syndrome.Methods: A 71-year-old woman with Von Hippel-Lindau syndrome presented with a giant retinal hemangioblastoma with extrascleral extension in her only remaining eye. She had no light perception in the right eye and intraocular pressure was 48. She requested enucleation because of chronic pain, but because of concern for significant bleeding given the size of the neoplasm, a trial of belzutifan was initiated.Results: Within 3 months of treatment initiation, the patient reported an 80% reduction in pain. Magnetic resonance imaging showed 30% reduction in longest tumor diameter. Dose adjustments were guided by serum hemoglobin levels, allowing the patient to remain on the medication for over a year with continued tumor regression on MRI and avoid enucleation.Conclusion: Retinal hemangioblastoma with extrascleral extension is exceedingly rare and its treatment is complex, often requiring enucleation or external beam radiotherapy. This report demonstrates the use of belzutifan to safely and successfully reduce ocular tumor burden of complicated retinal hemangioblastoma with extrascleral extension, ultimately decreasing the need for enucleation.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"66-69"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11649176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136400291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anterior uveitis, pigmentary retinopathy, and pars plana exudates in Celiac disease. 乳糜泻的前葡萄膜炎、色素视网膜病变和网膜部渗出。

Retinal Cases and Brief Reports Pub Date : 2024-12-31 DOI: 10.1097/ICB.0000000000001708

Aniruddha Agarwal, Surinder S Rana, Kirti Gupta

引用次数: 0

Nerve Fiber Layer Schisis in Coats Disease. Coats病的神经纤维层裂。

Retinal Cases and Brief Reports Pub Date : 2024-12-31 DOI: 10.1097/ICB.0000000000001709

Spencer S Burt, Yakub Bayhaqi, Shuibin Ni, Yifan Jian, J Peter Campbell, Benjamin K Young

引用次数: 0

OCT Angiography characteristics of Bilateral Mactel type 1: revealing the Aneurysmo occlusive variety. 双侧Mactel 1型的OCT血管造影特征：揭示动脉瘤闭塞的多样性。

Retinal Cases and Brief Reports Pub Date : 2024-12-31 DOI: 10.1097/ICB.0000000000001707

Amrita Pradhan, Ahana Sen, Ruchira Chowdhury, Survee Sharma, Bristi Majumdar, Surabhi Chattree, Debmalya Das, Eesh Nigam, Kumar Saurabh, Rupak Roy

引用次数: 0

Drusen Regression after Macula-involving Rhegmatogenous Retinal Detachment Repair. 累及黄斑的孔源性视网膜脱离修复后的Drusen消退。

Retinal Cases and Brief Reports Pub Date : 2024-12-31 DOI: 10.1097/ICB.0000000000001711

Kyle M Green, Taariq K Mohammed, Jonathan F Russell, Timothy M Boyce

{"title":"Drusen Regression after Macula-involving Rhegmatogenous Retinal Detachment Repair.","authors":"Kyle M Green, Taariq K Mohammed, Jonathan F Russell, Timothy M Boyce","doi":"10.1097/ICB.0000000000001711","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001711","url":null,"abstract":"Purpose: To investigate the effect of macula-involving rhegmatogenous retinal detachment (RRD) repair on drusen regression.Methods: A retrospective review was performed of patients with drusen who underwent macula-involving RRD repair. Longitudinal optical coherence tomography scans were reviewed by three graders, and each case was grouped into one of three categories: drusen regression, drusen persistence, or mixed.Results: 14 eyes with drusen that underwent macula-involving RRD repair were identified. Surgical repair consisted of pars plana vitrectomy (PPV) in 7 eyes, combined PPV and scleral buckle in 6 eyes, and primary buckle with cryotherapy in 1 eye. Regression of drusen occurred in 6 eyes (43%), persistence of drusen in 5 eyes (36%), and 3 eyes were categorized as mixed (21%). One patient with drusen regression with long-term follow up resulted in geographic atrophy.Conclusion: Although the course of drusen following repair of macula-involving RRDs was highly variable, roughly half of eyes demonstrated marked drusen regression.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optical Coherence Tomography Angiography findings in Syphilitic Outer Retinitis. 梅毒性外视网膜炎的光学相干断层血管造影表现。

Retinal Cases and Brief Reports Pub Date : 2024-12-31 DOI: 10.1097/ICB.0000000000001706

Luis Zeman, Mauricio Martínez Cartier, Cristóbal Couto, Ariel Schlaen

引用次数: 0

Epstein-Barr Virus-Associated Frosted Branch Angiitis: A Case Report and Brief Review. eb病毒相关霜状支血管炎1例报告及简要回顾

Retinal Cases and Brief Reports Pub Date : 2024-12-31 DOI: 10.1097/ICB.0000000000001710

Angela A Cao, Christian D Curran, Pedro Monsalve Diaz, Emily Hause, Dara Koozekanani, Max R Johnson, Karen R Armbrust

{"title":"Epstein-Barr Virus-Associated Frosted Branch Angiitis: A Case Report and Brief Review.","authors":"Angela A Cao, Christian D Curran, Pedro Monsalve Diaz, Emily Hause, Dara Koozekanani, Max R Johnson, Karen R Armbrust","doi":"10.1097/ICB.0000000000001710","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001710","url":null,"abstract":"Purpose: To report the clinical presentation, treatment course, and outcome of a case of bilateral frosted branch angiitis (FBA) and neuroretinitis associated with acute Epstein-Barr virus (EBV) infection in a pediatric patient with Turner Syndrome.Methods: Case report with multimodal ocular imaging and extensive systemic workup.Results: A 16-year-old female with Turner syndrome presented with acute bilateral vision loss, hearing loss, and ataxia. Ocular examination showed bilateral extensive perivascular sheathing, optic disc edema, and macular exudates. Fluorescein angiography showed focal retinal ischemia and late optic disc leakage in both eyes. Macular optical coherence tomography was remarkable for intraretinal and subretinal fluid with scattered hyperreflective foci in both eyes. MRI brain and orbits showed a supratentorial T2 signal without enhancement, consistent with inactive vasculopathy. Results of a broad systemic workup were notable only for elevated EBV viral capsid antigen IgM with undetectable EBV viral capsid antigen IgG. After treatment with intravenous methylprednisolone followed by oral prednisone, the patient's best corrected visual acuity in both eyes improved from 20/200 to 20/20.Conclusion: Ocular symptoms and imaging biomarkers in this case of EBV-associated FBA resolved after high-dose systemic corticosteroid monotherapy. Although treatment with antiviral medications is reported in other FBA cases associated with acute EBV infection, this case underscores the treatable nature of this disease without antivirals, the use of which are not supported by the broader literature for EBV infection or post-viral inflammation.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydroxychloroquine retinopathy in a 23-year-old male. 一名 23 岁男性的羟氯喹视网膜病变。

Retinal Cases and Brief Reports Pub Date : 2024-12-13 DOI: 10.1097/ICB.0000000000001704

Elodie Bousquet, Ahmad Santina, Swathi Somisetty, Veronica Romero Morales, Gary N Holland, David Sarraf

{"title":"Hydroxychloroquine retinopathy in a 23-year-old male.","authors":"Elodie Bousquet, Ahmad Santina, Swathi Somisetty, Veronica Romero Morales, Gary N Holland, David Sarraf","doi":"10.1097/ICB.0000000000001704","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001704","url":null,"abstract":"Purpose: To report a case of hydroxychloroquine (HCQ) retinopathy after long-term exposure in a 23-year-old male.Methods: Multimodal imaging including fundus photography, fundus autofluorescence (FAF), spectral domain optical coherence tomography (SD-OCT), and en face OCT were performed, in addition to functional testing with full-field electroretinography (ERG) and Humphrey visual field (HVF).Results: A 23-year-old man with a history of juvenile systemic lupus erythematosus and HCQ treatment for 13 years at a dosage of 200 mg/d (cumulative dose: 949 grams) presented to the retinal clinic (DS). Although fundus photography and FAF were unremarkable, SD-OCT and en face OCT showed paracentral ellipsoid zone loss with thinning of the outer nuclear layer, OS greater than OD consistent with HCQ retinopathy. HVF 10-2 showed possible nasal loss OU. Genetic testing revealed heterozygous mutations in the CNGA1 and CRX genes but full-field ERG was unremarkable without evidence of a cone dystrophy. Family history was negative for genetic disease.Conclusion: This report highlights a case of HCQ retinopathy in a young patient who started treatment at the age of 10 years. There are currently no specific guidelines for the screening of pediatric patients, and studies evaluating the effect of HCQ on children are lacking. Whether the genetic carrier status rendered the patient more susceptible to the toxic effect of HCQ remains to be determined.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0