Abeku A Koomson, Callum S Grewal, Meena Kapoor, Kamaljit S Balaggan
{"title":"BILATERAL SEQUENTIAL INFLAMMATORY FULL-THICKNESS MACULAR HOLES IN BIRDSHOT CHORIORETINOPATHY.","authors":"Abeku A Koomson, Callum S Grewal, Meena Kapoor, Kamaljit S Balaggan","doi":"10.1097/ICB.0000000000001749","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001749","url":null,"abstract":"<p><strong>Purpose: </strong>To report a novel case of bilateral sequential full-thickness macular holes in a patient with birdshot chorioretinopathy (BSCR).</p><p><strong>Methods: </strong>Case report.</p><p><strong>Results: </strong>A 57-year-old woman with BSCR undergoing systemic anti-inflammatory treatment developed progressive bilateral macular atrophy and reduced visual acuity. Further progression resulted in the development of a full-thickness macular hole (FTMH) in her left eye, which was successfully treated with vitrectomy, internal limiting membrane peeling using the inverted flap technique, and C3F8 gas injection. Unfortunately, she soon developed a FTMH in her right eye, which was also successfully repaired by vitrectomy.</p><p><strong>Conclusion: </strong>Chronic posterior uveitis in BSCR can result in macular atrophy, which in our patient progressed to bilateral FTMH formation. This complication of BSCR has never been reported before.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel Intraoperative FFA Reveals Neovascularization at Sclerotomy Site in Post Vitrectomy Hemorrhage.","authors":"Yawen Qin, Jie Zhong, Jie Li","doi":"10.1097/ICB.0000000000001726","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001726","url":null,"abstract":"<p><strong>Purpose: </strong>To report a case of long-term postoperative vitreous hemorrhage (PVH) of proliferative diabetic retinopathy after pars plana vitrectomy (PPV), which is most likely to be associated with neovascularization (NV) formed at the incision site of vitrectomy, and to recommend a better surgical technique for the diagnosis and treatment of such patients.</p><p><strong>Methods: </strong>Intraoperative fundus fluorescein angiography (FA) was performed using a customized intraoperative blue light excitation source and observed by a three-dimensional (3D) surgical observation system to explore the causes of recurrent PVH.</p><p><strong>Results: </strong>Intraoperative 3D-FA clearly showed the complete fluorescence image of the inward growing scleral NV at the PPV incision site and guided the surgical treatment of intraocular retinal laser photocoagulation of the NV.</p><p><strong>Conclusion: </strong>Intraoperative 3D-FA has a certain role in the diagnosis and treatment of unexplained PVH after PPV, and is a promising surgical auxiliary technology.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melissa M Medina Melo, Laura Quintero Arciniegas, Santiago Morales
{"title":"In-Vivo Surgical Approach of Subretinal Cysticercosis: A Case Report.","authors":"Melissa M Medina Melo, Laura Quintero Arciniegas, Santiago Morales","doi":"10.1097/ICB.0000000000001748","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001748","url":null,"abstract":"<p><strong>Purpose: </strong>To report the clinical and imaging findings of a patient with right eye progressive vision loss, in whom ocular neurocysticercosis was diagnosed. The patient underwent vitreoretinal surgery with previous antihelmintic treatment, resulting in a successful extraction of the subretinal cyst.</p><p><strong>Methods: </strong>A patient with subretinal neurocysticercosis underwent a combination of ophthalmic examination, fundus photography, ocular ultrasound, brain MRI, and surgery.</p><p><strong>Results: </strong>A 57-year-old female from La Guajira, Colombia presented with a 2-year history of unilateral subretinal neurocysticercosis and an overlying exudative inferior retinal detachment with multiple areas of RPE atrophy. Different methods of surgery were contemplated to achieve a favorable outcome, until deciding on a microincision vitrectomy surgery.</p><p><strong>Conclusion: </strong>An \"in vivo\" minimally invasive pars plana approach should be considered, given it has proven to be successful in removing intraocular cysts with no postoperative inflammatory response, preserving anatomic and functional integrity.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elisah M Huynh, Mahmood Khan, Yanhan Ren, Anton Orlin, Szilard Kiss, Benjamin W Botsford
{"title":"MULTIMODAL IMAGING IN DEFEROXAMINE-RELATED OCULAR TOXICITY: RAPID DEVELOPMENT DUE TO SUPRATHERPEUTIC DOSING AND PROGRESSION DESPITE DOSE REDUCTION.","authors":"Elisah M Huynh, Mahmood Khan, Yanhan Ren, Anton Orlin, Szilard Kiss, Benjamin W Botsford","doi":"10.1097/ICB.0000000000001746","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001746","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize evolution of deferoxamine-related retinal toxicity in a patient exposed to supratherapeutic doses of deferoxamine and progression despite dose reduction and cessation.</p><p><strong>Methods: </strong>Observational clinical case Report.</p><p><strong>Results: </strong>A 59-year-old female with history of beta thalassemia requiring biweekly blood transfusions developed peripheral visual field loss and nyctalopia after taking supratherapeutic dosage of deferoxamine. She demonstrated progressive RPE thickening and photoreceptor loss despite reduction in dosage as she was unable to initially discontinue the medication, as vision decreased from 20/25 and 20/30 to 20/60 and 20/50. This report highlights the ocular toxicities linked with deferoxamine and examines whether dosage decrease reverses its effects.</p><p><strong>Conclusion: </strong>Deferoxamine use can precipitate RPE changes, thickening, and photoreceptor loss that can progress despite dose-reduction and cessation.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Galen Y Hu, Casey H Zhang, Erez Nossek, Cen Zhang, Janet C Rucker, Patrick J Hughes, Yasha S Modi
{"title":"Multiple, Recurrent, Bilateral Branch Retinal Artery Occlusions Associated with Carotid Webs.","authors":"Galen Y Hu, Casey H Zhang, Erez Nossek, Cen Zhang, Janet C Rucker, Patrick J Hughes, Yasha S Modi","doi":"10.1097/ICB.0000000000001747","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001747","url":null,"abstract":"<p><strong>Purpose: </strong>We describe a case of bilateral, multiple, branch retinal artery occlusions (BRAO) associated with carotid webs.</p><p><strong>Methods: </strong>A thorough chart review was conducted for the patient. Relevant literature was systematically reviewed.</p><p><strong>Results: </strong>Eight cases of fibromuscular dysplasia (FMD) associated with retinal artery occlusions have been reported. Two additional cases of FMD with other ocular involvement have been described. No cases of carotid webs associated with retinal artery occlusions were found.</p><p><strong>Conclusion: </strong>Carotid webs, an uncommon variant of FMD, are a recognized causative etiology of arterial, ischemic stroke. The case described here of bilateral, multifocal BRAOs represents a unique manifestation of this variant of FMD. This diagnosis should be considered in the setting of an otherwise unrevealing BRAO workup, as recognition of this association may be sight and life-saving.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"RELENTLESS PLACOID CHORIORETINITIS RESPONSIVE TO INTRAVITREAL TRIAMCINOLONE AND SYSTEMIC ADALIMUMAB.","authors":"Jacqueline R Porteny, Andre J Witkin","doi":"10.1097/ICB.0000000000001531","DOIUrl":"10.1097/ICB.0000000000001531","url":null,"abstract":"<p><strong>Purpose: </strong>The authors describe a case of relentless placoid chorioretinitis that was responsive to intravitreal triamcinolone and systemic adalimumab, but suboptimally responsive to oral prednisone.</p><p><strong>Methods: </strong>: This is an interventional case report.</p><p><strong>Results: </strong>A 23-year-old woman presented with macular placoid chorioretinitis in the left eye and visual acuity of finger counting at 3 feet. Despite a 2-week course of 60 mg oral prednisone, the choroiditis expanded dramatically in the midperiphery. She was admitted to the hospital for high-dose IV corticosteroids, which stopped the progression of disease. After discharge, the patient was started on adalimumab and restarted oral prednisone; however, on resumption of oral prednisone 60 mg, the disease started to progress again over the next 2 weeks. An intravitreal injection of triamcinolone (intravitreal triamcinolone) 2 mg was given, which halted the progression of the disease for at least 9 weeks, at which time it was believed that the adalimumab started to also have an effect. The visual acuity 9 weeks after intravitreal triamcinolone had improved to 20/20. The patient was lost to follow-up after this point.</p><p><strong>Conclusion: </strong>This is a case of relentless placoid chorioretinitis that continued to progress despite high-dose oral corticosteroids, but which responded to intravitreal triamcinolone and systemic adalimumab. This indicates that intravitreal corticosteroids may represent an alternative treatment option to oral corticosteroids in the short-term management of macula-threatening noninfectious chorioretinitis, particularly in patients with a suboptimal response to oral corticosteroids.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"189-192"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hashem H Ghoraba, Michael Yu, Gina Yu, Sean Wang, Chris Or, Irmak Karaca, Quan Dong Nguyen
{"title":"OCULAR ISCHEMIC SYNDROME IN THE SETTING OF NORMAL CAROTID DUPLEX ULTRASOUND.","authors":"Hashem H Ghoraba, Michael Yu, Gina Yu, Sean Wang, Chris Or, Irmak Karaca, Quan Dong Nguyen","doi":"10.1097/ICB.0000000000001528","DOIUrl":"10.1097/ICB.0000000000001528","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to describe two cases of ocular ischemic syndrome (OIS) that were initially ruled out because of a negative carotid duplex ultrasound but eventually confirmed by angiography studies.</p><p><strong>Methods: </strong>This is a case series.</p><p><strong>Results: </strong>Case 1: A 67-year-old woman presented with symptoms suggestive of OIS, but carotid duplex ultrasound was negative, and the patient was diagnosed with occlusive retinal vasculitis due to retinal nonperfusion and vascular leakage on fluorescein angiography. Immunosuppressive therapy was initiated, but her symptoms did not improve. Computerized tomography angiography was significant for severe osteal stenosis of the aortic arch vessels. Left common carotid angioplasty and stenting resulted in complete resolution of the symptoms and vascular leakage of the left eye. Case 2: A 41-year-old man with cryoglobulinemia-associated vasculitis complained of symptoms consistent with OIS, which was initially ruled out through a negative carotid duplex ultrasound. Fluorescein angiography revealed delayed arterial filling with poor retinal perfusion. Magnetic resonance angiography revealed ophthalmic artery stenosis, which was attributed to the underlying systemic vasculitis.</p><p><strong>Conclusion: </strong>Computerized tomography angiography or magnetic resonance angiography should be performed to rule out OIS if duplex ultrasound is negative in the setting of high clinical suspicion. Carotid ostial and ophthalmic artery stenoses are rare but possible causes of OIS.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"221-224"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138802700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francesco Gelormini, Veronica Vallino, Mark P Breazzano, Barbara Pasini, Michele Reibaldi, Enrico Borrelli
{"title":"MULTIMODAL IMAGING OF A NOVEL MFSD8/CLN7 MUTATION ASSOCIATED WITH NONSYNDROMIC SYMMETRIC ADULT-ONSET MACULAR DYSTROPHY.","authors":"Francesco Gelormini, Veronica Vallino, Mark P Breazzano, Barbara Pasini, Michele Reibaldi, Enrico Borrelli","doi":"10.1097/ICB.0000000000001553","DOIUrl":"10.1097/ICB.0000000000001553","url":null,"abstract":"<p><strong>Purpose: </strong>The objective of this study was to report multimodal imaging features of a novel MFSD8/CLN7 pathogenic variant associated with bilateral and symmetric nonsyndromic macular dystrophy.</p><p><strong>Methods: </strong>A 63-year-old female patient presented complaining of a gradual subjective decline in VA in both eyes over the previous months. This patient underwent a comprehensive ophthalmological assessment, including multimodal retinal imaging and electrophysiological testing. Given suspicion for a hereditary retinal disorder, genetic testing was pursued.</p><p><strong>Results: </strong>The eye examination revealed blunted foveal reflexes and no lesions or abnormalities in the equatorial or anterior retinal periphery. Multimodal imaging showed a bilateral and almost symmetrical subfoveal interruption of the outer retinal layers, including an optical gap. Genetic testing revealed that the MFSD8/CLN7 gene exhibited a homozygous variant, specifically p.Ala484Val (c.1451C>T). This variant was identified as the likely causative factor for the condition.</p><p><strong>Conclusion: </strong>In this study, the authors describe the clinical findings of a previously unreported homozygous variant in the MFSD8/CLN7 gene, resulting in a nonsyndromic form of bilateral central macular dystrophy.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"169-173"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139984480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"DELAYED CLOSURE OF A FULL-THICKNESS MACULAR HOLE AFTER PARS PLANA VITRECTOMY WITH INTERNAL LIMITING MEMBRANE FLAP.","authors":"Shahanaz B Ahmed, Sufiyan Shaikh, Jason Ho","doi":"10.1097/ICB.0000000000001525","DOIUrl":"10.1097/ICB.0000000000001525","url":null,"abstract":"<p><strong>Background/purpose: </strong>The aim of this study is to describe a patient with delayed closure of a stage 3 full-thickness macular hole after pars plana vitrectomy.</p><p><strong>Methods: </strong>This is a retrospective case report. Details of the case were obtained from the electronic patient record system, Medisoft.</p><p><strong>Results: </strong>A 65-year-old man was referred with a left stage 3 full-thickness macular hole measuring 720 μ m and visual acuity of 6/36. He underwent phacovitrectomy, internal limiting membrane peel with an inverted internal limiting membrane flap, and C 3 F 8 gas tamponade. Seven weeks after surgery, the macular hole was smaller at 196 μ m but remained open. The patient was listed for repeat surgery; however, another 13 weeks later, the full-thickness macular hole demonstrated type 2 closure without further intervention.</p><p><strong>Conclusion: </strong>Delayed macular hole closure after pars plana vitrectomy is rare. In cases where there has been a substantial decrease in the size of a full-thickness macular hole after surgery without full closure, a short period of observation to allow for further closure may be appropriate before reconsidering surgery.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"236-239"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138801617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frank Mei, Jahan N Tajran, Mohamed R Mohamed, Kishan G Patel, Angeline L Wang
{"title":"ORBITAL COMPARTMENT SYNDROME AFTER PRIMARY SCLERAL BUCKLE SURGERY.","authors":"Frank Mei, Jahan N Tajran, Mohamed R Mohamed, Kishan G Patel, Angeline L Wang","doi":"10.1097/ICB.0000000000001533","DOIUrl":"10.1097/ICB.0000000000001533","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to illustrate a patient with orbital compartment syndrome after scleral buckle placement that was successfully treated with canthotomy and cantholysis.</p><p><strong>Methods: </strong>This is an observational case report.</p><p><strong>Results: </strong>A 26-year-old man underwent a primary scleral buckle repair for a chronic rhegmatogenous retinal detachment. On postoperative day four, the patient presented to the emergency room with pain and increased intraocular pressure. Initial treatment with conservative intraocular pressure-lowering agents was unsuccessful. The patient was diagnosed with delayed orbital compartment syndrome and was successfully managed with lateral canthotomy and inferior cantholysis in addition to aggressive steroid and antibiotic medical management.</p><p><strong>Conclusion: </strong>After scleral buckle placement with sub-Tenon anesthesia block, there may be a delayed presentation of orbital compartment syndrome. Recognition and management of this rare complication is important for preventing irreversible blindness.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"240-243"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138803785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}