Retinal Cases and Brief Reports最新文献_第2页

Paracentral Acute Middle Maculopathy Prompting Diagnosis of Severe Aortic Regurgitation and Ascending Aortic Aneurysm. 中央旁急性中黄斑病变提示严重主动脉反流和升主动脉瘤的诊断。

Retinal Cases and Brief Reports Pub Date : 2026-10-14 DOI: 10.1097/ICB.0000000000002002

George N Palexas

{"title":"Paracentral Acute Middle Maculopathy Prompting Diagnosis of Severe Aortic Regurgitation and Ascending Aortic Aneurysm.","authors":"George N Palexas","doi":"10.1097/ICB.0000000000002002","DOIUrl":"https://doi.org/10.1097/ICB.0000000000002002","url":null,"abstract":"Purpose: To report a case of paracentral acute middle maculopathy (PAMM) in which persistent paracentral dysfunction prompted cardiovascular investigation and diagnosis of severe aortic regurgitation, reduced ejection fraction, and ascending aortic aneurysm.Methods: Longitudinal ophthalmic assessment, multimodal retinal imaging, Humphrey SITA Central 10-2 testing, cardiovascular evaluation, surgical findings, histopathology, and targeted aortopathy genetic testing were reviewed.Results: A 44-year-old man presented with intermittent right-eye visual disturbance and persistent paracentral scotoma after non-explanatory neuroimaging. Unaided visual acuity remained 20/25 (6/7.5; approximately 0.10 logMAR) in each eye, intraocular pressure was 16-19 mmHg, and anterior-segment examination was unremarkable. Multimodal imaging supported PAMM, with structural OCT inner retinal/inner nuclear layer involvement and qualitative OCT-A/fluorescein angiographic parafoveal perfusion compromise. The affected inner retinal/inner nuclear layer region decreased from 45 micrometres to 32 micrometres. Right-eye Humphrey SITA Central 10-2 mean deviation worsened from -3.67 dB on 03 March 2020 to -5.19 dB in February 2026 despite unchanged central acuity. Cardiovascular assessment revealed a 5.5-cm ascending aortic aneurysm, severe aortic regurgitation, and left-ventricular ejection fraction of 49%. The patient underwent elective Bentall procedure, with postoperative ejection-fraction improvement to 55%. No postoperative quantitative OCT-A reperfusion claim is made.Conclusion: PAMM may warrant systemic cardiovascular assessment when ocular findings do not fully explain persistent paracentral dysfunction. This case supports cautious multidisciplinary evaluation while avoiding unsupported claims of causality, quantitative OCT-A perfusion deficit, or postoperative retinal reperfusion.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149197523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinoschisis-Associated Retinal Detachment in Choroideremia: A Surgical Conundrum. 脉络膜血症中视网膜裂相关视网膜脱离：一个外科难题。

Retinal Cases and Brief Reports Pub Date : 2026-10-14 DOI: 10.1097/ICB.0000000000002001

Brianna A Bass, Brandon J Kennedy, Christina J Flaxel, Zachary A Kroeger

{"title":"Retinoschisis-Associated Retinal Detachment in Choroideremia: A Surgical Conundrum.","authors":"Brianna A Bass, Brandon J Kennedy, Christina J Flaxel, Zachary A Kroeger","doi":"10.1097/ICB.0000000000002001","DOIUrl":"https://doi.org/10.1097/ICB.0000000000002001","url":null,"abstract":"Purpose: To describe a case of retinoschisis-associated retinal detachment (RD) in a patient with genetically confirmed choroideremia and discuss implications for surveillance and surgical management.Methods: A case report of a 43-year-old man with genotypically confirmed choroideremia, CHM c.242_245 deletion, who developed rhegmatogenous RD following progression of peripheral retinoschisis. Multimodal imaging, including optical coherence tomography (OCT), B-scan ultrasonography, ultrasound biomicroscopy (UBM), and fundus autofluorescence (AF) were utilized for diagnosis and surgical planning.Results: The patient presented with acute visual decline from 20/20 Snellen to 20/100 Snellen in the affected eye following progression of temporal retinoschisis into the fovea. OCT demonstrated schisis cavities with subretinal fluid extending to the fovea. B-scan demonstrated shallow temporal subretinal fluid involving the macula, and UBM was suggestive of multiple small anterior holes within the retinoschisis, though these were not clearly identified on examination with indirect fundoscopy. Surgical repair with a high posterior encircling scleral buckle (#277 tire) with cryopexy achieved foveal reattachment, schisis cavity collapse, and visual recovery to 20/25 Snellen.Conclusions: This case represents the first documented retinoschisis-associated RD in choroideremia. Progressive degeneration of the RPE, choroid, and retinal layers may create structural instability predisposing to RD when retinoschisis progresses. This mechanism should theoretically make surgical reattachment challenging. This case highlights the need for risk stratification, close follow-up, and early surgical intervention to prevent reversible vision loss in patients with retinoschisis, RD, and choroideremia.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149197528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ozanimod-associated Macular Edema: Case Report and Literature Review. 奥扎尼莫相关黄斑水肿：病例报告及文献回顾。

Retinal Cases and Brief Reports Pub Date : 2026-10-12 DOI: 10.1097/ICB.0000000000001998

Brittany C Tsou, Pawan Bhatnagar

引用次数: 0

Macular Laceration Following Intravitreal Injection in a Nanophthalmic Eye: Management with Pars Plana Vitrectomy. 纳米眼玻璃体注射后黄斑撕裂：玻璃体切除治疗。

Retinal Cases and Brief Reports Pub Date : 2026-10-12 DOI: 10.1097/ICB.0000000000001999

David Rs Veitch, Schalk H du Toit

{"title":"Macular Laceration Following Intravitreal Injection in a Nanophthalmic Eye: Management with Pars Plana Vitrectomy.","authors":"David Rs Veitch, Schalk H du Toit","doi":"10.1097/ICB.0000000000001999","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001999","url":null,"abstract":"Purpose: To report a case of macular laceration following intravitreal injection in a nanophthalmic eye and its surgical management.Methods: A nanophthalmic patient presented with visual decline after intravitreal bevacizumab injection. Multimodal imaging demonstrated a full-thickness macular defect, vitreous hemorrhage, and epiretinal membrane (ERM), consistent with suspected needle-induced injury. Following failed medical therapy, 27-gauge pars plana vitrectomy with internal limiting membrane peeling and gas tamponade was performed using modified sclerotomy placement.Results: Surgery was successfully completed with treatment of an intraoperative peripheral retinal break. At 3.5 months, visual acuity improved from hand movements to 20/80. Optical coherence tomography confirmed ERM resolution, retinal reattachment, and restoration of macular architecture without cystoid macular edema or uveal effusion.Conclusion: Macular laceration is a rare but potentially vision-threatening complication of intravitreal injection, with increased risk in anatomically crowded eyes such as nanophthalmos. Careful surgical planning allows successful vitrectomy with favorable anatomical and visual outcomes in this high-risk population.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Presumed Stellate Multiform Amelanotic Choroidopathy (SMACH) in Neurofibromatosis type 2-related schwannomatosis. 2型神经纤维瘤病相关神经鞘瘤病推定为星状多形态无色变性脉络膜病（SMACH）。

Retinal Cases and Brief Reports Pub Date : 2026-10-08 DOI: 10.1097/ICB.0000000000001992

Jiayue Wang, Fengqi Li, Zhenlong Ran

引用次数: 0

Dynamic Morphological Changes of Focal Choroidal Excavations in Bilateral Choroidal Osteoma. 双侧脉络膜骨瘤局灶性脉络膜挖掘的动态形态学改变。

Retinal Cases and Brief Reports Pub Date : 2026-10-05 DOI: 10.1097/ICB.0000000000001989

Lucrezia Barbieri, Chiara Preziosa, Giovanni Staurenghi, Marco Pellegrini

{"title":"Dynamic Morphological Changes of Focal Choroidal Excavations in Bilateral Choroidal Osteoma.","authors":"Lucrezia Barbieri, Chiara Preziosa, Giovanni Staurenghi, Marco Pellegrini","doi":"10.1097/ICB.0000000000001989","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001989","url":null,"abstract":"Purpose: To report the long-term evolution of bilateral focal choroidal excavations in a pediatric patient with choroidal osteoma.Methods: The patient was referred following incidental findings of yellowish lesions at the posterior pole in both eyes. At presentation, best-corrected visual acuity was 20/20 bilaterally. Multimodal imaging confirmed the presence of bilateral choroidal osteoma. During the 15-year follow-up, no choroidal neovascularization or exudation developed, and visual acuity remained stable. Over time, multiple bilateral focal choroidal excavations were documented.Results: These excavations demonstrated variable behavior, including progression, regression, and spontaneous resolution. Most focal choroidal excavations remained conforming, with one lesion in the right eye evolving into a non-conforming type before resolving. One of them transformed into a true choroidal depression, associated with tumor decalcification and choroidal thinning.Conclusion: The findings suggest that these excavations in choroidal osteoma may result from localized structural remodeling and focal decalcification, potentially serving as imaging biomarkers of tumor weakening. The bilateral, dynamic nature of FCEs, even in areas without clear decalcification, suggests that biomechanical or vascular factors may contribute.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral cytomegalovirus retinitis in the setting of acquired lymphopenia following administration of bendamustine. 苯达莫司汀治疗后获得性淋巴细胞减少的双侧巨细胞病毒视网膜炎。

Retinal Cases and Brief Reports Pub Date : 2026-09-23 DOI: 10.1097/ICB.0000000000001988

Christine I Clavell, James P Dossett, Kevin T Eid, Ghassan R Ghorayeb

{"title":"Bilateral cytomegalovirus retinitis in the setting of acquired lymphopenia following administration of bendamustine.","authors":"Christine I Clavell, James P Dossett, Kevin T Eid, Ghassan R Ghorayeb","doi":"10.1097/ICB.0000000000001988","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001988","url":null,"abstract":"Purpose: The aim of the study was to describe a case of bilateral cytomegalovirus (CMV) retinitis in a patient with non-Hodgkin lymphoma who developed prolonged immunosuppression after chemotherapy with bendamustine.Methods: This was a retrospective chart review.Results: A 60-year-old woman with no ocular history and a past medical history of stage 3 non-Hodgkin follicular lymphoma treated with bendamustine and rituximab presented with vision loss and floaters in her right eye. Funduscopic exam revealed dense vitritis with areas of retinal whitening and hemorrhaging involving the macula and superior mid-periphery. An anterior chamber paracentesis of the right eye returned positive for CMV. Her laboratory work-up revealed pancytopenia including CD4 lymphopenia which was likely secondary to bendamustine. Systemic therapy with valganciclovir was initiated, yet active retinitis developed in the left eye as well. A treat-and-extend regimen of intravitreal ganciclovir and foscarnet to both eyes was initiated with a visual acuity of 20/400 in the right eye and 20/20 in the left eye at the final follow-up.Discussion: Bendamustine can cause profound lymphopenia with reduced CD4 T-cell levels; risk of herpes virus retinitis is elevated in the setting of such immunosuppression. In HIV-negative patients, there is no specific treatment to raise the CD4 count. Prompt initiation and continued administration of systemic and local antiviral treatment can lead to disease control and preservation of vision while awaiting immune reconstitution.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149031518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Opportunistic Quambalaria fungal endophthalmitis in fumarate-treated multiple sclerosis complicated by multifocal postinfectious cerebral vasculopathy. 富马酸治疗多发性硬化症并发多灶性感染后脑血管病的机会性真菌眼内炎。

Retinal Cases and Brief Reports Pub Date : 2026-09-21 DOI: 10.1097/ICB.0000000000001987

Sameer Mohammad Khan, Matthew Lee, Fangzhi Jia, John Parratt, Richard J Symes

{"title":"Opportunistic Quambalaria fungal endophthalmitis in fumarate-treated multiple sclerosis complicated by multifocal postinfectious cerebral vasculopathy.","authors":"Sameer Mohammad Khan, Matthew Lee, Fangzhi Jia, John Parratt, Richard J Symes","doi":"10.1097/ICB.0000000000001987","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001987","url":null,"abstract":"Purpose: To describe the clinical course, multimodal imaging, management, and outcome of a case of endogenous Quambalaria fungal endophthalmitis.Methods: Single-patient case report.Results: A 66-year-old man with newly diagnosed multiple sclerosis on fumarate therapy treated with oral corticosteroids for a presumed intermediate uveitis, developed progressive left intraocular inflammation. Referral to a quaternary centre and diagnostic vitreous sampling identified Quambalaria cyanescens. on culture and panfungal polymerase chain reaction . A route of infection could not be established with certainty: a preceding ocular injury with plant material and an earlier lower-limb cellulitis each offered a plausible mechanism Despite intravitreal anti-fungal therapy, two pars plana vitrectomies and systemic antifungals, inflammation persisted until a period of intensive, repeated intravitreal voriconazole injections administered during inpatient admission resulted in clinical regression. Multifocal cerebral vasculopathy occurred in the immune reconstitution phase following improvement of Quambalaria infection.Conclusion: Quambalaria is an exceptionally rare ocular pathogen that can cause aggressive endophthalmitis. . Vitrectomy and intensive intravitreal voriconazole arrested an infection that had progressed despite treatment; the globe was preserved, although final visual acuity was light perception.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149013226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RETINAL ISCHEMIA AND HEMORRHAGES AFTER EMBOLIZATION OF INTRACRANIAL ANEURYSMS: A CASE SERIES. 颅内动脉瘤栓塞后视网膜缺血和出血：一个病例系列。

Retinal Cases and Brief Reports Pub Date : 2026-09-21 DOI: 10.1097/ICB.0000000000001986

Kiara M Corcoran Ruiz, Jenelle M Safadi, Amro Omari, Joseph Wahba, Alexander J Brucker

{"title":"RETINAL ISCHEMIA AND HEMORRHAGES AFTER EMBOLIZATION OF INTRACRANIAL ANEURYSMS: A CASE SERIES.","authors":"Kiara M Corcoran Ruiz, Jenelle M Safadi, Amro Omari, Joseph Wahba, Alexander J Brucker","doi":"10.1097/ICB.0000000000001986","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001986","url":null,"abstract":"Purpose: To describe retinal changes that can be associated with embolization of intracranial aneurysms.Methods: Retrospective case series of four patients. Standard ophthalmic exams were performed along with color fundus photographs, high-resolution optical coherence tomography, and fluorescein angiography.Results: Four patients underwent interventional therapy to close intracranial vascular aneurysms. The four patients ranged from 31 years to 78 years of age. Three were female while one was male. All were diagnosed with symptomatic cerebral aneurysms that were treated by embolization. All described visual symptoms immediately following interventional procedures. Retinal hemorrhages and ischemia were found in all patients during complete ophthalmologic evaluation. Multimodal imaging was carried out and documented evidence of various vascular changes such as retinal hemorrhages and vascular occlusion ranging from cotton wool spots to a cilioretinal artery occlusion.Conclusions: Retinal ischemia and hemorrhages are complications of ophthalmic and communicating segment aneurysm embolization, and while our series of patients were all symptomatic, peripheral asymptomatic lesions may also occur. We believe that patients and providers should be aware of these potential sight-threatening complications.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149013194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optic nerve avulsion and central retinal artery occlusion after penetrating orbital injury. 穿透性眼眶损伤后视神经撕脱及视网膜中央动脉闭塞。

Retinal Cases and Brief Reports Pub Date : 2026-09-17 DOI: 10.1097/ICB.0000000000001984

Benjamin Aboytes-Rios, Ramses Rosales-Diaz, Maria M Solbes-Gochicoa, Nicole Stephanie Pichardo-Loera, Jans Fromow-Guerra, Jose Dalma-Weiszhausz

{"title":"Optic nerve avulsion and central retinal artery occlusion after penetrating orbital injury.","authors":"Benjamin Aboytes-Rios, Ramses Rosales-Diaz, Maria M Solbes-Gochicoa, Nicole Stephanie Pichardo-Loera, Jans Fromow-Guerra, Jose Dalma-Weiszhausz","doi":"10.1097/ICB.0000000000001984","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001984","url":null,"abstract":"Purpose: To highlight a rare mechanism of optic nerve avulsion and central retinal artery occlusion secondary to penetrating orbital trauma, and to review the clinical and diagnostic findings that facilitate accurate identification of this uncommon pathology.Methods: The patient underwent an extensive ophthalmic examination, including wide-field fundus photography, fluorescein angiography, and transpalpebral B-scan ultrasonography.Results: A 9-year-old male presented with sudden vision loss following penetrating trauma to the left upper eyelid caused by a metal rod. Ophthalmologic examination revealed visual acuity limited to light perception and a linear wound in the left upper eyelid. Fundus examination showed peripapillary and perimacular hemorrhages, retinal pallor, and a cherry-red spot at the macula. Fluorescein angiography demonstrated delayed filling and blockage phenomenon at the peripapillary and perimacular levels, while transpalpebral ultrasound revealed a hypoechoic area in the sub-Tenon's space at the site of optic nerve exit. Given the poor visual prognosis, the patient was not considered a candidate for surgical intervention.Conclusion: This report describes an unusual case of optic nerve avulsion and central retinal artery occlusion following penetrating orbital trauma. Imaging modalities such as ultrasonography, computed tomography, and fluorescein angiography are critical for diagnosis in cases where direct ophthalmologic examination is limited by media opacity.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0