{"title":"DELAYED ONSET OF SPONTANEOUS LARGE FULL THICKNESS MACULAR HOLE CLOSURE.","authors":"Muntadher Al Karam, Rike Michels, Stephan Michels","doi":"10.1097/ICB.0000000000001750","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001750","url":null,"abstract":"<p><strong>Purpose: </strong>Reporting this rare case of spontaneous delayed-onset full-thickness macular hole (ftMH) closure after unsuccessful initial surgical treatment encourages to have new perspectives on the mechanism behind this retinal process.</p><p><strong>Methods: </strong>Uneventful 27-gauge vitrectomy was performed in a 71-year-old female patient for large (460 µm) macular hole (MH). The surgery was combined with peeling of the ILM, SF6 tamponade and head down positioning for 3 days. No closure of the MH was detected within 4 weeks after surgery and visual acuity remained unchanged. The patient refused a re-vitrectomy.</p><p><strong>Results: </strong>More than four years after surgery a progressive closure of the macular hole was detected clinically and on optical coherence tomography with recovery of vision to 0.4 LogMAR (20/50).</p><p><strong>Conclusion: </strong>This rare case shows that full mechanisms of macular hole closure yet remain unclear and need to be studied further.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Occult invasive fungal sinusitis in a patient with acute Vogt-Koyanagi-Harada Disease (VKHD).","authors":"Emily C Davis, Akshay S Thomas","doi":"10.1097/ICB.0000000000001754","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001754","url":null,"abstract":"<p><strong>Purpose: </strong>We present a case of the development of invasive fungal sinusitis in a patient with acute Vogt-Koyanagi-Harada Disease (VKHD).</p><p><strong>Methods: </strong>Observational case report.</p><p><strong>Results: </strong>A 39-year-old African American female presented with acute vision loss in both eyes and reported pain around her left eye. Examination revealed a bilateral posterior uveitis with significant macular edema and subretinal fluid in both eyes. Systemic and ocular findings were consistent with complete VKHD and the patient was put on oral glucocorticoids. At follow-up 2 weeks later, blood sugars were found to be severely elevated, and the patient was hospitalized. During hospitalization, the patient was taken off steroids. At follow-up, the uveitis appeared quiescent, but vision was still poor in the left eye. The patient reported a continued sense of pressure and now numbness around the left eye. An MRI revealed occult invasive fungal sinusitis and the patient was hospitalized for treatment. The patient recovered after surgery for debridement of the sinuses and several weeks of treatment with amphotericin B. At the most recent follow up, 18 months following the initial visit, the patient's visual acuity was 20/20 OD and 20/50 with eccentric viewing OS.</p><p><strong>Conclusion: </strong>Many forms of uveitis such as acute VKHD require use of oral glucocorticoids. However, proper use of glucocorticoids involves patient counseling on potential side-effects and the prescribing physician to identify potential life-threatening complications. In this case, failure to identify either the severely elevated blood sugars or occult fungal sinusitis could have resulted in significant patient morbidity or even mortality.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Polarization-sensitive optical coherence tomography features of the repair tissue following retinal pigment epithelium tear and functional correlation with visual outcomes.","authors":"Keiko Azuma, Daisuke Santo, Satoshi Sugiyama, Nobuyori Aoki, Shuichiro Aoki, Kohdai Kitamoto, Ryo Terao, Tatsuya Inoue, Ryo Obata","doi":"10.1097/ICB.0000000000001752","DOIUrl":"10.1097/ICB.0000000000001752","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate changes in melanin distribution and retinal sensitivity following a retinal pigment epithelium (RPE) tear in neovascular age-related macular degeneration (nAMD).</p><p><strong>Methods: </strong>Five cases of nAMD with RPE tears involving the fovea within 1 month of onset were examined. Using polarization-sensitive optical coherence tomography, entropy-a quantitative indicator of melanin distribution-was measured at baseline and 6 months at the level of Bruch's membrane. Retinal sensitivity was assessed with a microperimeter, and entropy was averaged across 25 grids within a 6-degree radius. The relationship between changes in entropy and retinal sensitivity was analyzed.</p><p><strong>Results: </strong>Entropy significantly increased in the tear area (from 0.19 to 0.22, p=0.026), whereas it decreased in the non-tear area. Retinal sensitivity also significantly increased in the tear area (from 12.7 to 16.3 dB, p=0.002). Although entropy and retinal sensitivity were not directly correlated in each area, their changes were significantly correlated, regardless of area type. Changes in central grid entropy were associated with changes in logarithm of the minimum angle of resolution visual acuity.</p><p><strong>Conclusion: </strong>Six months post RPE tear, entropy and retinal sensitivity increased in tear areas; entropy changes were linked to retinal sensitivity and visual acuity, indicating functional adjustments following the tear.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A case of successful ciliary body suture for recurrent membranous deposits around the intraocular lens in a patient with cyclodialysis.","authors":"Mitsuru Otsubo, Kouji Takarada, Tatsurou Taneda, Yuki Kamiya, Taiji Nagaoka","doi":"10.1097/ICB.0000000000001753","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001753","url":null,"abstract":"<p><strong>Purpose: </strong>To report a case of recurrent membranous deposits around an intraocular lens (IOL) that was effectively managed with ciliary body suturing following cyclodialysis.</p><p><strong>Methods: </strong>A 68-year-old male developed recurrent membranous deposits around an IOL following scleral fixation associated with traumatic ciliary body detachment, resulting in a decrease in vision to 20/300. The patient underwent ciliary body suturing and membrane excision.</p><p><strong>Results: </strong>Following ciliary body suturing and membrane excision, the recurrence of membranous deposits was prevented, and visual acuity improved to 20/25. No further depositions were observed, and additional surgery was not required.</p><p><strong>Conclusions: </strong>Ciliary body suturing was effective for managing recurrent membranous deposits around the IOL associated with cyclodialysis, suggesting its potential application in similar cases of traumatic eye injury.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SANDWICH TAMPONADE TECHNIQUE FOR THE MANAGEMENT OF GIANT RETINAL TEAR RETINAL DETACHMENT.","authors":"Beatrice Gallo, Aman Chandra","doi":"10.1097/ICB.0000000000001751","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001751","url":null,"abstract":"<p><strong>Purpose: </strong>Controversy exists regarding the best intraocular tamponade for the management of giant retinal tear rhegmatogenous retinal detachment (GRT-RRD). We describe the 'sandwich' technique for the short-term post-operative tamponade of RRD associated with GRT.</p><p><strong>Methods: </strong>Description of surgical technique and retrospective case series of eyes with GRT-RRD. Surgery consisted of 25-gauge pars plana vitrectomy (PPV) with heavy liquid (perfluoro-n-octane) and sulphur hexafluoride (100% SF6, 0.5 mL) gas used as post-operative intraocular tamponade, and removed after a mean of 11 (range 10-14) days with a second PPV with air tamponade.</p><p><strong>Results: </strong>three eyes of three patients (mean age 64 years) with GRT-RRD involving the inferior retina (2 fovea sparing and 1 fovea involving) were treated with PPV and 'sandwich' tamponade. In all cases best corrected visual acuity improved, successful retinal reattachment was achieved, and there were no intraoperative and post-operative complications.</p><p><strong>Conclusion: </strong>The 'sandwich' tamponade is a safe and effective short-term post-operative tamponade for GRT-RRD extending beyond the superior and inferior meridians. It has the advantage of providing tamponade to a large extensive GRT with no posturing requirement, and of avoiding ocular toxicity associated with the use of silicone oil.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abeku A Koomson, Callum S Grewal, Meena Kapoor, Kamaljit S Balaggan
{"title":"BILATERAL SEQUENTIAL INFLAMMATORY FULL-THICKNESS MACULAR HOLES IN BIRDSHOT CHORIORETINOPATHY.","authors":"Abeku A Koomson, Callum S Grewal, Meena Kapoor, Kamaljit S Balaggan","doi":"10.1097/ICB.0000000000001749","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001749","url":null,"abstract":"<p><strong>Purpose: </strong>To report a novel case of bilateral sequential full-thickness macular holes in a patient with birdshot chorioretinopathy (BSCR).</p><p><strong>Methods: </strong>Case report.</p><p><strong>Results: </strong>A 57-year-old woman with BSCR undergoing systemic anti-inflammatory treatment developed progressive bilateral macular atrophy and reduced visual acuity. Further progression resulted in the development of a full-thickness macular hole (FTMH) in her left eye, which was successfully treated with vitrectomy, internal limiting membrane peeling using the inverted flap technique, and C3F8 gas injection. Unfortunately, she soon developed a FTMH in her right eye, which was also successfully repaired by vitrectomy.</p><p><strong>Conclusion: </strong>Chronic posterior uveitis in BSCR can result in macular atrophy, which in our patient progressed to bilateral FTMH formation. This complication of BSCR has never been reported before.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Novel Intraoperative FFA Reveals Neovascularization at Sclerotomy Site in Post Vitrectomy Hemorrhage.","authors":"Yawen Qin, Jie Zhong, Jie Li","doi":"10.1097/ICB.0000000000001726","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001726","url":null,"abstract":"<p><strong>Purpose: </strong>To report a case of long-term postoperative vitreous hemorrhage (PVH) of proliferative diabetic retinopathy after pars plana vitrectomy (PPV), which is most likely to be associated with neovascularization (NV) formed at the incision site of vitrectomy, and to recommend a better surgical technique for the diagnosis and treatment of such patients.</p><p><strong>Methods: </strong>Intraoperative fundus fluorescein angiography (FA) was performed using a customized intraoperative blue light excitation source and observed by a three-dimensional (3D) surgical observation system to explore the causes of recurrent PVH.</p><p><strong>Results: </strong>Intraoperative 3D-FA clearly showed the complete fluorescence image of the inward growing scleral NV at the PPV incision site and guided the surgical treatment of intraocular retinal laser photocoagulation of the NV.</p><p><strong>Conclusion: </strong>Intraoperative 3D-FA has a certain role in the diagnosis and treatment of unexplained PVH after PPV, and is a promising surgical auxiliary technology.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melissa M Medina Melo, Laura Quintero Arciniegas, Santiago Morales
{"title":"In-Vivo Surgical Approach of Subretinal Cysticercosis: A Case Report.","authors":"Melissa M Medina Melo, Laura Quintero Arciniegas, Santiago Morales","doi":"10.1097/ICB.0000000000001748","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001748","url":null,"abstract":"<p><strong>Purpose: </strong>To report the clinical and imaging findings of a patient with right eye progressive vision loss, in whom ocular neurocysticercosis was diagnosed. The patient underwent vitreoretinal surgery with previous antihelmintic treatment, resulting in a successful extraction of the subretinal cyst.</p><p><strong>Methods: </strong>A patient with subretinal neurocysticercosis underwent a combination of ophthalmic examination, fundus photography, ocular ultrasound, brain MRI, and surgery.</p><p><strong>Results: </strong>A 57-year-old female from La Guajira, Colombia presented with a 2-year history of unilateral subretinal neurocysticercosis and an overlying exudative inferior retinal detachment with multiple areas of RPE atrophy. Different methods of surgery were contemplated to achieve a favorable outcome, until deciding on a microincision vitrectomy surgery.</p><p><strong>Conclusion: </strong>An \"in vivo\" minimally invasive pars plana approach should be considered, given it has proven to be successful in removing intraocular cysts with no postoperative inflammatory response, preserving anatomic and functional integrity.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elisah M Huynh, Mahmood Khan, Yanhan Ren, Anton Orlin, Szilard Kiss, Benjamin W Botsford
{"title":"MULTIMODAL IMAGING IN DEFEROXAMINE-RELATED OCULAR TOXICITY: RAPID DEVELOPMENT DUE TO SUPRATHERPEUTIC DOSING AND PROGRESSION DESPITE DOSE REDUCTION.","authors":"Elisah M Huynh, Mahmood Khan, Yanhan Ren, Anton Orlin, Szilard Kiss, Benjamin W Botsford","doi":"10.1097/ICB.0000000000001746","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001746","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize evolution of deferoxamine-related retinal toxicity in a patient exposed to supratherapeutic doses of deferoxamine and progression despite dose reduction and cessation.</p><p><strong>Methods: </strong>Observational clinical case Report.</p><p><strong>Results: </strong>A 59-year-old female with history of beta thalassemia requiring biweekly blood transfusions developed peripheral visual field loss and nyctalopia after taking supratherapeutic dosage of deferoxamine. She demonstrated progressive RPE thickening and photoreceptor loss despite reduction in dosage as she was unable to initially discontinue the medication, as vision decreased from 20/25 and 20/30 to 20/60 and 20/50. This report highlights the ocular toxicities linked with deferoxamine and examines whether dosage decrease reverses its effects.</p><p><strong>Conclusion: </strong>Deferoxamine use can precipitate RPE changes, thickening, and photoreceptor loss that can progress despite dose-reduction and cessation.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Galen Y Hu, Casey H Zhang, Erez Nossek, Cen Zhang, Janet C Rucker, Patrick J Hughes, Yasha S Modi
{"title":"Multiple, Recurrent, Bilateral Branch Retinal Artery Occlusions Associated with Carotid Webs.","authors":"Galen Y Hu, Casey H Zhang, Erez Nossek, Cen Zhang, Janet C Rucker, Patrick J Hughes, Yasha S Modi","doi":"10.1097/ICB.0000000000001747","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001747","url":null,"abstract":"<p><strong>Purpose: </strong>We describe a case of bilateral, multiple, branch retinal artery occlusions (BRAO) associated with carotid webs.</p><p><strong>Methods: </strong>A thorough chart review was conducted for the patient. Relevant literature was systematically reviewed.</p><p><strong>Results: </strong>Eight cases of fibromuscular dysplasia (FMD) associated with retinal artery occlusions have been reported. Two additional cases of FMD with other ocular involvement have been described. No cases of carotid webs associated with retinal artery occlusions were found.</p><p><strong>Conclusion: </strong>Carotid webs, an uncommon variant of FMD, are a recognized causative etiology of arterial, ischemic stroke. The case described here of bilateral, multifocal BRAOs represents a unique manifestation of this variant of FMD. This diagnosis should be considered in the setting of an otherwise unrevealing BRAO workup, as recognition of this association may be sight and life-saving.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}