Retinal Cases and Brief Reports最新文献_第10页

Epstein-Barr Virus Associated Frosted Branch Angiitis. eb病毒相关的霜状支血管炎。

Retinal Cases and Brief Reports Pub Date : 2025-02-21 DOI: 10.1097/ICB.0000000000001742

Julia L Xia, Jennifer M Lai, Alan G Palestine, Amit K Reddy

{"title":"Epstein-Barr Virus Associated Frosted Branch Angiitis.","authors":"Julia L Xia, Jennifer M Lai, Alan G Palestine, Amit K Reddy","doi":"10.1097/ICB.0000000000001742","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001742","url":null,"abstract":"Purpose: To describe two cases of frosted branch angiitis (FBA) in the setting of Epstein-Barr virus (EBV) infection.Methods: Retrospective case series of two patients at the University of Colorado Sue Anschutz-Rodgers Eye Center.Results: Case 1 is a 17-year-old female who presented with bilateral floaters and blurry vision two weeks after a diagnosis of mononucleosis. Visual acuity was 20/20 in both eyes and exam was significant for vitreous cell and FBA appearance to the retinal vasculature in both eyes. Treatment with oral prednisone and valacyclovir was initiated with improvement in vitritis and vascular sheathing. One month after all treatment was discontinued, there was a recurrence of vitritis that was treated with bilateral sub-Tenon's triamcinolone acetonide injections. Final visual acuity was 20/20 in both eyes with resolved vitritis. Case 2 is a 20-year-old male who presented with headache and acute bilateral vision loss. He was found to have a meningoencephalitis with cerebrospinal fluid positive for EBV that was treated with intravenous methylprednisolone and acyclovir. Visual acuity was count fingers in both eyes. Exam was significant for diffuse bilateral frosted branch angiitis which the subsequent development of bilateral bacillary detachments and neuroretinitis that required treatment with oral prednisone, oral acyclovir, and bilateral intravitreal dexamethasone implants, which resolved all ocular inflammation. Final visual acuity was 20/30 right eye and 20/25 left eye.Conclusion: Bilateral FBA may present following EBV infection and responds well to corticosteroids and antiviral therapy.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exudative retinal detachment in a pediatric patient with Rubinstein-Taybi syndrome. 鲁宾斯坦-泰比综合征患儿的渗出性视网膜脱离。

Retinal Cases and Brief Reports Pub Date : 2025-02-21 DOI: 10.1097/ICB.0000000000001740

Sergio Mendoza, Lindsay Klofas Kozek, Da Meng, Sandra Hoyek, Efren Gonzalez, Nimesh A Patel

{"title":"Exudative retinal detachment in a pediatric patient with Rubinstein-Taybi syndrome.","authors":"Sergio Mendoza, Lindsay Klofas Kozek, Da Meng, Sandra Hoyek, Efren Gonzalez, Nimesh A Patel","doi":"10.1097/ICB.0000000000001740","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001740","url":null,"abstract":"Purpose: To highlight findings of retinal exudation with exudative retinal detachment in a patient with Rubinstein-Taybi syndrome (RSTS) due to CREBBP mutation, successfully treated with laser, with the goal of adding to the known phenotypic spectrum of ophthalmic manifestations of RSTS.Methods: A case report of a pediatric patient evaluated with multimodal imaging including fundus photography and fluorescein angiography.Results: A 15-year-old female with RSTS caused by a frameshift mutation in CREBBP was referred for retinal examination under anesthesia. In additional to typical features of RSTS, including developmental delay, microcephaly, and broad thumbs and toes, she had an ocular history of bilateral nasolacrimal duct obstructions and intermittent exotropia. Dilated fundus examination revealed left iris coloboma, bilateral optic nerve colobomas, and exudation of the left temporal retina with associated exudative retinal detachment and inferotemporal hemorrhage. Fluorescein angiography demonstrated leakage and avascularity of both eyes, with diffuse leakage and nonperfusion noted in the left eye. The avascular areas of the right eye were treated prophylactically with laser as well as sub-Tenon's triamcinolone. The left retinal exudation initially improved with several rounds of laser treatment, however vitreoretinal membranes eventually developed, resulting in a focal tractional detachment requiring vitrectomy and lensectomy.Conclusion: Patients with RSTS have a wide spectrum of ophthalmic manifestations. Our patient demonstrated marked peripheral retinal avascularity and vascular leakage, ultimately resulting in a novel finding of sub-retinal exudation. Laser to the avascular retina led to initial regression of the exudation, however the patient ultimately developed a focal tractional detachment requiring surgery.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal imaging of a case of intraretinal silicone oil in an eye with retinochoroidal coloboma: Insights into possible routes of migration. 一例视网膜脉络膜结肠瘤视网膜内硅油的多模态成像：对可能的迁移途径的见解。

Retinal Cases and Brief Reports Pub Date : 2025-02-21 DOI: 10.1097/ICB.0000000000001741

Amit Bidasaria, Sampurna Bhattacharya, Aarzoo Juneja, Pragati Paul, Ahana Sen, Bristi Majumdar, Ruchira Chowdhury, Kumar Saurabh, Sourav Sinha, Rupak Roy

{"title":"Multimodal imaging of a case of intraretinal silicone oil in an eye with retinochoroidal coloboma: Insights into possible routes of migration.","authors":"Amit Bidasaria, Sampurna Bhattacharya, Aarzoo Juneja, Pragati Paul, Ahana Sen, Bristi Majumdar, Ruchira Chowdhury, Kumar Saurabh, Sourav Sinha, Rupak Roy","doi":"10.1097/ICB.0000000000001741","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001741","url":null,"abstract":"Purpose: We report multimodal imaging of intraretinal silicone oil in a case operated for coloboma-associated retinal detachment (RD) and provide imaging based anatomical insights of the route on entry of intraretinal emulsified silicone oil droplets.Method: A 19-year-old male presented with gradual onset diminution of vision in right eye for several years with worsening for 1 month. The patient was evaluated with examination, multimodal imaging, including fundus photography, optical coherence tomography, multicolor imaging, and green reflectance imaging.Result: The right eye showed large inferonasal chorioretinal coloboma sparing the fovea, with dull foveal reflex on color fundus photography, loss of foveal contour with multiple hyperreflective dots predominantly collected in the outer nuclear layer in the foveal region on optical coherence tomography, greenish hue in the foveal region with feather-like projections on multicolor imaging, and crystalline deposits on green reflectance imaging. This was diagnosed as collection of intraretinal silicone oil post-RD surgery in a case of chorioretinal coloboma.Conclusion: We highlight a possible pathway for the intraretinal entry of emulsified silicone oil particles in a case of chorioretinal coloboma.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical Autofluorescence Findings in Geographic Atrophy: The Influence of Age-Related Choroidal Atrophy. 地理萎缩中的非典型自发荧光发现：年龄相关性脉络膜萎缩的影响。

Retinal Cases and Brief Reports Pub Date : 2025-02-19 DOI: 10.1097/ICB.0000000000001739

Livia Faes, Jesse J Jung, John Sorenson, K Bailey Freund

{"title":"Atypical Autofluorescence Findings in Geographic Atrophy: The Influence of Age-Related Choroidal Atrophy.","authors":"Livia Faes, Jesse J Jung, John Sorenson, K Bailey Freund","doi":"10.1097/ICB.0000000000001739","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001739","url":null,"abstract":"Purpose: To describe atypical fundus autofluorescence (FAF) patterns in geographic atrophy (GA) secondary to age-related macular degeneration (AMD) with associated age-related choroidal atrophy (ARCA).Methods: Multimodal imaging of two cases using (pseudo-)color fundus photography, optical coherence tomography (OCT), fluorescein and indocyanine green angiography, and FAF employed with blue- and green excitation wavelengths on several devices (Spectralis, Heidelberg and (ultra-)widefield [UWF] FAF [California, Optos and EIDON, iCare]).Results: Two female patients, with foveal-involving GA secondary to AMD, were assessed. All eyes demonstrated concurrent features indicative of ARCA on multimodal imaging including a paucity of choroidal vasculature, reduced choroidal pigmentation, macular pigmentary changes, peripapillary atrophy, and subretinal drusenoid deposits. Clinically, progression of GA with coalescence of lobular lesions was observed. Notably, UWF FAF with green-(California) and blue excitation wavelengths (California and EIDON) revealed atypical patterns characterized by isofluorescent FAF signals (indistinguishable from surrounding tissue) or hyperautofluorescent GA lesions. In these cases, blue excitation wavelengths were more effective than green light for delineating GA, owing to increased contrast from hypoautofluorescence related to macular pigment surrounding the lesion.Conclusion: In patients with GA and concomitant ARCA, atypical FAF patterns on UWF imaging complicate the accurate delineation and monitoring of GA. Atypical FAF patterns appear due to the properties of the confocal apertures and postprocessing features of UWF imaging that allow for the detection of scleral autofluorescence in patients with reduced choroidal vasculature, pigment and thickness. In patients with concomitant ARCA, multimodal imaging plays a crucial role in precisely identifying and tracking GA progression.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143505947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Uveal Melanoma Masquerading as Choroidal Lymphoma. 葡萄膜黑色素瘤伪装成脉络膜淋巴瘤1例。

Retinal Cases and Brief Reports Pub Date : 2025-02-14 DOI: 10.1097/ICB.0000000000001738

Saleh Sahal H, Stepanian Rima, Juliano Joseph D, Folberg Robert, Laurie Lau-Sickon, Faia Lisa J, Weiner Adam J

{"title":"A Case of Uveal Melanoma Masquerading as Choroidal Lymphoma.","authors":"Saleh Sahal H, Stepanian Rima, Juliano Joseph D, Folberg Robert, Laurie Lau-Sickon, Faia Lisa J, Weiner Adam J","doi":"10.1097/ICB.0000000000001738","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001738","url":null,"abstract":"Purpose: To present a case of uveal melanoma masquerading as choroidal lymphoma.Methods: A retrospective case report in which medical and imaging records, including fundus photography, optical coherence tomography, fundus autofluorescence, fluorescein angiography, and ultrasonography were reviewed.Results: A 77-year-old woman presented with decreased vision was found to have a diffuse, shallow, yellow choroidal mass associated with RPE pigmentary changes and exudative detachment in her right eye. Multi-modal imaging demonstrated thickened choroid with a \"lumpy-bumpy\" appearance on OCT, \"leopard-spotting\" on fundus autofluorescence, and a shallow \"table-top\" configuration on B scan. Systemic workup was unremarkable. The patient elected to undergo treatment with low-dose external beam radiation for presumed choroidal lymphoma. There was no response to radiation prompting retinochoroidal biopsy, which revealed spindle-cell uveal melanoma and resulted in enucleation.Conclusion: We present a case of uveal melanoma masquerading as choroidal lymphoma. This case highlights that uveal melanoma can rarely masquerade as other entities, including uveal lymphoma.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chorioretinitis following Bacillus Calmette-Guerin Treatment for Bladder Cancer. 卡介苗治疗膀胱癌后的绒毛膜视网膜炎。

Retinal Cases and Brief Reports Pub Date : 2025-02-14 DOI: 10.1097/ICB.0000000000001736

Nithya Boopathiraj, Isabella V Wagner, Ross Powers, Arman Mashayekhi

{"title":"Chorioretinitis following Bacillus Calmette-Guerin Treatment for Bladder Cancer.","authors":"Nithya Boopathiraj, Isabella V Wagner, Ross Powers, Arman Mashayekhi","doi":"10.1097/ICB.0000000000001736","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001736","url":null,"abstract":"Purpose: To report a rare case of multifocal chorioretinitis subsequent to intravesical Bacillus Calmette-Guerin (BCG) therapy for bladder cancer.Methods: Case report.Results: A 74-year-old man presented with ill-defined visual changes in his right eye (RE), along with constitutional symptoms such as low-grade fever, chills with rigors, night sweats, headache, dry cough, memory problems, and unintentional weight loss. These symptoms occurred 11 months after receiving intravesical BCG treatment for bladder cancer. His visual acuity in the RE was 20/30. Examination of his RE revealed multiple yellow white chorioretinal lesions, and optical coherence tomography imaging showed focal involvement of the choroid and overlying neurosensory retina. Blood-based testing utilizing next generation sequencing for detection of microbial cell free DNA (Karius test ®) was positive for Mycobacterium tuberculosis complex. The patient was treated with 12 months of triple therapy consisting of isoniazid, rifampin, and ethambutol. The chorioretinal lesions showed complete regression to flat scars, with no evidence of recurrence 15 months after discontinuation of systemic treatment.Conclusion: Despite being rare, the possibility of mycobacterial chorioretinitis should be considered in patients with new-onset visual symptoms following intravesical BCG for treatment of bladder cancer.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A curious case of endogenous Ramularia endophthalmitis presenting as acute angle closure. 一个奇怪的内源性雷姆拉菌性眼内炎的病例，表现为急性闭角。

Retinal Cases and Brief Reports Pub Date : 2025-02-12 DOI: 10.1097/ICB.0000000000001734

Williamson Jeremy P, Sarafian Richard Y, Pham David, Park Joseph J

引用次数: 0

Chorioretinal Findings in Intraocular IgG4-Related Disease: A Case Report and Review of the Literature. 眼内igg4相关疾病的绒毛膜视网膜表现：1例报告及文献复习

Retinal Cases and Brief Reports Pub Date : 2025-02-12 DOI: 10.1097/ICB.0000000000001735

Maja Magazin, Skyler G Jones, Alexis Fazio, Dilip A Thomas, Diego Espinosa-Heidmann

{"title":"Chorioretinal Findings in Intraocular IgG4-Related Disease: A Case Report and Review of the Literature.","authors":"Maja Magazin, Skyler G Jones, Alexis Fazio, Dilip A Thomas, Diego Espinosa-Heidmann","doi":"10.1097/ICB.0000000000001735","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001735","url":null,"abstract":"Purpose: This manuscript reports intraocular IgG4-related disease (IgG4-RD) presenting as panuveitis with a large subretinal mass and contralateral orbital mass. It includes a literature review highlighting IgG4-RD's diagnostic challenges, emphasizing clinical, histopathologic, and multimodal-imaging findings.Methods: PubMed was searched for \"all fields\" with keywords \"IgG4\" AND \"retina\" AND \"choroid\" from 1974 to March 2024, revealing 16 cases of 23 eyes detailing IgG4-related chorioretinal manifestations.Results: The most common presenting symptom was painful vision loss (31%). Chorioretinal findings included: large subretinal or choroidal masses (35%), multifocal subretinal lesions (26%), and retinal detachment (22%). Associated ophthalmic findings included: scleritis or sclerouveitis (52%), vitritis (48%), orbital disease (13%), and papillitis (9%). IgG4+/IgG ratios in ocular tissue varied 20-54.5%. IgG4+ plasma cells per high power field ranged 50-133. Ophthalmic modalities used to aid in diagnosis included B-scan ultrasonography (US-B, 56%), optical coherence tomography (OCT, 31%), fluorescein angiography (FA, 25%), fundus-autofluorescence (FAF, 13%), and indocyanine-green angiography (ICGa, 13%). Masses on B-scan were heterogenous or homogenous with medium-to-high reflectivity. Magnetic resonance imaging (MRI) evaluation was hypointense on T2-weighted imaging (75%) and hyperintense on T1-weighted imaging (38%) with progressive contrast enhancement (50%). Management required a multidisciplinary approach with steroid and steroid-sparing agents.Conclusion: IgG4-RD has diverse and variable ocular presentations and diagnostic manifestations. Definitive diagnosis is made via biopsy. Further studies are necessary for non-invasive diagnosis.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isolated vitritis as the presenting feature of disseminated Mycobacterium chelonae subspecies gwanakae, a novel subspecies. 分离性玻璃体炎是一种播散性龟分枝杆菌亚种，一种新的亚种。

Retinal Cases and Brief Reports Pub Date : 2025-02-12 DOI: 10.1097/ICB.0000000000001733

Samantha S Massenzio, Ajay E Kuriyan, Tatyana Milman, Nicole D Pecora, Matthew A Pettengill, John J Zurlo, Jordan D Deaner

{"title":"Isolated vitritis as the presenting feature of disseminated Mycobacterium chelonae subspecies gwanakae, a novel subspecies.","authors":"Samantha S Massenzio, Ajay E Kuriyan, Tatyana Milman, Nicole D Pecora, Matthew A Pettengill, John J Zurlo, Jordan D Deaner","doi":"10.1097/ICB.0000000000001733","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001733","url":null,"abstract":"Purpose: To report a case of isolated vitritis as the presenting feature of a disseminated infection with Mycobacterium chelonae subspecies gwanakae, a novel subspecies.Methods: Case report.Results: A 66-year-old male who presented with progressive floaters and blurred vision was found to have isolated vitritis of the left eye. Diagnostic vitrectomy revealed acid-fast bacilli in the vitreous. Whole genome sequencing identified the organism as Mycobacterium chelonae subspecies gwanakae, a recently identified novel subspecies. The patient was admitted for further evaluation and treatment. Punch biopsies of the numerous ulcerative skin lesions revealed acid-fast bacilli. Magnetic resonance imaging revealed osteomyelitis underlying the soft tissue infections, requiring incision and drainage. Biopsy of the bone also revealed acid-fast bacilli. He was treated with weekly intravitreal amikacin and empiric intravenous azithromycin, imipenem, and tobramycin. His ocular infection responded well to treatment with resolution of the vitritis and improvement in visual acuity. Unfortunately, his systemic condition deteriorated, and he declined further intervention, ultimately succumbing to his systemic infection 12 weeks after presentation.Conclusion: Isolated vitritis can be the presenting feature of a severe disseminated Mycobacterium chelonae subspecies gwanakae infection.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ciliary Neurotrophic Factor Implant in Geographic Atrophy from Age-related Macular Degeneration: A Long-Term Case Study. 睫状神经营养因子植入治疗老年性黄斑变性导致的地理萎缩：一项长期病例研究。

Retinal Cases and Brief Reports Pub Date : 2025-02-06 DOI: 10.1097/ICB.0000000000001725

Sakshi Shiromani, Donna Leef, Nieraj Jain, Jiong Yan

{"title":"Ciliary Neurotrophic Factor Implant in Geographic Atrophy from Age-related Macular Degeneration: A Long-Term Case Study.","authors":"Sakshi Shiromani, Donna Leef, Nieraj Jain, Jiong Yan","doi":"10.1097/ICB.0000000000001725","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001725","url":null,"abstract":"Purpose: To report a case of thirteen-year long progression of geographic atrophy (GA) from dry age-related macular degeneration (AMD) with ciliary neurotrophic factor (CNTF) implant, NT-501, in one eye, compared to the untreated contralateral eye.Methods: Using sequential images from 2012 to 2024, the macular GA and peripapillary atrophy was identified as areas of definitely decreased autofluorescence on fundus autofluorescence (FAF) and clearly delineated areas of hyperreflectivity on near infrared reflectance (NIR-R). Optical coherence tomography B scans confirmed areas of complete retinal pigment epithelium and outer retinal atrophy to support FAF grading.Results: A 76-year-old male received the CNTF implant in the right eye in August 2011. Macular GA area on short wavelength FAF exhibited growth from 4.51 mm2 (8/2012) to 14.46 mm2 (6/2020), in the treated right eye, and from 3.2 mm2 to 14.92 mm2 in the untreated left eye. The linearized growth rates were 0.21 mm/y (right) and 0.26 mm/y (left), showing a 16.3% difference. A similar pattern was seen on green laser FAF from 2018 to 2024, with peripapillary atrophy progression rates of 0.2 mm2/y (right) and 1.03 mm2/y (left).Conclusions: Notably, the implanted eye, exhibited less progression of macular GA and peripapillary atrophy. While acknowledging the limitations of a single case, we highlight the potential benefits of using the CNTF implant, a one-time surgical procedure, in reducing the treatment burden for atrophic AMD patients. We hope to see further reports from other sites that participated in this compassionate use protocol for NT-501 in atrophic AMD.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0