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EPSTEIN-BARR VIRUS-ASSOCIATED FROSTED BRANCH ANGIITIS: A CASE REPORT AND BRIEF REVIEW. eb病毒相关霜状支血管炎1例报告及简要回顾
Retinal Cases and Brief Reports Pub Date : 2026-03-01 DOI: 10.1097/ICB.0000000000001710
Angela A Cao, Christian D Curran, Pedro Monsalve Diaz, Emily Hause, Dara Koozekanani, Max R Johnson, Karen R Armbrust
{"title":"EPSTEIN-BARR VIRUS-ASSOCIATED FROSTED BRANCH ANGIITIS: A CASE REPORT AND BRIEF REVIEW.","authors":"Angela A Cao, Christian D Curran, Pedro Monsalve Diaz, Emily Hause, Dara Koozekanani, Max R Johnson, Karen R Armbrust","doi":"10.1097/ICB.0000000000001710","DOIUrl":"10.1097/ICB.0000000000001710","url":null,"abstract":"<p><strong>Purpose: </strong>The objective of this study was to report the clinical presentation, treatment course, and outcome of a case of bilateral frosted-branch angiitis and neuroretinitis associated with acute Epstein-Barr virus (EBV) infection in a pediatric patient with Turner syndrome.</p><p><strong>Methods: </strong>This was a case report with multimodal ocular imaging and extensive systemic workup.</p><p><strong>Results: </strong>A 16-year-old adolescent girl with Turner syndrome presented with acute bilateral vision loss, hearing loss, and ataxia. Ocular examination showed bilateral extensive perivascular sheathing, optic disk edema, and macular exudates. Fluorescein angiography showed focal retinal ischemia and late optic disk leakage in both eyes. Macular optical coherence tomography was remarkable for intraretinal and subretinal fluid with scattered hyperreflective foci in both eyes. Magnetic resonance imaging of the brain and orbits showed a supratentorial T2 signal without enhancement, consistent with inactive vasculopathy. Results of a broad systemic workup were notable only for elevated EBV viral capsid antigen IgM with undetectable EBV viral capsid antigen IgG. After treatment with IV methylprednisolone followed by oral prednisone, the patient's best-corrected visual acuity in both eyes improved from 20/200 to 20/20.</p><p><strong>Conclusion: </strong>Ocular symptoms and imaging biomarkers in this case of EBV-associated frosted branch angiitis resolved after high-dose systemic corticosteroid monotherapy. Although treatment with antiviral medications is reported in other frosted branch angiitis cases associated with acute EBV infection, this case underscores the treatable nature of this disease without antivirals, the use of which is not supported by the broader literature for EBV infection or postviral inflammation.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"239-245"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
VITREOUS CYTOKINE PROFILE IN AN EYE WITH A VASOPROLIFERATIVE TUMOR. 血管增殖性肿瘤眼玻璃体细胞因子分析。
Retinal Cases and Brief Reports Pub Date : 2026-03-01 DOI: 10.1097/ICB.0000000000001705
Lucy V Cobbs, Alexis Kaiser, Rusdeep Mundae, Carol L Shields, Kenneth J Wald, Yasha Modi
{"title":"VITREOUS CYTOKINE PROFILE IN AN EYE WITH A VASOPROLIFERATIVE TUMOR.","authors":"Lucy V Cobbs, Alexis Kaiser, Rusdeep Mundae, Carol L Shields, Kenneth J Wald, Yasha Modi","doi":"10.1097/ICB.0000000000001705","DOIUrl":"10.1097/ICB.0000000000001705","url":null,"abstract":"<p><strong>Purpose: </strong>We present a patient with a primary vasoproliferative tumor (VPT) accompanied by vitreous haze and an epiretinal membrane. We report for the first time the vitreous cytokine profile from an eye with a primary VPT to explore the relationship between intraocular inflammation and these tumors.</p><p><strong>Methods: </strong>Retrospective chart review of a single patient case.</p><p><strong>Results: </strong>Twenty-five-gauge pars plana vitrectomy with membrane peel and vitreous biopsy was performed. Peripheral vitreous shave exposed an inferior gray-red mass located at the ora serrata, consistent with VPT. Treatment with confluent, long duration endolaser was performed. Vitreous cytology was negative for malignancy. A 13-cytokine panel (Associated Regional and University Pathologists, Inc, Laboratories, Salt Lake City, UT) revealed elevated interleukin-6 (13.3 pg/mL; normal ≤2.0) and interleukin-8 (6.0 pg/mL; normal ≤3.0). At 1 month postoperatively, visual acuity improved from 20/40 to 20/25 in the right eye, with mild anterior vitreous inflammation and regression of the VPT.</p><p><strong>Conclusion: </strong>Proinflammatory and proangiogenic cytokines were elevated in the vitreous of this patient's eye with a primary VPT. We suggest that the endothelial cells and macrophages that comprise VPTs could secrete these cytokines into the vitreous, resulting in vitreous haze and an overzealous fibrotic response manifested as epiretinal membrane formation.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"177-179"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MULTIMODAL IMAGING FINDINGS OF THE FELLOW EYE IN STELLATE NONHEREDITARY IDIOPATHIC FOVEOMACULAR RETINOSCHISIS. 星状非遗传性特发性中央黄斑视网膜裂(SNIFR)的同侧眼多模态影像学表现。
Retinal Cases and Brief Reports Pub Date : 2026-03-01 DOI: 10.1097/ICB.0000000000001718
Sebastiano Del Fabbro, Lorenzo Bianco, Alessio Antropoli, Soufiane Bousyf, Lorenza Bruno, Alessandro Arrigo, Angela Malegori, Maria Vittoria Cicinelli, Francesco Bandello, Maurizio Battaglia Parodi
{"title":"MULTIMODAL IMAGING FINDINGS OF THE FELLOW EYE IN STELLATE NONHEREDITARY IDIOPATHIC FOVEOMACULAR RETINOSCHISIS.","authors":"Sebastiano Del Fabbro, Lorenzo Bianco, Alessio Antropoli, Soufiane Bousyf, Lorenza Bruno, Alessandro Arrigo, Angela Malegori, Maria Vittoria Cicinelli, Francesco Bandello, Maurizio Battaglia Parodi","doi":"10.1097/ICB.0000000000001718","DOIUrl":"10.1097/ICB.0000000000001718","url":null,"abstract":"<p><strong>Purpose: </strong>This study examines the multimodal imaging findings in two cases of unilateral stellate nonhereditary idiopathic foveomacular retinoschisis, including detailed findings from the unaffected fellow eye.</p><p><strong>Methods: </strong>Macular spectral domain optical coherence tomography and 3 × 3 mm optical coherence tomography angiography, microperimetry, and full-field electroretinography for both the affected and the fellow eye were reviewed.</p><p><strong>Results: </strong>The multimodal imaging findings were consistent across the two cases (71-year-old woman and 60-year-old woman). Optical coherence tomography imaging of the affected eyes revealed cystoid spaces between the outer nuclear layer and the outer plexiform layer, with the vascular network remaining intact, indicating no alterations in vessel flow. Microperimetry showed slightly lower pointwise sensitivity in both eyes compared with a normative database.</p><p><strong>Conclusion: </strong>Although stellate nonhereditary idiopathic foveomacular retinoschisis typically presents as a unilateral condition, our findings suggest that patients may have an inherent structural predisposition to macular schisis, resulting in subtle functional impairments. We hypothesize that the structural damage may involve the macular Muller cells. These observations highlight the importance of further studies to understand stellate nonhereditary idiopathic foveomacular retinoschisis's pathophysiology and inform therapeutic approaches.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"233-238"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
OPTICAL COHERENCE TOMOGRAPHY FEATURES OF ATYPICAL CONGENITAL HYPERTROPHY OF RETINAL PIGMENT EPITHELIUM IN A PATIENT WITH FAMILIAL ADENOMATOUS POLYPOSIS. 一名家族性腺瘤性息肉病患者视网膜色素上皮非典型先天性肥大的光学相干断层扫描特征。
Retinal Cases and Brief Reports Pub Date : 2026-03-01 DOI: 10.1097/ICB.0000000000001722
Stefano Mennecozzi, Elena Spada, Riccardo Sacconi, Francesco Bandello, Giuseppe Querques
{"title":"OPTICAL COHERENCE TOMOGRAPHY FEATURES OF ATYPICAL CONGENITAL HYPERTROPHY OF RETINAL PIGMENT EPITHELIUM IN A PATIENT WITH FAMILIAL ADENOMATOUS POLYPOSIS.","authors":"Stefano Mennecozzi, Elena Spada, Riccardo Sacconi, Francesco Bandello, Giuseppe Querques","doi":"10.1097/ICB.0000000000001722","DOIUrl":"10.1097/ICB.0000000000001722","url":null,"abstract":"<p><strong>Purpose: </strong>To describe optical coherence tomography features of atypical congenital hypertrophy of retinal pigment epithelium (RPE) associated with familial adenomatous polyposis.</p><p><strong>Methods: </strong>Case report.</p><p><strong>Results: </strong>A 34-year-old patient diagnosed with familial adenomatous polyposis was referred to our clinic for fundus examination. We characterized the lesions we found using multimodal imaging (infrared, autofluorescence, optical coherence tomography, and widefield and ultra-widefield fundus image). We described three possible stages of progression of the lesions in a single patient, and we found a possible evolutionary stage with a \"2 binary reflective sign.\"</p><p><strong>Conclusion: </strong>Congenital hypertrophy of RPE lesions can show a progression from only RPE hyperreflectivity to complete outer retinal atrophy and even intraretinal RPE migration. We hypothesize that the two binary reflective sign could represent an hemorrhage between RPE and outer retina, which could lead, together with the reduced catabolic activity of pathologic RPE, to overlying retinal atrophy.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"214-218"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ENORMOUS BILATERAL OPTIC DISK DRUSEN PRESENTING AS A CENTRAL RETINAL VEIN AND CILIORETINAL ARTERY OCCLUSION. 巨大的双侧视盘囊肿表现为视网膜中央静脉和睫状体视网膜动脉阻塞。
Retinal Cases and Brief Reports Pub Date : 2026-03-01 DOI: 10.1097/ICB.0000000000001727
Amirreza Naderi, Richard F Spaide
{"title":"ENORMOUS BILATERAL OPTIC DISK DRUSEN PRESENTING AS A CENTRAL RETINAL VEIN AND CILIORETINAL ARTERY OCCLUSION.","authors":"Amirreza Naderi, Richard F Spaide","doi":"10.1097/ICB.0000000000001727","DOIUrl":"10.1097/ICB.0000000000001727","url":null,"abstract":"<p><strong>Purpose: </strong>To report a case of combined cilioretinal artery and central retinal vein occlusion in a patient with extremely large, asymptomatic optic disk drusen.</p><p><strong>Methods: </strong>A patient with sudden vision loss underwent a comprehensive examination, including multimodal imaging.</p><p><strong>Results: </strong>A 45-year-old man with no previous visual symptoms presented with a combined cilioretinal artery and central retinal vein occlusion in the right eye. The optic nerve in the right eye was slightly hyperemic and the nerve appeared normal in the left eye. His optic nerves did not have a nodular appearance but showed subtle hyperautofluorescence. A hematologic and clotting work-up was unrevealing. Optical coherence tomography revealed an exceptionally large, deeply embedded optic disk druse (1,604 × 1,390 µ m) that almost spanned the width of the optic canal, starting from 464 µ m beneath the optic disk surface extending to below any visible lamina cribrosa. The right eye demonstrated a paracentral scotoma, while a minimal visual field defect was observed in the left eye despite the presence of a large-sized (1,125 × 803 µ m) druse.</p><p><strong>Conclusion: </strong>While optic disk drusen are typically small nodular aggregates in the prelaminar optic nerve head, this patient had an enormous buried solitary druse of the optic nerve in each eye. The unexpected size and location of the drusen, along with the lack of preceding symptoms, suggest that they may not be detected in routine evaluations, thus necessitating multimodal imaging. The redundancy of nerve fibers in the optic nerve may allow significant asymptomatic damage before vascular occlusion.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"173-176"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143392579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrent Paracentral Acute Middle Maculopathy Secondary to Pulmonary Arterial Hypertension: A Case Report. 继发于肺动脉高压的复发性中央旁急性中黄斑病变1例。
Retinal Cases and Brief Reports Pub Date : 2026-02-25 DOI: 10.1097/ICB.0000000000001895
Akira Tanikawa, Akane Sobue, Taku Wakabayashi, Motohiro Kamei, Kotaro Tsuboi
{"title":"Recurrent Paracentral Acute Middle Maculopathy Secondary to Pulmonary Arterial Hypertension: A Case Report.","authors":"Akira Tanikawa, Akane Sobue, Taku Wakabayashi, Motohiro Kamei, Kotaro Tsuboi","doi":"10.1097/ICB.0000000000001895","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001895","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to report the case of paracentral acute middle maculopathy (PAMM) associated with pulmonary arterial hypertension (PAH), and to highlight its potential as an early indicator of systemic hypoxemia.</p><p><strong>Methods: </strong>This is a case report.</p><p><strong>Results: </strong>A 76-year-old Japanese woman presented with bilateral visual disturbances and was found to have PAMM lesions on optical coherence tomography. Her initial best-corrected visual acuity (BCVA) was 20/25 in both eyes. Over the three-year follow-up, recurrent PAMM lesions appeared in various retinal locations, coinciding with progressive visual decline and worsening cardiopulmonary function. The patient experienced repeated hospitalizations due to systemic deterioration. After the initiation of home oxygen therapy, no new PAMM lesions were observed during follow-up; however, progressive vascular dropout in the central macula led to irreversible vision loss. Her BCVA declined to 20/200 in the right eye and 20/30 in the left eye at the last visit.</p><p><strong>Conclusion: </strong>The definitive diagnosis of PAH requires invasive testing and is therefore frequently delayed. This case suggests that PAMM may serve as a useful ocular indicator prompting early systemic evaluation. Recognizing PAMM lesions could facilitate earlier diagnosis and intervention in patients with underlying hypoxemic conditions such as PAH.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Sleeping Wolf - Widefield OCT Angiography Revelations of Insidious Systemic Lupus Erythematous-Associated Retinal Vasculitis. 狼疮红斑相关视网膜血管炎的广角OCT血管造影揭示。
Retinal Cases and Brief Reports Pub Date : 2026-02-24 DOI: 10.1097/ICB.0000000000001891
Devayu A Parikh, Aaron C Brown, David J Merriott, Amanda Wong, Avnish Deobhakta, Carl S Wilkins, Richard B Rosen
{"title":"The Sleeping Wolf - Widefield OCT Angiography Revelations of Insidious Systemic Lupus Erythematous-Associated Retinal Vasculitis.","authors":"Devayu A Parikh, Aaron C Brown, David J Merriott, Amanda Wong, Avnish Deobhakta, Carl S Wilkins, Richard B Rosen","doi":"10.1097/ICB.0000000000001891","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001891","url":null,"abstract":"<p><strong>Purpose: </strong>To describe a case of minimally symptomatic, insidious systemic-lupus-erythematous (SLE) retinal vasculitis revealed with widefield multimodal imaging.</p><p><strong>Methods: </strong>Report of a case.</p><p><strong>Results: </strong>A 56-year-old woman presented with a vague history of visual blur in her left eye for 3 weeks. While her central acuity was relatively preserved, fundus examination was notable for scattered cotton-wool spots in a Purtscher-like retinopathy presentation. Widefield angiographic imaging revealed profound peripheral non-perfusion with some focal arteriolar vasculitis. Systemic work-up confirmed the diagnosis of SLE and high-dose intravenous steroid therapy was initiated. Immune modulatory therapy with mycophenolate mofetil and rituximab infusions were subsequently added to achieve control.</p><p><strong>Conclusions: </strong>Retinal vasculitis is a rare manifestation of SLE which may present in the absence of, or prior to central nervous system involvement. Visual prognosis is extremely guarded, necessitating aggressive immunosuppression and often pan-retinal photocoagulation. Widefield optical coherence tomography angiography may have a role in screening otherwise asymptomatic SLE patients for retinopathy as well as utility in monitoring treatment response.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multimodal Imaging in Lipemia Retinalis. 视网膜脂血症的多模态成像。
Retinal Cases and Brief Reports Pub Date : 2026-02-24 DOI: 10.1097/ICB.0000000000001892
Rouzbeh Abbasgholizadeh, Mai Alhelaly, Alberto Quarta, Ceren Soylu, Srinivas R Sadda
{"title":"Multimodal Imaging in Lipemia Retinalis.","authors":"Rouzbeh Abbasgholizadeh, Mai Alhelaly, Alberto Quarta, Ceren Soylu, Srinivas R Sadda","doi":"10.1097/ICB.0000000000001892","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001892","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the multimodal imaging characteristics of the development and resolution of lipemia retinalis in a patient with severe hypertriglyceridemia.</p><p><strong>Methods: </strong>Evaluation included ultra-widefield (UWF) pseudocolor and autofluorescence imaging, UWF optical coherence tomography (OCT), fluorescein angiography, indocyanine green angiography, and ultra-widefield OCT angiography.</p><p><strong>Results: </strong>A 43-year-old man with type 2 diabetes and a history of pancreatitis presented for routine screening. UWF pseudocolor imaging revealed diffuse creamy-white vessels most prominent beyond the posterior pole, and OCT demonstrated corresponding hyperreflectivity in the vascular lumens, while angiographic studies confirmed preserved perfusion. Laboratory tests showed a triglyceride level of 5,885 mg/dL and a cholesterol of 876 mg/dL. After initiation of appropriate lipid-lowering therapy, triglycerides decreased to 167 mg/dL and cholesterol to 148 mg/dL within one month, with apparent normalization of the vascular appearance and resolution of OCT findings.</p><p><strong>Conclusion: </strong>Lipemia retinalis is a reversible manifestation of intravascular chylomicronemia. UWF imaging and OCT are particularly useful for documentation and follow-up. Prompt recognition should lead to urgent systemic therapy to reduce the risk of acute pancreatitis and cardiovascular complications.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined Central Retinal Vein and Artery Occlusion Following Head Trauma: A Case Report. 颅脑外伤后合并视网膜中央静脉和动脉闭塞1例。
Retinal Cases and Brief Reports Pub Date : 2026-02-24 DOI: 10.1097/ICB.0000000000001894
Christopher Phung, Sukriti Mohan, Hassan Shah, Alexis Warren
{"title":"Combined Central Retinal Vein and Artery Occlusion Following Head Trauma: A Case Report.","authors":"Christopher Phung, Sukriti Mohan, Hassan Shah, Alexis Warren","doi":"10.1097/ICB.0000000000001894","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001894","url":null,"abstract":"<p><strong>Purpose: </strong>To describe a case of combined central retinal vein and artery occlusion following a motor vehicle accident.</p><p><strong>Methods: </strong>The patient's medical history, exam findings, and lab and imaging results were reviewed through an electronic medical record.</p><p><strong>Results: </strong>A 14-year-old female presented with blunt head trauma after a motor vehicle-pedestrian collision and was found to have a left frontal epidural hematoma with midline shift, extensive skull fractures, and impending uncal herniation resulting in clinical deterioration and seizure activity. The patient underwent emergent craniotomy. Initial ophthalmic exam revealed corneal abrasions without globe injury. By hospital day 4, the patient noticed unilateral acute vision decline and the ophthalmology team was consulted. Visual acuity in the left eye was counting fingers, and retinal hemorrhages, macular whitening, and tortuous vessels were seen on exam. Optical coherence tomography and fluorescein angiography 5 days later confirmed combined central retinal artery and vein occlusion. Hematologic workup and neuroimaging were unrevealing. By 9-month follow-up, retinal hemorrhages had resolved and left eye visual acuity improved to 20/300.</p><p><strong>Conclusion: </strong>Combined central retinal vein and artery occlusion is a potential ophthalmic complication of significant head and ocular trauma, warranting careful monitoring by ophthalmologists.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topical Drop Therapy for Failing Macular Holes after Internal Limiting Flap Surgery. 局部滴药治疗内限制瓣术后黄斑孔洞失败。
Retinal Cases and Brief Reports Pub Date : 2026-02-24 DOI: 10.1097/ICB.0000000000001893
Mohammad Z Siddiqui, Gaurav K Shah, Kevin J Blinder
{"title":"Topical Drop Therapy for Failing Macular Holes after Internal Limiting Flap Surgery.","authors":"Mohammad Z Siddiqui, Gaurav K Shah, Kevin J Blinder","doi":"10.1097/ICB.0000000000001893","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001893","url":null,"abstract":"<p><strong>Purpose: </strong>Vitrectomy with an internal limiting membrane (ILM) flap has been used in the repair of macular holes (MH). Topical drops have been attempted for smaller MHs with limited data. This study aims to demonstrate the effectiveness of a topical drop regimen in failing MHs after ILM flap surgery.</p><p><strong>Methods: </strong>Review of 3 eyes with open MHs after vitrectomy with ILM flap. Preoperative visual acuity, MH size, tamponade used during surgery, time-to-hole closure, and final visual acuity were collected.</p><p><strong>Results: </strong>Average MH size among all eyes was 743.3µm (+ 150.4). At the postoperative visit, the MHs were open. All eyes were started on topical steroid, nonsteroidal, and carbonic anhydrase inhibitor drops twice daily for a mean time of 33 days (+ 11 days). There was successful closure of the MHs with topical therapy in all cases.</p><p><strong>Conclusions: </strong>Topical therapy may aid in post-operative MH closure.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147318816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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