Retinal Cases and Brief Reports最新文献

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ACUTE POST-TRAUMATIC ENDOPHTHALMITIS SECONDARY TO BACILLUS PUMILUS / SAFENSIS. 继发于枯草杆菌/萨福氏菌的急性外伤后眼内炎。
Retinal Cases and Brief Reports Pub Date : 2024-05-01 DOI: 10.1097/ICB.0000000000001391
Tyler Etheridge, Cole Swiston, Roger P Harrie, Paul S Bernstein
{"title":"ACUTE POST-TRAUMATIC ENDOPHTHALMITIS SECONDARY TO BACILLUS PUMILUS / SAFENSIS.","authors":"Tyler Etheridge, Cole Swiston, Roger P Harrie, Paul S Bernstein","doi":"10.1097/ICB.0000000000001391","DOIUrl":"10.1097/ICB.0000000000001391","url":null,"abstract":"<p><strong>Purpose: </strong>To report a case of post-traumatic endophthalmitis secondary to Bacillus pumilus/safensis .</p><p><strong>Methods: </strong>Observational case report of a single patient.</p><p><strong>Results: </strong>A 62-year-old man presented with a traumatic corneal laceration because of baling wire while working on a sheep farm. Appropriate corneal laceration repair with injection of intravitreal antibiotics (ceftazidime, clindamycin, and vancomycin) was performed. A single organism, identified as B. pumilus or Bacillus safensis, was isolated from the vitreous aspirate. A subsequent pars plana vitrectomy, pars plana lensectomy, anterior capsulotomy, and fluid-air exchange was required because of severe inflammatory reaction from retained lens material, retinal edema, and vitreous opacities. Vision improved from hand motion to 20/60 at the three-month follow-up visit.</p><p><strong>Conclusion: </strong>We describe a case of acute post-traumatic endophthalmitis secondary to B. pumilus/safensis.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10656842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HAIR TRANSPLANTATION COMPLICATED BY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS SEPSIS AND ENDOGENOUS ENDOPHTHALMITIS. 植发手术并发耐甲氧西林金黄色葡萄球菌败血症和内源性眼内炎。
Retinal Cases and Brief Reports Pub Date : 2024-05-01 DOI: 10.1097/ICB.0000000000001384
Joseph R Abraham, Rishi P Singh, Sunil K Srivastava, Danny A Mammo
{"title":"HAIR TRANSPLANTATION COMPLICATED BY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS SEPSIS AND ENDOGENOUS ENDOPHTHALMITIS.","authors":"Joseph R Abraham, Rishi P Singh, Sunil K Srivastava, Danny A Mammo","doi":"10.1097/ICB.0000000000001384","DOIUrl":"10.1097/ICB.0000000000001384","url":null,"abstract":"<p><strong>Purpose: </strong>To describe a case of endogenous endophthalmitis as a complication from hair transplantation.</p><p><strong>Methods: </strong>Case report of a 53-year-old man with a history of recent hair transplantation.</p><p><strong>Results: </strong>The patient presented with a febrile illness and blurry vision 1 week after hair transplantation. Infectious workup included blood cultures positive for methicillin-resistant Staphylococcus aureus, and he was treated with IV antibiotics. Initial ocular examination demonstrated 20/30 and hand motions in the right and left eyes, respectively, with significant vitritis. He underwent vitreous tap and injections of vancomycin and dexamethasone in both eyes and removal of purulent staple from the site of recently transplanted hair. His ocular and systemic symptoms improved. Approximately 3 months after initial clearing of the initial infection he had recurrence of bacteremia that prompted repeat intravitreal and systemic antibiotics. His vision returned to baseline with mild residual optic nerve pallor and atrophic retinal changes in the left eye.</p><p><strong>Conclusion: </strong>Hair transplantation is associated with minimal systemic complications, but in rare cases, sepsis is possible and can result in intraocular seeding causing endophthalmitis. MRSA endogenous endophthalmitis frequently results in negative vitreous taps and treatment outcomes in the literature have been shown to vary widely including a return to baseline vision as in the described case.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10633734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PARACENTRAL ACUTE MIDDLE MACULOPATHY IN GIANT CELL ARTERITIS. 巨细胞动脉炎的中枢旁急性黄斑病变(PAMM)。
Retinal Cases and Brief Reports Pub Date : 2024-05-01 DOI: 10.1097/ICB.0000000000001381
Francesco Pellegrini, Kevin Mairot, Alessandra Cuna, Andrew G Lee
{"title":"PARACENTRAL ACUTE MIDDLE MACULOPATHY IN GIANT CELL ARTERITIS.","authors":"Francesco Pellegrini, Kevin Mairot, Alessandra Cuna, Andrew G Lee","doi":"10.1097/ICB.0000000000001381","DOIUrl":"10.1097/ICB.0000000000001381","url":null,"abstract":"<p><strong>Purpose: </strong>To describe a representative case and review the literature on paracentral acute middle maculopathy (PAMM) and giant cell arteritis (GCA).</p><p><strong>Methods: </strong>A review of the English-language ophthalmic literature was performed using the search terms of PAMM, giant cell arteritis, and temporal arteritis.</p><p><strong>Results: </strong>A 72-year-old woman with PAMM as the presenting ophthalmic manifestation of GCA was described with a review of the prior cases from the literature. It was found that there were 26 cases of PAMM in GCA. In 19 of 26 cases, PAMM was associated with no other fundus abnormalities and was only seen on multimodal imaging including optical coherence tomography.</p><p><strong>Conclusion: </strong>PAMM can cause acute paracentral visual loss, and GCA should be suspected in all cases of PAMM of the elderly patients, even when isolated and not associated with constitutional symptoms of GCA.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9195121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CHRONIC CENTRAL SEROUS CHORIORETINOPATHY IN THE PEDIATRIC POPULATION: A CASE SERIES. 小儿慢性中央性浆液性脉络膜视网膜病变:病例系列。
Retinal Cases and Brief Reports Pub Date : 2024-05-01 DOI: 10.1097/ICB.0000000000001380
John N Stoffer, Jared J Ebert, Maura Di Nicola, Blake A Isernhagen, Arjun B Sood, Robert F Dundervill, Basil K Williams
{"title":"CHRONIC CENTRAL SEROUS CHORIORETINOPATHY IN THE PEDIATRIC POPULATION: A CASE SERIES.","authors":"John N Stoffer, Jared J Ebert, Maura Di Nicola, Blake A Isernhagen, Arjun B Sood, Robert F Dundervill, Basil K Williams","doi":"10.1097/ICB.0000000000001380","DOIUrl":"10.1097/ICB.0000000000001380","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this article was to describe 3 cases of chronic central serous chorioretinopathy (CSCR) in the pediatric patient population.</p><p><strong>Methods: </strong>Retrospective case series.</p><p><strong>Results: </strong>The authors report three pediatric patients with CSCR. All patients initially presented after failed vision screens or during routine office examinations. All patients presented with macula-involving subretinal fluid (SRF) and multimodal imaging features consistent with CSCR. At the last follow-up, one patient had minimal residual SRF, one patient had a small recurrence of SRF, and one patient had persistent SRF.</p><p><strong>Conclusion: </strong>Although CSCR classically occurs in adults, it can be seen in pediatric patients. Given the rarity of this condition in the pediatric population, CSCR may go undetected and underreported, with diagnosis resulting from failed vision screens.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9209551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
THREE CASES OF ACUTE RETINAL NECROSIS WITH ATYPICAL FUNDUS FINDINGS. 三例急性视网膜坏死伴非典型眼底检查结果。
Retinal Cases and Brief Reports Pub Date : 2024-05-01 Epub Date: 2024-04-18 DOI: 10.1097/ICB.0000000000001379
Shinichiro Chujo, Hisashi Matsubara, Atsushi Ichio, Yoshitsugu Matsui, Masahiko Sugimoto, Mineo Kondo
{"title":"THREE CASES OF ACUTE RETINAL NECROSIS WITH ATYPICAL FUNDUS FINDINGS.","authors":"Shinichiro Chujo, Hisashi Matsubara, Atsushi Ichio, Yoshitsugu Matsui, Masahiko Sugimoto, Mineo Kondo","doi":"10.1097/ICB.0000000000001379","DOIUrl":"10.1097/ICB.0000000000001379","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the mechanism for the development of segmental granular lesions along the retinal vessels in eyes with acute retinal necrosis.</p><p><strong>Method: </strong>This was a retrospective analysis of the medical records of three eyes of three patients who were diagnosed with acute retinal necrosis that had atypical segmental granular lesions aligned along the retinal vessels.</p><p><strong>Results: </strong>The segmental granular lesions were present on the retinal arteries and veins throughout the retina. Optical coherence tomography showed that the granular lesions protruded into the vitreous cavity. Histopathologic examinations confirmed that the lesions were made up of lymphocytes.</p><p><strong>Conclusion: </strong>We suggest that the granular lesions were formed by a mechanism similar to that of HTLV-1-associated uveitis. We also found that the granular lesions disappeared soon after vitrectomy.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11027986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10643437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RAPID ONSET HYDROXYCHLOROQUINE TOXICITY. 快速发作的羟氯喹毒性。
Retinal Cases and Brief Reports Pub Date : 2024-05-01 Epub Date: 2023-12-08 DOI: 10.1097/ICB.0000000000001393
Brida M Jeltsch, David Sarraf, Darius Madjdpour, James V M Hanson, Fatma K Pfiffner, Samuel Koller, Wolfgang Berger, Daniel Barthelmes, Mayss Al-Sheikh
{"title":"RAPID ONSET HYDROXYCHLOROQUINE TOXICITY.","authors":"Brida M Jeltsch, David Sarraf, Darius Madjdpour, James V M Hanson, Fatma K Pfiffner, Samuel Koller, Wolfgang Berger, Daniel Barthelmes, Mayss Al-Sheikh","doi":"10.1097/ICB.0000000000001393","DOIUrl":"10.1097/ICB.0000000000001393","url":null,"abstract":"<p><strong>Purpose: </strong>Hydroxychloroquine (HCQ) can cause irreversible damage to the retina, especially when taken over longer periods. The American Academy of Ophthalmology recommends a regimen for dosing, screening, and monitoring of patients treated with HCQ. We present an unusual case of a rapid development of severe HCQ-associated retinopathy already after 2 years after commencing HCQ treatment.</p><p><strong>Methods: </strong>Observational case report. Clinical examination, optical coherence tomography, fundus autofluorescence imaging, perimetry, and full-field and multifocal electroretinography were performed. Ancillary tests included neoplastic and paraneoplastic work-up, vitamin levels, and whole-exome sequencing, to rule out other potential causes of a panretinal degeneration.</p><p><strong>Results: </strong>We report on a 58-year-old woman with rheumatoid arthritis, treated initially with 200 mg HCQ daily for 1 year (daily dose 3.6 mg/kg), then 400 mg daily for 1 year (daily dose 7.2 mg/kg), and a cumulative dose of 216 g. Her medical history was otherwise unremarkable. No family history for inherited retinal conditions. She was referred due to a rapid and sudden progressive and severe concentric visual field constriction, 2 years after commencing HCQ treatment.</p><p><strong>Conclusion: </strong>This case of a rapid-onset, severe panretinal degeneration shortly after start of HCQ treatment suggests underlying mechanisms and risk factors for HCQ toxicity in addition to those previously reported and a potential need for supplementary screening tests to prevent HCQ toxicity. American Academy of Ophthalmology dosing guidelines of 5 mg/kg should be strictly adhered to in patients receiving HCQ therapy.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10806972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SPATIAL PATTERN OF RETINAL PIGMENT EPITHELIUM TEAR DEVELOPMENT AND PROGRESSION AFTER ANTIVASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. 抗血管内皮生长因子治疗新生血管性老年黄斑变性后视网膜色素上皮撕裂发展和恶化的空间模式。
Retinal Cases and Brief Reports Pub Date : 2024-05-01 DOI: 10.1097/ICB.0000000000001386
Takuma Fukui, Keijiro Ishikawa, Satomi Shiose, Kumiko Kano, Kenichiro Mori, Shoji Notomi, Koh-Hei Sonoda
{"title":"SPATIAL PATTERN OF RETINAL PIGMENT EPITHELIUM TEAR DEVELOPMENT AND PROGRESSION AFTER ANTIVASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION.","authors":"Takuma Fukui, Keijiro Ishikawa, Satomi Shiose, Kumiko Kano, Kenichiro Mori, Shoji Notomi, Koh-Hei Sonoda","doi":"10.1097/ICB.0000000000001386","DOIUrl":"10.1097/ICB.0000000000001386","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to demonstrate the spatial pattern of retinal pigment epithelium (RPE) tear development and progression after antivascular endothelial growth factor therapy for neovascular age-related macular degeneration.</p><p><strong>Methods: </strong>We retrospectively reviewed six eyes with neovascular age-related macular degeneration that showed RPE tears after administration of intravitreal antivascular endothelial growth factor agents and were followed up for 12 months. The patterns of RPE tear development and progression were evaluated by analyzing positional relationships among the locations of the choroidal neovascularization membrane and pigment epithelial detachment (PED) area at baseline and the tear area using spectral-domain optical coherence tomography, color photography, fluorescein angiography, and fundus autofluorescence images.</p><p><strong>Results: </strong>Pretear OCT images revealed fibrovascular PED in all eyes, one of which showed complications of hemorrhagic PED after treatment. In five eyes, RPE tears developed at the PED edge located on the opposite side of the choroidal neovascularization membrane. In the eye showing hemorrhagic PED, the RPE tear developed along the wide area of the PED edge. The torn RPE monolayer contracted toward the side of the choroidal neovascularization membrane in all eyes, and RPE loss involved the fovea in five eyes that showed significantly worse visual acuity (VA) after 12 months in comparison with the baseline value before the tear (logMAR VA; 0.3 vs. 1.29; P < 0.02).</p><p><strong>Conclusion: </strong>The location of choroidal neovascularization membrane in PED determines the spatial pattern of RPE tear development and progression and helps to predict the visual outcome after RPE tears.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10608145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ACUTE EXUDATIVE POLYMORPHOUS VITELLIFORM MACULOPATHY AS THE INITIAL PRESENTATION OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION. 全标题:作为人类免疫缺陷病毒感染初期表现的急性渗出性多形性玻璃体黄斑病。
Retinal Cases and Brief Reports Pub Date : 2024-05-01 DOI: 10.1097/ICB.0000000000001375
Laëtitia Jessy Niegowski, Issam Er-Rachiq, Francesca Amoroso, Eric H Souied, Alexandra Miere
{"title":"ACUTE EXUDATIVE POLYMORPHOUS VITELLIFORM MACULOPATHY AS THE INITIAL PRESENTATION OF HUMAN IMMUNODEFICIENCY VIRUS INFECTION.","authors":"Laëtitia Jessy Niegowski, Issam Er-Rachiq, Francesca Amoroso, Eric H Souied, Alexandra Miere","doi":"10.1097/ICB.0000000000001375","DOIUrl":"10.1097/ICB.0000000000001375","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the occurrence of acute exudative polymorphous vitelliform maculopathy as the initial presentation in a HIV-positive patient.</p><p><strong>Methods: </strong>Observational case report of one patient and literature review.</p><p><strong>Results: </strong>An active 21-year-old white woman presented to the emergency department with anterior segment complaints. Her best-corrected visual acuity was 20/20 in both eyes. Fundus examination revealed numerous, polymorphous, bleb-like lesions at the posterior pole, corresponding, on structural imaging (optical coherence tomography) to subretinal detachments. The bleb-like lesions on infrared imaging were slightly autofluorescent on fundus autofluorescence. Swept-source optical coherence tomography angiography showed signal attenuation because of the presence of subretinal fluid in the choriocapillaris segmentation. Multimodal imaging findings were suggestive for acute exudative polymorphous vitelliform maculopathy. Hence, a systemic blood workup was performed. The workup returned positive for HIV, and an antiviral therapy was introduced.</p><p><strong>Conclusion: </strong>The fortuitous diagnosis of HIV having as the initial presentation acute exudative polymorphous vitelliform maculopathy in an asymptomatic patient highlights the value of a thorough clinical examination and multimodal imaging in correctly diagnosing this rare disorder and its cause. This case report could prove helpful to clinicians faced with this rare scenario.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9195118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SUBFOVEAL CHOROIDAL TUBERCULOMA IN A HEALTHY YOUNG WOMAN CAUSED BY MYCOBACTERIUM BOVIS. 一名健康年轻女性眼底脉络膜下结核瘤,由牛分枝杆菌引起。
Retinal Cases and Brief Reports Pub Date : 2024-05-01 DOI: 10.1097/ICB.0000000000001377
Maya J Schopp, Piotr Strzalkowski, Stefan Dithmar
{"title":"SUBFOVEAL CHOROIDAL TUBERCULOMA IN A HEALTHY YOUNG WOMAN CAUSED BY MYCOBACTERIUM BOVIS.","authors":"Maya J Schopp, Piotr Strzalkowski, Stefan Dithmar","doi":"10.1097/ICB.0000000000001377","DOIUrl":"10.1097/ICB.0000000000001377","url":null,"abstract":"<p><strong>Purpose: </strong>To describe a case of a macular tuberculoma in a young and healthy woman after developing a tuberculous lymphadenitis caused by Mycobacterium bovis .</p><p><strong>Methods: </strong>Retrospective case report.</p><p><strong>Results: </strong>Tuberculous lymphadenitis caused by M. bovis was detected after biopsy and histological examination as well as polymerase chain reaction test testing of cervical lymph nodes in a 20-year-old patient. An interferon gamma was positive. Shortly starting antitubercular therapy, the patient developed visual deterioration caused by a single yellowish subretinal structure in the macula of the right eye. Optical coherence tomography showed a dome-shaped, hyperreflective, subfoveal choroidal lesion with subtle subretinal fluid. Antitubercular therapy with isoniazid, rifampicin, ethambutol, and pyrazinamide was performed, and the deescalation therapy with isoniazid and rifampicin was extended to 7 months. Further examinations showed regression of choroidal tuberculoma to a scar.</p><p><strong>Conclusion: </strong>This is the first reported case of choroidal tuberculoma after tuberculous lymphadenitis caused by M. bovis .</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9291917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TOCILIZUMAB RESOLVES REFRACTORY MACULAR EDEMA ASSOCIATED TO RETINITIS PIGMENTOSA. 托西珠单抗可缓解与视网膜色素变性相关的难治性黄斑水肿。
Retinal Cases and Brief Reports Pub Date : 2024-05-01 DOI: 10.1097/ICB.0000000000001389
Silvia Méndez-Martínez, Nieves Pardiñas Barón, Francisco de Asís Bartol-Puyal, Borja Arias Del Peso, María Pilar Ruiz Del Tiempo, Álvaro Lesta Arnal, Oscar Ruiz Moreno, Javier Manero Ruiz, Luis Pablo Júlvez
{"title":"TOCILIZUMAB RESOLVES REFRACTORY MACULAR EDEMA ASSOCIATED TO RETINITIS PIGMENTOSA.","authors":"Silvia Méndez-Martínez, Nieves Pardiñas Barón, Francisco de Asís Bartol-Puyal, Borja Arias Del Peso, María Pilar Ruiz Del Tiempo, Álvaro Lesta Arnal, Oscar Ruiz Moreno, Javier Manero Ruiz, Luis Pablo Júlvez","doi":"10.1097/ICB.0000000000001389","DOIUrl":"10.1097/ICB.0000000000001389","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this report is to describe the resolution of refractory cystoid macular edema (CME) associated to retinitis pigmentosa (RP) with IV tocilizumab in three patients.</p><p><strong>Methods: </strong>Retrospective study of a series of consecutive cases of patients treated with off-label IV tocilizumab (anti IL6) for CME refractory to acetazolamide 250 mg for 3 months. Patients were diagnosed with RP by fundus appearance, electrophysiology, visual fields, and genetic testing. A complete ophthalmic examination including spectral-domain optical coherence tomography was performed.</p><p><strong>Results: </strong>Three patients with RP and CME refractory to acetazolamide 250 mg for 3 months were treated with monthly IV tocilizumab for at least six months.All patients resolved CME and improved visual acuity after the third month of IV tocilizumab, resolving systemic and ocular adverse events related to previous treatments for CME. Tocilizumab was well tolerated with no other adverse events.</p><p><strong>Discussion: </strong>CME causes visual impairment in RP, but current treatments are usually deficient. Tocilizumab has been successfully used as treatment for refractory CME in uveitis, retinal dystrophies, and autoimmune retinopathies. This article reports, for the first time, the long-term resolution of refractory CME in RP with IV tocilizumab.</p>","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10608146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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