Retinal Cases and Brief Reports最新文献_第9页

Bilateral Ischemic Retinal Vasculopathy Following Haploidentical Hematopoietic Stem Cell Transplantation: A Case Report of Atypical Presentation in a Young Patient. 单倍体造血干细胞移植后的双侧缺血性视网膜血管病变：一例不典型表现的年轻患者报告。

Retinal Cases and Brief Reports Pub Date : 2026-05-19 DOI: 10.1097/ICB.0000000000001933

Gabriela Yea-Huey Yang, Eduardo A Novais, Guilherme Sturzeneker, Heloisa Nascimento, Melina Veiga Rodrigues, Iracema Esteves, Rubens Belfort

{"title":"Bilateral Ischemic Retinal Vasculopathy Following Haploidentical Hematopoietic Stem Cell Transplantation: A Case Report of Atypical Presentation in a Young Patient.","authors":"Gabriela Yea-Huey Yang, Eduardo A Novais, Guilherme Sturzeneker, Heloisa Nascimento, Melina Veiga Rodrigues, Iracema Esteves, Rubens Belfort","doi":"10.1097/ICB.0000000000001933","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001933","url":null,"abstract":"Purpose: To report a rare and challenging case of an atypical and bilateral ischemic retinal vasculopathy in a young patient following haploidentical bone marrow transplantation (BMT).Methods: Case report and literature review on ocular complications after hematopoietic stem cell transplantation (HSCT).Results: A 29-year-old woman presented with an atypical and bilateral ischemic retinal vasculopathy after haploidentical BMT, with a partial response to corticosteroids and anti-vascular endothelial growth factor therapy. Serial changes were documented using optical coherence tomography.Conclusion: Ocular complications unrelated to graft-versus-host disease are generally uncommon after HSCT but can lead to significant and prolonged visual impairment. Retinal ischemic vasculopathy post-HSCT may present with typical and atypical features, each carrying distinct clinical manifestations and prognostic implications. While the typical form is well characterized in the literature, bilateral ischemic retinal vasculopathy following haploidentical HSCT remains unreported. Potential contributing factors include endothelial injury, microvascular occlusion, and immune-mediated mechanisms associated with HSCT. Moreover, medications used during and after transplantation-such as corticosteroids and immunosuppressants-may have ocular side effects that contribute to retinal complications. This case underscores the importance of early ophthalmologic evaluation in post-HSCT patients with visual symptoms, even in the absence of graft-versus-host disease.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147977055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minimizing Risk in Scleral Buckle Surgery: A Novel Approach to Belt Loop Creation Using a Guarded Diamond Blade. 将巩膜扣手术的风险降至最低：一种使用防护金刚石刀片制造带环的新方法。

Retinal Cases and Brief Reports Pub Date : 2026-05-19 DOI: 10.1097/ICB.0000000000001934

Joaquin Sosa-Lockward, David W Borden, Catherin I Negron, Charles F Zhang, Audina M Berrocal

{"title":"Minimizing Risk in Scleral Buckle Surgery: A Novel Approach to Belt Loop Creation Using a Guarded Diamond Blade.","authors":"Joaquin Sosa-Lockward, David W Borden, Catherin I Negron, Charles F Zhang, Audina M Berrocal","doi":"10.1097/ICB.0000000000001934","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001934","url":null,"abstract":"Purpose: To describe a novel technique for scleral belt loop formation during scleral buckle (SB) surgery using a guarded diamond limbal relaxing incision (LRI) blade to minimize the risk of scleral perforation and improve groove consistency.Methods: A conventional scleral buckle procedure was performed for rhegmatogenous retinal detachment (RRD) with the placement of a #240 encircling band. Four partial-thickness scleral grooves were created in each quadrant using a guarded diamond LRI blade with a preset depth of 150 µm. The band was passed through the resulting belt loops and secured with a Watzke sleeve. Operative efficiency, tissue resistance, and groove quality were assessed intraoperatively.Results: The guarded diamond blade enabled single-pass formation of uniform scleral grooves with minimal resistance and excellent visualization. No intraoperative complications were observed, including scleral perforation, hypotony, or hemorrhage. Groove creation was rapid and reproducible.Conclusion: Use of a guarded diamond LRI blade for scleral belt loop creation provides a precise, efficient, and low-risk alternative to traditional dissection techniques. This approach may improve surgical safety and efficiency.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147977081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RAPIDLY GROWING CHOROIDAL METASTASIS SIMULATING IMMUNE-RELATED CHOROIDAL ADVERSE REACTION. 快速生长的脉络膜转移模拟免疫相关脉络膜不良反应。

Retinal Cases and Brief Reports Pub Date : 2026-05-19 DOI: 10.1097/ICB.0000000000001935

Anastasiia N Panfilova, Vitaliy V Potemkin, Taisiia A Doktorova, Alexey A Suetov, Dmitrii S Maltsev

{"title":"RAPIDLY GROWING CHOROIDAL METASTASIS SIMULATING IMMUNE-RELATED CHOROIDAL ADVERSE REACTION.","authors":"Anastasiia N Panfilova, Vitaliy V Potemkin, Taisiia A Doktorova, Alexey A Suetov, Dmitrii S Maltsev","doi":"10.1097/ICB.0000000000001935","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001935","url":null,"abstract":"Purpose: To describe a clinical case of a patient with multifocal breast cancer and a choroidal metastasis rapidly growing despite targeted cancer therapy and simulating immune-related choroidal adverse reaction.Methods: The patient received multimodal imaging including wide-field color fundus photography, spectral domain optical coherence tomography (OCT), ultra-widefield OCT angiography, fundus autofluorescence, fluorescein angiography, indocyanine green angiography. Additionally, MRI imaging and B-scan ultrasonography was performed.Results: A 35-year-old woman with medical history of metastatic multifocal breast cancer on the fifth course of adjuvant targeted therapy with trastuzumab and docetaxel was presented with flickering in the right eye. Fundus examination revealed central flat choroidal lesion with serous retinal detachment. OCT demonstrated a bacillary layer detachment and mild choroidal thickening. After fluorescein angiography and B-scan ultrasonography a Vogt-Koyanagi-Harada-like reaction was suspected. No response was observed after initiation of systemic glucocorticosteroids. The lesion and associated subretinal exudation rapidly progressed for over a month when the lesion demonstrated signs of choroidal metastasis and extraocular metastasis were identified.Conclusion: Choroidal metastases can develop despite ongoing systemic cancer therapy as a result of acquired resistance. A rapid growth of choroidal metastasis may simulate Vogt-Koyanagi-Harada-like reaction and requires extensive multimodal imaging and close follow-up.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147977104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exudative Diabetic-Radiation Retinopathy with Lipemia Retinalis Mimicking Cytomegalovirus Retinitis. 渗出性糖尿病辐射视网膜病变伴脂血症视网膜模拟巨细胞病毒视网膜炎。

Retinal Cases and Brief Reports Pub Date : 2026-05-19 DOI: 10.1097/ICB.0000000000001938

Natasha Kesav, Debra A Goldstein, Lee M Jampol

{"title":"Exudative Diabetic-Radiation Retinopathy with Lipemia Retinalis Mimicking Cytomegalovirus Retinitis.","authors":"Natasha Kesav, Debra A Goldstein, Lee M Jampol","doi":"10.1097/ICB.0000000000001938","DOIUrl":"https://doi.org/10.1097/ICB.0000000000001938","url":null,"abstract":"Purpose: To describe a case in which a retinal lesion mimicking cytomegalovirus (CMV) retinitis prompted investigation that revealed severe hypertriglyceridemia as an associated factor in exudative diabetic and radiation retinopathy.Methods: Observational case report with multimodal imaging and aqueous PCR analysis.Results: A 38-year-old man with a history of leukemia, bone marrow transplantation, ocular and whole boddy irradiation, and type 1 diabetes presented for routine follow-up. A new granular retinal lesion raised suspicion for viral retinitis. Aqueous PCR testing for CMV, HSV, and VZV were negative. Systemic evaluation subsequently demonstrated triglycerides of 2,496 mg/dL. The findings were consistent with severe exudative diabetic and radiation retinopathy in the setting of extreme hypertriglyceridemia. He was treated with intravitreal bevacizumab and lipid-lowering therapy with observed improvement in retinal exudation, hemorrhages, and lipemia retinalis.Conclusion: A retinal lesion resembling CMV retinitis led to recognition of marked dyslipidemia associated with exudative retinopathy. Clinicians should be aware that dense, confluent exudation may mimic viral necrosis, and systemic lipid assessment is warranted in such cases.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147977045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subluxated Cosmetic IOL in the Vitreous Cavity in a Post-Traumatic Aniridia Patient: A Modified Fusion-Flanged Intrascleral Fixation Approach. 外伤性无虹膜患者玻璃体内半脱位整形人工晶状体：一种改良的融合缘巩膜内固定方法。

Retinal Cases and Brief Reports Pub Date : 2026-05-19 DOI: 10.1097/ICB.0000000000001936

Antonio Berarducci, Giulia Maria Pia Bisceglia, Mariateresa Laborante, Antonio Laborante

引用次数: 0

EPSTEIN-BARR VIRUS-ASSOCIATED FROSTED BRANCH ANGIITIS. eb病毒相关的霜状支血管炎。

Retinal Cases and Brief Reports Pub Date : 2026-05-01 DOI: 10.1097/ICB.0000000000001742

Julia L Xia, Jennifer M Lai, Alan G Palestine, Amit K Reddy

{"title":"EPSTEIN-BARR VIRUS-ASSOCIATED FROSTED BRANCH ANGIITIS.","authors":"Julia L Xia, Jennifer M Lai, Alan G Palestine, Amit K Reddy","doi":"10.1097/ICB.0000000000001742","DOIUrl":"10.1097/ICB.0000000000001742","url":null,"abstract":"Purpose: To describe two cases of frosted branch angiitis in the setting of Epstein-Barr virus infection.Methods: Retrospective case series of two patients at the University of Colorado Sue Anschutz-Rodgers Eye Center.Results: Case 1 is a 17-year-old female patient who presented with bilateral floaters and blurry vision 2 weeks after a diagnosis of mononucleosis. Visual acuity was 20/20 in both eyes and examination was significant for vitreous cell and frosted branch angiitis appearance to the retinal vasculature in both eyes. Treatment with oral prednisone and valacyclovir was initiated with improvement in vitritis and vascular sheathing. One month after all treatment was discontinued, there was a recurrence of vitritis that was treated with bilateral sub-Tenon triamcinolone acetonide injections. Final visual acuity was 20/20 in both eyes with resolved vitritis. Case 2 is a 20-year-old male patient who presented with headache and acute bilateral vision loss. He was found to have a meningoencephalitis with cerebrospinal fluid positive for Epstein-Barr virus that was treated with IV methylprednisolone and acyclovir. Visual acuity was count fingers in both eyes. Fundus examination revealed diffuse bilateral frosted branch angiitis which the subsequent development of bilateral bacillary detachments and neuroretinitis that required treatment with oral prednisone, oral acyclovir, and bilateral intravitreal dexamethasone implants, which resolved all ocular inflammation. Final visual acuity was 20/30 in the right eye and 20/25 in the left eye.Conclusion: Bilateral frosted branch angiitis may present after Epstein-Barr virus infection and responds well to corticosteroids and antiviral therapy.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"316-322"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A CURIOUS CASE OF ENDOGENOUS RAMULARIA ENDOPHTHALMITIS PRESENTING AS ACUTE ANGLE CLOSURE. 一个奇怪的内源性雷姆拉菌性眼内炎的病例，表现为急性闭角。

Retinal Cases and Brief Reports Pub Date : 2026-05-01 DOI: 10.1097/ICB.0000000000001734

Jeremy P Williamson, Richard Y Sarafian, David Pham, Joseph J Park

{"title":"A CURIOUS CASE OF ENDOGENOUS RAMULARIA ENDOPHTHALMITIS PRESENTING AS ACUTE ANGLE CLOSURE.","authors":"Jeremy P Williamson, Richard Y Sarafian, David Pham, Joseph J Park","doi":"10.1097/ICB.0000000000001734","DOIUrl":"10.1097/ICB.0000000000001734","url":null,"abstract":"Purpose: To report on an interesting case of fungal endogenous endophthalmitis in a patient who was referred in for acute angle closure. A unique presentation with a novel pathogen, Ramularia, identified on vitreous sampling.Methods: Case report.Results: This report describes a patient referred for presumed angle closure with a painful red left eye, an intraocular pressure of 39 mmHg, and perception to light vision. Ramularia species DNA-a novel fungus-was identified on polymerase chain reaction from sterile vitreous sampling during subsequent vitrectomy, performed because of worsening vision. Following vitrectomy, the patient improved with topical voriconazole and oral posaconazole, which was second-line therapy after oral voriconazole caused hepatoxicity. The patient had a good visual outcome with a final visual acuity of 20/50, 18 months after presentation.Conclusion: This case highlights the unique presentation, treatment, and good outcome of a patient with endogenous endophthalmitis from a novel fungus, Ramularia .","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"299-301"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PATCHY ATROPHIC PERIVASCULAR LESIONS IN VITREORETINAL LYMPHOMAS: A CASES SERIES. 玻璃体视网膜淋巴瘤的斑片状萎缩性血管周围病变：1例系列。

Retinal Cases and Brief Reports Pub Date : 2026-05-01 DOI: 10.1097/ICB.0000000000001761

Maxime Desira, Thibault Ruiz, Magali Sampo, Thierry David, Pierre Gascon

{"title":"PATCHY ATROPHIC PERIVASCULAR LESIONS IN VITREORETINAL LYMPHOMAS: A CASES SERIES.","authors":"Maxime Desira, Thibault Ruiz, Magali Sampo, Thierry David, Pierre Gascon","doi":"10.1097/ICB.0000000000001761","DOIUrl":"10.1097/ICB.0000000000001761","url":null,"abstract":"Purpose: Vitreoretinal lymphoma (VRL) is a rare but aggressive intraocular malignancy, often presenting diagnostic challenges because of its masquerade syndrome characteristics. This study reports on two atypical cases of VRL, highlighting the presence of patchy atrophic perivascular retinal lesions, a feature not commonly emphasized in the literature.Methods: Cases series.Results: The first case involves an 83-year-old woman with primary VRL in her right eye, where progressive atrophic retinal lesions were noted despite systemic chemotherapy. The second case describes a 77-year-old woman with secondary VRL, previously in remission from cerebral lymphoma, who also developed perivascular atrophic lesions in her right eye. These lesions were observed to increase in both number and size over time, even in the absence of active vitreoretinal infiltration or systemic disease relapse.Conclusion: These cases suggest that the patchy atrophic perivascular lesions may be indicative of VRL. The atrophic progression, despite local disease control, underscores the importance of recognizing such patterns as part of the broader spectrum of VRL manifestations. It contributes to the ongoing discussion of minimal residual disease in VRL management.","PeriodicalId":53580,"journal":{"name":"Retinal Cases and Brief Reports","volume":" ","pages":"369-374"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DELAYED ONSET OF SPONTANEOUS LARGE FULL THICKNESS MACULAR HOLE CLOSURE. 自发性大全层黄斑孔闭合延迟发生。

Retinal Cases and Brief Reports Pub Date : 2026-05-01 DOI: 10.1097/ICB.0000000000001750

Muntadher Al Karam, Rike Michels, Stephan Michels

引用次数: 0

PRESUMED MITOMYCIN C-INDUCED RETINAL TOXICITY AFTER COMBINED CATARACT AND XEN GEL STENT SURGERY. 推测丝裂霉素c在白内障和Xen凝胶支架联合手术后引起视网膜毒性。

Retinal Cases and Brief Reports Pub Date : 2026-05-01 DOI: 10.1097/ICB.0000000000001729

Jared J Tuttle, Shannon D Scarboro, John C Fitzpatrick, Clio A Harper

引用次数: 0