Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis最新文献_第8页

Understanding the interaction of estrogenic ligands with estrogen receptors: a survey of the functional and binding kinetic studies. 了解雌激素受体与雌激素配体的相互作用:功能和结合动力学研究综述。

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2020-01-01 Epub Date: 2020-05-07 DOI: 10.1080/26896583.2020.1761204

Jingwei Jin, Panpan Wu, Xinyue Zhang, Dongli Li, Wing-Leung Wong, Yu-Jing Lu, Ning Sun, Kun Zhang

{"title":"Understanding the interaction of estrogenic ligands with estrogen receptors: a survey of the functional and binding kinetic studies.","authors":"Jingwei Jin, Panpan Wu, Xinyue Zhang, Dongli Li, Wing-Leung Wong, Yu-Jing Lu, Ning Sun, Kun Zhang","doi":"10.1080/26896583.2020.1761204","DOIUrl":"https://doi.org/10.1080/26896583.2020.1761204","url":null,"abstract":"The investigation of estrogen actions and their interaction characteristics with estrogen receptors (ERs) to induce unique functional features inside cells have allowed us to understand better the regulation of many vital physiological and cellular processes in humans. The biological effects of estrogenic ligands or compounds are mediated via estrogen receptors that act as the ligand-activated transcription factors. Therefore, the study on ligand-ER interaction properties and mechanism of ligand-ER complexes binding to specific estrogen response elements located in the promoters of target genes are very critical to realize the complicated biological process regulated by the endogenous estrogens. Several reviews have provided comprehensive and updated information on the influence of estrogen receptors in health and disease. However, the mechanism of estrogen-ERs binding and affinity aspects at molecular level is relatively under-investigated. This review thus aims to shed light on the significance of the binding kinetics of ligand-ER interactions because the information provide great assistance to define how a ligand or a drug can communicate with physiology to produce a desired therapeutic response. In addition, the most frequently used methodologies for the binding kinetic study are highlighted over the last decade.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"38 2","pages":"142-168"},"PeriodicalIF":2.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/26896583.2020.1761204","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38015717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Antibody-based detection of lysine modification of hepatic protein in mice treated with retrorsine. 逆转录酶处理小鼠肝蛋白赖氨酸修饰的抗体检测。

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2020-01-01 DOI: 10.1080/26896583.2020.1832411

Ting Cheng, Weiwei Li, Xiaojing Yang, Huali Wang, Fan Zhang, Na Li, Ge Lin, Jiang Zheng

{"title":"Antibody-based detection of lysine modification of hepatic protein in mice treated with retrorsine.","authors":"Ting Cheng, Weiwei Li, Xiaojing Yang, Huali Wang, Fan Zhang, Na Li, Ge Lin, Jiang Zheng","doi":"10.1080/26896583.2020.1832411","DOIUrl":"https://doi.org/10.1080/26896583.2020.1832411","url":null,"abstract":"Many pyrrolizidine alkaloids (PAs), an important class of natural products, are hepatotoxic and carcinogenic. Increased attention has been paid to PA poisoning cases worldwide. Generally, most PAs themselves are not toxic. However, reactive intermediates formed from PAs by metabolic oxidation have been linked to toxicity and carcinogenesis. PAs themselves are generally not toxic, and their reactive metabolites resulting from metabolic oxidation are considered to be an essential responsible for PA toxicities. Protein modification by the electrophilic metabolites is proposed to play a key role in PA-induced cytotoxicity. The present study investigated the interaction of lysine residues of proteins with reactive metabolites of toxic PAs. Antibodies selectively recognizing lysine-based protein adduction were prepared and characterized. ELISA and immunoblot methods, in the presence and absence of synthetic model PA adducts, were used to test specific binding of the antibodies to modified lysine residues of BSA and to hepatic proteins extracted from mice treated with retrorsine. The lysine residue adduction was also detected in the tissues of retrorsine-treated mice by use of an immunohistochemical approach. In conclusion, the prepared antibodies selectively recognized the lysine adducts and may be used for the investigation of mechanisms of toxic action of PAs.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"38 4","pages":"315-328"},"PeriodicalIF":2.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/26896583.2020.1832411","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38767140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toxic impacts and industrial potential of graphene. 石墨烯的毒性影响和工业潜力。

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2020-01-01 Epub Date: 2020-09-08 DOI: 10.1080/26896583.2020.1812335

Trupti N Patel, Priyanka R, Yash Vashi, Priyanjali Bhattacharya

引用次数: 5

Inflammatory and immunological changes caused by noise exposure: A systematic review. 噪声暴露引起的炎症和免疫变化:系统综述。

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2020-01-01 Epub Date: 2020-03-18 DOI: 10.1080/26896583.2020.1715713

Amirreza Abouee-Mehrizi, Yahya Rasoulzadeh, Tohid Kazemi, Mehran Mesgari-Abbasi

{"title":"Inflammatory and immunological changes caused by noise exposure: A systematic review.","authors":"Amirreza Abouee-Mehrizi, Yahya Rasoulzadeh, Tohid Kazemi, Mehran Mesgari-Abbasi","doi":"10.1080/26896583.2020.1715713","DOIUrl":"https://doi.org/10.1080/26896583.2020.1715713","url":null,"abstract":"Today, due to the growth of industries and spread of the use of various instruments and devices that produce high noise levels, it is necessary to pay more attention to the effects of exposure to noise on organs and tissues in the body. The importance of the immune system in fighting external and pathogenic factors has raised the need to consider external factors (such as harmful physical factors) and make efforts to avoid producing them. In this systematic review, 811 potentially relevant studies were found in Google Scholar, PubMed, and Web of Science databases, of which 32 different English-written articles were included in the study. The method of searching and systematically reviewing articles was based on the assessment tool of the multiple systematic reviews (AMSTAR) method. The results of this study suggested that noise could affect the function of the immune system and its components by affecting other systems and organs of the body, including the central nervous system, auditory system, circulatory system, and endocrine gland. Moreover, it can be hypothesized that noise affects immune system by producing the NADPH oxidase (Nox) and reactive oxygen species (ROS).","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"38 1","pages":"61-90"},"PeriodicalIF":2.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/26896583.2020.1715713","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37926198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Harmful algal blooms and liver diseases: focusing on the areas near the four major rivers in South Korea 有害藻华和肝病：重点关注韩国四大河流附近地区

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2019-10-02 DOI: 10.1080/10590501.2019.1674600

Seungjun Lee, Jinnam Kim, B. Choi, Gi-Doo Kim, Jiyoung Lee

{"title":"Harmful algal blooms and liver diseases: focusing on the areas near the four major rivers in South Korea","authors":"Seungjun Lee, Jinnam Kim, B. Choi, Gi-Doo Kim, Jiyoung Lee","doi":"10.1080/10590501.2019.1674600","DOIUrl":"https://doi.org/10.1080/10590501.2019.1674600","url":null,"abstract":"Abstract Freshwater harmful algal blooms (HABs) have become a global concern because blooms contain cyanotoxins that can cause liver damage and other negative health impacts. In South Korea, HABs have been frequently observed along the major rivers (Han, Geum, Nakdong, and Youngsan) in recent years. However, there are hardly any studies that report a linkage between HABs and human health, especially along the four major rivers where dams, weirs, and reservoirs were constructed, and sediments were dredged under the Four Major Rivers Project (FMRP) that ended in 2012. The goals of this study were to summarize spatial distribution patterns of HABs and investigate a potential association between HABs and liver diseases. Chlorophyll-a concentration was used to estimate bloom intensity since it was the only available bloom-related parameter that covers the entire rivers. Liver disease data (ICD-10 codes: K71–K77) were sorted by administrative districts. Generalized linear mixed model was used to analyze the bloom, liver diseases, and population data (2005–2016). The results show that chlorophyll-a levels significantly increased since 2013, except Han River region. There was a significant association between HAB intensity and incidence rate of liver diseases, except Han River area, and the extent of association significantly increased after the completion of the FMRP. For future studies, more in-depth epidemiological investigations are warranted in those areas to accurately determine more specific associations between HABs and liver diseases as well as other bloom-related diseases and symptoms. In addition, identification of major exposure pathways to cyanotoxins is needed to better protect public health in those bloom-affected areas.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"37 1","pages":"356 - 370"},"PeriodicalIF":2.5,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2019.1674600","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46311536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Phytotoxic effect of silver nanoparticles on seed germination and growth of terrestrial plants 银纳米粒子对陆地植物种子萌发和生长的植物毒性作用

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2019-10-02 DOI: 10.1080/10590501.2019.1676600

Shruti Budhani, Nzube Prisca Egboluche, Z. Arslan, Hongtao Yu, Hua Deng

{"title":"Phytotoxic effect of silver nanoparticles on seed germination and growth of terrestrial plants","authors":"Shruti Budhani, Nzube Prisca Egboluche, Z. Arslan, Hongtao Yu, Hua Deng","doi":"10.1080/10590501.2019.1676600","DOIUrl":"https://doi.org/10.1080/10590501.2019.1676600","url":null,"abstract":"Abstract Silver nanoparticles (AgNP) exhibit size and concentration dependent toxicity to terrestrial plants, especially crops. AgNP exposure could decrease seed germination, inhibit seedling growth, affect mass and length of roots and shoots. The phytotoxic pathway has been partly understood. Silver (as element, ion or AgNP) accumulates in roots/leaves and triggers the defense mechanism at cellular and tissue levels, which alters metabolism, antioxidant activities and related proteomic expression. Botanical changes (either increase or decrease) in response to AgNP exposure include reactive oxygen species generation, superoxide dismutase activities, H2O2 level, total chlorophyll, proline, carotenoid, ascorbate and glutathione contents, etc. Such processes lead to abnormal morphological changes, suppression of photosynthesis and/or transpiration, and other symptoms. Although neutral or beneficial effects are also reported depending on plant species, adverse effects dominate in majority of the studies. More in depth research is needed to confidently draw any conclusions and to guide legislation and regulations.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"37 1","pages":"330 - 355"},"PeriodicalIF":2.5,"publicationDate":"2019-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2019.1676600","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42820866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

A comprehensive review on enzymatic degradation of the organophosphate pesticide malathion in the environment 有机磷农药马拉硫磷在环境中的酶降解研究综述

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2019-09-30 DOI: 10.1080/10590501.2019.1654809

Smita S. Kumar, P. Ghosh, S. K. Malyan, J. Sharma, Vivek Kumar

引用次数: 53

Occupational exposure to aflatoxins and health outcomes: a review 黄曲霉毒素职业暴露与健康结果综述

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2019-09-12 DOI: 10.1080/10590501.2019.1664836

Ruth Nabwire Wangia, L. Tang, Jia-Sheng Wang

{"title":"Occupational exposure to aflatoxins and health outcomes: a review","authors":"Ruth Nabwire Wangia, L. Tang, Jia-Sheng Wang","doi":"10.1080/10590501.2019.1664836","DOIUrl":"https://doi.org/10.1080/10590501.2019.1664836","url":null,"abstract":"Abstract Aflatoxins [AFs] are secondary metabolites of the fungus species Aspergillus spp. Both animal and epidemiological studies provided sufficient evidence on the carcinogenic, immunotoxic, mutagenic, and genotoxic potential of AFs. While ingestion is the main route of exposure for AFs through consumption of contaminated food products, agricultural workers and personnel who handle AF-contaminated grains are also at higher risk of exposure via inhalation. The main objective of the review is to provide a comprehensive overview of past scientific studies on occupational exposure to AFs, high-risk occupations, and disease outcomes. A search of peer-reviewed articles was done on PubMed and Web of Science Databases. A total of 164 papers was identified and 61 journal articles were selected for further review. High risk occupations include animal husbandry and processing of grain cereals and/or animal feed. Primary liver cancer and respiratory cancers were the most reported as a result of occupational exposure to AFs. For future studies, improved study designs, better characterization of AFs exposure in an occupational setting, and use of biomarkers are recommended in order to promote better understanding of occupational exposure to AFs and the resulting disease burden among workers.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"37 1","pages":"215 - 234"},"PeriodicalIF":2.5,"publicationDate":"2019-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2019.1664836","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45443021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Epigenetic modifications associated with pathophysiological effects of lead exposure 与铅暴露的病理生理效应相关的表观遗传修饰

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2019-08-12 DOI: 10.1080/10590501.2019.1640581

Madiha Khalid, M. Abdollahi

引用次数: 30

Editorial Board Page: EOV 编委会页面:EOV

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2017-10-02 DOI: 10.1080/10590501.2017.1416559

引用次数: 0