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Review of electronic cigarettes as tobacco cigarette substitutes: Their potential human health impact. 审查作为烟草香烟替代品的电子香烟：其对人类健康的潜在影响。
IF 2.5 4区 环境科学与生态学
Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2016-10-01 DOI: 10.1080/10590501.2016.1236604
Ki-Hyun Kim, Ehsanul Kabir, Shamin Ara Jahan
{"title":"Review of electronic cigarettes as tobacco cigarette substitutes: Their potential human health impact.","authors":"Ki-Hyun Kim, Ehsanul Kabir, Shamin Ara Jahan","doi":"10.1080/10590501.2016.1236604","DOIUrl":"10.1080/10590501.2016.1236604","url":null,"abstract":"<p><p>Electronic cigarettes (ECs) are devised to deliver nicotine in a vapor rather than in smoke without tar. ECs are hence advertised as being safer than tobacco cigarette products as the chemical compounds inhaled in the former are believed to be fewer and less toxic than those of the latter. Hazardous chemicals (e.g., formaldehyde) are nonetheless found to be generated incidentally by contacting the heated wire (i.e., the oxidation of glycerol/glycol in e-liquid). Although the extent of their release varies by several variables (e.g., the type of e-liquid, puffing rate, and the battery voltage), their exposure may also contribute to negative health effects. As the use of ECs may be much safer than that of common tobacco products, the former can be used as an aid to cut down or quit the latter. However, relatively little is yet known about the health effects of the EC on a long-term basis. Moreover, the use of EC cannot be clearly substantiated for renormalizing smoking behavior by current evidence. Behavior studies of the EC consumer suggest that the sufficient data for aerosol generation and chemical analysis should be acquired to establish reliable guides for its composition and consumption. In light of the urgent demand for such guidelines, this review examines the basic aspects of EC-related pollutants and their health effects.</p>","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2016.1236604","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59700860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Mycotoxin in the food supply chain—implications for public health program 食品供应链中的霉菌毒素——对公共卫生计划的影响
IF 2.5 4区 环境科学与生态学
Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2016-10-01 DOI: 10.1080/10590501.2016.1236607
D. Milićević, I. Nastasijević, Z. Petrović
{"title":"Mycotoxin in the food supply chain—implications for public health program","authors":"D. Milićević, I. Nastasijević, Z. Petrović","doi":"10.1080/10590501.2016.1236607","DOIUrl":"https://doi.org/10.1080/10590501.2016.1236607","url":null,"abstract":"ABSTRACT Mycotoxins are a group of naturally occurring toxic chemical substances, produced mainly by microscopic filamentous fungal species. Regarding potential synergisms or even mitigating effects between toxic elements, mycotoxin contamination will continue to be an area of concern for producers, manufacturers, regulatory agencies, researchers, and consumers in the future. In Serbia, recent drought and then flooding confirmed that mycotoxins are one of the foodborne hazards most susceptible to climate change. In this article, we review key aspects of mycotoxin contamination of the food supply chain and implications for public health from the Serbian perspective.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2016.1236607","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59700914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
Editorial Board EOV 编辑委员会EOV
IF 2.5 4区 环境科学与生态学
Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2016-10-01 DOI: 10.1080/10590501.2016.1270019
{"title":"Editorial Board EOV","authors":"","doi":"10.1080/10590501.2016.1270019","DOIUrl":"https://doi.org/10.1080/10590501.2016.1270019","url":null,"abstract":"","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2016.1270019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59700962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arsenic and its compounds in mushrooms: A review 蘑菇中砷及其化合物的研究进展
IF 2.5 4区 环境科学与生态学
Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2016-09-16 DOI: 10.1080/10590501.2016.1235935
J. Falandysz, L. Rizal
{"title":"Arsenic and its compounds in mushrooms: A review","authors":"J. Falandysz, L. Rizal","doi":"10.1080/10590501.2016.1235935","DOIUrl":"https://doi.org/10.1080/10590501.2016.1235935","url":null,"abstract":"ABSTRACT The purpose of this article is to review the detail concentration of arsenic in some species of mushrooms as well as organic and inorganic forms of arsenic in the substrates where wild and cultivated edible mushrooms grow. We also briefly review the molecular forms of arsenic in mushrooms. There is still a lack of experimental data from the environment for a variety of species from different habitats and for different levels of geogenic arsenic in soil. This information will be useful for mushrooms consumers, nutritionists, and food regulatory agencies by describing ways to minimize arsenic content in edible mushrooms and arsenic intake from mushroom meals.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2016-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2016.1235935","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59700790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 42
Azo dyes and human health: A review 偶氮染料与人体健康研究进展
IF 2.5 4区 环境科学与生态学
Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2016-09-16 DOI: 10.1080/10590501.2016.1236602
K. Chung
{"title":"Azo dyes and human health: A review","authors":"K. Chung","doi":"10.1080/10590501.2016.1236602","DOIUrl":"https://doi.org/10.1080/10590501.2016.1236602","url":null,"abstract":"ABSTRACT Synthetic azo dyes are widely used in industries. Gerhardt Domagk discovered that the antimicrobial effect of red azo dye Prontosil was caused by the reductively cleaved (azo reduction) product sulfanilamide. The significance of azo reduction is thus revealed. Azo reduction can be accomplished by human intestinal microflora, skin microflora, environmental microorganisms, to a lesser extent by human liver azoreductase, and by nonbiological means. Some azo dyes can be carcinogenic without being cleaved into aromatic amines. However, the carcinogenicity of many azo dyes is due to their cleaved product such as benzidine. Benzidine induces various human and animal tumors. Another azo dye component, p-phenylenediamine, is a contact allergen. Many azo dyes and their reductively cleaved products as well as chemically related aromatic amines are reported to affect human health, causing allergies and other human maladies.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2016-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2016.1236602","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59700851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 547
New clues on carcinogenicity-related substructures derived from mining two large datasets of chemical compounds 从两个大的化合物数据集中获得的致癌相关亚结构的新线索
IF 2.5 4区 环境科学与生态学
Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2016-03-17 DOI: 10.1080/10590501.2016.1166879
A. Golbamaki, E. Benfenati, N. Golbamaki, A. Manganaro, Erinc Merdivan, A. Roncaglioni, G. Gini
{"title":"New clues on carcinogenicity-related substructures derived from mining two large datasets of chemical compounds","authors":"A. Golbamaki, E. Benfenati, N. Golbamaki, A. Manganaro, Erinc Merdivan, A. Roncaglioni, G. Gini","doi":"10.1080/10590501.2016.1166879","DOIUrl":"https://doi.org/10.1080/10590501.2016.1166879","url":null,"abstract":"ABSTRACT In this study, new molecular fragments associated with genotoxic and nongenotoxic carcinogens are introduced to estimate the carcinogenic potential of compounds. Two rule-based carcinogenesis models were developed with the aid of SARpy: model R (from rodents' experimental data) and model E (from human carcinogenicity data). Structural alert extraction method of SARpy uses a completely automated and unbiased manner with statistical significance. The carcinogenicity models developed in this study are collections of carcinogenic potential fragments that were extracted from two carcinogenicity databases: the ANTARES carcinogenicity dataset with information from bioassay on rats and the combination of ISSCAN and CGX datasets, which take into accounts human-based assessment. The performance of these two models was evaluated in terms of cross-validation and external validation using a 258 compound case study dataset. Combining R and H predictions and scoring a positive or negative result when both models are concordant on a prediction, increased accuracy to 72% and specificity to 79% on the external test set. The carcinogenic fragments present in the two models were compared and analyzed from the point of view of chemical class. The results of this study show that the developed rule sets will be a useful tool to identify some new structural alerts of carcinogenicity and provide effective information on the molecular structures of carcinogenic chemicals.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2016-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2016.1166879","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59700782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
The mycotoxin definition reconsidered towards fungal cyclic depsipeptides 真菌毒素的定义重新考虑到真菌环沉积肽
IF 2.5 4区 环境科学与生态学
Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2016-03-10 DOI: 10.1080/10590501.2016.1164561
L. Taevernier, E. Wynendaele, Leen De Vreese, C. Burvenich, B. de Spiegeleer
{"title":"The mycotoxin definition reconsidered towards fungal cyclic depsipeptides","authors":"L. Taevernier, E. Wynendaele, Leen De Vreese, C. Burvenich, B. de Spiegeleer","doi":"10.1080/10590501.2016.1164561","DOIUrl":"https://doi.org/10.1080/10590501.2016.1164561","url":null,"abstract":"ABSTRACT Currently, next to the major classes, cyclic depsipeptides beauvericin and enniatins are also positioned as mycotoxins. However, as there are hundreds more fungal cyclic depsipeptides already identified, should these not be considered as mycotoxins as well? The current status of the mycotoxin definition revealed a lack of consistency, leading to confusion about what compounds should be called mycotoxins. Because this is of pivotal importance in risk assessment prioritization, a clear and quantitatively expressed mycotoxin definition is proposed, based on data of widely accepted mycotoxins. Finally, this definition is applied to a set of fungal cyclic depsipeptides, revealing that some of these should indeed be considered as mycotoxins.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2016-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2016.1164561","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59700416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
To quit or not: Vulnerability of women to smoking tobacco 戒烟与否:女性吸烟的脆弱性
IF 2.5 4区 环境科学与生态学
Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2016-01-02 DOI: 10.1080/10590501.2015.1131539
Se-Jung Park, B. Yi, Ho-Sun Lee, Woo-Yeon Oh, Hyun-Kyung Na, M. Lee, Mihi Yang
{"title":"To quit or not: Vulnerability of women to smoking tobacco","authors":"Se-Jung Park, B. Yi, Ho-Sun Lee, Woo-Yeon Oh, Hyun-Kyung Na, M. Lee, Mihi Yang","doi":"10.1080/10590501.2015.1131539","DOIUrl":"https://doi.org/10.1080/10590501.2015.1131539","url":null,"abstract":"ABSTRACT Tobacco smoking is currently on the rise among women, and can pose a greater health risk. In order to understand the nature of the increase in smoking prevalence among women, we focused on the vulnerability of women to smoking behaviors—smoking cessation or tobacco addiction—and performed a systematic review of the socioeconomic and intrinsic factors as well as tobacco ingredients that affect women's susceptibility to smoking tobacco. We observed that nicotine and other tobacco components including cocoa-relatives, licorice products, and menthol aggravate tobacco addiction in women rather than in men. Various genetic and epigenetic alterations in dopamine pathway and the pharmaco-kinetics and -dynamic factors of nicotine also showed potential evidences for high susceptibility to tobacco addiction in women. Therefore, we suggest systemic approaches to prevent tobacco smoking–related health risks, considering gene–environment–gender interaction.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2016-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2015.1131539","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59700336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
7-cysteine-pyrrole conjugate: A new potential DNA reactive metabolite of pyrrolizidine alkaloids 7-半胱氨酸-吡咯偶联物:一种新的潜在的吡咯利西啶生物碱DNA反应代谢物
IF 2.5 4区 环境科学与生态学
Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2016-01-02 DOI: 10.1080/10590501.2015.1135593
Xiaobo He, Q. Xia, Liang Ma, P. Fu
{"title":"7-cysteine-pyrrole conjugate: A new potential DNA reactive metabolite of pyrrolizidine alkaloids","authors":"Xiaobo He, Q. Xia, Liang Ma, P. Fu","doi":"10.1080/10590501.2015.1135593","DOIUrl":"https://doi.org/10.1080/10590501.2015.1135593","url":null,"abstract":"ABSTRACT Pyrrolizidine alkaloids (PAs) require metabolic activation to exert cytotoxicity, genotoxicity, and tumorigenicity. We previously reported that (±)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts are responsible for PA-induced liver tumor formation in rats. In this study, we determined that metabolism of riddelliine and monocrotaline by human or rat liver microsomes produced 7-cysteine-DHP and DHP. The metabolism of 7-glutathionyl-DHP by human and rat liver microsomes also generated 7-cysteine-DHP. Further, reaction of 7-cysteine-DHP with calf thymus DNA in aqueous solution yielded the described DHP-derived DNA adducts. This study represents the first report that 7-cysteine-DHP is a new PA metabolite that can lead to DNA adduct formation.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2016-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2015.1135593","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59700401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Ed Board EOV 教育板EOV
IF 2.5 4区 环境科学与生态学
Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2014-10-02 DOI: 10.1080/10590501.2014.990744
{"title":"Ed Board EOV","authors":"","doi":"10.1080/10590501.2014.990744","DOIUrl":"https://doi.org/10.1080/10590501.2014.990744","url":null,"abstract":"","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2014-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2014.990744","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59700275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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