Occupational exposure to aflatoxins and health outcomes: a review

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2019-09-12 DOI:10.1080/10590501.2019.1664836

Ruth Nabwire Wangia, L. Tang, Jia-Sheng Wang

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引用次数: 26

Abstract

Abstract Aflatoxins [AFs] are secondary metabolites of the fungus species Aspergillus spp. Both animal and epidemiological studies provided sufficient evidence on the carcinogenic, immunotoxic, mutagenic, and genotoxic potential of AFs. While ingestion is the main route of exposure for AFs through consumption of contaminated food products, agricultural workers and personnel who handle AF-contaminated grains are also at higher risk of exposure via inhalation. The main objective of the review is to provide a comprehensive overview of past scientific studies on occupational exposure to AFs, high-risk occupations, and disease outcomes. A search of peer-reviewed articles was done on PubMed and Web of Science Databases. A total of 164 papers was identified and 61 journal articles were selected for further review. High risk occupations include animal husbandry and processing of grain cereals and/or animal feed. Primary liver cancer and respiratory cancers were the most reported as a result of occupational exposure to AFs. For future studies, improved study designs, better characterization of AFs exposure in an occupational setting, and use of biomarkers are recommended in order to promote better understanding of occupational exposure to AFs and the resulting disease burden among workers.

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黄曲霉毒素职业暴露与健康结果综述

摘要黄曲霉毒素是真菌曲霉属的次级代谢产物。动物和流行病学研究都为黄曲霉毒素的致癌、免疫毒性、致突变性和遗传毒性潜力提供了充分的证据。虽然摄入是黄曲霉毒素通过食用受污染的食品而暴露的主要途径，农业工人和处理AF污染谷物的人员也有更高的吸入暴露风险。该综述的主要目的是全面概述过去关于AF职业暴露、高风险职业和疾病结果的科学研究。在PubMed和Web of Science数据库上搜索了同行评审的文章。共鉴定了164篇论文，并选择了61篇期刊文章进行进一步审查。高风险职业包括畜牧业和谷物和/或动物饲料加工。原发性肝癌癌症和呼吸系统癌症是因职业暴露于AF而报告最多的。对于未来的研究，建议改进研究设计，更好地描述职业环境中的AF暴露，并使用生物标志物，以促进更好地了解职业暴露于AFs和由此产生的工人疾病负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.