Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis最新文献

{"title":"Assessing carcinogenic and mutagenic hazards in firefighting: a comprehensive review.","authors":"Radosław Makowski, Wioletta Rogula-Kozłowska, Andrzej Polanczyk","doi":"10.1080/26896583.2025.2530275","DOIUrl":"https://doi.org/10.1080/26896583.2025.2530275","url":null,"abstract":"<p><p>This review aims to critically assess the carcinogenic and mutagenic risks associated with firefighting, with a focus on cancer incidence, cancer mortality and other chronic health outcomes. Firefighting is widely recognized as a high-risk occupation due to repeated exposure to hazardous substances, including polycyclic aromatic hydrocarbons (PAHs) and other combustion by-products. An extensive review of empirical studies, meta-analyses, and institutional reports was conducted, considering not only direct fireground exposure but also risks arising from contaminated personal protective equipment (PPE) and indoor air pollution within fire stations. The findings establish a consistent link between firefighting and elevated risks of multiple cancers and chronic diseases. The complexity of modern -firefighting -environments, amplified by evolving materials, under--ventilated fires, and inadequate decontamination practices, further intensifies these risks. The review highlights the urgent need for advanced protective gear, standardized decontamination protocols, routine health surveillance, and policy reforms. It underscores the importance of multidisciplinary collaboration in developing effective strategies to safeguard the health of firefighters, who play a vital role in ensuring public safety.</p>","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":" ","pages":"1-30"},"PeriodicalIF":1.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential anticancer effects and toxicity of flavones luteolin and apigenin <i>in vivo</i>.","authors":"Xilin Li, Yuxi Li, Si Chen, Lei Guo, Nan Mei","doi":"10.1080/26896583.2025.2527437","DOIUrl":"https://doi.org/10.1080/26896583.2025.2527437","url":null,"abstract":"<p><p>Luteolin and apigenin, which are abundantly present in various vegetables, fruits, and herbs, have emerged as noteworthy candidates for therapeutic applications. Traditionally recognized for their anti-inflammatory and antioxidant activities, both luteolin and apigenin have recently demonstrated the ability to inhibit cancer cell growth across multiple cancer types <i>in vitro</i> and in animal models. This review provides a comprehensive summary of <i>in vivo</i> evidence supporting the anticancer effects of luteolin and apigenin, highlighting their mechanisms of action. The review encompasses studies on their effects on liver, lung, gastric, colon, breast, pancreatic, prostate, and skin cancers in animals. We also discuss the toxicity profiles of luteolin and apigenin. Despite the encouraging preclinical results, neither luteolin nor apigenin has yet been proven to be an effective agent against cancer in clinical trials. Therefore, this review also addresses the current challenges in translating the promising anticancer effects of flavones into clinical success, emphasizing the need for further research using advanced animal models and appropriate administration routes to increase the translational value of preclinical studies. This literature review aims to enhance understanding of the anticancer and toxicological effects of luteolin and apigenin, rather than serving as a risk assessment.</p>","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":" ","pages":"1-37"},"PeriodicalIF":1.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatotoxicity of usnic acid and underlying mechanisms.","authors":"Si Chen, Zhen Ren, Lei Guo","doi":"10.1080/26896583.2024.2366737","DOIUrl":"10.1080/26896583.2024.2366737","url":null,"abstract":"<p><p>Since usnic acid was first isolated in 1844 as a prominent secondary lichen metabolite, it has been used for various purposes worldwide. Usnic acid has been claimed to possess numerous therapeutic properties, including antimicrobial, anti-inflammatory, antiviral, anti-proliferative, and antipyretic activities. Approximately two decades ago, crude extracts of usnic acid or pure usnic acid were marketed in the United States as dietary supplements for aiding in weight loss as a \"fat-burner\" and gained popularity in the bodybuilding community; however, hepatotoxicity was documented for some usnic acid containing products. The US Food and Drug Administration (FDA) received numerous reports of liver toxicity associated with the use of dietary supplements containing usnic acid, leading the FDA to issue a warning letter in 2001 on a product, LipoKinetix. The FDA also sent a recommendation letter to the manufacturer of LipoKinetix, resulting in the withdrawal of LipoKinetix from the market. These events triggered investigations into the hepatotoxicity of usnic acid and its mechanisms. In 2008, we published a review article titled \"Usnic Acid and Usnea Barbata Toxicity\". This review is an updated version of our previous review article and incorporates additional data published since 2008. The purpose of this review is to provide a comprehensive summary of the understanding of the liver toxicity associated with usnic acid, with a particular focus on the current understanding of the putative mechanisms of usnic acid-related hepatotoxicity.</p>","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":" ","pages":"1-22"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced deep learning algorithms in oral cancer detection: Techniques and applications.","authors":"Dipali Wankhade, Chitra Dhawale, Mrunal Meshram","doi":"10.1080/26896583.2024.2445957","DOIUrl":"10.1080/26896583.2024.2445957","url":null,"abstract":"<p><p>As the 16^th most common cancer globally, oral cancer yearly accounts for some 355,000 new cases. This study underlines that an early diagnosis can improve the prognosis and cut down on mortality. It discloses a multifaceted approach to the detection of oral cancer, including clinical examination, biopsies, imaging techniques, and the incorporation of artificial intelligence and deep learning methods. This study is distinctive in that it provides a thorough analysis of the most recent AI-based methods for detecting oral cancer, including deep learning models and machine learning algorithms that use convolutional neural networks. By improving the precision and effectiveness of cancer cell detection, these models eventually make early diagnosis and therapy possible. This study also discusses the importance of techniques in image pre-processing and segmentation in improving image quality and feature extraction, an essential component of accurate diagnosis. These techniques have shown promising results, with classification accuracies reaching up to 97.66% in some models. Integrating the conventional methods with the cutting-edge AI technologies, this study seeks to advance early diagnosis of oral cancer, thus enhancing patient outcomes and cutting down on the burden this disease is imposing on healthcare systems.</p>","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":" ","pages":"133-158"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143016123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An integrated computational and graphical approach for evaluating the geochemistry and health risks of nitrate-contaminated water for six age groups.","authors":"Johnbosco C Egbueri, Johnson C Agbasi, Mohamed ElKashouty, Mohd Yawar Ali Khan, Sani I Abba, Nazia Khan","doi":"10.1080/26896583.2024.2436804","DOIUrl":"10.1080/26896583.2024.2436804","url":null,"abstract":"<p><p>Nitrate contamination in drinking water poses significant health risks, particularly in rapidly urbanizing areas of developing countries. This study presents an integrated computational and graphical approach to evaluate the geochemistry and health risks of nitrate-contaminated water for six age groups in Southeast, Nigeria. The research employed a detailed methodology combining water nutrient pollution index (WNPI), nitrate pollution index (NPI), water pollution index (WPI), geochemical plotting techniques, stoichiometry, and health risk computations. Water samples from several locations were analyzed for physicochemical parameters and nitrate concentrations. Results revealed predominantly acidic conditions and varying levels of nitrate contamination. Geochemical analysis indicated that silicate weathering and ion exchange processes were the primary influences on water chemistry. The WPI identified 14.29% of samples as \"extremely polluted\" (WPI > 1), while the WNPI classified 7.14% of samples as \"moderately polluted\" (WNPI > 1). However, the NPI categorized the samples as safe, indicating low nitrate inputs from anthropogenic sources. Health risk assessments indicated low-moderate risks, with the highest total hazard index of 0.839 for the 6-12 months age group; thus, higher vulnerability for infants. Oral exposure was found to be the dominant pathway, contributing over 99.90% to the total risk. This research provides crucial insights for achieving the Sustainable Development Goals (SDGs) related to water quality and public health protection. The integrated approach offers a robust framework for water resource management and interventions in risk-prone areas. Future research should focus on expanding the spatial coverage, incorporating sensitivity analyses, and exploring advanced technologies for real-time monitoring and predictive modeling of water quality.</p>","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":" ","pages":"82-115"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking the potential of AI: Machine learning and deep learning models for predicting carcinogenicity of chemicals.","authors":"Wenjing Guo, Jie Liu, Fan Dong, Huixiao Hong","doi":"10.1080/26896583.2024.2396731","DOIUrl":"10.1080/26896583.2024.2396731","url":null,"abstract":"<p><p>The escalating apprehension surrounding the carcinogenic potential of chemicals emphasizes the imperative need for efficient methods of assessing carcinogenicity. Conventional experimental approaches such as in vitro and in vivo assays, albeit effective, suffer from being costly and time-consuming. In response to this challenge, new alternative methodologies, notably machine learning and deep learning techniques, have attracted attention for their potential in developing carcinogenicity prediction models. This article reviews the progress in predicting carcinogenicity using various machine learning and deep learning algorithms. A comparative analysis on these developed models reveals that support vector machine, random forest, and ensemble learning are commonly preferred for their robustness and effectiveness in predicting chemical carcinogenicity. Conversely, models based on deep learning algorithms, such as feedforward neural network, convolutional neural network, graph convolutional neural network, capsule neural network, and hybrid neural networks, exhibit promising capabilities but are limited by the size of available carcinogenicity datasets. This review provides a comprehensive analysis of current machine learning and deep learning models for carcinogenicity prediction, underscoring the importance of high-quality and large datasets. These observations are anticipated to catalyze future advancements in developing effective and generalizable machine learning and deep learning models for predicting chemical carcinogenicity.</p>","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":" ","pages":"23-50"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transgenerational effects of bisphenol S exposure on the development of experimental asthma.","authors":"Terumi Midoro-Horiuti, Yoko Murakami, Kazuyo Kuzume, Rachel M Toler, Kangling Zhang","doi":"10.1080/26896583.2025.2507408","DOIUrl":"10.1080/26896583.2025.2507408","url":null,"abstract":"<p><p>Early exposure to bisphenol A (BPA) is associated with increased asthma prevalence. To examine the effects of the most widely used BPA substitute, bisphenol S (BPS), on the development of childhood asthma, we conducted the study using the mouse model of early exposure. To simulate the burden from the human chronic exposure, we used a short-term exposure with 10 µg/ml BPS in the drinking water of female BALB/c mice (F0) from one week before pregnancy until the weaning of F1 pups. The pups were sensitized with low doses of ovalbumin (OVA) injection on postnatal day 4 and inhalation of OVA two weeks later. Twenty-four hours after the last inhalation, allergen-specific IgE and IgG1 levels, airway inflammation, and hyperresponsiveness were assessed. Non-OVA-sensitized females were mated with non-exposed male mice for the next generation at eight weeks of age. The resulting pups were sensitized, and the asthma phenotype was examined up to F4. Pups exposed to BPS displayed an asthma phenotype in response to their sensitization. We observed enhanced asthma phenotype in the F1-F4 derived from BPS-exposed F0 females compared to those derived from non-exposed females. Maternal exposure to BPS caused the multigenerational effects on the development of experimental asthma.</p>","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":" ","pages":"228-242"},"PeriodicalIF":2.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An efficient enzymatic system for studying structure-carcinogenicity relationships: metabolism of pyrrolizidine alkaloids by human liver microsomes in the presence of calf thymus DNA, resulting in the formation of DNA adducts.","authors":"Xiaobo He, Qingsu Xia, Matthew S Bryant, Peter P Fu","doi":"10.1080/26896583.2024.2424091","DOIUrl":"10.1080/26896583.2024.2424091","url":null,"abstract":"<p><p>Pyrrolizidine alkaloids (PAs) form a family of toxic and carcinogenic phytochemicals found in plants worldwide. The metabolism of toxic PAs, both <i>in vivo</i> and <i>in vitro</i>, generates four (±)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5<i>H</i>-pyrrolizine (DHP)-derived DNA adducts, namely, DHP-dG-3, DHP-dG-4, DHP-dA-3, and DHP-dA-4, as documented in previous research. We have proposed that these DHP-DNA adducts play a pivotal role in the induction of liver tumor by PAs in rats and mice, serving as potential common biological biomarkers for PA exposure and carcinogenesis. In this study, we found that the metabolism of PAs and PA <i>N</i>-oxides by human liver microsomes, in the presence of calf thymus DNA, results in the formation of DNA adducts. This process serves as a convenient and biologically significant platform for investigating the structure-carcinogenicity relationships of PAs.</p>","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":" ","pages":"117-132"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poly- and per-fluoroalkyl substances toxicity on skeletal and cognitive well-being: a comprehensive review.","authors":"Vikas C Roy, Rajni Bala, Sakshi Mehta","doi":"10.1080/26896583.2025.2460884","DOIUrl":"10.1080/26896583.2025.2460884","url":null,"abstract":"<p><p>Poly- and per-fluoroalkyl substances (PFAS) are a large group of synthetic compounds having a wide array of use in consumer products and industries, such as fire suppressant foam, nonstick cookware, paper, water-proof textiles, surfactants, aeronautics, and cosmetics. This widespread distribution of PFAS, their capacity to accumulate in living organisms, and their harmful effects represent a rising concern for public health. A multitude of studies have presented information on exposure to PFAS and a broad spectrum of adverse health outcomes through animal models and observational studies. Here, we have reviewed various studies that are related to PFAS toxicity on bone and brain and its underlying mechanisms. PFAS have well-established toxicological effects on bone, such as reduced osteoblastic and increased osteoclastic activity, increased activation of peroxisome proliferator activated receptor-γ (PPAR-γ), and increased expression of WNT11. With respect to brain, PFAS have been linked with autism, somnolence, sleep disturbances, glioma, Alzheimer's, decreased cognition, increased expression of Glycogen Synthase β (GSK3β). Further research is required in several areas, such as age-specific toxicological effects of PFAS, impact of various other PFAS compounds beyond perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), and involvement of peroxisome proliferator-activated receptors in PFAS-induced toxicity. Regarding brain toxicity, extensive research in adults is required as there is currently a relative scarcity of studies in this age group when compared to the available research conducted on children and older individuals.</p>","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":" ","pages":"159-183"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of endocrine disruptors in cosmetics on reproductive function in males and females.","authors":"Ahmed Lasaneya, Queen Saikia, Sagarika Dutta, Jogen Candra Kalita","doi":"10.1080/26896583.2025.2498831","DOIUrl":"https://doi.org/10.1080/26896583.2025.2498831","url":null,"abstract":"<p><p>The cosmetic and personal care product (PCP) industries have bloomed in the last ten years. Many new brand names have established themselves with various lucrative advertisements, luring youths into their primary customers. Many chemicals infused into daily day-night creams or shampoo conditioners have been established as Endocrine Disrupting Chemicals (EDC). The unseen side of the coin has been flipped in this article in an attempt to relate the rising infertility issue with these products. The study aims to explore the potential adverse effects and risk assessment of the EDCs of cosmetics and personal care products, which highlights a thorough review to indicate whether chemicals such as parabens, phthalates, or UV filters are safe for reproductive physiology. EDCs may cause severe negative impacts on the reproductive systems of both males and females which include reproductive problems such as polycystic ovarian syndrome, hypospadias, cryptorchidism, ovarian cancer, endometriosis, and poor sperm quality. Despite the widespread usage and purchase of cosmetic products in the present world, little research has been conducted on the possible effects of cosmetic EDCs on health. Consequently, further in-depth research needs to be performed in this field for a better understanding of the reproductive risks caused by cosmetic EDCs.</p>","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"43 2","pages":"184-207"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144050821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}