与铅暴露的病理生理效应相关的表观遗传修饰

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2019-08-12 DOI:10.1080/10590501.2019.1640581

Madiha Khalid, M. Abdollahi

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引用次数: 30

摘要

不同发育阶段的铅暴露已经证明了剂量、持续时间、性别和组织特异性病理生理结果，这是由于表观遗传调控的改变，包括(a) DNA甲基化、(b)组蛋白修饰、(c) mirna和(d)染色质可及性。铅诱导的表观遗传调控改变导致神经毒性和神经外毒性病理生理结果。铅的神经毒性作用包括记忆和学习功能障碍、行为障碍、注意缺陷多动障碍、自闭症谱系障碍、衰老、阿尔茨海默病、牛头病和神经变性。铅的神经外毒性作用包括体重改变、代谢紊乱、心血管疾病、造血功能紊乱和生殖功能障碍。铅暴露无论是在生命早期还是在发育的任何阶段都会导致不良的病理生理结果，这种结果往往会持续一生。

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Epigenetic modifications associated with pathophysiological effects of lead exposure

Abstract Lead (Pb) exposure during different stages of development has demonstrated dose, duration, sex, and tissue-specific pathophysiological outcomes due to altered epigenetic regulation via (a) DNA methylation, (b) histone modifications, (c) miRNAs, and (d) chromatin accessibility. Pb-induced alteration of epigenetic regulation causes neurotoxic and extra-neurotoxic pathophysiological outcomes. Neurotoxic effects of Pb include dysfunction of memory and learning, behavioral disorder, attention deficit hyperactivity disorder, autism spectrum disorder, aging, Alzheimer’s disease, tauopathy, and neurodegeneration. Extra-neurotoxic effects of Pb include altered body weight, metabolic disorder, cardiovascular disorders, hematopoietic disorder, and reproductive impairment. Pb exposure either early in life or at any stage of development results in undesirable pathophysiological outcomes that tends to sustain and maintain for a lifetime.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.