Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis最新文献_第9页

Review of Ginkgo biloba-induced toxicity, from experimental studies to human case reports 综述银杏叶诱导的毒性，从实验研究到人类病例报告

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2017-01-02 DOI: 10.1080/10590501.2016.1278298

N. Mei, Xiaoqing Guo, Zhen Ren, Daisuke Kobayashi, K. Wada, Lei Guo

{"title":"Review of Ginkgo biloba-induced toxicity, from experimental studies to human case reports","authors":"N. Mei, Xiaoqing Guo, Zhen Ren, Daisuke Kobayashi, K. Wada, Lei Guo","doi":"10.1080/10590501.2016.1278298","DOIUrl":"https://doi.org/10.1080/10590501.2016.1278298","url":null,"abstract":"ABSTRACT Ginkgo biloba seeds and leaves have been used as a traditional herbal remedy for thousands of years, and its leaf extract has been consumed as a botanical dietary supplement for decades. Ginkgo biloba extract is a complex mixture with numerous components, including flavonol glycosides and terpene lactones, and is one of the most widely sold botanical dietary supplements worldwide. Concerns about potential health risks for the general population have been raised because of the widespread human exposure to Ginkgo biloba and its potential toxic and carcinogenic activities in rodents. The National Toxicology Program conducted 2-year gavage studies on one Ginkgo biloba leaf extract and concluded that there was clear evidence of carcinogenic activity of this extract in mice based on an increased incidence of hepatocellular carcinoma and hepatoblastoma. Recently, Ginkgo biloba leaf extract has been classified as a possible human carcinogen (Group 2B) by the International Agency for Research on Cancer. This review presents updated information on the toxicological effects from experimental studies both in vitro and in vivo to human case reports (caused by ginkgo seeds or leaves), and also summarizes the negative results from relatively large clinical trials.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"35 1","pages":"1 - 28"},"PeriodicalIF":2.5,"publicationDate":"2017-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2016.1278298","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43594191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 101

Immunotoxicity of mercury: Pathological and toxicological effects 汞的免疫毒性:病理和毒理学效应

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2017-01-02 DOI: 10.1080/10590501.2016.1278299

Faheem Maqbool, K. Niaz, F. Hassan, Fazlullah Khan, M. Abdollahi

引用次数: 44

A new drug design strategy: Killing drug resistant bacteria by deactivating their hypothetical genes 一种新的药物设计策略:通过使假定的基因失活来杀死耐药细菌

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2016-10-01 DOI: 10.1080/10590501.2016.1236605

T. Wong, Jimmy Kuo

引用次数: 2

Review of electronic cigarettes as tobacco cigarette substitutes: Their potential human health impact. 审查作为烟草香烟替代品的电子香烟：其对人类健康的潜在影响。

IF 1.2 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2016-10-01 DOI: 10.1080/10590501.2016.1236604

Ki-Hyun Kim, Ehsanul Kabir, Shamin Ara Jahan

{"title":"Review of electronic cigarettes as tobacco cigarette substitutes: Their potential human health impact.","authors":"Ki-Hyun Kim, Ehsanul Kabir, Shamin Ara Jahan","doi":"10.1080/10590501.2016.1236604","DOIUrl":"10.1080/10590501.2016.1236604","url":null,"abstract":"<p><p>Electronic cigarettes (ECs) are devised to deliver nicotine in a vapor rather than in smoke without tar. ECs are hence advertised as being safer than tobacco cigarette products as the chemical compounds inhaled in the former are believed to be fewer and less toxic than those of the latter. Hazardous chemicals (e.g., formaldehyde) are nonetheless found to be generated incidentally by contacting the heated wire (i.e., the oxidation of glycerol/glycol in e-liquid). Although the extent of their release varies by several variables (e.g., the type of e-liquid, puffing rate, and the battery voltage), their exposure may also contribute to negative health effects. As the use of ECs may be much safer than that of common tobacco products, the former can be used as an aid to cut down or quit the latter. However, relatively little is yet known about the health effects of the EC on a long-term basis. Moreover, the use of EC cannot be clearly substantiated for renormalizing smoking behavior by current evidence. Behavior studies of the EC consumer suggest that the sufficient data for aerosol generation and chemical analysis should be acquired to establish reliable guides for its composition and consumption. In light of the urgent demand for such guidelines, this review examines the basic aspects of EC-related pollutants and their health effects.</p>","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"34 1","pages":"262-275"},"PeriodicalIF":1.2,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59700860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mycotoxin in the food supply chain—implications for public health program 食品供应链中的霉菌毒素——对公共卫生计划的影响

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2016-10-01 DOI: 10.1080/10590501.2016.1236607

D. Milićević, I. Nastasijević, Z. Petrović

引用次数: 27

Editorial Board EOV 编辑委员会EOV

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2016-10-01 DOI: 10.1080/10590501.2016.1270019

引用次数: 0

Arsenic and its compounds in mushrooms: A review 蘑菇中砷及其化合物的研究进展

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2016-09-16 DOI: 10.1080/10590501.2016.1235935

J. Falandysz, L. Rizal

引用次数: 42

Azo dyes and human health: A review 偶氮染料与人体健康研究进展

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2016-09-16 DOI: 10.1080/10590501.2016.1236602

K. Chung

引用次数: 547

New clues on carcinogenicity-related substructures derived from mining two large datasets of chemical compounds 从两个大的化合物数据集中获得的致癌相关亚结构的新线索

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2016-03-17 DOI: 10.1080/10590501.2016.1166879

A. Golbamaki, E. Benfenati, N. Golbamaki, A. Manganaro, Erinc Merdivan, A. Roncaglioni, G. Gini

{"title":"New clues on carcinogenicity-related substructures derived from mining two large datasets of chemical compounds","authors":"A. Golbamaki, E. Benfenati, N. Golbamaki, A. Manganaro, Erinc Merdivan, A. Roncaglioni, G. Gini","doi":"10.1080/10590501.2016.1166879","DOIUrl":"https://doi.org/10.1080/10590501.2016.1166879","url":null,"abstract":"ABSTRACT In this study, new molecular fragments associated with genotoxic and nongenotoxic carcinogens are introduced to estimate the carcinogenic potential of compounds. Two rule-based carcinogenesis models were developed with the aid of SARpy: model R (from rodents' experimental data) and model E (from human carcinogenicity data). Structural alert extraction method of SARpy uses a completely automated and unbiased manner with statistical significance. The carcinogenicity models developed in this study are collections of carcinogenic potential fragments that were extracted from two carcinogenicity databases: the ANTARES carcinogenicity dataset with information from bioassay on rats and the combination of ISSCAN and CGX datasets, which take into accounts human-based assessment. The performance of these two models was evaluated in terms of cross-validation and external validation using a 258 compound case study dataset. Combining R and H predictions and scoring a positive or negative result when both models are concordant on a prediction, increased accuracy to 72% and specificity to 79% on the external test set. The carcinogenic fragments present in the two models were compared and analyzed from the point of view of chemical class. The results of this study show that the developed rule sets will be a useful tool to identify some new structural alerts of carcinogenicity and provide effective information on the molecular structures of carcinogenic chemicals.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"34 1","pages":"113 - 97"},"PeriodicalIF":2.5,"publicationDate":"2016-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2016.1166879","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"59700782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

The mycotoxin definition reconsidered towards fungal cyclic depsipeptides 真菌毒素的定义重新考虑到真菌环沉积肽

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2016-03-10 DOI: 10.1080/10590501.2016.1164561

L. Taevernier, E. Wynendaele, Leen De Vreese, C. Burvenich, B. de Spiegeleer

引用次数: 21