三氯生:抗菌机制、抗生素相互作用、临床应用和人类健康。

IF 1.2 4区 环境科学与生态学 Q4 ENVIRONMENTAL SCIENCES
Prabin Shrestha, Yongmei Zhang, Wen-Jen Chen, Tit-Yee Wong
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引用次数: 25

摘要

三氯生在工业和家庭产品中的大规模应用造成了许多健康和环境问题。尽管存在对其耐药性和其他问题的担忧,三氯生仍然是一种对抗许多传染性生物体的有效药物。了解三氯生与不同抗生素、细菌和人类的交叉相互作用可以为该药物的风险评估提供急需的信息。我们综述了目前对三氯生的抗菌机制、微生物如何对三氯生产生耐药性以及三氯生与不同抗生素的协同和拮抗作用的认识。综述了目前有关三氯生临床应用及其对胎儿/儿童发育影响的文献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Triclosan: antimicrobial mechanisms, antibiotics interactions, clinical applications, and human health.

The large-scale applications of Triclosan in industrial and household products have created many health and environmental concerns. Despite the fears of its drug-resistance and other issues, Triclosan is still an effective drug against many infectious organisms. Knowing the cross-interactions of Triclosan with different antibiotics, bacteria, and humans can provide much-needed information for the risk assessment of this drug. We review the current understanding of the antimicrobial mechanisms of Triclosan, how microbes become resistant to Triclosan, and the synergistic and antagonistic effects of Triclosan with different antibiotics. Current literature on the clinical applications of Triclosan and its effect on fetus/child development are also summarized.

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CiteScore
4.60
自引率
0.00%
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10
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