Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis最新文献_第7页

Synergistic and antagonistic interactions of triclosan with various antibiotics in bacteria. 三氯生与细菌中各种抗生素的增效和拮抗作用。

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2020-01-01 Epub Date: 2020-07-10 DOI: 10.1080/26896583.2020.1781494

Prabin Shrestha, Jie Ni, Tit-Yee Wong

{"title":"Synergistic and antagonistic interactions of triclosan with various antibiotics in bacteria.","authors":"Prabin Shrestha, Jie Ni, Tit-Yee Wong","doi":"10.1080/26896583.2020.1781494","DOIUrl":"https://doi.org/10.1080/26896583.2020.1781494","url":null,"abstract":"Triclosan (TCS), a well-studied antimicrobial compound and an environmental pollutant, is present in many household products. A systematic survey of TCS-antibiotic-bacteria interactions is lacking. We wish to understand the origin of such interactions by testing 16 phylogenetically well-characterized bacteria for their sensitivities to 6 different classes of antibiotics with or without the presence of TCS. Our results show that TCS interacts synergistically with some antibiotics against some Bacilli species. TCS could also interact antagonistically with other antibiotics against certain bacteria, including pathogens such as Pseudomonas aeruginosa and Stenotrophomonas maltophilia. Antagonism between drugs often coincided with the concomitant enhanced removal of Ethidium bromide (EtBr) from the cells. Enterococcus faecalis shows a unique response to TCS. High levels of TCS inhibits E. faecalis. Cells survive at lower TCS concentrations, and these cells can remove EtBr more readily than unexposed cells. At even lower TCS concentration, cell-growth is inhibited again, causing the culture to exhibit a unique extra inhibition zone around the TCS-disk. The TCS-antibiotic-bacteria interaction profiles of some bacteria do not follow their bacterial phylogenetic relations. This suggests that such interactions may be related to horizontal gene transfer among different bacteria.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"38 3","pages":"187-203"},"PeriodicalIF":2.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/26896583.2020.1781494","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38145284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Photo-enhanced enzyme-like activities of BiOBr/PtRu hybrid nanostructures. 光增强BiOBr/PtRu杂化纳米结构的类酶活性。

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2020-01-01 Epub Date: 2020-12-26 DOI: 10.1080/26896583.2020.1814081

Chuang Liu, Yingying Yan, Yuanyang Mao, Weiwei He

{"title":"Photo-enhanced enzyme-like activities of BiOBr/PtRu hybrid nanostructures.","authors":"Chuang Liu, Yingying Yan, Yuanyang Mao, Weiwei He","doi":"10.1080/26896583.2020.1814081","DOIUrl":"https://doi.org/10.1080/26896583.2020.1814081","url":null,"abstract":"The combination of semiconductor and metal nanocomponents represents an effective way for design of photocatalysts with high efficiency. It is expected that this strategy can be applied to design photo-regulated nanozymes. To prove this concept, BiOBr/PtRu hybrid nanostructures have been fabricated by depositing PtRu nanoparticles on BiOBr nanosheets through a templating co-reduction method. The formation of BiOBr/PtRu hybrid nanostructures was confirmed by TEM, XRD and XPS. BiOBr/PtRu hybrid nanostructures exhibited excellent enzyme-like activities (peroxidase, oxidase, ferroxidase) as well as the ability to scavenge DPPH free radicals. When exposed to light irradiation (λ > 420 nm), it was found that BiOBr/PtRu hybrid nanostructures not only exhibit improved photocatalytic degradation, but also exhibit enhanced peroxidase- and oxidase-like activity. Due to the photocatalytic effect and the higher charge separation and utilization efficiency caused by heterojunctions, a light-enhanced enzyme-like activity mechanism was proposed. These results will be of value to design high efficiency nanozymes using light for biological and environmental applications.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"38 4","pages":"299-314"},"PeriodicalIF":2.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/26896583.2020.1814081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38746003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Pulmonary toxicity is a common phenomenon of toxic pyrrolizidine alkaloids. 肺毒性是毒性吡咯利西啶类生物碱的常见现象。

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2020-01-01 Epub Date: 2020-04-27 DOI: 10.1080/26896583.2020.1743608

Zijing Song, Yisheng He, Jiang Ma, Peter P Fu, Ge Lin

{"title":"Pulmonary toxicity is a common phenomenon of toxic pyrrolizidine alkaloids.","authors":"Zijing Song, Yisheng He, Jiang Ma, Peter P Fu, Ge Lin","doi":"10.1080/26896583.2020.1743608","DOIUrl":"https://doi.org/10.1080/26896583.2020.1743608","url":null,"abstract":"The hepatotoxic pyrrolizidine alkaloids (PAs) are metabolically activated in the liver to form reactive dehydro-PAs, which generate pyrrole-protein adducts leading to hepatotoxicity. Monocrotaline, but not other PAs, is also pneumotoxic, supposedly due to the migration of the liver-generated corresponding dehydro-PA into the lung to form pyrrole-protein adducts to induce pneumotoxicity. The present study investigated whether other PAs are also pneumotoxic. Metabolic activation of four representative hepatotoxic PAs, monocrotaline, retrorsine, riddelliine and clivorine, was investigated using rat liver or lung S9 incubation. All PAs produced pyrrole-protein adducts significantly in rat liver S9 but negligible in lung S9 fraction, revealing that liver is the key organ responsible for metabolic activation generating dehydro-PAs. Furthermore, these four PAs and another two PAs present in the alkaloid extract of Gynura segetum, a widely used PA-producing herb responsible for human PA poisonings in China, were orally administered to rats using the same hepatotoxic dose of 0.2 mmol/kg. All six PAs induced pneumotoxicity in rats within 48 h. The results demonstrated that pneumotoxicity could be a common phenomenon of PAs and the liver-derived dehydro-PAs might move to the lung and form pyrrole-protein adducts, leading to pulmonary toxicity.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"38 2","pages":"124-140"},"PeriodicalIF":2.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/26896583.2020.1743608","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38015718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Triclosan: antimicrobial mechanisms, antibiotics interactions, clinical applications, and human health. 三氯生:抗菌机制、抗生素相互作用、临床应用和人类健康。

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2020-01-01 DOI: 10.1080/26896583.2020.1809286

Prabin Shrestha, Yongmei Zhang, Wen-Jen Chen, Tit-Yee Wong

引用次数: 25

Role of lead in dental diseases. 铅在牙病中的作用。

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2020-01-01 DOI: 10.1080/26896583.2020.1834313

Madiha Khalid, Mohammad Abdollahi

{"title":"Role of lead in dental diseases.","authors":"Madiha Khalid, Mohammad Abdollahi","doi":"10.1080/26896583.2020.1834313","DOIUrl":"https://doi.org/10.1080/26896583.2020.1834313","url":null,"abstract":"Lead (Pb) is ubiquitous in our environment and causes many pathophysiological health effects, including dental diseases. Dental Pb levels are considered good biological indicators of environmental and occupational Pb exposure. Pb in blood and saliva causes imbalances in the growth of oral microflora. The pH of saliva decreases, interferes with and interacts with bone-seeking elements, changes oral inflammatory parameters, generates reactive oxygen species, causes oxidative damage, and delays the mineralization process, leading to dental diseases. Pb's dental diseases include periodontitis, enamel lesions and defects, fluorosis, Burton's line, and tooth loss. Environmental and physiological factors, including age, gender, tooth type and position, pregnancy and lactation, eating and drinking habits, smoking habits, and exposures from Pb-contaminated residential and occupational areas, affect the distribution of Pb in blood, bone, and saliva, which contributes to dental diseases. However, living and working in Pb free areas can prevent environmental and occupational Pb exposure. Healthy lifestyles and eating habits, prohibiting smoking and alcohol drinking, further help prevent Pb exposure. Also, the fluoridation of water, salt, and milk provide nutritional supplements of trace elements, which can help prevent teeth from absorbing Pb from the environment, thereby reducing the risk of dental diseases.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"38 4","pages":"329-361"},"PeriodicalIF":2.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/26896583.2020.1834313","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38767138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Ecological and toxicological manifestations of microplastics: current scenario, research gaps, and possible alleviation measures. 微塑料的生态和毒理学表现:现状、研究差距和可能的缓解措施。

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2020-01-01 DOI: 10.1080/10590501.2019.1699379

Amrik Bhattacharya, S K Khare

{"title":"Ecological and toxicological manifestations of microplastics: current scenario, research gaps, and possible alleviation measures.","authors":"Amrik Bhattacharya, S K Khare","doi":"10.1080/10590501.2019.1699379","DOIUrl":"https://doi.org/10.1080/10590501.2019.1699379","url":null,"abstract":"Microplastics (MPs) and associated contaminants have become a major environmental concern. From available literature, their ubiquitous presence is now well established. However, the kind and level of toxicological impacts these MPs accomplish on various life forms are not well understood. Nevertheless, the environmental toxicity of MP is now being revealed gradually with supporting studies involving groups of lower organisms. Additionally, the presence of microplastics also disturbs the functions of ecosystem through affecting the vulnerable life forms, thus ecological manifestations of MPs also need to be analyzed. The present review encompasses an overview of toxicological effects mediated by various types of MPs present in the environment; it covers the types of toxicity they may cause and other effects on humans and other species. In this review, aquatic systems are used as primary models to describe various eco-toxicological effects of MPs. Various research gaps as well as methods to alleviate the level of MPs, and future strategies are also comprehensively highlighted in the review.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"38 1","pages":"1-20"},"PeriodicalIF":2.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/10590501.2019.1699379","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37926199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Ascorbate exacerbates iron toxicity on intestinal barrier function against Salmonella infection. 抗坏血酸加剧铁毒性对肠道屏障功能对沙门氏菌感染。

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2020-01-01 Epub Date: 2020-04-27 DOI: 10.1080/26896583.2020.1729632

Tengjiao Guo, Yisheng Yang, Jiayou Zhang, Yu Miao, Feifei Lin, Suqin Zhu, Caili Zhang, Haohao Wu

{"title":"Ascorbate exacerbates iron toxicity on intestinal barrier function against Salmonella infection.","authors":"Tengjiao Guo, Yisheng Yang, Jiayou Zhang, Yu Miao, Feifei Lin, Suqin Zhu, Caili Zhang, Haohao Wu","doi":"10.1080/26896583.2020.1729632","DOIUrl":"https://doi.org/10.1080/26896583.2020.1729632","url":null,"abstract":"Ascorbic acid is often used to enhance iron absorption in nutritional interventions, but it produces pro-oxidant effects in the presence of iron. This study aimed to evaluate ascorbate's role in iron toxicity on intestinal resistance against foodborne pathogens during iron supplementation/fortification. In polarized Caco-2 cell monolayers, compared to the iron-alone treatment, the iron-ascorbate co-treatment caused more than 2-fold increase in adhesion, invasion and translocation of Salmonella enterica serovar Typhimurium. According to 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, lactate dehydrogenase release and transepithelial electrical resistance, the iron-ascorbate co-treatment resulted in reduced cell viability and increased impairment of cell membrane and paracellular permeability compared to the iron-alone treatment. Butylated hydroxytoluene protected cells against these prooxidant toxicities of ascorbate. Ascorbate completely restored iron-induced intracellular oxidant burst and depletion of cytosolic antioxidant reserve, according to dichlorodihydrofluorescein fluorescence and intracellular reduced glutathione levels. In Salmonella-infected C57BL/6 mice, iron-ascorbate co-supplementation resulted in greater loss of body weight and appetite, lower survival rate, shorter colon length, heavier intestinal microvilli damage, and more intestinal pathogen colonization and translocation than the iron-alone supplementation. Overall, ascorbate would exacerbate iron toxicity on intestinal resistance against Salmonella infection through pro-oxidant impairment of intestinal epithelial barrier from extracellular side and/or by facilitating intestinal pathogen colonization.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"38 1","pages":"91-107"},"PeriodicalIF":2.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/26896583.2020.1729632","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37926242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Current mechanistic perspectives on male reproductive toxicity induced by heavy metals. 重金属诱发男性生殖毒性的机制研究进展。

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2020-01-01 Epub Date: 2020-07-10 DOI: 10.1080/26896583.2020.1782116

Brilliance Onyinyechi Anyanwu, Orish Ebere Orisakwe

{"title":"Current mechanistic perspectives on male reproductive toxicity induced by heavy metals.","authors":"Brilliance Onyinyechi Anyanwu, Orish Ebere Orisakwe","doi":"10.1080/26896583.2020.1782116","DOIUrl":"https://doi.org/10.1080/26896583.2020.1782116","url":null,"abstract":"Environmental and occupational exposures to heavy metals have led to various deleterious damages to the biological system of which infertility is one of them. Infertility is a global public health concern, affecting 15% of all couples of reproductive age. Out of the 100% cases of reported infertility among couples, 40% of the cases are related to male factors; including decreased semen quality. This review focuses on the recent mechanistic perspectives of heavy metal-induced male reproductive toxicity. The associated toxic metal-mediated mechanisms of male reproductive toxicity include ion mimicry, disruption of cell signaling pathways, oxidative stress, altered gene expression, epigenetic regulation of gene expression, apoptosis, disruption of testis/blood barrier, inflammation and endocrine disruption. The current literature suggests that non-coding RNAs (ncRNAs) mediate paternal intergenerational epigenetic inheritance and thus has a direct functional importance, as well as possess novel biomarker potential, for male reproductive toxicity. To identify the specific ncRNAs with the most profound impacts on heavy metal-induced male reproductive toxicity should be thrust of further research.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"38 3","pages":"204-244"},"PeriodicalIF":2.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/26896583.2020.1782116","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38139192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Understanding the interaction of estrogenic ligands with estrogen receptors: a survey of the functional and binding kinetic studies. 了解雌激素受体与雌激素配体的相互作用:功能和结合动力学研究综述。

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2020-01-01 Epub Date: 2020-05-07 DOI: 10.1080/26896583.2020.1761204

Jingwei Jin, Panpan Wu, Xinyue Zhang, Dongli Li, Wing-Leung Wong, Yu-Jing Lu, Ning Sun, Kun Zhang

{"title":"Understanding the interaction of estrogenic ligands with estrogen receptors: a survey of the functional and binding kinetic studies.","authors":"Jingwei Jin, Panpan Wu, Xinyue Zhang, Dongli Li, Wing-Leung Wong, Yu-Jing Lu, Ning Sun, Kun Zhang","doi":"10.1080/26896583.2020.1761204","DOIUrl":"https://doi.org/10.1080/26896583.2020.1761204","url":null,"abstract":"The investigation of estrogen actions and their interaction characteristics with estrogen receptors (ERs) to induce unique functional features inside cells have allowed us to understand better the regulation of many vital physiological and cellular processes in humans. The biological effects of estrogenic ligands or compounds are mediated via estrogen receptors that act as the ligand-activated transcription factors. Therefore, the study on ligand-ER interaction properties and mechanism of ligand-ER complexes binding to specific estrogen response elements located in the promoters of target genes are very critical to realize the complicated biological process regulated by the endogenous estrogens. Several reviews have provided comprehensive and updated information on the influence of estrogen receptors in health and disease. However, the mechanism of estrogen-ERs binding and affinity aspects at molecular level is relatively under-investigated. This review thus aims to shed light on the significance of the binding kinetics of ligand-ER interactions because the information provide great assistance to define how a ligand or a drug can communicate with physiology to produce a desired therapeutic response. In addition, the most frequently used methodologies for the binding kinetic study are highlighted over the last decade.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"38 2","pages":"142-168"},"PeriodicalIF":2.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/26896583.2020.1761204","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38015717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Antibody-based detection of lysine modification of hepatic protein in mice treated with retrorsine. 逆转录酶处理小鼠肝蛋白赖氨酸修饰的抗体检测。

IF 2.5 4区环境科学与生态学

Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis Pub Date : 2020-01-01 DOI: 10.1080/26896583.2020.1832411

Ting Cheng, Weiwei Li, Xiaojing Yang, Huali Wang, Fan Zhang, Na Li, Ge Lin, Jiang Zheng

{"title":"Antibody-based detection of lysine modification of hepatic protein in mice treated with retrorsine.","authors":"Ting Cheng, Weiwei Li, Xiaojing Yang, Huali Wang, Fan Zhang, Na Li, Ge Lin, Jiang Zheng","doi":"10.1080/26896583.2020.1832411","DOIUrl":"https://doi.org/10.1080/26896583.2020.1832411","url":null,"abstract":"Many pyrrolizidine alkaloids (PAs), an important class of natural products, are hepatotoxic and carcinogenic. Increased attention has been paid to PA poisoning cases worldwide. Generally, most PAs themselves are not toxic. However, reactive intermediates formed from PAs by metabolic oxidation have been linked to toxicity and carcinogenesis. PAs themselves are generally not toxic, and their reactive metabolites resulting from metabolic oxidation are considered to be an essential responsible for PA toxicities. Protein modification by the electrophilic metabolites is proposed to play a key role in PA-induced cytotoxicity. The present study investigated the interaction of lysine residues of proteins with reactive metabolites of toxic PAs. Antibodies selectively recognizing lysine-based protein adduction were prepared and characterized. ELISA and immunoblot methods, in the presence and absence of synthetic model PA adducts, were used to test specific binding of the antibodies to modified lysine residues of BSA and to hepatic proteins extracted from mice treated with retrorsine. The lysine residue adduction was also detected in the tissues of retrorsine-treated mice by use of an immunohistochemical approach. In conclusion, the prepared antibodies selectively recognized the lysine adducts and may be used for the investigation of mechanisms of toxic action of PAs.","PeriodicalId":53200,"journal":{"name":"Journal of Environmental Science and Health Part C-Toxicology and Carcinogenesis","volume":"38 4","pages":"315-328"},"PeriodicalIF":2.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/26896583.2020.1832411","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38767140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0