Chronic Stress最新文献

{"title":"Evaluating the Effectiveness of a Creative Arts and Philosophical Inquiry Intervention Rooted in Self-Determination Theory to Promote Adaptive Coping with Eco-Anxiety among Elementary School Children: A Pilot Randomized Cluster Trial.","authors":"Terra Léger-Goodes, Catherine M Herba, Jonathan Smith, David Lefrançois, Marc-André Éthier, Jasmine Piché, Catherine Malboeuf-Hurtubise","doi":"10.1177/24705470261442334","DOIUrl":"https://doi.org/10.1177/24705470261442334","url":null,"abstract":"<p><strong>Background: </strong>Children's exposure to climate change information through educational and media channels can lead to experiencing eco-anxiety. When children use maladaptive coping strategies such as avoidance and de-emphasizing the seriousness of the threat, their anxiety and distress levels increase significantly. Research indicates that creative arts and existential psychology interventions grounded in self-determination theory may promote healthier coping mechanisms like creating meaning.</p><p><strong>Methods: </strong>This randomized cluster pilot study examined whether a creative arts and philosophical inquiry intervention could foster adaptive coping strategies in elementary school children. Eighty-seven students across four classrooms participated. The experimental group (<i>n</i> = 46) received a seven-week intervention addressing eco-anxiety themes, while control groups (<i>n</i> = 41) remained on a waiting list. Pre- and post-intervention questionnaires assessed climate change coping strategies, eco-anxiety dimensions, and self-determination.</p><p><strong>Results: </strong>Results showed significant decreases in overall eco-anxiety, affective eco-anxiety, and rumination eco-anxiety scores from pre- to post-intervention, regardless of group assignment. No significant interaction effects emerged between the intervention and time on any of the measured variables, indicating the intervention did not produce differential outcomes compared to the control condition.<b>Implications:</b> Results suggest that discussing climate change in the classroom through artistic creation and philosophical inquiry did not promote adaptive coping nor impact eco-anxiety. The observed reductions in eco-anxiety across both groups could reflect external factors or contamination effects rather than intervention effectiveness. Future research should employ longitudinal designs with larger, more diverse samples and incorporate more sensitive measurement tools, shorter questionnaires, and child-appropriate assessments to better understand intervention impacts on children's climate-related mental health.</p>","PeriodicalId":52315,"journal":{"name":"Chronic Stress","volume":"10 ","pages":"24705470261442334"},"PeriodicalIF":0.0,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147788786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coping with Climate Change: Correlates of Adaptive and Maladaptive Coping in Young People.","authors":"Tara J Crandon, James G Scott, Fiona J Charlson, Hannah J Thomas","doi":"10.1177/24705470261437486","DOIUrl":"10.1177/24705470261437486","url":null,"abstract":"<p><strong>Background: </strong>Climate anxiety is a rational response to climate change that can impact wellbeing, particularly for young people. As the climate crisis unfolds, promoting psychological resilience and adaptive coping will help young people to maintain health and wellbeing long-term. This study examined the correlates of adaptive and maladaptive forms of coping in young people.</p><p><strong>Methods: </strong>A sample of Australian young people aged 12-25 years (<i>N</i> = 741, M_age = 18.5 years) were recruited via social media and panel sampling. Young people completed an online questionnaire comprised of the Climate Coping Scale (CCS), comprising Adaptive Coping (meaning-focused coping, emotion-focused coping, and problem-focused coping) and the Maladaptive Coping (impaired regulation, distancing and de-emphasising). Hypothesised correlates (ie, affective symptoms of climate distress, agency, pro-environmental behaviour, efficacy beliefs, autonomy, and perceived social support) were also measured.</p><p><strong>Results: </strong>Young people who experienced affective symptoms of climate distress were more likely to engage in adaptive styles of coping (meaning-focused, emotion-focused, and problem-focused coping; β = .37, .37, .64, respectively), and were less likely to employ maladaptive coping styles (de-emphasise or distance themselves from climate change; β = -.24, -.45, respectively), or experience impaired regulation (β = -.77). Pro-environmental behaviour was associated with greater use of adaptive coping styles (meaning-focused, emotion-focused, and problem-focused coping; β = .15, .16, .25, respectively), but also greater de-emphasising the threats of climate change (β = .11). Those who felt more socially supported were more likely to use meaning-focused and emotion-focused coping (β = .10, .14, respectively). Efficacy beliefs, agency and autonomy were related to coping in diverse ways.</p><p><strong>Conclusion: </strong>Affective symptoms of climate distress are related to more helpful forms of coping and less maladaptive coping. Rather than focus on reducing affective symptoms, it may be best to validate emotional experiences and support individuals to engage in adaptive coping. Interventions that focus on increasing agency and autonomy should be delivered with care, by taking into account a young person's coping skills and resources. Overall, these findings provide evidence on what can support adaptive coping and psychological resilience in the face of climate change.</p>","PeriodicalId":52315,"journal":{"name":"Chronic Stress","volume":"10 ","pages":"24705470261437486"},"PeriodicalIF":0.0,"publicationDate":"2026-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13033858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Stress Accumulates: Interacting Effects of Childhood Adversity, Multidimensional Victimization, and Protective Resources on Adolescent Suicidal Behaviors.","authors":"Omowunmi Iyanda, Ayodeji E Iyanda","doi":"10.1177/24705470261437060","DOIUrl":"10.1177/24705470261437060","url":null,"abstract":"<p><strong>Background: </strong>Adolescent suicide is a leading cause of death globally and remains a major public health concern in the United States. Chronic stress perspectives suggest that suicidal behaviors emerge from cumulative and interacting stress exposures that become biologically and psychologically embedded across development. This study applies an integrated chronic stress framework to examine how adverse childhood experiences (ACEs), victimization, and protective relational resources jointly shape suicide-related behaviors among U.S. high school students.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis of the 2023 combined National Youth Risk Behavior Surveillance System dataset (N = 254,675). National-level proportional outcomes included serious suicidal ideation, suicide planning, suicide attempts, and medically treated suicide attempts. Standardized composite indices were constructed for ACEs, victimization, and protective resources (school connectedness and parental monitoring). Fractional logistic regression models estimated average marginal effects (AMEs), adjusting for persistent sadness/hopelessness, poor mental health, sleep duration, unstable housing, and demographic characteristics. Interaction terms tested cumulative and conditional stress processes.</p><p><strong>Results: </strong>Higher ACE and victimization indices were independently associated with greater prevalence of all suicide-related outcomes. A one-unit increase in the ACE index was associated with increased ideation (AME = 0.0534, 95%CI [0.0411, 0.0656]) and attempts (AME = 0.0240, 95%CI [0.0148, 0.0332]). Victimization demonstrated comparable or stronger associations, particularly for planning (AME = 0.0723, 95% CI [0.0605, 0.0841]) and attempts (AME = 0.0571, 95%CI [0.0472, 0.0670]). Protective resources were inversely associated with planning (AME = -0.0130, 95%CI [-0.0192, -0.0067]) and attempts (AME = -0.0110, 95%CI [-0.0159, -0.0060]). Interaction analyses revealed diminishing marginal effects at higher combined levels of ACEs and victimization (eg, ACE × victimization for ideation AME = -0.0395, 95% CI [-0.0567, -0.0223]), indicating nonlinear accumulation of stress burden. A significant three-way interaction for ideation (AME = 0.0193, 95%CI [0.0045, 0.0342]) suggested conditional buffering by protective resources. Persistent sadness/hopelessness remained the strongest correlate across outcomes.</p><p><strong>Conclusions: </strong>Adolescent suicidality reflects cumulative and interacting stress processes rather than isolated risk factors. Early adversity establishes foundational stress load, ongoing victimization compounds risk, and protective relational assets provide partial-but not complete-buffering. These findings support multilevel prevention strategies that reduce chronic stress exposure while strengthening relational protection across developmental contexts.</p>","PeriodicalId":52315,"journal":{"name":"Chronic Stress","volume":"10 ","pages":"24705470261437060"},"PeriodicalIF":0.0,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13018685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intersecting Impacts of Family Income and Minority Status on Depression and Suicidal Behaviors Among Young Adults.","authors":"Ayodeji Iyanda, Ijeoma Ruth Chukwuemeka, Omowunmi Iyanda, Ihuoma Remita Uchenna, Opeyemi Omotunde Adebisi, Temitope Joshua Adeusi, Temilola Salami","doi":"10.1177/24705470261437485","DOIUrl":"10.1177/24705470261437485","url":null,"abstract":"<p><strong>Background: </strong>Depression and suicidal behaviors among young adults have emerged as pressing public health concerns in the United States. This study examined the prevalence and predictors of depression and suicidal behaviors among U.S. young adults, focusing on the intersecting roles of family structure, economic status, and minority status. Guided by intersectionality, minority stress, and family stress frameworks, the research addressed how structural disadvantages and social marginalization contribute to mental health disparities in the study population.</p><p><strong>Methods: </strong>This cross-sectional study used data from the Spatial Social Network and Environmental Exposure (SSNE) Project containing sample of 2446 young adults aged 18-29 years. Chi-square test examined group differences by family income and minority status, while logistic regression models identified predictors of depression, suicidal ideation and suicidal behaviors, controlling for demographic and social factors.</p><p><strong>Results: </strong>Overall, 60.3% of participants reported depressive symptoms, while 50.6% endorsed passive suicidal thoughts, 41.8% reported active suicidal ideation, and 16.6% indicated preparatory suicidal behaviors. Young adults from single-parent, lower-income households showed the highest levels of depression (70.8%) and suicidality, with elevated odds persisting even among single-parent households in mid-upper income categories. Minority participants (racial and LGBTQ+) exhibited substantially higher rates of depression (74.8%) and active suicidal ideation (57.8%) compared with non-minority group. Younger adults (18-24 years) demonstrated increased vulnerability to depression and suicidality, whereas higher parental education and stronger peer support served as protective factors.</p><p><strong>Conclusion: </strong>Findings highlight the compounded influence of family structure, socioeconomic status, and minority stress on young adult mental health. Policies and interventions that address family dynamics, economic inequality, and social inclusion are critical for reducing depression and suicidality in vulnerable populations.</p>","PeriodicalId":52315,"journal":{"name":"Chronic Stress","volume":"10 ","pages":"24705470261437485"},"PeriodicalIF":0.0,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13018690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Self-Efficacy as the Key Mechanism in Student Help-Seeking: A Commentary on Patricio et al (2025)\".","authors":"","doi":"10.1177/24705470261432026","DOIUrl":"10.1177/24705470261432026","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1177/24705470261416642.].</p>","PeriodicalId":52315,"journal":{"name":"Chronic Stress","volume":"10 ","pages":"24705470261432026"},"PeriodicalIF":0.0,"publicationDate":"2026-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Employment, Relationship, and Parenting Stress Among Post-9/11 Veterans: Life Before and After the COVID-19 Pandemic.","authors":"Kimberly J McCarthy, Keith R Aronson, Mary M Mitchell, Daniel F Perkins","doi":"10.1177/24705470261432617","DOIUrl":"10.1177/24705470261432617","url":null,"abstract":"<p><p>The COVID-19 pandemic took a heavy toll on the mental and physical health of U.S. citizens, particularly among females. This study used a large sample of post-9/11 veterans to examine how their psychological stress levels and satisfaction with certain aspects of life changed prior to and then after the COVID-19 pandemic. Life domains included employment, social, relationships, and parenting. Data examined were collected from a large sample of post-9/11 veterans approximately four years after leaving the military (pre-COVID-19; n = 5258) and six years after separation (post-COVID-19; n = 3180). Data on the relationship and parenting domains were gathered from post-9/11 veterans living with a partner or married or cohabitating (n = 4714), while data on parenting was collected from those who had children aged 18 or younger (<i>n</i> = 3835). In general, female post-9/11 veterans reported significantly higher levels of stress both before and after COVID-19 and lower levels of life satisfaction relative to their male veteran peers. Female veterans also evidenced steeper increases in stress and declines in satisfaction from pre-to-post-COVID-19. Work, child-rearing, and household management demands of the COVID-19 pandemic disproportionately affected female veterans. As a result, the gender-specific vulnerabilities found in this study were not surprising. To bolster the well-being of female veterans who may face future life shocks, such as a pandemic, targeted support such as respite care and female veteran support groups should be available.</p>","PeriodicalId":52315,"journal":{"name":"Chronic Stress","volume":"10 ","pages":"24705470261432617"},"PeriodicalIF":0.0,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12988269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147464210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of War-Related Stress and Resilience among Palestinian Nursing Students Experiencing Chronic War Exposure.","authors":"Rabia H Haddad, Ahmad M Al-Bashaireh, Razan Haddad, Ashraf J Abuejheisheh","doi":"10.1177/24705470261434080","DOIUrl":"10.1177/24705470261434080","url":null,"abstract":"<p><strong>Background: </strong>Nursing students who are currently enrolled in colleges and live in conflict-torn regions have faced unique and sustained experiences of psychological distress related to both the demands of their studies and their long history of living under constant war-related pressure. Palestinian nursing students face challenges to their resilience from long-term armed conflict, continuous military escalations, ongoing states of military occupation and warfare, ongoing trauma, and continuing uncertainty.</p><p><strong>Objectives: </strong>This study aimed to identify predictors of war-related stress and resilience among Palestinian nursing students who were exposed to war on a long-term basis.</p><p><strong>Method: </strong>This study used a descriptive, cross-sectional design to collect data from 650 nursing students attending Al-Quds University from March to May 2025. A structured questionnaire was used to collect sociodemographic and academic characteristics, to assess the level of war-related stress and levels of resilience. The war-related stress scale and the resilience inventory were used to assess war-related stress and the level of resilience among students. Multiple linear regression was used to analyze predictions of war-related stress and resilience.</p><p><strong>Results: </strong>The mean score for war-related stress was 3.30 ± 1.36. Almost half of students reported moderate to high levels of stress. The mean resilience score was 4.33 ± 2.98, and the majority possessed normal levels of resilience. The relationship between older age, enrollment in upgrading courses, greater academic success, and low-income stress from war is significant. Students who are married also reported significantly less stress than unmarried students. Female students and students with low and high incomes are less resilient than other students; first-year nursing students are less resilient than fourth-year nursing students. The regression analyses accounted for 11.9% of the variance in war-related stress and 6.9% of the variance in resilience.</p><p><strong>Conclusion: </strong>Palestinian nursing students experience high levels of psychological stress from the continuous long-term conflict in which they live, and resilience is influenced by sociodemographic and academic characteristics. Therefore, there is an urgent need for gender-sensitive, academic, focused resilience building and mental health supports in nursing education programs for students affected by the conflict.</p>","PeriodicalId":52315,"journal":{"name":"Chronic Stress","volume":"10 ","pages":"24705470261434080"},"PeriodicalIF":0.0,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12988265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147464199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-traumatic Stress Disorder and Resilience in Medical Students: A Multicenter Study from 13 Latin American Countries.","authors":"Mario J Valladares-Garrido, J Pierre Zila-Velasque, Ludwing A Zeta Solis, David Astudillo Rueda, Renzo Acosta-Porzoliz, C Ichiro Peralta Chiguala, Fatima Jiménez-Mozo, Christopher G Valdiviezo-Morales, E Sebastian Benavides Alburqueque, Estrella Christabel Porras Núñez, Helena Dominguez-Troncos, Víctor J Vera-Ponce, Danai Valladares-Garrido, César J Pereira-Victorio, Carlos Culquichicón, Oriana Rivera-Lozada, Cristian Diaz-Velez","doi":"10.1177/24705470261430113","DOIUrl":"10.1177/24705470261430113","url":null,"abstract":"<p><strong>Background: </strong>Despite efforts in the literature to address posttraumatic stress disorder (PTSD) linked to COVID-19, there is a knowledge gap in understanding the specific role of resilience as a potential mitigator in this scenario, particularly in the setting of future medical professionals.</p><p><strong>Methods: </strong>We conducted a cross-sectional, multicenter study among medical students from 13 Latin American countries between June and September 2020, using a non-probabilistic convenience sampling strategy. PTSD symptoms, resilience, sleep quality, insomnia, burnout syndrome, physical activity, and socioeducational variables were assessed using validated instruments. Associations between PTSD and resilience, as well as other covariates, were evaluated using generalized linear models with Poisson distribution and robust variance, reporting prevalence ratios (PR) and 95% confidence intervals (95% CI). A total of 2019 medical students were included in the analysis.</p><p><strong>Results: </strong>The prevalence of PTSD was 12.3% (95%CI: 10.88-13.79) and 37.5% had high resilience (95%CI: 35.38-39.65). Students with high levels of resilience had a 37% lower prevalence of PTSD compared with students with low resilience (PR: 0.63).</p><p><strong>Conclusions: </strong>Higher levels of resilience were associated with a lower prevalence of PTSD symptoms among medical students. These findings underscore the substantial psychological impact of the COVID-19 pandemic on this population and support the implementation of institutional resilience-building and mental health support strategies, integrated into medical education, as a preventive approach to mitigate the mental health consequences of future epidemics and health-related disasters.</p>","PeriodicalId":52315,"journal":{"name":"Chronic Stress","volume":"10 ","pages":"24705470261430113"},"PeriodicalIF":0.0,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13009770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147516680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiome and Vocalization Biomarkers of Infant Distress, Maternal Depression and Parenting Styles.","authors":"Anna Ligezka, Brian A Lynch, Maria Saliba, Martha P Corral-Frias, Stephen Johnson, Jun Chen, Summer V Allen, Jennifer M Frank, Jennifer L Vande Voort, Paul E Croarkin, Magdalena Romanowicz","doi":"10.1177/24705470261425120","DOIUrl":"https://doi.org/10.1177/24705470261425120","url":null,"abstract":"<p><strong>Introduction: </strong>Psychiatric disorders have their genesis in early life. Standard screening approaches during well child visits for pathological infant distress, maternal depression, and dysfunctional parenting behaviors are likely inadequate. Microbiome measures and infant vocalizations have promise as scalable psychiatric biomarkers for infants. The purpose of this study was to examine associations among infant gut colonization based on microbiome measurements with maternal distress and maternal depressive symptoms in a sample of infants.</p><p><strong>Methods: </strong>This study sought to examine infant microbiome correlates of infant distress, parent-infant interactions, maternal distress, and maternal depressive symptoms. We collected (<i>N</i> = 31) microbiome samples, infant vocalizations during vaccination, and behavioral measures during a 4 month well child visit (WCV) and did a battery of clinical assessments to assess for maternal depression, parent-child interactions, family characteristics and family stress. Whole-genome SHOTGUN sequencing was utilized to identify three types of associations: alpha-diversity using Shannon and Inverse-Simpson indexes, beta-diversity using Bray-Curtis and Jaccard distances, and differential abundance using LinDA. Spectral measures of infant cries were also modeled to assess potential relationships with clinical assessments and the microbiome.</p><p><strong>Results: </strong>There were 19 phyla, 417 genera, and 1246 species identified with taxonomic classification. Maternal distress as measured by PHQ-9 scores obtained when infants were 2 months old were associated with 4 bacterial species (<i>Actinomyces johnsonii, Bilophila wadsworthia, Clostridium dakarense</i> and <i>Ruminococcus flavefaciens</i>; FDR < 0.1) and beta-diversity (<i>p</i> = 0.006-BC; <i>p</i> = 0.005-Jaccard). Infant cries with greater high frequency band power (<i>p</i> < 0.03) and a greater high-to-mid frequency ratio-metrics (<i>p</i> < 0.05) were associated with altered α-diversity of the microbiome. No correlations were present between maternal PHQ-9 at 4 months, PSI-IV and microbiome diversity.</p><p><strong>Conclusion: </strong>The present findings suggest that an infant stress (assessed by quality of crying) is associated with lower microbiome diversity. Decreased diversity reflects an unhealthy microbiome. Parental depressive symptoms may also influence infant microbiome. Future interventional studies focused on the quality of the infant-caregiver relationship should examine related changes in intestinal microbiota.</p>","PeriodicalId":52315,"journal":{"name":"Chronic Stress","volume":"10 ","pages":"24705470261425120"},"PeriodicalIF":0.0,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12954002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reelin, the HPA Axis, and Chronic Stress: Implications for the Neurobiology of Depression.","authors":"Sophie A Thom, Ciara S Halvorson, Brady S Reive, Carla L Sànchez-Lafuente, Lisa E Kalynchuk, Hector J Caruncho","doi":"10.1177/24705470261427267","DOIUrl":"https://doi.org/10.1177/24705470261427267","url":null,"abstract":"<p><p>Stress and associated dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is central to major depression etiology, as HPA axis hyperactivity and hypercortisolism are common occurrences in individuals with depression. Reelin, an extracellular matrix glycoprotein that plays numerous roles in brain development and function, is downregulated in several neuropsychiatric disorders. Reelin and its receptors are present throughout the HPA axis, and research has found that reelin levels are decreased in animal models of chronic stress in the hypothalamus. There may therefore be roles for reelin in regulating aspects of healthy HPA axis function and for reelin supplementation in restoring various facets of HPA axis function in chronic stress conditions, particularly those associated with HPA axis inhibition and stimulation. This review aims to summarize proposed roles for reelin in HPA axis activity, with a focus on the direct and indirect roles of reelin in restoring HPA axis homeostasis in chronic stress and depression. This review will explore possible interactions between reelin and the HPA axis in chronic stress conditions in order to expand our understanding of the mechanisms underlying the neurobiology of depression.</p>","PeriodicalId":52315,"journal":{"name":"Chronic Stress","volume":"10 ","pages":"24705470261427267"},"PeriodicalIF":0.0,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12932893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147312403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}