Chronic Stress最新文献

{"title":"Disrupting the Climate Distress Cascade: Testing Community-Grounded Theories of Change Using Secondary Data From a Cross-Sectional Canadian Study.","authors":"Aayush Sharma, Tim K Takaro, Carmen H Logie, Maliha Ibrahim, Kiffer G Card","doi":"10.1177/24705470261472655","DOIUrl":"10.1177/24705470261472655","url":null,"abstract":"<p><strong>Background: </strong>Climate change is increasingly recognized as a source of significant psychological distress. How can we best minimize its mental health impacts? This study examines community-grounded theories of change by modelling how cognitive, emotional, and social processes shape climate-related psychological distress and adaptation.</p><p><strong>Methods: </strong>This cross-sectional study surveyed Canadian adults, measuring climate change perceptions (reality, causes, consequences, and psychological distance), climate worry, psychological distress, climate change anxiety, resilience, social support, belonging, and pro-environmental behaviour. Structural equation modelling (SEM) was used to test three theoretically informed models: (1) a cascade from climate perceptions to distress via worry and impairment, (2) a social-ecological model of support, resilience, and belonging, and action and (3) a combined model integrating cognitive, emotional, and social pathways.</p><p><strong>Results: </strong>Of 840 participants, 665 completed the survey. The mean sample age was 45·3 years (SD = 18·17). 70·3% identified as women, 18·3% as men, and 11·4% as gender diverse. Model 1 and Model 2 showed excellent fit. Model 3, which had a strong fit, showed that greater climate change perceptions predicted higher climate worry (β = 0·46, p <0·001), which led to greater impairment (β = 0·91, p <0·001), which led to distress (β = 0·32, p <0·001). Greater climate change perceptions had a buffering effect on impairment (β = -0·21, p < 0·001) and predicted distress (β = 0·55, p < 0·001). Stronger social networks predicted increased belonging (β = 0·85, p <0·001) and resilience (β = 0·61, p <0·001), each of which buffered psychological distress (resilience: β = -0·29, p <0·001; belonging: β = -0·06, p = 0·028). Resilience was a buffer against climate change perceptions (β = -0·43, p <0·001) and climate change worry (β = -0·28, p <0·001). Pro-environmental action predicted stronger climate change perceptions and climate worry (perceptions: β = 0·38, p <0·001; worry: β = 0·33, p <0·001).</p><p><strong>Conclusion: </strong>These findings support the value of community-based and psychologically informed approaches for minimizing climate-related psychological distress. Interventions that prioritize social support and emotional skills, together with accurate climate communication, may be critical for fostering mental health and collective resilience in a changing climate.</p>","PeriodicalId":52315,"journal":{"name":"Chronic Stress","volume":"10 ","pages":"24705470261472655"},"PeriodicalIF":0.0,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148867967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Clinically Significant Childhood Trauma and Dissociative Symptoms in a Multicenter Sample of Italian Psychiatric Outpatients.","authors":"Costanzo Frau, Roberta Spiga","doi":"10.1177/24705470261478704","DOIUrl":"https://doi.org/10.1177/24705470261478704","url":null,"abstract":"<p><strong>Background: </strong>Childhood trauma is highly prevalent among psychiatric populations and represents a major risk factor for a wide range of mental disorders. Exposure to childhood maltreatment has also been consistently associated with dissociative symptomatology, yet epidemiological data from Italian psychiatric outpatient populations remain limited. This study examined the prevalence of clinically significant childhood trauma and its association with dissociative symptoms in a multicentre sample of Italian psychiatric outpatients.</p><p><strong>Methods: </strong>This cross-sectional study included 104 psychiatric outpatients recruited from Community Mental Health Centres across Sardinia. Participants completed the Childhood Trauma Questionnaire-Short Form (CTQ-SF) and the Dissociative Experiences Scale-II (DES-II). Participants scoring at or above the moderate threshold on at least one CTQ-SF subscale were classified as trauma-exposed. Descriptive analyses examined the prevalence of clinically significant childhood trauma exposure, and group comparisons were conducted to evaluate differences in dissociative symptoms.</p><p><strong>Results: </strong>Clinically significant childhood trauma exposure was reported by 76.9% of participants. Trauma-exposed participants reported significantly higher levels of dissociative symptoms than non-trauma-exposed participants (M = 24.3 vs. 16.1). An independent-samples t-test indicated a significant group difference, t(102) = 1.99, p = .049, with a moderate effect size (d = 0.46).</p><p><strong>Conclusions: </strong>Childhood trauma and dissociative symptoms appear highly prevalent among individuals receiving care in community mental health services. These findings support the clinical relevance of routinely assessing both trauma exposure and dissociative symptomatology and highlight the potential value of trauma-informed approaches within public mental health settings.</p>","PeriodicalId":52315,"journal":{"name":"Chronic Stress","volume":"10 ","pages":"24705470261478704"},"PeriodicalIF":0.0,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13487069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Hair Cortisol Levels Is Associated With Coronary Artery Calcification in Middle-Aged Women but Not in Men.","authors":"Fredrik Iredahl, Elvar Theodorsson, Tomas Faresjö, Michael P Jones, Andrea Lebena, Per Dahlqvist, Åshild Faresjö","doi":"10.1177/24705470261476161","DOIUrl":"10.1177/24705470261476161","url":null,"abstract":"<p><strong>Background: </strong>Chronic stress exposure has been linked to cardiovascular risk factors and cardiovascular diseases, but not to coronary artery calcification (CAC). Hair cortisol concentrations is a potential biomarker of chronic stress. Atherosclerosis is the predominant cardiovascular disease and the leading cause of death in developed countries. Coronary artery calcification is a sign of atherosclerosis in the coronary arteries and predicts coronary heart disease. Most men and women are to some degree affected by coronary artery calcification at the age of 65.</p><p><strong>Objectives: </strong>To analyse if increased hair cortisol levels are associated with CAC in a middle-aged population with special focus on women. Further, to analyse the relative importance of HCC for CACs in relation to established cardiovascular risk factors.</p><p><strong>Methods: </strong>Hair samples, cardiac computed tomography data, health questionnaires, and anthropometric measures were collected in 4821 men and women aged 50-65 years, from the Swedish Cardio Pulmonary bioImage Study. A competitive radioimmunoassay was used to analyze cortisol levels in extracts of hair. Correlation, descriptive, regression and path analyses were applied.</p><p><strong>Results: </strong>A significant association between high HCC and high CAC score was found among women (p=0.007), but not among men. HCC was significantly directly associated with a higher CAC score among women, as were the other classical cardiovascular risk factors.</p><p><strong>Conclusion: </strong>The amount of calcified plaque (CAC score) in the coronary arteries of women was significantly associated with higher cortisol levels in hair, while this association was not observed in men.</p>","PeriodicalId":52315,"journal":{"name":"Chronic Stress","volume":"10 ","pages":"24705470261476161"},"PeriodicalIF":0.0,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13462509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148723542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anger as a Bridge: Understanding How Climate Change Anxiety Shapes Well-Being.","authors":"Mariana Pinho, Enrickson Varsori","doi":"10.1177/24705470261468139","DOIUrl":"10.1177/24705470261468139","url":null,"abstract":"<p><strong>Background: </strong>Climate change anxiety is increasingly recognized as a mental health concern, with emerging evidence linking it to poorer well-being and highlighting the need to clarify its cognitive-emotional and functional dimensions.</p><p><strong>Methods: </strong>The current research explored the relationship between climate anxiety and mental health outcomes, using a large nationally representative sample.</p><p><strong>Results: </strong>The results revealed that climate change anxiety was positively related to negative affect and anger. Climate anxiety cognitive impairment was positively related to positive affect and life satisfaction. However, climate anxiety functional impairment showed a different pattern, being negatively associated with life satisfaction at the bivariate level but no longer remaining a significant predictor once generalized anxiety state and trait were included in the model. Climate change anxiety showed moderate positive correlations with generalized anxiety, both state and trait. Finally, in exploratory cross-sectional mediation models, anger statistically accounted for part of the association between climate change anxiety and both negative affect and life satisfaction, but not positive affect.</p><p><strong>Conclusion: </strong>This study contributes to a more nuanced understanding of the psychological processes involved in climate anxiety and its relation with subjective well-being.</p>","PeriodicalId":52315,"journal":{"name":"Chronic Stress","volume":"10 ","pages":"24705470261468139"},"PeriodicalIF":0.0,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13452935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148702314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Multilevel Impact of Parental Burnout on Mothers and Preschool Children\".","authors":"","doi":"10.1177/24705470261462627","DOIUrl":"https://doi.org/10.1177/24705470261462627","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1177/24705470261442343.].</p>","PeriodicalId":52315,"journal":{"name":"Chronic Stress","volume":"10 ","pages":"24705470261462627"},"PeriodicalIF":0.0,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13396572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric Properties and Network Structure of the Domain-Specific Climate Change Distress Scale.","authors":"Martin Weiß, Julian Gutzeit","doi":"10.1177/24705470261469261","DOIUrl":"10.1177/24705470261469261","url":null,"abstract":"<p><strong>Background: </strong>Climate change increasingly poses a threat to psychological health. The Domain-Specific Climate Change Distress Scale (DCCDS) was developed to capture climate-related distress across six thematic (ecology, existence, food supply, future generations, society, and wealth) and one generic domain. Building on its theoretical foundation, the present study extends initial validation efforts by providing large-scale psychometric data and normative values, drawing on a large, diverse sample to further substantiate the scale's psychometric properties and practical utility.</p><p><strong>Methods: </strong>We pooled data from seven independent German-speaking samples (N = 894; Mage = 39.2, SD = 13.5; 53% women). We replicated the bifactor S-1 model using confirmatory factor analysis (CFA), tested measurement invariance across gender, and estimated a regularized network. Exploratory graph analysis (EGA) served as a dimensionality check. Bootstrap stability analyses and a network comparison test (NCT) assessed the robustness of network indices and gender differences.</p><p><strong>Results: </strong>CFA confirmed acceptable fit of the bifactor S-1 model. Metric invariance across gender was fully supported; partial scalar invariance was established after freeing intercepts for three items. In the regularized network, items related to food supply, future generations, and generic climate anxiety showed the highest centrality. EGA identified six stable empirical dimensions, with society and wealth items loading onto a single community. NCT revealed equivalent global network structure across gender. Gender-stratified and age-stratified normative percentiles are provided.</p><p><strong>Conclusion: </strong>The DCCDS demonstrates robust psychometric properties across independent samples and is largely measurement-equivalent across gender. Findings support its use for individual diagnostics and group comparisons in climate psychology research and clinical settings. The empirical identification of six rather than seven dimensions further invites reconsideration of the Society and Wealth domain distinction. Normative data facilitate score interpretation in applied settings.</p>","PeriodicalId":52315,"journal":{"name":"Chronic Stress","volume":"10 ","pages":"24705470261469261"},"PeriodicalIF":0.0,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13380697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148521622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Sharing Heritage Makes People less Lonely\" - Integration of Heritage Activities and Social Work With Migrant Children and Teenagers in Sweden.","authors":"Elisabeth Punzi, Maria Dasenaki, Monica Nordenfors","doi":"10.1177/24705470261458921","DOIUrl":"10.1177/24705470261458921","url":null,"abstract":"<p><strong>Background: </strong>Children and teenagers with a migrant background often experience a stressful sense of \"in-betweenness,\" navigating between the heritage of their country of origin and that of their new country. Integrating elements from both cultures can foster a positive identity and enhance a sense of belonging-defined as feeling included, secure, and connected. Belonging is especially important during adolescence, a period marked by transition and identity formation.</p><p><strong>Methods: </strong>This study explores how cultural heritage may be incorporated into social work with migrant children and teenagers. The study was conducted in Angered, a diverse district of Gothenburg, Sweden, and is based on qualitative interviews with ten social workers who work with migrant children and teenagers. Using thematic analysis, three main themes were generated: Community and relationships, Integrating heritage, and Ask, listen, try.</p><p><strong>Results: </strong>The participants emphasized the importance of supporting young people's connections both to the heritage fo their families' countries of origin and the Swedish heritage. Heritage activities - not leats holiday celebrations and food traditions - were seen as bridges between cultures that could mitigate a sense of in-betweenness. While many youths feel pride and belonging within their local neighborhood, this can sometimes limit their identification with the broader city and society. The participants therefore strive to broaden perspectives and counteract stereotypes by creating opportunities for interaction across backgrounds. Integrating heritage from both the country of origin and Sweden was viewed as essential for positive identity development. Young people should not feel pressured to choose one culture but instead be supported in \"mixing heritages\" to form unique identities. Activities like sports and creative expressions were also considered valuable, as they enable participation regardless of language proficiency.</p><p><strong>Conclusion: </strong>Heritage activities can be integrated into social work with migrant children and teenagers, which increases the opportunities to provide culturally responsible interventions. Social workers should approach the children and teenagers as cocreators of activities asking them and their families about their needs and ideas, while also guiding them toward new opportunities. By proactively incorporating heritage into social work, practitioners can mitigate stressful experiences of in-betweenness, strengthen belonging, and build trust in social services.</p>","PeriodicalId":52315,"journal":{"name":"Chronic Stress","volume":"10 ","pages":"24705470261458921"},"PeriodicalIF":0.0,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13338544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation and Polish Adaptation of the Doomscrolling Scale.","authors":"Aleksandra M Rogowska, Davide Marengo, Gabriela Chlebowska","doi":"10.1177/24705470261462663","DOIUrl":"10.1177/24705470261462663","url":null,"abstract":"<p><strong>Introduction: </strong>Doomscrolling refers to a problematic pattern of compulsive engagement with negative or distressing news, particularly through social media, which may be difficult to interrupt despite its adverse emotional consequences, such as high distress and low well-being levels. However, more research is required to explain the link between doomscrolling and mental health in the context of other phenomena related to addiction-like behavior, such as problematic social media use (PSMU) and fear of missing out (FOMO). This study examines for assessing doomscrolling in the Polish cultural setting associations between doomscrolling, maladaptive media use and mental health dimensions.</p><p><strong>Methods: </strong>The total sample of 585 adults aged 18 to 79 (<i>M</i> = 27.66, <i>SD</i> = 10.37), including 49% men, participated in the cross-sectional study. The sample was divided into Sample 1 (<i>n</i> = 291) and Sample 2 (<i>n</i> = 294) to examine structural validity using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA), respectively. The following tools were used to assess criterion validity: Bergen Social Media Addiction Scale (BSMAS), Fear of Missing Out scale (FOMO), the 4-item Patient Health Questionnaire (PHQ-4), and the Satisfaction with Life Scale (SWLS).</p><p><strong>Results: </strong>Both EFA and CFA revealed a one-factor structure for the DS-15, with a single factor explaining 65% of the variance in doomscrolling. Reliability of the DS-15 was 0.96 for Cronbach's α and McDonald's ω, in both samples, and an adequate fit to the data in Sample 2, including χ²/<i>df</i> = 2.44, SRMR = 0.042, RMSEA = 0.070 (95% CI = 0.029; 0.112), and CFI = 0.964. Although EFA yielded a one-factor solution for the brief 4-item version of the scale (DS-4), the fit indices were unacceptable in CFA. Doomscrolling, assessed by the DS-15, was negatively related to life satisfaction and positively related to daily smartphone and social media use, PSMU, FOMO, distress symptoms, and self-rated socioeconomic status. No relationships were found between doomscrolling and age, gender, and education levels.</p><p><strong>Conclusions: </strong>The unidimensional DS-15 is a valid and reliable instrument for assessing doomscrolling in Polish-language samples. It is not recommended to use the short version of the Doomscrolling Scale.</p>","PeriodicalId":52315,"journal":{"name":"Chronic Stress","volume":"10 ","pages":"24705470261462663"},"PeriodicalIF":0.0,"publicationDate":"2026-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13287408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148320595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ecological Emotions in a Climate-Vulnerable Nation: Eco-Anxiety, Eco-Guilt, and Eco-Grief Among Gen Z Filipinos.","authors":"Marc Eric S Reyes, Ma Criselda T Pacquing, Karen Katrina V Trinidad, Jia Isabel C Balmaceda, Aaron Jac J Clemente, Andrea Clarisse M De Jesus, Ruth Johanna A Gool, Alekshia Quinne A Isidro, Charles A Ogunbode","doi":"10.1177/24705470261458542","DOIUrl":"10.1177/24705470261458542","url":null,"abstract":"<p><p>Ongoing global environmental change has given rise to a growing body of research on emotional and affective responses to ecological degradation. This study investigated eco-anxiety, eco-guilt, and eco-grief among Generation Z Filipinos, thereby contributing to the Global South perspective in a literature dominated by Western samples. Using a mixed-methods sequential explanatory (QUAN → qual) design, Study 1 employed a cross-sectional survey of 616 Gen Z Filipinos (aged 18-29) using the Eco-Anxiety Questionnaire, Eco-Guilt Questionnaire, and Ecological Grief Questionnaire. Study 2 involved qualitative interviews with nine participants. Quantitative findings revealed that participants exhibited high levels of habitual ecological worry, eco-guilt, and eco-grief, but relatively low functional impairment from eco-anxiety. Significant gender differences emerged, with females reporting higher levels of habitual ecological worry, eco-guilt, and eco-grief than males, although both genders experienced similar negative consequences. Place of residence also mattered: rural residents reported significantly greater negative consequences from eco-anxiety than urban residents, despite comparable levels of ecological worry, guilt, and grief. Qualitative analysis identified five themes-<i>Gendered Emotional Expression, Responsibility Rooted in Nurturing Roles, Emotional Resonance and Collective Grief, Proximity to Environmental Harm,</i> and <i>Disruption of Tradition and Place Identity</i>-that illuminate how gender socialization and environmental exposure shape ecological emotions. Our preliminary empirical insights and findings highlight the importance of recognizing ecological emotions as legitimate psychological phenomena warranting further investigations and attention in mental health practice and environmental education, particularly among climate-vulnerable youth populations.</p>","PeriodicalId":52315,"journal":{"name":"Chronic Stress","volume":"10 ","pages":"24705470261458542"},"PeriodicalIF":0.0,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13247379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148220752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Method for Measuring Dissociative Effects of Sub-Anesthetic Doses of Ketamine in Juvenile Female Rats.","authors":"Alexis M Klinner, David S Middlemas","doi":"10.1177/24705470261451166","DOIUrl":"10.1177/24705470261451166","url":null,"abstract":"<p><p>Treatment-resistant juvenile depression is a globally prevalent issue, with a need for better pharmacotherapy. Typically, Selective Serotonin Reuptake Inhibitors are front line, but recently there is interest in examining using ketamine or esketamine adjunct in adolescents. In this study, a novel method is used to explore the adverse effects of sub-anesthetic doses of ketamine in a female pre-pubescent rat model, to assess its potential clinical implications. We assessed the severity and duration of dissociative behavior at three sub-anesthetic doses of ketamine (40, 50, and 60 mg•kg^-1). Dissociative behaviors cause a subject to feel apart from their reality and ketamine is often abused for such effects. Dissociative behaviors, such as circling and ataxia, were observed following ketamine administration, with higher doses leading to increased severity and duration of symptoms up to 120 min post-injection. Our findings revealed that increasing doses of ketamine intensified both the severity and duration of dissociative behaviors. In conclusion, these results suggest a correlation underlying ketamine's rapid-acting antidepressant effect, particularly with higher sub-anesthetic doses associated with more pronounced dissociative behaviors and a rapid-acting antidepressant effect. Further investigation into ketamine's impact on longer-term dissociative effects is warranted to deepen our understanding of its therapeutic risks of ketamine treatment of adolescent depression.</p>","PeriodicalId":52315,"journal":{"name":"Chronic Stress","volume":"10 ","pages":"24705470261451166"},"PeriodicalIF":0.0,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13201937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148044440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}