Colloid and Polymer Science最新文献

{"title":"Enhancing photochromism of solution-cast polymer-heteropolyacid nanocomposites by co-solvent addition to the casting solution","authors":"Alexander A. Gorbachev,&nbsp;Oleg N. Tretinnikov","doi":"10.1007/s00396-026-05643-4","DOIUrl":"10.1007/s00396-026-05643-4","url":null,"abstract":"<div><p>Casting aqueous solutions of certain water-soluble polymers with heteropolyacids (cluster compounds of early-transition metal oxides) gives photochromic nanocomposites that are currently attracting considerable attention as functional materials for inkless and erasable printing, sensors, smart windows. Here, with the goal of improving the performance of such nanocomposites in these applications, effects of low-volatile polyol co-solvent (ethylene glycol, EG) addition to aqueous poly(vinyl alcohol)-heteropolyacid (PVA-HPA) solutions on the photochromic response of PVA-HPA nanocomposite films cast from these solutions are investigated. The main and unexpected finding of this study is that although the films from EG-containing solutions are EG free (due to its complete evaporation from the films during drying) and thus compositionally identical to those from solutions without EG, their photochromic efficiency increases (up to 50%) with increasing EG concentration in the casting solution. It is concluded that this phenomenon is caused by the molecular plasticization of PVA by low-volatile polyol co-solvent in the course of evolution of the cast film from a liquid to a solid state. Namely, polyol molecules prevent intra- and inter-chain hydrogen bonding and preserve the mobility of PVA chains in the cast solution during water evaporation, and thus facilitate the formation of a larger number of PVA-HPA hydrogen bonds on the surface of HPA nanoparticles needed for the photoinduced PVA-to-HPA electron transfers causing photochromism. Overall, this work shows the importance and means of controlling the polymer chain dynamics and intra-/inter-chain interactions for the fabrication of polymer matrix-based nanocomposites with improved properties via solution casting techniques.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":520,"journal":{"name":"Colloid and Polymer Science","volume":"304 8","pages":"2053 - 2059"},"PeriodicalIF":2.9,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148613806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyphenol-loaded supramolecular hydrogels based on cyclodextrin as wound dressings","authors":"Fei Liang,&nbsp;Yancheng Liu,&nbsp;Bowen Duan,&nbsp;Yihan Feng,&nbsp;Na Xie","doi":"10.1007/s00396-026-05641-6","DOIUrl":"10.1007/s00396-026-05641-6","url":null,"abstract":"<div><p>Developing polyphenol-loaded hydrogels can not only address the poor antibacterial and anti-inflammatory performance of single hydrogels, but also overcome the disadvantages of low bioavailability and poor stability of bioactive polyphenols. A novel cyclodextrin supramolecular drug-loaded hydrogel was constructed in this study, using carboxymethyl-β-cyclodextrin and polyethylene glycol-functionalized chitosan as raw materials, β-glycerophosphate sodium as the crosslinking agent and tannic acid (TA) as the drug model. The construction was realized through the synergistic effects of chemical crosslinking, electrostatic interaction, host-guest interaction, hydrogen bonding interaction, as well as supramolecular assembly driven by multiple interaction. Influence of various factors on the gelation time was investigated, and the properties of swelling, adsorption, rheology, antioxidant, drug-controlled release, antibacterial, and biocompatibility were systematically evaluated. Under optimal conditions, the gelation time of the cyclodextrin supramolecular hydrogel was 18 s, and the adsorption capacity for TA reached 315.2 mg/g, achieving controlled, sustained and long-lasting release. When the concentration of the drug-loaded gel reached 25 µg/mL, the DPPH radical scavenging rate was 91.9%, indicating excellent antioxidant properties. The antibacterial rates against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i> were 98.4% and 98.9%, respectively, demonstrating good antibacterial performance. The cytotoxicity was grade 0, indicating good biocompatibility. Based on the in vitro evaluation results, this cyclodextrin-based supramolecular hydrogel shows promising potential as a wound dressing for the treatment of difficult-to-heal wounds, providing a feasible candidate for the development of novel medical dressing in the medical field.</p></div>","PeriodicalId":520,"journal":{"name":"Colloid and Polymer Science","volume":"304 8","pages":"2039 - 2052"},"PeriodicalIF":2.9,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148613558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemically polymerized polyaniline: a study on the role of dopants and surfactants in modifying multi-functional properties","authors":"B. V. Sahana,&nbsp;R. Swetha,&nbsp;C. Kavitha,&nbsp;M. Uday Kumar,&nbsp;Latha Kumari","doi":"10.1007/s00396-026-05639-0","DOIUrl":"10.1007/s00396-026-05639-0","url":null,"abstract":"<div><p>In the present work, a chemical polymerization route was employed to synthesize polyaniline (PANI) with tailored properties through strategic variations in dopants and surfactants. The structural evolution induced by these modifications was systematically tracked via powder X-ray diffraction (pXRD), and the crystallite size estimated from XRD analysis was found to vary in the range of 1.4–9.9 nm, confirming the nanocrystalline nature of the synthesized PANI samples. Morphological analyses using scanning electron microscopy (SEM) and revealed particle sizes in the range of 30–85 nm, indicating the formation of agglomerated nanostructures composed of smaller crystallites, while energy-dispersive x-ray spectroscopy (EDS) confirmed phase purity. Transmission electron microscopy (TEM) confirmed distinctive particle size, surface features, and polycrystalline nature and SEM analysis Fourier transform infrared (FTIR) and Raman spectroscopy were used to identify functional groups and probe the chemical structure, respectively. UV-Visible spectroscopy indicated direct and indirect bandgap energies in the ranges of 2.4–2.8 eV and 1.41–1.47 eV, respectively reflecting tunable optoelectronic characteristics. Thermal stability was analyzed by thermogravimetric analysis (TGA/DSC). The key finding of this work lies in establishing a clear correlation between specific dopant–surfactant combinations and enhanced electrical performance. Impedance analysis demonstrated that PANI doped with HCl, and PANI incorporating H₂SO₄ as a dopant with DBSA as a surfactant exhibited the highest electrical conductivity, depicting values of 1.58 × 10⁻⁴ S/cm and 4.09 × 10⁻⁴ S/cm, respectively. This systematic approach provides new insights into the design of highly conductive PANI-based materials for applications in sensors, flexible electronics, and energy storage devices.</p></div>","PeriodicalId":520,"journal":{"name":"Colloid and Polymer Science","volume":"304 8","pages":"2017 - 2037"},"PeriodicalIF":2.9,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148613557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ZIF@polymer monolith as small-caliber vascular prosthesis prototype based on controlled release of heparin and its application in sterilization","authors":"Lu Zhou,&nbsp;Xiaozhou Yu,&nbsp;Shuxiang Lyu,&nbsp;Xiaoyuan Liao,&nbsp;Zhen Li,&nbsp;Yue Yao,&nbsp;Haoling Zhang","doi":"10.1007/s00396-026-05610-z","DOIUrl":"10.1007/s00396-026-05610-z","url":null,"abstract":"<div><p>A novel small-caliber vascular prosthesis prototype (SCVPs) with antibacterial application is proposed based on the controlled delivery of heparin from ZIF@polymer monolith. The traditional powdery small-caliber vascular prosthesis material has the disadvantages of difficult separation and easy agglomeration, which limits its applications. Heparin (HP)-loaded porous ZIF-8/Polymer (PEG, PVA, and PVP) monoliths were fabricated using a freeze-casting method in liquid nitrogen (− 196 ℃) for controlled heparin release and sterilization. The incorporation of ZIF-8/Polymer significantly improved the antibacterial performance of the samples, prolonged the slow-release time of heparin sodium, and also resulted in better mechanical properties. The samples synthesized at a heparin sodium concentration of 0.36 mg·mL⁻¹ exhibited good sustained release of heparin sodium when used as artificial antigenic matrix. Among these materials, the cured HP@ZIF-8 sample had a retarded release time of up to 15 h, with a cumulative release of 223.56 μg at 24 h. With PVA as the optimal polymer, heavy metal ions from the cured HP@ZIF-8 material can cause severe toxic damage to the internal structure of bacteria, interfere with bacterial metabolism, and thus show obvious antibacterial effects.</p></div>","PeriodicalId":520,"journal":{"name":"Colloid and Polymer Science","volume":"304 8","pages":"2007 - 2015"},"PeriodicalIF":2.9,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148305749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SnO2 nanoparticle dispersed polyvinyl alcohol, chitosan and polybenzoxazine inter-crosslinked composite membrane having higher proton transport characteristics","authors":"G. Durgadevi,&nbsp;R Abinesh,&nbsp;C. Karikal Chozhan,&nbsp;A. Chandramohan,&nbsp;Dinakaran Kannaiyan","doi":"10.1007/s00396-026-05635-4","DOIUrl":"10.1007/s00396-026-05635-4","url":null,"abstract":"<div><p>An efficient proton transporting poly(vinyl alcohol)/chitosan/polybenzoxazine (PVA/CS/PBZ) composite membrane embedded with SnO₂ nanoparticles was successfully synthesized via the sol-gel method, with cross-linking of PVA using dialdehyde, and thin film formation achieved through the doctor blade technique. This study focused on enhancing proton conductivity in nanocomposite membranes for proton exchange membrane cells (PEMCs) by incorporatingSnO₂ nanoparticles (NPs) into the PVA/CS/PBZ matrix. The ion exchange capacity(IEC) ofthe base polymer with dialdehyde-modified PVA reached 0.25 mmol/g, while the addition of SnO₂ NPs at 2% and 3% increased IEC to 1.45 and 1.63 mmol/g, respectively. Water uptake behavior improved with SnO₂ loading, and membrane thickness swelling was significantly reduced, indicating better dimensional stability. Notably, proton conductivity was enhanced in all nanocomposite variants, with the 3% SnO₂-loaded membrane achieving the highest conductivity of 0.094 S/cm at 90 °C—demonstrating a 29.8% improvement in membrane stability over the unmodified matrix. The CS/PBZ/PVA/3 wt% SnO₂ membrane demonstrates a higher terminal voltage (OCV) and maintains better electrochemical unit potential across the entire current density range compared to the unmodified CS/PBZ/PVA membrane.</p></div>","PeriodicalId":520,"journal":{"name":"Colloid and Polymer Science","volume":"304 8","pages":"1989 - 2005"},"PeriodicalIF":2.9,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148613104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid degradation of thermosetting ester epoxides and comprehensive recovery of degradation products","authors":"Wen Li,&nbsp;Menghan Zhang,&nbsp;Yi Zhang,&nbsp;Yu Tan,&nbsp;Xinyue Mao,&nbsp;Yaping Zhang,&nbsp;Bo Liu,&nbsp;Hanbing Ma","doi":"10.1007/s00396-026-05629-2","DOIUrl":"10.1007/s00396-026-05629-2","url":null,"abstract":"<div><p>The volume of discarded thermosetting epoxy composites is increasing. Traditional landfill disposal not only pollutes the environment, but also generates significant resource waste. Promoting their degradation and recycling has emerged as a critical problem for industry sustainability. This work uses ester-based epoxy resins as monomers to rapidly degrade thermosetting ester-epoxy/amine cures in mild circumstances. After concentration and filtration, components such ethylene glycol, sodium carboxylate salts, and nitrogen-containing polyols can be easily extracted from the degradation solution. Specifically, sodium carboxylate salts can be re-synthesized into epoxy resins with identical molecular structures to the original epoxy resin via acidification and epoxidization. Purified regenerated nitrogen-containing polyols combine with diphenyl phosphonyl chloride to form a new flame retardant. When incorporated into standard bisphenol A epoxy/anhydride curing systems at a 25 wt% concentration, this flame retardant elevates the flame retardancy rating from non-rated to V-0 compared to untreated epoxy/anhydride cures, the limiting oxygen index reaches 28.7%, while total smoke release decreases by 12.3%. Concurrently, the mechanical properties of the cured material improved, with tensile strength increasing by 32.8% and elongation at break rising by 50.8%, demonstrating excellent overall performance. Building on previous research that demonstrated the rapid deterioration of ester-based epoxy/amine cured materials and the efficient recovery of sodium carboxylate from degradation solutions, this study enhanced the degradation rate of ester-based epoxy/amine cured materials. Simultaneously, nitrogen-containing polyols found in breakdown products were recovered and reused, resulting in complete recovery and usage of all components from ester-based epoxy/amine cured composites.</p></div>","PeriodicalId":520,"journal":{"name":"Colloid and Polymer Science","volume":"304 8","pages":"1975 - 1988"},"PeriodicalIF":2.9,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148613495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrostatic modulation of particle adsorption and interfacial elasticity enables enhanced stability in polar-oil-based Pickering emulsions","authors":"Yuanchen Hua,&nbsp;Yunfei Wang,&nbsp;Junyan Shen,&nbsp;Aoyun Fan,&nbsp;Ye Liu,&nbsp;Lei Yang","doi":"10.1007/s00396-026-05642-5","DOIUrl":"10.1007/s00396-026-05642-5","url":null,"abstract":"<div><p>In conventional Pickering emulsions, particle adsorption at the oil–water interface is primarily governed by physicochemical attributes such as particle size and wettability. However, when both the oil–water interface and particles carry surface charges, electrostatic interactions may become the dominant factor governing particle adsorption. To investigate this effect, silica particles with surface potentials ranging from − 51 to + 54 mV were dispersed in an aqueous phase containing a nonionic surfactant, with amino-functionalized polydimethylsiloxane serving as the oil phase. Interfacial oscillatory rheological measurements were conducted to characterize interfacial viscoelasticity. Two charge-regulation strategies modulated particle (<span>(:{zeta:}_{text{p}})</span>) and oil-water interface potentials (<span>(:{zeta:}_{text{o}})</span>): one reduced |<span>(:{zeta:}_{text{p}})</span>| via chemical modification, the other lowered pH to decrease |<span>(:{zeta:}_{text{p}})</span>| and increase |<span>(:{zeta:}_{text{o}})</span>|. Emulsification experiments further evaluated long-term stability. The results demonstrate that in polar oil–water Pickering emulsions, coordinated modulation of <span>(:{zeta:}_{text{p}})</span> and <span>(:{zeta:}_{text{o}})</span> governs particle interfacial adsorption and the development of interfacial viscoelasticity, thereby determining emulsion stability. Negatively charged particles exhibited stronger adsorption and higher elasticity at positively charged interfaces, whereas like-charged combinations resulted in limited adsorption. Among negatively charged particles, those with <span>(:{zeta:}_{text{p}})</span> ≈ −22 mV produced denser interfacial packing and higher elasticity than strongly anionic particles (<span>(:{zeta:}_{text{p}})</span> ≈ −51 mV). Charge-regulation experiments, including ionic-strength–dependent <span>(:zeta:)</span> and interfacial-rheology tests, confirm that enhanced viscoelasticity arises from optimizing the balance between interface–particle electrostatic attraction (proportional to <span>(:{zeta:}_{text{o}})</span>·<span>(:{zeta:}_{text{p}})</span>) and particle–particle electrostatic repulsion (proportional to <span>(:{zeta:}_{p}^{2})</span>). Emulsion stability was quantified by long-term storage and centrifugal stability tests, demonstrating an extension of stability from ≈ 55 days to &gt; 180 days under optimized charge conditions.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":520,"journal":{"name":"Colloid and Polymer Science","volume":"304 8","pages":"1961 - 1973"},"PeriodicalIF":2.9,"publicationDate":"2026-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148613547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and characterization of silica nanoparticle–reinforced PAA/PEG dual-network hydrogels with high compressive strength after swelling","authors":"Kai Luan,&nbsp;Ru Chen,&nbsp;Minjie Qu,&nbsp;Zhiao Si,&nbsp;Huaibing Bai,&nbsp;Xiaomei Shi","doi":"10.1007/s00396-026-05640-7","DOIUrl":"10.1007/s00396-026-05640-7","url":null,"abstract":"<div><p>To enhance the mechanical performance of the hydrogel after swelling, polyacrylic acid (PAA)/polyethylene glycol (PEG) dual-network hydrogels modified by nano-silica (SiO₂) were prepared via free radical polymerisation. PAA molecular chains were subjected to chemical crosslinking via a crosslinking agent in conjunction with SiO₂–KH570 to form a chemically crosslinked network. PEG chains subsequently interpenetrated this network, generating a dual-network hydrogel structure. Hydrogel preparation parameters were optimised by varying the neutralisation degree and PEG molecular weight, followed by systematic evaluation of its structure and properties. The results demonstrated that the neutralization degree primarily influences the mechanical properties by regulating the balance between electrostatic repulsion and hydrogen bond dissipation. The molecular weight of PEG determines the rigidity and flexibility of the hydrogel cross-linking network. Furthermore, the compressive performance of the hydrogel was enhanced by the introduction of nano-SiO₂. Addition of 0.5% SiO₂ increased the compressive strength to 425 kPa (an increase of 117.2%) and compressive strain to 83.85% (an increase of 12.6%), whereas equilibrium swelling rate was maintained at 161.3 g/g. This study provides a theoretical basis for the design of high-performance hydrogels by clarifying the synergistic effects of chemical crosslinking and physical entanglement toughening of hydrogels.</p></div>","PeriodicalId":520,"journal":{"name":"Colloid and Polymer Science","volume":"304 8","pages":"1941 - 1960"},"PeriodicalIF":2.9,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148613379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the effect of piperidinium-based ionic liquids on the cetylpyridinium chloride and amitriptyline hydrochloride system: micellization, density function theory and antibacterial activity","authors":"Nafseen Ahmed,&nbsp;Mohammad Tariq,&nbsp;Juhi Saraswat,&nbsp;Rajan Patel,&nbsp;Mohd Sajid Ali,&nbsp;Abbul Bashar Khan","doi":"10.1007/s00396-026-05630-9","DOIUrl":"10.1007/s00396-026-05630-9","url":null,"abstract":"<div><p>The modulation of surfactant and drug self-assembly by ionic liquids (ILs) is a key strategy for enhancing the efficacy of drug delivery and antimicrobial systems. This study investigates the micellization behaviour of cetylpyridinium chloride (CPC), a cationic surfactant, in the absence and presence of ionic liquids (ILs), namely 1-butyl-1-methylpiperidinium chloride ([C₄C₁pip][Cl]) and 1-butyl-1-methylpiperidinium bromide ([C₄C₁pip][Br]). Furthermore, the interaction of CPC with the antidepressant drug amitriptyline hydrochloride (AMT) was analysed in IL media to evaluate the mixed micellization behaviour. Conductometric measurements at various temperatures revealed that both piperidinium ILs significantly lower the CMC of CPC, with the bromide IL inducing a more pronounced effect. Thermodynamic parameters (<span>({{Delta}:text{G}}_{m}^{o})</span>, <span>({{Delta}:text{H}}_{m}^{o})</span>, and <span>({{Delta}:text{S}}_{m}^{o})</span>) were calculated to understand the spontaneity, enthalpic/entropic contributions, and the role of ILs in modulating aggregation. The findings show that adding ILs significantly lowers the CMC of CPC, suggesting improved micellar stability resulting from the combined effects of hydrophobic and electrostatic interactions. Strong synergism in the CPC–AMT mixed systems is confirmed by the negative values of the interaction parameter (<span>({beta};^{m})</span>). Moreover, the molecular-level experimental data are supported by quantum-chemical simulations that provide insight into the relative stability and reactivity of CPC, AMT, as well as the ILs [C₄C₁pip][Cl] and [C₄C₁pip][Br]. The antibacterial activity of CPC, AMT, ILs, and their binary and ternary mixtures was estimated against <i>Escherichia coli</i> (<i>E. Coli</i>) and <i>Staphylococcus aureus</i> (<i>S. aureus</i>). The enhanced activity is attributed to the cooperative membrane-disrupting capability of the surfactant, IL, and drug molecules. Overall, the study demonstrates that ILs can effectively modulate micellar self-assembly and enhance biological performance, offering promising prospects for the design of multifunctional drug delivery and antimicrobial systems.</p></div>","PeriodicalId":520,"journal":{"name":"Colloid and Polymer Science","volume":"304 8","pages":"1923 - 1939"},"PeriodicalIF":2.9,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148613039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physically crosslinked triple network hydrogels with optimized self healing properties as a drug delivery vehicle","authors":"Aleyna Tuğçe Efecan,&nbsp;Emel Tamahkar,&nbsp;Ecem Çiçek,&nbsp;Batuhan Nuray,&nbsp;Zeynep Ciğeroğlu,&nbsp;Bengi Özkahraman,&nbsp;Elife Kıldalı,&nbsp;Gökçe Taner,&nbsp;Filiz Boran,&nbsp;Safa Şenaysoy,&nbsp;Hüseyin Lekesiz","doi":"10.1007/s00396-026-05637-2","DOIUrl":"10.1007/s00396-026-05637-2","url":null,"abstract":"<div><p>The aim of this paper was to develop a novel triple network (TN) hydrogel via optimization of the composition of the hydrogel regarding self healing property. Poly hydroxyethyl methacrylate (PHEMA), gelatin and polyvinyl alcohol (PVA) based hydrogels were synthesized as first, second and third network structures respectively. The TN hydrogels were prepared via copolymerization, thermal gelation and freeze-thawing respectively. The three dimensional structure was formed through non-covalent interactions between polymer chains. The Box-Behnken design model was applied to the independent variables of the amounts of poly ethylene glycoldiacrylate (PEGDA) (X1), glutaraldehyde (X2) and gelatin (X3) against a dependent variable (self healing score). The further characterization of the TN hydrogel with ‘best’ self healing capability was performed with SEM, swelling, in-vitro hydrolytic degradation, in vitro cytotoxicity against L929 cell lines and mechanical tests. The cumulative release of lidocaine from TN hydrogel matrix was investigated for 48 h. The TN hydrogel with self healing capability, high biocompatibility, highly porous structure, high swelling capacity, moderate mechanical strength presented high potential as a drug delivery vehicle for various biomedical applications.</p></div>","PeriodicalId":520,"journal":{"name":"Colloid and Polymer Science","volume":"304 8","pages":"1897 - 1908"},"PeriodicalIF":2.9,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148613297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}