ORL; journal for oto-rhino-laryngology and its related specialties最新文献

{"title":"Minimally Invasive Skull Base Approach Styloidectomy for Treatment of Eagle Syndrome.","authors":"Victoria Fonseca, Makayla R Matthews, Trevor Hackman","doi":"10.1159/000551089","DOIUrl":"10.1159/000551089","url":null,"abstract":"<p><strong>Introduction: </strong>Eagle syndrome is an underrecognized condition caused by the elongation of the styloid process or calcification of the stylohyoid ligament, with an unknown true incidence. It is diagnosed clinically through symptoms related to compression of the surrounding neurovascular and musculoskeletal structures, along with radiographic confirmation of styloid elongation. Symptoms are variable and may include neck pain, dysphagia, tinnitus, dizziness, headaches, otalgia, and cognitive complaints. Surgical management via intraoral or transcervical approaches is the current standard of care. We propose a novel minimally invasive skull base approach designed to allow complete styloid removal with reduced tissue dissection.</p><p><strong>Methods: </strong>A retrospective review was conducted in patients who underwent this minimally invasive skull base approach for Eagle syndrome between November 2020 and June 2024. Of 102 identified patients, 90 met the inclusion criteria. Demographics, operative time, intraoperative and postoperative complications, narcotic use, and symptom improvement were extracted from the electronic medical record. Data were analyzed using Excel.</p><p><strong>Results: </strong>Patients were predominantly female (73.3%) and white (90%). The mean operative time for unilateral styloid removal was 53 min (±21.2). The most common postoperative complication was temporary numbness (42.2%), with resolution reported in 63.2% of affected patients. Overall, 86.7% (n = 78) of patients reported complete or partial symptom improvement by or before the 3-month follow-up.</p><p><strong>Conclusion: </strong>The minimally invasive skull base approach for Eagle syndrome demonstrates symptom improvement rates comparable to traditional intraoral and transcervical techniques while offering shorter operative times and limited tissue dissection. This approach appears to be an effective alternative surgical option with an acceptable complication profile.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"239-246"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147319350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Etiology and Outcomes of Acquired Unilateral Vocal Fold Paralysis: A Multicenter Retrospective Study in Peninsular Malaysia.","authors":"Nadhirah Mohd Shakri, Jason Yun Bing Lo, Marina Mat Baki, Zahirrudin Zakaria, Nik Fariza Husna Nik Hassan, Syarifah Nafisah Syed Hamzah, Bao Ling Wong, Puvanaeswaran Dakshinamurthi, Mawaddah Azman","doi":"10.1159/000546457","DOIUrl":"10.1159/000546457","url":null,"abstract":"<p><strong>Introduction: </strong>Unilateral vocal fold paralysis (UVFP) results from either mechanical or neurological causes, significantly impacting voice, breathing, and swallowing functions. Thyroid and parathyroid surgeries are commonly implicated as surgical causes; however, nonsurgical etiologies remain diverse. Some studies have suggested a change in the trend of UVFP etiologies over time, likely due to advancements in surgical techniques, improved diagnostics, and evolving healthcare practices. This study examines trends in etiology and outcomes of UVFP with early interventions in a multicenter setting in Malaysia over 2 decades.</p><p><strong>Methods: </strong>A retrospective, multicenter review of UVFP cases was conducted over two periods: 2004-2012 and 2013-2021. Data on patient demographics, UVFP etiology, laterality, and intervention outcomes were analyzed. Interventions included voice therapy alone or in combination with early surgical interventions. Statistical analysis was performed to compare trends and outcomes across periods.</p><p><strong>Results: </strong>Thyroid and parathyroid surgeries remained the predominant surgical cause of UVFP. Iatrogenic UVFP was more commonly right-sided, while nonsurgical cases predominantly involved the left side. No significant differences were observed in the distribution of surgical and nonsurgical etiologies between the two study periods. Early interventions demonstrated significantly better voice outcomes compared to voice therapy alone (p < 0.05).</p><p><strong>Conclusion: </strong>This is the first long-term, multicenter study in Malaysia addressing UVFP trends and outcomes. Early surgical interventions provide superior outcomes compared to conservative approaches, highlighting the need for timely diagnosis and management to optimize patient care.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"108-115"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Different Types of Concha Bullosa on Olfactory Function.","authors":"Süheyla Kandemir, Gözde Pamuk, Ramazan Tiken, Erim Pamuk, Adnan Özdemir","doi":"10.1159/000547417","DOIUrl":"10.1159/000547417","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to compare the effects of different types of concha bullosa (CB) on olfactory function using paranasal computed tomography (CT) findings and the Sniffin' Sticks test.</p><p><strong>Methods: </strong>A total of 107 patients (69 women and 38 men) were evaluated. The study group included 79 patients with CB, while the control group comprised 28 patients without CB. CB cases were classified into three subtypes according to the Bolger classification: lamellar (n = 28), bulbous (n = 25), and extensive (n = 26). Paranasal CT scans were assessed by a radiologist to measure the olfactory cleft width, the distance between the turbinate and septum, and the volume of the turbinate bullosa. All participants completed the SNOT-22 and NOSE questionnaires. Olfactory function was evaluated using the Sniffin' Sticks test, and examinations were conducted by an otolaryngology specialist.</p><p><strong>Results: </strong>There were no significant differences between the groups in terms of age and gender (p > 0.05). The Sniffin' Sticks test score was significantly higher in the control group than in the CB group (p < 0.001). The control group had significantly higher odor scores than the lamellar and extensive groups (p = 0.002 and p = 0.042, respectively) but not the bulbous group (p = 0.133). The volume of the CB (vertical axis and horizontal axis of CB) was significantly greater in the extensive CB group than in the lamellar and bulbous groups (both p < 0.001). No significant differences were observed in the right, left, or total olfactory cleft widths among the four groups (p > 0.05).</p><p><strong>Conclusion: </strong>Olfactory function, as measured by the Sniffin' Sticks test, was significantly better in the control group compared to the CB group. However, there were no significant differences in olfactory performance among the different CB subtypes. Additionally, olfactory cleft width did not differ significantly between groups. These findings suggest that while the presence of CB may be associated with reduced olfactory function, the subtype of CB and cleft width may not play a major role. Moreover, the reduction of olfactory function due to CB was minimal and not clinically meaningful.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"69-76"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hearing Aid Satisfaction and Usage Patterns across Age Groups: A Cross-Sectional Analysis.","authors":"Nagihan Gülhan Yaşar, İrem Şi̇şko Ağgünlü, Agah Yeni̇çeri̇, Burak Hazır, Mustafa Çolak, Ayşe Seçil Kayalı Dinç, Melih Çayönü","doi":"10.1159/000548356","DOIUrl":"10.1159/000548356","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate hearing aid satisfaction and usage patterns across different age groups and to investigate the impact of hearing aids on quality of life.</p><p><strong>Material and methods: </strong>Hearing aid satisfaction and perceived benefit were evaluated using the International Outcome Inventory for Hearing Aids (IOI-HA), administered via phone interview after at least 6 months of use. A total of 850 patients who were prescribed hearing aids for the first time at the Department of Otorhinolaryngology between January 2020 and January 2023 were retrospectively analyzed.</p><p><strong>Results: </strong>The mean age of participants was 65.4 ± 13.4 years, and the prevalence of sensorineural hearing loss increased significantly with age. Pure tone thresholds and word recognition scores (WRSs) were lower in the older age groups. However, no significant differences were found in IOI-HA scores across the age categories. The WRS was the only significant predictor of total IOI-HA scores (B = 0.016, p = 0.009, R2 = 0.010). Behind-the-ear hearing aids were more commonly used among older participants.</p><p><strong>Conclusions: </strong>Hearing aid satisfaction did not differ according to age, and the severity of hearing loss alone was not a strong determinant. Speech discrimination ability was identified as a consistent predictor of perceived benefit.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"162-169"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145007037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Learning Curve of Upper Aerodigestive Tract Foreign Body Management for Otorhinolaryngology Residents.","authors":"Ching-Ching Chiu,&nbsp;Chien-Yu Huang,&nbsp;Keng-Ming Chang,&nbsp;Sheng-Chiao Lin,&nbsp;Yu-Hsi Liu,&nbsp;Pei-Hsun Liao,&nbsp;Chuan-Jen Hung,&nbsp;Chin-Fang Cho,&nbsp;Jyun-Yi Liao,&nbsp;Yun-Ying She,&nbsp;Bor-Hwang Kang","doi":"10.1159/000517307","DOIUrl":"https://doi.org/10.1159/000517307","url":null,"abstract":"<p><strong>Introduction: </strong>Foreign body ingestion is the most common reason for otolaryngology specialist consultations in emergency departments. Among the different types of foreign bodies, fish bones are the most common, particularly in Asian populations. In Taiwan, upper aerodigestive tract foreign bodies (UADT-FBs) are mostly managed by residents in the otorhinolaryngology (ORL) department. Considering the learning curve required for all procedures, different management types between residents, and possible resulting safety issues, this study explored the outcomes of UADT-FB management by residents in different years of ORL training.</p><p><strong>Materials and methods: </strong>The medical records of 2,283 patients who visited Kaohsiung Veterans General Hospital's Emergency Department for UADT-FB during June 2013-August 2019 were retrospectively reviewed. The reviewed data included the demographic data of enrolled patients, outcomes of foreign body management, and follow-up chart records of the patients.</p><p><strong>Results: </strong>Among the 2,283 patients, 1,324 (58%) were found to be negative for foreign bodies, and foreign bodies in 951 (41.7%) were removed immediately. In the negative finding (NF) group, 2 (4.9%) patients were later found to be positive for foreign bodies during follow-up in the outpatient department. One (2.4%) patient developed a deep neck infection and esophageal perforation. The percentage of NFs decreased from 62.58% in residents in the first half of their first year (R1a) to 54% for third-year residents (R3). Comparing R1a with R3, the number needed to harm for retained UADT-FBs after patients visited the emergency department was 12.2.</p><p><strong>Discussion/conclusion: </strong>This study provides data from 1 referral center regarding the management of UADT-FBs. With increasing resident training, the percentage of NFs declined from 62.58 to 54%. Young residents, especially those in the first 6 months of their training, should have senior residents perform a second examination if UADT-FBs are not found in suspected cases.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"193-199"},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000517307","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39263322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Mobility Group Box-1 Protein and Interleukin 33 Expression in Allergic Rhinitis.","authors":"Nongping Zhong,&nbsp;Qing Luo,&nbsp;Xiaoyan Huang,&nbsp;Jieqing Yu,&nbsp;Jing Ye,&nbsp;Jian Zhang","doi":"10.1159/000519575","DOIUrl":"https://doi.org/10.1159/000519575","url":null,"abstract":"<p><strong>Background: </strong>Allergic rhinitis (AR) is characterized by an inflammatory reaction. High mobility group box 1 (HMGB1) protein and interleukin (IL)-33 are damage-associated molecular pattern molecules and have many characteristics similar to pro-inflammatory cytokines. However, the role of IL-33 and HMGB1 in AR remains unclear. The aim of this study is to explore the role of HMGB1 and IL-33 in AR.</p><p><strong>Methods: </strong>Twenty patients with AR (AR group) and 10 normal controls (normal group) were enrolled in this study. HMGB1 and IL-33 expression were analyzed by immunohistochemistry in epithelial cells of the inferior turbinate mucosa samples. Then, the human nasal mucosa epithelial cells (HNECs) were cultured in vitro, and the house dust mite allergen (Derp1) was used to stimulate the cells. Quantitative real-time PCR and ELISA assay were performed to detect HMGB1 and IL-33 expression in HNECs.</p><p><strong>Results: </strong>The expression of HMGB1 and IL-33 in the nasal mucosa was higher in the AR group than in the normal group, with a statistically significant difference (p < 0.05). In HNECs of AR, the expression of both HMGB1 and IL-33 in stimulated groups was higher than that in non-stimulated groups. The differences were statistically significant (p < 0.05). In addition, they increased gradually with the prolonging time and the concentration of the added Derp1.</p><p><strong>Conclusions: </strong>The expression of HMGB1 and IL-33 were both increased in AR. HMGB1 and IL-33 may have a close relationship in AR.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"315-323"},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39642808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning Algorithms as a Computer-Assisted Decision Tool for Oral Cancer Prognosis and Management Decisions: A Systematic Review.","authors":"Carlos M Chiesa-Estomba,&nbsp;Manuel Graña,&nbsp;Alfonso Medela,&nbsp;Jon A Sistiaga-Suarez,&nbsp;Jerome R Lechien,&nbsp;Christian Calvo-Henriquez,&nbsp;Miguel Mayo-Yanez,&nbsp;Luigi Angelo Vaira,&nbsp;Alberto Grammatica,&nbsp;Giovanni Cammaroto,&nbsp;Tareck Ayad,&nbsp;Johannes J Fagan","doi":"10.1159/000520672","DOIUrl":"https://doi.org/10.1159/000520672","url":null,"abstract":"<p><strong>Introduction: </strong>Despite multiple prognostic indicators described for oral cavity squamous cell carcinoma (OCSCC), its management still continues to be a matter of debate. Machine learning is a subset of artificial intelligence that enables computers to learn from historical data, gather insights, and make predictions about new data using the model learned. Therefore, it can be a potential tool in the field of head and neck cancer.</p><p><strong>Methods: </strong>We conducted a systematic review.</p><p><strong>Results: </strong>A total of 81 manuscripts were revised, and 46 studies met the inclusion criteria. Of these, 38 were excluded for the following reasons: use of a classical statistical method (N = 16), nonspecific for OCSCC (N = 15), and not being related to OCSCC survival (N = 7). In total, 8 studies were included in the final analysis.</p><p><strong>Conclusions: </strong>ML has the potential to significantly advance research in the field of OCSCC. Advantages are related to the use and training of ML models because of their capability to continue training continuously when more data become available. Future ML research will allow us to improve and democratize the application of algorithms to improve the prediction of cancer prognosis and its management worldwide.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"278-288"},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39928422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prospective Study of the Effect of Tinnitus Sound Matching Degree on the Efficacy of Customized Sound Therapy in Patients with Chronic Tinnitus.","authors":"JinYu Wang,&nbsp;Juan Ding,&nbsp;Jing Song,&nbsp;Li Hu,&nbsp;Ning Cong,&nbsp;Zhao Han","doi":"10.1159/000517631","DOIUrl":"https://doi.org/10.1159/000517631","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to explore and compare the customized sound therapy effect between tinnitus sound matching and nonmatching patients in tinnitus customized sound therapy and therapy-related influencing factors.</p><p><strong>Methods: </strong>This prospective study investigated a total of 100 patients with unilateral chronic tinnitus who received customized sound therapy. The participants were dichotomously divided into matching (group A) and nonmatching (group B) groups after 4 stages of tinnitus matching via the tinnitus assistant app (provided by Sound Ocean Company, SuZhou, China). Each group consists of 50 participants. Before and 6 months after the treatment, Hospital Anxiety and Depression Scale (HADS), tinnitus handicap inventory (THI), and tinnitus loudness Visual Analog Scale (VAS) were used to evaluate the customized sound therapy effect and explore other related influencing factors.</p><p><strong>Results: </strong>(1) The HADS-A, HADS-D, THI, and VAS scores of 2 groups were both significantly decreased after treatment. (2) The HADS-A and THI scores improved markedly in group A than that in group B, which could be related to the hearing loss of the tinnitus side ear before treatment; the lighter the degree of hearing loss, the better the improvement. No statistically significant differences were detected in HADS-D and VAS scores between the 2 groups, and also, these were not related to the degree of hearing loss. The differences in age, gender, and tinnitus duration did not show any statistically significant effect on the improvement of the 2 groups.</p><p><strong>Conclusions: </strong>Both tinnitus sound matching and nonmatching of the customized sound therapy brought a significant effect to tinnitus participants. Our study also suggests that THI and HADS-A scores of those with tinnitus matching participants improved markedly as compared to those of nonmatching participants, and the customized sound therapy effect is negatively correlated with the severity of hearing loss.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"229-237"},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39384064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initial Presentation of Granulomatosis with Polyangiitis as Progressive Skull Base Osteomyelitis.","authors":"Hannan A Qureshi,&nbsp;Anshu Bandhlish,&nbsp;Robert P DeConde,&nbsp;Ian M Humphreys,&nbsp;Waleed M Abuzeid,&nbsp;Aria Jafari","doi":"10.1159/000518971","DOIUrl":"https://doi.org/10.1159/000518971","url":null,"abstract":"<p><p>A healthy man in his 30s presented with a 2-week history of severe bitemporal pain and pressure. He was initially treated for presumed acute rhinosinusitis, but his symptoms continued to worsen and underwent endoscopic sinus surgery at an outside community facility. He developed left abducens nerve palsy postoperatively, and magnetic resonance imaging (MRI) demonstrated evidence of extensive skull base osteomyelitis. He was initiated on intravenous (IV) broad-spectrum antibiotics but was subsequently found to have prostatic and submandibular sterile fluid collections. The patient subsequently developed new right abducens and left vagal nerve palsies and underwent revision endoscopic sinus surgery. Pathology revealed extensive inflammation, necrotizing granulomas, and evidence of small and medium vessel vasculitis. Extensive laboratory workup was negative, except for anti-PR-3 antibody positivity. Given the characteristic findings on pathology and laboratory findings, the patient was diagnosed with granulomatosis with polyangiitis (GPA). High-dose glucocorticoid therapy as well as rituximab infusion were promptly initiated. He had marked improvement in his symptoms and resolution of his right CN VI palsy but left-sided CN VI and CN X palsies persisted. This patient presented without the typical rhinologic manifestations of GPA, and rather presented with progressive sinusitis, skull base osteomyelitis with associated cranial neuropathies, and aseptic systemic abscesses. Prompt diagnosis of GPA is particularly important in those with otorhinolaryngological manifestations, as early initial immunosuppressive therapy has been linked to lower relapse and mortality rates. Vigilance and early differentiation between GPA and other forms of sinusitis is of critical importance, particularly when symptoms are refractory to standard rhinosinusitis therapies.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"342-346"},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39474150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptome Analysis Identified 2 New lncRNAs Associated with the Metastasis of Papillary Thyroid Carcinoma.","authors":"Shizhi He,&nbsp;Abdeyrim Arikin,&nbsp;Jiaming Chen,&nbsp;Tianqiao Huang,&nbsp;Zhen Wu,&nbsp;Lingwa Wang,&nbsp;Fan Yang,&nbsp;Yunxia Li,&nbsp;Yifan Yang,&nbsp;Ru Wang,&nbsp;Meng Lian,&nbsp;Qi Zhong,&nbsp;Jugao Fang","doi":"10.1159/000518085","DOIUrl":"https://doi.org/10.1159/000518085","url":null,"abstract":"<p><strong>Introduction: </strong>Papillary thyroid microcarcinoma (PTMC) is a specific subgroup of papillary thyroid carcinoma and defined with the dimension ≤1 cm by the WHO. Although it shows a relatively high 10-year livability, the metastasis of PTMC into other tissues and organs seriously affects the daily life of patients with relatively high mortality. Therefore, the genetic basis for the metastasis of PTMC needs to be explored for effective therapeutic targets. Here, we conducted a series of comparative analysis of the transcriptional expression profile between PTMC patients with and without lymph node metastasis.</p><p><strong>Methods: </strong>Gene expression profile and gene function were analyzed using RNA extracted from pathological tissues of 12 patients with PTMC, and the core biomarkers closely related to its metastasis were identified.</p><p><strong>Results: </strong>Our results showed that 7,507 genes and 42 RNAs showed remarkably different expression patterns. More sophisticated analysis showed that the high expression of 2 lncRNAs (T077499 and T004533) resulted in the metastasis of PTMC, which suggests that the expression pattern of the 2 lncRNAs may act as a potential biomarker for pathogenesis and prognosis of PTMC metastasis.</p><p><strong>Conclusion: </strong>Our findings preliminarily reveal the molecular mechanisms for PTMC metastasis, which will provide vital reference for subsequent studies about the genetic basis and molecular targeted therapy for PTMC metastasis.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"247-254"},"PeriodicalIF":1.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39654647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}