{"title":"Transoral robotic surgery with laser for head and neck cancers: a feasibility study.","authors":"Marco Benazzo, Pietro Canzi, Antonio Occhini","doi":"10.1159/000337092","DOIUrl":"https://doi.org/10.1159/000337092","url":null,"abstract":"<p><strong>Aims: </strong>To assess the feasibility of a flexible thulium laser coupled with a novel robotic introducer for head and neck cancers.</p><p><strong>Methods: </strong>In a prospective nonrandomized clinical trial, 58 patients were evaluated. When indicated, transoral robotic surgery (TORS) with laser was performed using an Intuitive da Vinci S System with the Intuitive Surgical® Endo Wrist Introducer, 5Fr to hold and position thulium surgical laser fibers.</p><p><strong>Results: </strong>Six patients underwent TORS with laser for early supraglottic and oropharyngeal squamous cell carcinomas. All approaches were successfully completed without the need for microscopic/open conversion or positive margins to the final pathological study. No intraoperative adverse events occurred and recovery was relatively quick, with no evidence of disease recurrence at the time of reporting, the short observation time notwithstanding.</p><p><strong>Conclusions: </strong>In our preliminary experience, TORS with laser showed feasible and promising results. Further studies are mandatory to demonstrate thulium laser benefits in surgical and oncological practice.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"124-8"},"PeriodicalIF":1.3,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000337092","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39970996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Laser ablation of a large tongue hemangioma with remifentanil analgosedation in the ORL endoscopy suite.","authors":"Joshua H Atkins, Jeff E Mandel, Natasha Mirza","doi":"10.1159/000328341","DOIUrl":"https://doi.org/10.1159/000328341","url":null,"abstract":"<p><p>We present a unique, practical, and safe approach to the clinical management of a young male with a large tongue hemangioma who presented for serial surgical treatment of the lesion. Laser ablation was undertaken in the operating room under topical anesthesia with remifentanil analgosedation without the use of supplemental oxygen. Significant involution of the hemangioma was achieved without complication while the patient was awake, cooperative, and able to protect his airway. The application of remifentanil infusion for analgosedation during airway surgery is described. The utility of pharmacokinetic modeling in these applications is discussed along with the use of non-invasive respiratory inductance plethysmography to monitor ventilation during opioid sedation. The concept of analgosedation for airway surgery is introduced and relative risk versus benefit considerations of the approach in comparison to general anesthesia are discussed. This approach can be conceived of as an ORL endoscopy suite model for limited airway procedures.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"166-9"},"PeriodicalIF":1.3,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000328341","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40111440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Borba, C Cernea, F Dias, P Faria, C Bacchi, L Brandão, A Costa
{"title":"Expression profile of p63 in 127 patients with laryngeal squamous cell carcinoma.","authors":"M Borba, C Cernea, F Dias, P Faria, C Bacchi, L Brandão, A Costa","doi":"10.1159/000319904","DOIUrl":"https://doi.org/10.1159/000319904","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate p63 expression in laryngeal squamous cell carcinoma and its prognostic significance.</p><p><strong>Methods: </strong>p63 expression was examined by immunohistochemistry and scored in 127 patients with laryngeal squamous cell carcinomas.</p><p><strong>Results: </strong>Sixty-two cases had scored 3, sixty had scored 2, four had scored 1 and one case did not show any expression (48.8, 47.2, 3.1 and 0.8%, respectively). Overall survival was 73.9% at 24 months and 59.5% at 60 months. The disease-free survival was 77.2 and 75.1%, and the disease-specific survival was 79 and 67% at 24 and 60 months, respectively. Uni- and multivariate analysis identified that decreased immunoexpression of protein p63 was a statistically significant factor for the risk of recurrence and death by cancer.</p><p><strong>Conclusions: </strong>p63 expression was highly prevalent in laryngeal squamous cell carcinomas, and its underexpression was correlated with a worse prognosis.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"319-24"},"PeriodicalIF":1.3,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000319904","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40074123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Speech perception with cochlear implants as measured using a roving-level adaptive test method.","authors":"Sabine Haumann, Thomas Lenarz, Andreas Büchner","doi":"10.1159/000318872","DOIUrl":"https://doi.org/10.1159/000318872","url":null,"abstract":"<p><strong>Aims: </strong>This paper uses a new method of speech testing where the hearing aid or cochlear implant (CI) users are tested in a more realistic listening situation.</p><p><strong>Methods: </strong>Groups of 11 subjects matched for performance with 5 different CI systems, for a total of 55 subjects, were tested with an adaptive test regime where the presentation level of the speech signal roved by ±10 or ±15 dB.</p><p><strong>Results: </strong>Speech reception thresholds varied widely between -4.8 and 17.3 dB with the ±15 dB roving condition being more difficult than the ±10 dB roving condition. We also found significant differences in speech reception threshold between groups using different devices.</p><p><strong>Conclusion: </strong>The test method used in our study, which attempts to test CI users in a more realistic listening situation, is sensitive to the effects of various subject-specific and technical parameters on everyday speech perception with CIs.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"312-8"},"PeriodicalIF":1.3,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000318872","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40074122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bilge Karabulut, Ilknur Bostanci, Mahmut Kacar, Gokhan Karaca, Pinar Kosar
{"title":"Transcutaneous cervical and transabdominal ultrasonography as a diagnostic tool in gastroesophageal reflux in childhood.","authors":"Bilge Karabulut, Ilknur Bostanci, Mahmut Kacar, Gokhan Karaca, Pinar Kosar","doi":"10.1159/000319900","DOIUrl":"https://doi.org/10.1159/000319900","url":null,"abstract":"<p><strong>Background/aim: </strong>The aim of this study is to investigate if there is a diagnostic expressive difference in the angle of His, upper and lower esophageal diameter (UED and LED), wall thickness of cervical esophagus (WTCE) measured by cervical and transabdominal ultrasonography (USG) between children with (+) and without gastroesophageal reflux (GER-).</p><p><strong>Methods: </strong>50 children were separated into 2 groups. Group 1 was the control group (n = 30) consisting of children who had no symptoms of GER and had no GER detected in USG. Group 2 was the study group (n = 20) consisting of children with complaints related to GER, and who were GER+ by USG and esophageal pH monitoring. The USG examinations were completed after having observed 3 episodes of reflux or after 30 min if no reflux was detected. The angle of His, UED, LED and WTCE were measured. In 24-hour esophageal pH monitoring, acid contact to the proximal or distal probe greater than 5.0% of the total time below pH 4 was accepted as pathologic reflux.</p><p><strong>Results: </strong>The age range of the 50 children (30 boys) was 4-13 years. Between the 2 groups there were no differences with regard to age and gender. Values of UED, LED and WTCE were statistically higher in group 2 compared with group 1. The angle of His was higher in the control group, but this was not statistically significant.</p><p><strong>Conclusion: </strong>Our study is the first in the literature that shows that measuring UED, LED and WTCE by USG, which is a noninvasive, readily available repeatable, cheap and fast technique, has a high diagnostic value in children with suspected GER.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"300-4"},"PeriodicalIF":1.3,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000319900","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40064581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Expression of IL-17 and its role in bone destruction in human middle ear cholesteatoma.","authors":"Takuo Haruyama, Masayuki Furukawa, Takeshi Kusunoki, Junko Onoda, Katsuhisa Ikeda","doi":"10.1159/000319897","DOIUrl":"https://doi.org/10.1159/000319897","url":null,"abstract":"<p><strong>Purpose: </strong>The present study was designed to elucidate the immunoreactivity and protein level of IL-17 in human cholesteatomas.</p><p><strong>Procedures: </strong>The expression and localization of IL-17 and receptor activator of nuclear factor κB ligand (RANKL) were examined by immunohistochemistry in tissue specimens collected from 24 patients with cholesteatomas. The cellular sources of IL-17 were assessed by double staining with CD4. The level of IL-17 protein was determined using an enzyme-linked immunosorbent assay. The degree of bone destruction was compared with the IL-17 immunoreactivity.</p><p><strong>Results: </strong>IL-17 immunoreactivity was detected in the inflammatory cells in the granulation tissues and there were increased levels of IL-17 protein. The localization of IL-17 expression coincided with CD4-positive lymphocytes. IL-17 was correlated with the cells positive for RANKL. The degree of bone destruction was dependent on the number of infiltrated IL-17-positive cells. IL-17-driven pathology was observed in the congenital type as compared with the acquired type.</p><p><strong>Conclusions: </strong>The present study suggests that IL-17 is related to the pathogenesis of the disease.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"325-31"},"PeriodicalIF":1.3,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000319897","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40074124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katrien Vermeire, Andrea Kleine Punte, Paul Van de Heyning
{"title":"Better speech recognition in noise with the fine structure processing coding strategy.","authors":"Katrien Vermeire, Andrea Kleine Punte, Paul Van de Heyning","doi":"10.1159/000319748","DOIUrl":"https://doi.org/10.1159/000319748","url":null,"abstract":"<p><strong>Background: </strong>Recently, a new speech coding strategy named 'fine structure processing' (FSP) has been launched.</p><p><strong>Methods: </strong>32 subjects, all users of the MED-EL PULSARCI(100) system, have been switched over from a TEMPO+ to an OPUS 2 speech processor. In 22 subjects, the FSP strategy could be implemented (FSP group), in 10 patients not (high-definition continuous interleaved sampling, HDCIS, group). Subjects were tested with the Tempo+ (CIS+) just before switch-over and after 12 months of OPUS 2 (FSP/HDCIS) use. Performance with FSP/HDCIS was tested at switch-over, and after 1, 3, 6 and 12 months. A sentence-in-noise test and a Speech Spatial and Qualities of Hearing Scale (SSQ) questionnaire were assessed at each test interval.</p><p><strong>Results: </strong>In the FSP group, the speech reception threshold shows a deterioration of 3.3 dB (n.s.) at the acute switch-over interval, but a significant improvement over time (p < 0.001) with a final benefit of 6.5 dB after 12 months of FSP use. A significant improvement over time can also be seen on the spatial subscore of the SSQ questionnaire (p = 0.009). No significant differences could be seen in the HDCIS group.</p><p><strong>Conclusion: </strong>The results show that by enhancing fine structure coding in the lower frequencies, as implemented in the FSP coding strategy, speech perception in noise can be enhanced.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"305-11"},"PeriodicalIF":1.3,"publicationDate":"2010-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000319748","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40074121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sofia Lyford-Pike, Patrick K Ha, Heather A Jacene, John R Saunders, Ralph P Tufano
{"title":"Limitations of PET/CT in determining need for neck dissection after primary chemoradiation for advanced head and neck squamous cell carcinoma.","authors":"Sofia Lyford-Pike, Patrick K Ha, Heather A Jacene, John R Saunders, Ralph P Tufano","doi":"10.1159/000237737","DOIUrl":"https://doi.org/10.1159/000237737","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of our study was to evaluate PET/CT in predicting residual nodal disease after primary chemoradiation (CRT) for head and neck cancer (HNSCC) with N2 disease or greater.</p><p><strong>Design: </strong>A retrospective cohort analysis was conducted. Thirty-eight patients received primary CRT for HNSCC with N2 or greater disease, PET/CT after treatment and neck dissection from January 2003 to December 2006. PET/CT results were correlated with pathology results from neck dissection specimens for each respective side.</p><p><strong>Results: </strong>Forty-six neck regions were analyzed. Nine were determined to have either PET/CT result reports (n = 5) or pathology reports (n = 4) that were indeterminate. PET/CT demonstrated a sensitivity and specificity of 57.1 and 73.9%, respectively, an accuracy of 67.5%, a positive predictive value of 57.1% and a negative predictive value of 73.9% when compared to the final pathology.</p><p><strong>Conclusion: </strong>PET/CT is neither highly sensitive nor highly specific for identifying residual nodal metastases after CRT for advanced-stage HNSCC. Physicians should not rely solely on PET/CT to determine interventions on the neck after CRT. A standardization of language for reporting findings and risk of residual disease is needed.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"251-6"},"PeriodicalIF":1.3,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000237737","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40032865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jing Ye, Hongmeng Yu, Wolfgang Draf, Chunquan Zheng, Dehui Wang
{"title":"Technique and results of the anterior-to-posterior-to-anterior approach in revision endoscopic sinus surgery.","authors":"Jing Ye, Hongmeng Yu, Wolfgang Draf, Chunquan Zheng, Dehui Wang","doi":"10.1159/000240648","DOIUrl":"https://doi.org/10.1159/000240648","url":null,"abstract":"<p><strong>Objective: </strong>To perform the anterior-to-posterior-to-anterior technique in revision endoscopic sinus surgery, and to assess the effects and safety of this technique in treating recurrent chronic sinusitis and nasal polyps.</p><p><strong>Methods: </strong>One hundred and thirteen patients with recurrent chronic sinusitis and nasal polyps received anterior-to-posterior-to-anterior revision endoscopic sinus surgery. This surgical technique has 5 important steps, including exposing the choana, enlarging the maxillary sinus ostium, opening the sphenoid sinus and posterior ethmoid sinus anteriorly to posteriorly, resecting the ethmoid sinus posteriorly to anteriorly, and opening the frontal sinus posteriorly to anteriorly. The choana, maxillary sinus ostium, middle turbinate remnant, and the roof and lateral wall of the sphenoid sinus are 4 stable anatomic reference points.</p><p><strong>Results: </strong>Twelve months postoperatively, the mean SNOT-22 score had improved by 18.48 and 100 (88.50%) patients had an improvement in nasal obstruction; thick nasal discharge, loss of smell or taste, and facial pain/pressure improvements were noted in 102 (90.27%), 64 (56.64%) and 76 (67.26%) patients, respectively. Postoperative endoscopic evaluation after 12 months indicated that 29 (25.66%), 12 (10.62%), 5 (4.42%), 6 (5.31%), and 2 (1.77%) patients had mucosal edema, nasal discharge, synechiae, polyps, and crusting, respectively. No severe complications were observed.</p><p><strong>Conclusion: </strong>The anterior-to-posterior-to-anterior technique is an effective and safe approach to revision endoscopic sinus surgery. The 4 stable anatomic reference points are helpful for preventing severe complications in total ethmoidectomy.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"257-62"},"PeriodicalIF":1.3,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000240648","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40041868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ménière's disease is a viral neuropathy.","authors":"Richard R Gacek","doi":"10.1159/000189783","DOIUrl":"https://doi.org/10.1159/000189783","url":null,"abstract":"<p><p>Morphological and clinical evidence supports a viral neuropathy in Ménière's disease (MD). Quantitative examination of 11 sectioned temporal bones (TBs) from 8 patients with a history of MD revealed a significant loss of vestibular ganglion cells in both the endolymph hydropic (EH) and non-EH ears. Transmission electron microscopy of vestibular ganglion cells excised from a patient with MD revealed viral particles enclosed in transport vesicles. Antiviral treatment controlled vertigo in 73 of 86 patients with vestibular neuronitis (85%) and 32 of 35 patients with MD (91%).</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"78-86"},"PeriodicalIF":1.3,"publicationDate":"2009-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000189783","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39989734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}