ORL; journal for oto-rhino-laryngology and its related specialties最新文献

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Role of leukotriene inhibitors in the postoperative management of nasal polyps. 白三烯抑制剂在鼻息肉术后治疗中的作用。

IF 1.3

ORL; journal for oto-rhino-laryngology and its related specialties Pub Date : 2005-01-01 DOI: 10.1159/000086016

Badr E Mostafa, Hossam Abdel Hay, Hussam E Mohammed, Mohammed Yamani

{"title":"Role of leukotriene inhibitors in the postoperative management of nasal polyps.","authors":"Badr E Mostafa, Hossam Abdel Hay, Hussam E Mohammed, Mohammed Yamani","doi":"10.1159/000086016","DOIUrl":"https://doi.org/10.1159/000086016","url":null,"abstract":"This was a prospective double blind comparative study on 40 patients. It compared the effects of the leukotriene receptor antagonist montelukast and beclomethasone nasal spray on the post-operative course of patients with sinonasal polyps. All patients underwent endoscopic sphenoethmoidectomy and were randomized post-operatively into two groups. Group I: 20 patients (9 females and 11 males) age 17 to 67 (32.4 +/- 9.5 years), receiving 10 mg montelukast orally daily and Group II: 20 patients (6 females and 14 males) age 17 years to 57 years (33.5 +/- 11.9 years), receiving 400 ug beclomethasone local sprays daily. All patients were followed up for 1 year and a symptom score was recorded throughout this period. There was a significant reduction in symptom scores in both groups throughout the study period. In the montelukast group improvement was more marked in itching, post-nasal discharge and headache. The control of sneezing and rhinorrhea was comparable in both groups with a marginal advantage of montelukast. Steroids had a more marked effect on smell disturbances and obstruction. There was no difference in the recurrence rate or in the need for rescue medications between both groups. Both drugs seem to have a complementary action and further studies are needed to determine which patients should receive which treatment.","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"148-53"},"PeriodicalIF":1.3,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000086016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41017125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 55

The nasal airflow in noses with septal perforation: a model study. 鼻中隔穿孔鼻腔气流的模型研究。

IF 1.3

ORL; journal for oto-rhino-laryngology and its related specialties Pub Date : 2005-01-01 DOI: 10.1159/000085958

S Grützenmacher, R Mlynski, C Lang, S Scholz, R Saadi, G Mlynski

{"title":"The nasal airflow in noses with septal perforation: a model study.","authors":"S Grützenmacher, R Mlynski, C Lang, S Scholz, R Saadi, G Mlynski","doi":"10.1159/000085958","DOIUrl":"https://doi.org/10.1159/000085958","url":null,"abstract":"Background: Septal perforation is a common clinical problem in rhinology. Affected patients suffer from a dry nose, crusts as well as recurrent epistaxis and sometimes an inspiratory whistle. The aim of this study was to investigate the underlying flow dynamic mechanisms.Methods: The physical flow effects of such pathologies were examined in functional nose models (box models) and anatomically exact models of the nose. Therefore, septal perforations of different sizes and localisations were studied in straight and deviated nasal septa.Results and conclusions: It could be seen that the localisation of the perforation has no impact on the flow pattern. In large septal perforations, the air jet collides with the posterior edge of the perforation and disintegrates turbulently. Since airflow is physiologically turbulent in the posterior part of the nose, posterior perforations do not cause clinical complaints. The inspiratory whistling sound during respiration is based on the principle of a lip whistle. Large perforations do not cause a whistling sound. The necessary high flow velocity needed in large perforations is usually not achievable.","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"142-7"},"PeriodicalIF":1.3,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000085958","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41017124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

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