ORL; journal for oto-rhino-laryngology and its related specialties最新文献

{"title":"Expression of Concern.","authors":"","doi":"10.1159/orl/aegag011","DOIUrl":"https://doi.org/10.1159/orl/aegag011","url":null,"abstract":"","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"1"},"PeriodicalIF":1.3,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nasal Morphometric Differences Associated with Septal Deviation Severity on Computed Tomography: A Cross-Sectional Anatomical Study.","authors":"Hilal Melis Altintas, Gözde Cingöz, Tugçe Akin, Ibrahim Hira, Ali Köksal, Berin Tugtag Demir","doi":"10.1159/orl/aegag012","DOIUrl":"https://doi.org/10.1159/orl/aegag012","url":null,"abstract":"<p><strong>Introduction: </strong>Nasal septal deviation (NSD) may coexist with variation in the surrounding nasal framework, but its association with nasal proportions and bony-pyramid geometry remains incompletely characterized. This study evaluated the associations of NSD severity and continuous nasal septal deviation angle (NSDA) with computed tomography (CT)-derived nasal morphometric parameters.</p><p><strong>Methods: </strong>This retrospective cross-sectional study included 150 adults, with 50 in each NSD severity category. HC3-robust analysis of covariance adjusted for age, sex, and deviation side was applied across nine morphometric outcomes with false discovery rate (FDR) correction. Secondary models treated NSDA as a continuous exposure. Reliability was assessed in a severity-balanced 50-case subset.</p><p><strong>Results: </strong>Adjusted group effects were significant for the frontal facial angle (FFA), the internasal angle (INA), both nasal bone length-to-nose length (NBL/NL) ratios, and root-based nose length (R-NL; FDR-adjusted p = 0.008-0.049). Severe deviation was associated with a lower INA and lower ratios than mild deviation, and with greater R-NL and FFA than moderate deviation. Continuous models confirmed a lower INA, lower ratios, and lower suture-based nasal bone length, and greater R-NL, per 5° higher NSDA. Decomposition indicated that the lower suture-based ratio was driven mainly by lower nasal-bone length, whereas the lower root-based ratio was driven mainly by greater nose length. Interobserver intraclass correlation coefficients were 0.870-0.970.</p><p><strong>Conclusion: </strong>Greater NSD severity was associated with lower NBL/NL ratios and INA and greater R-NL in this severity-balanced cohort. These findings characterize anatomical covariation in nasal proportion and geometry; their value for surgical decision-making requires prospective evaluation.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"1"},"PeriodicalIF":1.3,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical and Oncological Outcomes Following Excision of Head and Neck Non-Melanoma Skin Cancer.","authors":"Joëlle T Koning, Peter J F M Lohuis, Victor J Kroon, Luuk M Janssen, Jasper J Quak, David R Colnot, Justin E Swartz, Veronica C M Koot, Marieke A D Peters, Pepijn A Borggreven, Rick van de Langenberg","doi":"10.1159/orl/aegag007","DOIUrl":"https://doi.org/10.1159/orl/aegag007","url":null,"abstract":"<p><strong>Objectives: </strong>Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) frequently arise in the head and neck region and require careful surgical management. This study aimed to evaluate the surgical and oncological outcomes of head and neck non-melanoma skin cancer (NMSC) treated with conventional excision by ENT surgeons in a large regional hospital without routine use of Mohs micrographic surgery.</p><p><strong>Methods: </strong>In this single-center retrospective cohort study, all consecutive primary BCC and SCC cases treated by ENT surgeons between 2018 and 2022 were included. The primary outcome was incomplete excision.</p><p><strong>Results: </strong>A total of 821 tumors were excised, including 422 BCCs and 399 SCCs. Of the BCCs, 374 tumors (89%) were completely excised, and incomplete excision was associated with infiltrative growth (OR 2.29, 95% CI 1.24-4.21, p=0.008). Of the SCCs, 353 (88%) were completely excised with sufficient margins, 32 (8%) had close margins (<2 mm), and 14 (4%) had involved margins. When combined, 46 tumors (12%) showed incomplete excision. Poor differentiation (OR 3.17, 95% CI 1.16-8.70, p=0.025), T2/T3 tumors (OR 3.96, 95% CI 1.61-9.74, p=0.003 and OR 6.90, 95% CI 3.28-14.50, p<0.001), tumor diameter 20-40 mm (OR 3.76, 95% CI 1.86-7.61, p<0.001) and deep invasion (OR 5.08, 95% CI 2.43-10.61, p<0.001) were associated with incomplete excision. Metastasis occurred in 8 SCC cases (2%), and recurrence occurred in seven cases (five SCCs, two BCCs).</p><p><strong>Conclusion: </strong>In this cohort, head and neck NMSC managed with conventional excision by ENT surgeons showed favorable surgical outcomes, with relatively low rates of incomplete excision and low observed rates of metastasis and recurrence. These findings suggest that conventional excision remains an effective treatment option in settings where Mohs micrographic surgery is not routinely available.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"1"},"PeriodicalIF":1.3,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corticosteroid Burden and Hearing Outcomes in Eosinophilic Otitis Media With and Without Biologic Therapy: A Pilot Retrospective Cohort Study.","authors":"Takashi Wada, Yasuhiro Arai, Yoshihiro Aizawa, Kiyoshi Sakasai, Hiromitsu Hatakeyama, Nobuhiko Oridate","doi":"10.1159/orl/aegag008","DOIUrl":"https://doi.org/10.1159/orl/aegag008","url":null,"abstract":"<p><strong>Introduction: </strong>Eosinophilic otitis media (EOM) is a refractory, type 2-driven form of otitis media that often requires repeated local and/or systemic corticosteroid therapy. Biologic agents prescribed for comorbid type 2 airway disease may improve EOM outcomes; however, comparative real-world data remain limited. Therefore, we aimed to evaluate changes in EOM severity, air-conduction pure-tone average (PTA), and corticosteroid treatment burden in patients with EOM treated with and without biologic therapy in a single-center retrospective cohort.</p><p><strong>Methods: </strong>We retrospectively reviewed consecutive patients with EOM treated at a single tertiary center. The index date was defined as initiation of biologic therapy (dupilumab or mepolizumab) in the biologics group and initiation of EOM-directed corticosteroid therapy (systemic and/or intratympanic) in the non-biologics group. Post-index outcomes were assessed within a prespecified 10-14-month window, selecting the visit closest to 12 months. The primary analysis was conducted at the patient level, averaging bilateral ear outcomes when applicable. Primary outcomes were the EOM severity score (0-10) and air-conduction PTA (0.5/1/2/4 kHz).</p><p><strong>Results: </strong>Fourteen patients (24 ears) were included (mean age: 57.3±9.3 years; three men/11 women), with seven patients per group. Follow-up timing was standardized (median: 12.5 months; interquartile range [IQR]: 12.0-13.0). Baseline severity score and air-conduction PTA differed between groups (4.9±1.7 vs. 5.7±1.1; 39.6±19.0 vs. 55.0±19.0 dB, respectively). Severity improved in both groups; however, the between-group difference in change did not reach statistical significance (p=0.077). Air-conduction PTA improved within the biologics group (p=0.031); however, the between-group difference in PTA change was not significant (p=0.249). Systemic corticosteroids were discontinued in the biologics group (0.00±0.00 mg/day) but remained required in the non-biologics group (1.35±1.55 mg/day; p=0.011).</p><p><strong>Conclusion: </strong>In this pilot real-world cohort, biologic therapy used for comorbid type 2 airway disease was associated with a reduced corticosteroid burden and lower post-index EOM severity. Air-conduction PTA improved within the biologics group; however, the between-group difference in PTA change was not statistically significant, and the hearing findings should therefore be considered exploratory. These preliminary findings should be interpreted cautiously and may help inform adequately powered future studies.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"1"},"PeriodicalIF":1.3,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological Considerations in Evaluating Olfactory Training for Post-COVID-19 Parosmia: Comments on Xu et al.","authors":"Regin William","doi":"10.1159/orl/aegag001","DOIUrl":"https://doi.org/10.1159/orl/aegag001","url":null,"abstract":"","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"1"},"PeriodicalIF":1.3,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Taste loss and aging.","authors":"Yunmeng Zhu, Thomas Hummel","doi":"10.1159/orl/aegag009","DOIUrl":"https://doi.org/10.1159/orl/aegag009","url":null,"abstract":"<p><strong>Background: </strong>There is a certain degree of \"redundancy\" in the taste system to maintain a stable whole-mouth taste sensation. However, as the compensatory redundancy of the taste system becomes inadequate to offset age related structural and functional deterioration, older adults exhibit heightened vulnerability to taste impairment.</p><p><strong>Summary: </strong>Taste thresholds of older people have an upward trend. At suprathreshold levels, older people tend to be less sensitive to the changes of the concentration of tastants. The taste identification capacity also tends to decrease as aging. The extent of age-related taste loss varies in relation to specific taste qualities, tastant compounds, tastant concentrations (at the suprathreshold level), sites of stimulus presentation, and gender. Other factors, such as increased morbidity, increased administration of medications makes older people more vulnerable to perceptible/diagnosed taste loss.</p><p><strong>Key messages: </strong>The extent of biological-aging-related taste loss is related to taste quality, compound, concentration, stimulation site and gender.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"1"},"PeriodicalIF":1.3,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149122869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multidimensional Approach to 12-Month Response to Mepolizumab in Severe Chronic Rhinosinusitis with Nasal Polyps: A Real-World Single-Centre Study.","authors":"Juan David Gutiérrez-Posso, Aitor Zabala López de Maturana","doi":"10.1159/orl/aegag005","DOIUrl":"10.1159/orl/aegag005","url":null,"abstract":"<p><strong>Introduction: </strong>Although randomised clinical trials have demonstrated the efficacy of mepolizumab in severe chronic rhinosinusitis with nasal polyps (CRSwNP), treatment response in routine clinical practice extends beyond sinonasal outcomes alone and often requires simultaneous assessment of symptom burden, asthma control, and eosinophilic inflammation. Real-world multidimensional evaluations remain limited. This study aimed to evaluate the 12-month clinical response to mepolizumab in patients with severe, uncontrolled CRSwNP using a structured multidimensional assessment framework.</p><p><strong>Methods: </strong>This retrospective single-centre real-world study included adult patients with severe, uncontrolled CRSwNP treated with mepolizumab. All patients had undergone at least two prior endoscopic sinus surgeries and had evidence of type 2 inflammation. Response at 12 months was evaluated across five domains: endoscopic findings, quality of life, nasal symptoms, olfactory symptoms, and asthma control and absence of systemic corticosteroid rescue treatment. Overall response was classified as excellent, partial, or no response. Changes in Nasal Polyp Score (NPS), Sinonasal Outcome Test-22 (SNOT-22), visual analogue scale (VAS) scores, Asthma Control Test (ACT), and blood eosinophil counts were analysed.</p><p><strong>Results: </strong>Ten patients were included. Improvements were observed in NPS (5.3-2.7; p = 0.008), SNOT-22 (63.9-34.6; p = 0.004), nasal VAS (7.0-4.3; p = 0.047), olfactory VAS (9.0-5.9; p = 0.008), ACT (16.2-21.2; p = 0.047), and blood eosinophils (502.2-77.0 cells/µL; p = 0.004). According to the revised multidimensional assessment framework, 5 patients (50%) achieved an excellent response and 5 patients (50%) achieved a partial response. One patient required rescue systemic corticosteroids during follow-up. No patient fulfilled the predefined criteria for non-response.</p><p><strong>Conclusion: </strong>In this small real-world cohort, mepolizumab was associated with improvement across multiple clinically relevant domains in patients with severe CRSwNP. These findings should be considered exploratory and require confirmation in larger prospective studies.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"1"},"PeriodicalIF":1.3,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"Methodological Considerations in Evaluating Olfactory Training for Post-COVID-19 Parosmia: Comments on Xu et al.\"","authors":"Xinni Xu, Kristóf Peter Ludányi, Jerry Hadi Juratli, Fruzsina Németh, Dávid Nagy, Helga Kraxner, Thomas Hummel","doi":"10.1159/orl/aegag006","DOIUrl":"10.1159/orl/aegag006","url":null,"abstract":"","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"1"},"PeriodicalIF":1.3,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148836057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Perspectives on a Hypothetical Olfactory Implant: A French Survey.","authors":"Hakim Benkhatar, Caroline Bigot-Rablet, Jean-Michel Maillard, Claire Martin","doi":"10.1159/orl/aegag002","DOIUrl":"10.1159/orl/aegag002","url":null,"abstract":"<p><strong>Introduction: </strong>Smell loss severely impacts quality of life, and current treatment options remain limited. Emerging concepts such as olfactory implants, combining an external electronic nose and an intracranial neurostimulator, raise important questions regarding patient perceptions, expectations, and acceptability.</p><p><strong>Methods: </strong>The French patient organization <ext-link ext-link-type=\"uri\" xlink:href=\"https://Anosmie.org\" xmlns:xlink=\"http://www.w3.org/1999/xlink\">Anosmie.org</ext-link> conducted an online survey among members experiencing smell loss. The study aimed to explore patient perceptions and expectations regarding a hypothetical olfactory implant. Questions addressed demographics, cause and duration of smell loss, perceived impact on quality of life, expectations and concerns related to such a device, its acceptability, and willingness to engage in future research.</p><p><strong>Results: </strong>A total of 226 patients completed the survey. The majority were women (71.7%), aged between 51 and 70 years (69%). Most participants reported anosmia (72.1%), lasting more than 4 years in 74.5% of cases. Causes were classified as idiopathic (39%), post-viral (32.3%), post-traumatic (25.2%), and toxic (3.5%). The perceived impact on quality of life and mental well-being was strong in 80.1% and 60.6% of cases, respectively. Openness toward an olfactory implant was high: 94.2% would consider it as a potential option, and 66.4% expressed willingness to engage in future research. Expected benefits were mainly related to food enjoyment and safety. Main concerns included fear of surgery, potential side effects, device visibility, and uncertain efficacy.</p><p><strong>Conclusion: </strong>This survey highlights a substantial unmet need among patients with smell loss and provides insight into their perceptions and expectations regarding a potential neuroprosthetic solution. The findings suggest a high level of interest, conditioned by safety, efficacy, discretion, and clear information.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"1"},"PeriodicalIF":1.3,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148805364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated Fractures of the Nose Are Associated with Olfactory Impairment.","authors":"Tanja Krueger, Jana Bauer-Armbruster, Thomas Hummel","doi":"10.1159/orl/aegag004","DOIUrl":"10.1159/orl/aegag004","url":null,"abstract":"<p><strong>Introduction: </strong>Many studies investigated olfactory function following head trauma, but surprisingly few studies looked at smell loss following fractures of the nose. The aim of this study was to examine whether isolated fractures of the nose are associated with olfactory dysfunction.</p><p><strong>Methods: </strong>A total of 97 participants (49 patients in the fracture group, 48 participants in the control group) were included in this cross-sectional study. The fracture and control groups were matched in terms of gender and age. Time since fracture varied, starting from 28 days to a maximum of 2 years. Olfaction was tested using the \"Sniffin' Sticks\" test battery (odour threshold, discrimination, and identification) and further data were collected using a basic questionnaire as well as via ENT examination with nasal endoscopy.</p><p><strong>Results: </strong>Compared to controls, the scores for odour discrimination and odour identification were lower in the fracture group (mean odour identification: 11.5 vs. 12.8; mean odour discrimination: 11.2 vs. 12.6; p < 0.05). Odour thresholds were also decreased in the trauma group (mean odour thresholds: 6.8 vs. 8.1; p = 0.06). General olfactory function scores (TDI score) correlated negatively with the time since fracture (p < 0.001), possibly indicating further decrease of function following trauma.</p><p><strong>Conclusion: </strong>Fractures of the nose are associated with a decrease in olfactory function, which is found especially for odour discrimination and odour identification.</p>","PeriodicalId":520736,"journal":{"name":"ORL; journal for oto-rhino-laryngology and its related specialties","volume":" ","pages":"1"},"PeriodicalIF":1.3,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148762759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}