JBRA assisted reproduction最新文献

{"title":"Knowledge, attitude, and intentions towards fertility preservation in cancer patients among healthcare workers in Northern India.","authors":"Neena Malhotra,&nbsp;Monica Gupta,&nbsp;Anshu Yadav,&nbsp;Perumail Vanamail,&nbsp;Reeta Mahey","doi":"10.5935/1518-0557.20210087","DOIUrl":"https://doi.org/10.5935/1518-0557.20210087","url":null,"abstract":"<p><strong>Objective: </strong>To study the knowledge, attitude, and intentions towards fertility preservation (FP) in cancer patients among healthcare workers (HCWs) in Northern India.</p><p><strong>Methods: </strong>The survey discussed in this study was a 23-item structured questionnaire on oncofertility designed based on previous studies on the topic. A link to the questionnaire was sent through WhatsApp to healthcare workers involved in the care of cancer patients. Their responses were analyzed subsequently.</p><p><strong>Results: </strong>More than a third (37.7%) of the 750 HCWs contacted answered the questionnaire. The group included gynecologists, surgeons, and oncologists. Although 90% of the respondents were aware of the harmful effects of cancer therapy on ovarian function, 76% claimed they had only partial knowledge about fertility preservation (FP). Only a fourth of the respondents were aware of the time needed for oocyte cryopreservation and a third had knowledge of the number of semen samples required for FP. Among HCWs involved in the care of young cancer patients, only 50% reported that they had referred patients for FP. The most common reason for not referring patients for FP was lack of knowledge about FP (43%). More than 90% claimed they wanted to improve their knowledge about oncofertility through continued medical education programs and seminars.</p><p><strong>Conclusions: </strong>The study emphasizes the need for establishing well-structured networks to improve knowledge about FP among HCWs, so that cancer patients are offered the chance of using their gametes to have children after they have been cured from cancer.</p>","PeriodicalId":520656,"journal":{"name":"JBRA assisted reproduction","volume":" ","pages":"305-309"},"PeriodicalIF":1.5,"publicationDate":"2022-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39573282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of peri-ovarian hematoma following oocyte retrieval in a pooling cycle IVF: Case report.","authors":"Garima Sachdeva,&nbsp;Devi R,&nbsp;Kamini A Rao,&nbsp;Madhuri Vidyashankar P","doi":"10.5935/1518-0557.20210079","DOIUrl":"https://doi.org/10.5935/1518-0557.20210079","url":null,"abstract":"<p><p>Here we report a case of peri-ovarian hematoma following ovum pick-up in a patient in a pooling cycle IVF (in vitro fertilization). We have attempted to discuss the possible mechanisms for the development of hematoma in such patients, the common clinical presentation, monitoring, and management of these cases. The decision to operate or to manage conservatively forms an important aspect of managing such patients. This case report can help to keep the clinicians alert while managing this subgroup of patients.</p>","PeriodicalId":520656,"journal":{"name":"JBRA assisted reproduction","volume":" ","pages":"362-365"},"PeriodicalIF":1.5,"publicationDate":"2022-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39606149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between anti-Müllerian hormone, age, and number of oocytes: A retrospective study in a Brazilian in vitro fertilization center.","authors":"Isadora Ferreira Kozlowski,&nbsp;Matheus Campos Carneiro,&nbsp;Vinicius Bonato da Rosa,&nbsp;Alessandro Schuffner","doi":"10.5935/1518-0557.20210083","DOIUrl":"https://doi.org/10.5935/1518-0557.20210083","url":null,"abstract":"Objective Is the AMH level correlated with age and number of mature oocytes retrieved from stimulated cycles? Methods This descriptive, retrospective, observational study included the data of about 1500 patients submitted to Assisted Reproductive Technology treatments in a clinic in Brazil between July 2012 and April 2019. Patients not submitted to IVF and/or without AMH level records were excluded. The study included women with fertility issues aged 20-50 years submitted to IVF. A total of 733 patients were included. The patients were divided by age into three groups (≤35 years old; 36-39 years old; ≥40 years old). Results The mean AMH concentration ranged from 2.65 to 1.35 ng/mL and was significantly different between the groups. The mean total number of retrieved oocytes ranged from 9.5 to 5.42 and was significantly different between the groups. The mean number of mature oocytes ranged from 7.14 to 4.58. There was no significant difference in the number of mature oocytes between patients aged 36-39 years and ≥40 years. Negative correlations were observed between patient age and total number of retrieved oocytes (-0.3354) and number of mature oocytes (-0.2839). AMH was negatively correlated with age (-0.3257), although positive correlations with total number of oocytes (0.6702) and number of mature oocytes (0.5770) were observed. Conclusions This is the largest study performed with Brazilian patients to correlate AMH levels, age, number of oocytes, and number of mature oocytes from controlled ovarian stimulation cycles. Our data showed that as age increases, AMH levels, number of retrieved oocytes, and number of mature oocytes decrease significantly. However, no significant difference in number of mature oocytes was observed when patients aged 36-39 and ≥40 years were compared. In addition, a positive correlation was found between serum AMH levels and total number of retrieved and mature oocytes from stimulated cycles.","PeriodicalId":520656,"journal":{"name":"JBRA assisted reproduction","volume":" ","pages":"214-221"},"PeriodicalIF":1.5,"publicationDate":"2022-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39650395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of semen parameters in consecutive ejaculates with short abstinence period in oligospermic males.","authors":"Vinuta Kulkarni,&nbsp;Pankaj Kaingade,&nbsp;Namrata Kulkarni,&nbsp;Tejal Bhalerao,&nbsp;Amar Nikam","doi":"10.5935/1518-0557.20210073","DOIUrl":"https://doi.org/10.5935/1518-0557.20210073","url":null,"abstract":"<p><strong>Objective: </strong>Human sperm parameters varies widely among men and even between consecutive samples in the same individual with respect to their concentration, motility, morphology, and DNA fragmentation. Less is known about the characteristics of sperm in short abstinence periods. Hence, the current study was conducted to determine the influence of consecutive ejaculate on above parameters after short abstinence period in oligospermic males.</p><p><strong>Methods: </strong>This observational study was conducted from January 2018 to February 2019 and included 67 men undergoing primary infertility treatment at the SDM Fertility Centre, Dharwad, India. The first semen sample was provided after an abstinence period of 2-7 days, while the second sample was collected 1-3 h after the first. The two consecutive semen samples were analyzed according to the 2010 WHO criteria for semen analysis and their parameters were compared. Sperm DNA fragmentation was also measured.</p><p><strong>Results: </strong>Most of the participants were aged of 31 to 40 years (68.6%). The majority of them had the second sample collected after a 1-hour interval (88%); 10.4% of the subjects had the second sample collected after a 2-hour interval; the remaining 1.4% had the second sample collected after a 3-hour interval. Mean concentration (mill/ml), total motility, and progressive motility (%) were significantly higher in the second sample (p<0.05). The second sample also showed lower DNA fragmentation than the first ejaculate sample.</p><p><strong>Conclusions: </strong>Our study inferred that consecutive semen samples collected 1-3 hours apart might have a role in managing subfertility in oligospermic males. Further research, possibly a randomized clinical trial, is needed to explore this association.</p>","PeriodicalId":520656,"journal":{"name":"JBRA assisted reproduction","volume":" ","pages":"310-314"},"PeriodicalIF":1.5,"publicationDate":"2022-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39893519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Nanoalumina on Sex Hormones and Fetuses in Pregnant Rats.","authors":"Hossein Soltaninejad,&nbsp;Hadi Zare-Zardini,&nbsp;Mohammad Amir Amirkhani,&nbsp;Masoomeh Mohammadzadeh,&nbsp;Akram Ghadiri-Anari,&nbsp;Mahtab Ordouei,&nbsp;Ashraf Alemi,&nbsp;Adel Ghorani-Azam","doi":"10.5935/1518-0557.20210045","DOIUrl":"https://doi.org/10.5935/1518-0557.20210045","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed at investigating the effect of nanoalumina on sex hormones, and fetuses in pregnant rats.</p><p><strong>Methods: </strong>In this study, sixty-four pregnant rats were divided into eight groups. The control and the injection-control group received normal food and water, and 0.5 ml of distilled water, respectively. Treatment groups were treated with 25, 50, 100, 250, 500, and 1000µg/ml concentrations of Nanoalumina from the 7th day until the 18th day of pregnancy. On the 18th day, the rats were investigated in terms of their hormone levels. We evaluated the number of healthy and aborted offspring, as well as fetus size.</p><p><strong>Results: </strong>Nanoalumina caused an increase in progesterone hormones at the concentrations of 250, and 500µg/ml, and a significant reduction in estrogen hormone and aborted fetuses at the concentrations of 250 and 500µg/ml (p<0.05). The largest and smallest size of fetuses were observed in 500µg/ml and 1000µg/ml, respectively. The highest number of aborted fetuses was observed in the group treated with the 500µg/ml concentration. There was no aborted fetuses with 25, 50,100, control, and injection-control groups.</p><p><strong>Conclusions: </strong>Due to nanoalumina toxicity, it must be used with caution.</p>","PeriodicalId":520656,"journal":{"name":"JBRA assisted reproduction","volume":" ","pages":"241-246"},"PeriodicalIF":1.5,"publicationDate":"2022-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39329033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Different Doses of Melatonin on in Vitro Maturation of Human Follicular Fluid-Derived Oocyte-Like Cells.","authors":"Saeed Azandeh,&nbsp;Mahin Taheri Moghadam,&nbsp;Mohammad Rashno,&nbsp;Mahvash Zargar,&nbsp;Pardis Abed Zadeh","doi":"10.5935/1518-0557.20210086","DOIUrl":"https://doi.org/10.5935/1518-0557.20210086","url":null,"abstract":"<p><strong>Objective: </strong>Human follicular fluid (FF) contains different cell populations including mesenchymal stem cells. Studies tried to improve their differentiation to oocyte and use them in infertility treatments. Using an antioxidant may improve the quality of these cells. The present study investigated the effects of different doses of melatonin on FF-derived cells grown to oocyte-like cells (OLC).</p><p><strong>Methods: </strong>Cell viability (MTT assay), flow cytometry, and ICC staining were utilized to evaluate CD105 and CD34 expression; colony forming unit assay (CFU-F) capability, qRT-PCR were used to investigate ZP1, ZP2, ZP3, GDF9, and SCP3 expression. AMH, Estradiol and Progesterone levels in the supernatant were measured. Morphological characteristics of fibroblast-like cells changing to a round shape were seen specifically in the group treated with melatonin 10-7M after 2 weeks.</p><p><strong>Results: </strong>There was no difference between control and treatment groups for MTT and CFU assays. ICC staining was positive for CD105 marker and negative for CD34 hematopoietic stem cell marker. qRT-PCR results indicated that ZP1, ZP2, GDF9, and SCP3 expression increased in the group treated with melatonin 10-7M in Week 2, while ZP3 decreased in this group. Progesterone and AMH were detected in differentiation medium.</p><p><strong>Conclusions: </strong>Melatonin may improve in vitro formation of OLCs.</p>","PeriodicalId":520656,"journal":{"name":"JBRA assisted reproduction","volume":" ","pages":"288-298"},"PeriodicalIF":1.5,"publicationDate":"2022-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39631398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Structure of a School-Based Sexual and Reproductive Health Education Program: A Qualitative Study.","authors":"Zahra Bostani Khalesi,&nbsp;Masoomeh Adib,&nbsp;Abdolhosein Emami Sigaroudi","doi":"10.5935/1518-0557.20210072","DOIUrl":"https://doi.org/10.5935/1518-0557.20210072","url":null,"abstract":"<p><strong>Objective: </strong>Training programs on sexual and reproductive health rank among the most effective strategies to empower individuals and engage in self-care in this field. This study aimed to explore the structure of a school-based sexual and reproductive health education program.</p><p><strong>Methods: </strong>A qualitative, inductive, content-analysis approach was used in this study. Participants were selected through a purposeful sampling method. Data were collected through individual in-depth interviews with 21 students; 7 key informants; and 3 focus group discussions with parents. Interviews were recorded and transcribed into text manually. Data analysis was carried out using the content analysis method and the MAXQDA11 software.</p><p><strong>Results: </strong>Three categories of health services emerged from the analysis of participant experiences: 1) empowerment-based education model; 2) optimal educational characteristics; and 3) adolescent-friendly sexual and reproductive health services.</p><p><strong>Conclusions: </strong>The study found that sexual and reproductive health education programs for adolescent girls should be based on empowerment, desirable educational characteristics, and adolescent-friendly mechanisms.</p>","PeriodicalId":520656,"journal":{"name":"JBRA assisted reproduction","volume":" ","pages":"299-304"},"PeriodicalIF":1.5,"publicationDate":"2022-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39691148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between assisted reproductive technology-induced pregnancy and fetal cardiac anomalies.","authors":"Mahvash Zargar,&nbsp;Maryam Rahimi,&nbsp;Mojgan Barati,&nbsp;Farideh Moramazi,&nbsp;Abdolrahman Emami Moghadam,&nbsp;Parastoo Moradi Choghakabodi","doi":"10.5935/1518-0557.20210088","DOIUrl":"https://doi.org/10.5935/1518-0557.20210088","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the incidence of fetal heart defects in assisted reproductive technology (ART)-induced pregnancies compared to natural pregnancies as well as to detect their fetal and maternal risk factors associated with ART.</p><p><strong>Methods: </strong>In this retrospective cohort study, we collected data from the medical records belonging to 2877 pregnant women's fetuses, who underwent fetal echocardiography for various reasons, including ART, over the last 3 years.</p><p><strong>Results: </strong>There were no major cardiac anomaly in the ART-induced pregnancies, while it was seen in 1.32% of natural pregnancies; so, ART did not increase the risk of major cardiac anomalies. However, the incidence of fetal mild cardiac anomalies among fetuses derived from ART-induced pregnancies (51.43%) was significantly higher than that of natural pregnancies (44.43%, p=0.03). None of the ART-induced pregnancies had a history of a child with cardiac disease (vs. 7.56% in natural pregnancies). Also, the increased nuchal thickness (NT) and extra-cardiac anomalies were significantly more prevalent among natural pregnancies, indicating a significant negative correlation between ART and these two risk factors [χ2=10.24, r: -0.06, 95% CI(-0.0974 to -0.0221) and χ2=47.25, r: -0.129, 95% CI(-0.1656 to -0.0913), p<0.01, respectively]. The adjusted odds ratio of developing fetal mild cardiac anomalies were 1.37 times higher greater for ART-induced pregnancies compared to natural pregnancies [95% CI(1.072-1.769), p=0.01].</p><p><strong>Conclusions: </strong>Although the likelihood of developing fetal mild cardiac anomalies was 1.37 times higher for ART-induced pregnancy compared to natural pregnancy, ART did not increase the risk of major cardiac anomalies Although the likelihood of developing fetal mild cardiac anomalies was 1.37 times higher for ART-induced pregnancy compared to natural pregnancy, ART did not increase the risk of major cardiac anomalies.</p>","PeriodicalId":520656,"journal":{"name":"JBRA assisted reproduction","volume":" ","pages":"329-334"},"PeriodicalIF":1.5,"publicationDate":"2022-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39567073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paternal adaptation and related factors in Iranian fathers.","authors":"Negin Jazayeri Nezhad,&nbsp;Zahra Bostani Khalesi,&nbsp;Maryam Niknami","doi":"10.5935/1518-0557.20210044","DOIUrl":"https://doi.org/10.5935/1518-0557.20210044","url":null,"abstract":"Objective Although fathers are an essential element in family health, they are often overlooked by the healthcare system and are not given enough information on how to care for their infants and spouses. In this regard, understanding the characteristics or predictors of paternal adaptation might help healthcare providers design and implement interventions to foster paternal adaptation. The present study looked into paternal adaptation and related factors in Iranian fathers. Methods This cross-sectional study included 298 fathers seen at 41 comprehensive healthcare centers in Rasht. The sampling method was stratified and each comprehensive health center was considered as a separate group. We measured paternal adaptation using the standardized paternal adaptation questionnaire (PAQ) with 38 items and five domains. Results The results indicated that paternal adaptation scores were statistically different based on child age, length of marriage, and history of miscarriage (p<0.05). Father age presented a significant inverse correlation with the adaptation score, with lower paternal adaptation scores observed in older fathers (r=-0.115, p=0.048). Conclusions The most significant factors related to paternal adaptation were history of miscarriage, satisfaction with family wellbeing welfare and income level, nationality of the father, maternal age, and satisfaction with married life.","PeriodicalId":520656,"journal":{"name":"JBRA assisted reproduction","volume":" ","pages":"208-213"},"PeriodicalIF":1.5,"publicationDate":"2022-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39369070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between mutations in the FMR1 gene and ovarian dysfunction in Brazilian patients.","authors":"Cinthia Ramos,&nbsp;Maristela Ocampos,&nbsp;Ingrid Tremel Barbato,&nbsp;Viviane Margareth Scantamburlo Niehues,&nbsp;Maria da Graça Bicalho,&nbsp;Renato Nisihara","doi":"10.5935/1518-0557.20210063","DOIUrl":"https://doi.org/10.5935/1518-0557.20210063","url":null,"abstract":"<p><strong>Objective: </strong>Our study aimed to identify mutations in the FMR1 gene in a group of Brazilian women diagnosed with primary ovarian insufficiency (POI).</p><p><strong>Methods: </strong>This cross-sectional study included patients aged under 40 years with confirmed POI from a convenience sample of patients seen from June 2017 to December 2018 at a University Hospital in Curitiba, Brazil. Genomic DNA was extracted and analyzed using FragilEase(tm) PCR kits (PerkinElmer), a commercially available test that enables the quantification of CGG trinucleotide repeat expansions in the FMR1 gene.</p><p><strong>Results: </strong>A total of 52 patients with an average age of 35.8±3.97 years were included. Fifty (96.1%) had normal alleles with 18 to 43 CGG repeats. The most frequent CGG-repeat sizes were 28 and 30. Two patients (3.8%) presented mutations in the FMR1 gene. The first had alleles with 19/97 CGG repeats, was categorized as a premutation carrier for FXS, and had a son with cognitive impairment. The second had alleles with 21/45 CGG repeats and was described as belonging to the gray zone.</p><p><strong>Conclusions: </strong>In our study, 3.8% of the females with POI had mutations in the FMR1 gene. The most frequent allele sizes were 28 and 30 CGG repeats.</p>","PeriodicalId":520656,"journal":{"name":"JBRA assisted reproduction","volume":" ","pages":"237-240"},"PeriodicalIF":1.5,"publicationDate":"2022-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9118958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39453511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}