European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery最新文献

{"title":"Letter to the editor regarding article: \"Efficacy and safetyof mepolizumab in the treatment of CRSwNP in the real-life setting: a review of the literature\".","authors":"Zusheng Du, Huikang Wang, Xicheng Song, Yu Zhang","doi":"10.1007/s00405-026-10699-7","DOIUrl":"https://doi.org/10.1007/s00405-026-10699-7","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"melatonin and oxidative DNA damage in REM- and NREM-related obstructive sleep apnea: an exploratory analysis of sleep-stage phenotypes\".","authors":"Xinru Liu, Sidian Yao, Xian Jiang","doi":"10.1007/s00405-026-10702-1","DOIUrl":"10.1007/s00405-026-10702-1","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149225699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in obstructive sleep apnea beyond conventional oxygenation metrics.","authors":"Huijuan Cheng, Zhe Zhang, Feng Lu","doi":"10.1007/s00405-026-10703-0","DOIUrl":"https://doi.org/10.1007/s00405-026-10703-0","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of middle turbinate resection versus preservation during endoscopic sinus surgery in patients with chronic rhinosinusitis: a systematic review and meta-analysis.","authors":"Muath Abdullah Almaimoni, Jarallah Hamad Alghazi, Nawaf Ali H Alagrafy, Dema F Alharby, Abdullah Seraye Alseraye, Khalid Saleh A Alsuhaibany, Omar Ibrahim Alanazi, Sameer Al-Bahkaly","doi":"10.1007/s00405-026-10608-y","DOIUrl":"https://doi.org/10.1007/s00405-026-10608-y","url":null,"abstract":"<p><strong>Background: </strong>Chronic rhinosinusitis (CRS) is a common inflammatory disease that significantly impairs quality of life. When symptoms persist despite medical therapy, endoscopic sinus surgery (ESS) is performed. During ESS, whether to resect or preserve the middle turbinate remains controversial: resection may improve access and reduce postoperative obstruction, while preservation maintains anatomy and may support normal healing and airflow. Evidence comparing both approaches is limited and inconsistent, so their relative efficacy and safety remain unclear.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted across various databases until January 2026 to identify relevant studies. The quality was assessed using the ROB2 and Newcastle-Ottawa Scale (NOS) tools and the analysis was performed using R software.</p><p><strong>Results: </strong>The search identified 4,265 records; after screening and full-text assessment, 31 studies were included. Compared with preservation, middle turbinate resection showed a statistically significant improvement in Lund-Kennedy endoscopic score (MD = - 0.58), while symptom improvement measured by SNOT showed no significant difference. Resection significantly reduced postoperative adhesion/synechiae (RR = 0.35) and sinus ostium restenosis (RR = 0.41). For secondary outcomes, olfaction and POSE scores did not differ significantly between groups, and crustation and middle meatal antrostomy patency were not significantly different. Postoperative bleeding risk was higher with resection (RR = 2.24), whereas lateralization (RR = 0.29) and polyp recurrence (RR = 0.58) were lower with resection.</p><p><strong>Conclusion: </strong>Middle turbinate resection during ESS for CRS appears to improve postoperative endoscopic healing and patency-related outcomes (including reduced synechiae and ostial restenosis), but it does not confer a consistent advantage in patient-reported symptoms and is associated with a higher risk of postoperative bleeding; therefore, MT management should be individualized and anatomy-/risk-guided rather than routine.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional outcomes of conventional air- and bone-conduction hearing aids in patients with unilateral sensorineural hearing loss.","authors":"Ruijie Wang, Hengzhen Xie, Zongyun Zhang, Dawei Li, Dongjie Jiang, Junyu Liu, Zhaohao Zhang, Jianfen Luo, Haibo Wang, Lei Xu","doi":"10.1007/s00405-026-10705-y","DOIUrl":"https://doi.org/10.1007/s00405-026-10705-y","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Purpose: &lt;/strong&gt;To explore speech performance in multi-talker environments, subjective satisfaction with hearing and spatial ability, and factors influencing outcomes in patients with unilateral sensorineural hearing loss (USNHL) fitted with conventional hearing aids (HAs).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A total of 32 native Mandarin-speaking individuals with USNHL were retrospectively enrolled. Patients were fitted with either air-conduction (AC) or bone-conduction (BC) HAs based on individual suitability. Real-ear measurements (REM) were performed for AC HA fitting according to NAL-NL2 (adults) or DSL v5 (pediatric) prescriptive targets. At the initial fitting session, speech perception in noise was assessed under multi-talker conditions across three spatial configurations representing binaural squelch, summation, and head shadow effects. The Chinese version of the Speech, Spatial and Qualities of Hearing Scale (C-SSQ12) was administered to evaluate subjective performance. Follow-up assessments at 6 months included speech perception testing, re-administration of the C-SSQ12, and an overall satisfaction survey.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Comparing aided and unaided conditions at the initial HA fitting, no significant differences in speech recognition threshold (SRT) were observed under S&lt;sub&gt;0&lt;/sub&gt;N&lt;sub&gt;0&lt;/sub&gt;, S&lt;sub&gt;0&lt;/sub&gt;N&lt;sub&gt;SSD&lt;/sub&gt;, or S&lt;sub&gt;SSD&lt;/sub&gt;N&lt;sub&gt;NH&lt;/sub&gt; configurations (p = 0.5983,p = 0.1008, p = 0.9375, respectively). At 6-month follow-up (n = 12), no significant improvements in speech perception were detected compared to baseline (p &gt; 0.05 for all configurations). However, regarding C-SSQ12 outcomes (n = 26), scores for questions assessing spatial localization (Questions 6 and 7) showed significant improvements at 6 months compared to baseline (r=-0.5691, p = 0.004 and r=-0.6674, p &lt; 0.001, respectively), while the score for music perception (Question 10) declined (r=-0.5254, p = 0.007). The effect sizes were all large according to Cohen's standards. At initial fitting, a negative correlation was observed between hearing loss duration and SRT variation under S&lt;sub&gt;SSD&lt;/sub&gt;N&lt;sub&gt;NH&lt;/sub&gt; (r =-0.3549, p = 0.0463), and a negative correlation was found between worse ear pure-tone average (PTA) and ∆SRT under S&lt;sub&gt;0&lt;/sub&gt;N&lt;sub&gt;SSD&lt;/sub&gt; (r=-0.4057, p = 0.0212). Pre-aided speech was correlated negatively with ΔSRTs under all three conditions (p all &lt; 0.05). The worse ear PTA was positively correlated with improvement in total C-SSQ12 score at 6 months (r = 0.4743, p = 0.0144).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Within a 6-month adaptation period, patients with USNHL fitted with conventional HAs demonstrated limited improvements in only two items of subjective spatial perception abilities, while the majority of subjective domains and all objective measures of binaural speech-in-noise performance showed no significant benefit. Hearing loss duration, pre-aided speech, and worse ear PTA emerged as factors influe","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does local steroid therapy improve outcomes in acute otitis media with serous labyrinthitis? A retrospective analysis.","authors":"H T Fischer, F Keller, C Schmit, F Theurl, M Santer, A Hils, L Stecher, F Koller, L Schmutzler, T Gottfried, J Schmutzhard, B Hofauer, D Dejaco","doi":"10.1007/s00405-026-10616-y","DOIUrl":"https://doi.org/10.1007/s00405-026-10616-y","url":null,"abstract":"<p><strong>Purpose: </strong>Sensorineural hearing loss represents a rare but clinically relevant complication of acute otitis media (AOM). Although intratympanic glucocorticoid (GC) therapy is established in other cochleovestibular disorders, its efficacy in this context remains insufficiently investigated. The aim of this study was to retrospectively assess whether local intratympanic glucocorticoid application is associated with improved clinical outcomes in patients with acute otitis media-related sensorineural hearing loss.</p><p><strong>Methods: </strong>A retrospective analysis was performed on patients diagnosed with AOM-associated inner ear involvement between January 2014 and November 2024. Patients were stratified according to GC treatment regimen: (1) intratympanic application of glucocorticoids (IC), (2) no intratympanic application of glucocorticoids (NIC). Subgroup analyses were performed according to the surgical drainage method and severity of inner ear involvement. Primary endpoint was improvement in bone-conduction pure-tone average (BCPTA4).</p><p><strong>Results: </strong>A total of 137 patients were included (IC: 44, NIC: 93). Sex, affected side and subjective improvement did not differ significantly between both groups (all p > 0.08). Both groups demonstrated significant hearing improvement following treatment (p < 0.001). Although numerical trends favored the NIC group across different severity levels, no statistically significant differences in BCPTA4 improvement were observed between treatment modalities (p = 0.8); however, the non-randomized design and baseline group differences limit interpretation. In exploratory analyses, Ventilation Tube Insertion (VT) and CO₂-laser myringotomy (LP) were associated with significant hearing recovery (p < 0.001).</p><p><strong>Conclusions: </strong>Both treatment regimens (IC, NIC) led to significant hearing improvement in AOM-associated inner ear involvement. In this non-randomized comparison, no statistically significant difference in BCPTA4 improvement was detected between groups; however, selection bias, baseline imbalances and residual confounding may have obscured small treatment effects. These findings do not constitute evidence of equivalence.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Longitudinal correlations of subjective, functional, and objective voice parameters following radiotherapy for early glottic carcinoma.","authors":"Abdulaziz Marzouq Al-Rashidi, Hossam Mohamed El Dessouky, Ahmed Mohamed ELdemerdash, Aisha Fawzy Abdel-Hady, Sahar Saad Shohdi","doi":"10.1007/s00405-026-10670-6","DOIUrl":"https://doi.org/10.1007/s00405-026-10670-6","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the letter to the editor regarding \"Intracapsular tonsillectomy in adults with obstructive sleep apnoea and large tonsils\".","authors":"Henrik M Sjöblom, Jaakko M Piitulainen","doi":"10.1007/s00405-026-10729-4","DOIUrl":"https://doi.org/10.1007/s00405-026-10729-4","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum vitamin D and olfactory function: a threshold effect rather than a dose-response gradient? Comment on Baran et al.","authors":"Ahmet Faruk Erdem","doi":"10.1007/s00405-026-10649-3","DOIUrl":"https://doi.org/10.1007/s00405-026-10649-3","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stromal tumor-infiltrating lymphocytes (sTIL) in laryngeal squamous cell carcinoma: association with pharyngocutaneous fistula, recurrence, and mortality.","authors":"Selçuk Erol, B Barış Büyük, Ayşegül Erol, Nazan Bozdoğan, Felat Toprak, Ayça Arslan","doi":"10.1007/s00405-026-10680-4","DOIUrl":"https://doi.org/10.1007/s00405-026-10680-4","url":null,"abstract":"<p><strong>Purpose: </strong>Previous studies suggest a favorable prognostic role for tumor-infiltrating lymphocytes in laryngeal squamous cell carcinoma, although findings vary by immune-cell phenotype, assessment method, tumor compartment, and cohort characteristics. This study evaluated associations between sTIL percentage and pharyngocutaneous fistula, recurrence, and mortality after surgery.</p><p><strong>Methods: </strong>This single-center retrospective cohort included 81 patients who underwent primary or salvage total laryngectomy between January 2019 and March 2024. sTIL was assessed on H&E sections according to International TILs Working Group guidelines. Because sTIL was non-normally distributed (Shapiro-Wilk W = 0.908; p < 0.001), non-parametric tests were used. Associations were assessed using Mann-Whitney U, Kruskal-Wallis, chi-square/Fisher's exact tests, and Spearman correlation. Survival was analyzed using Kaplan-Meier and Cox regression.</p><p><strong>Results: </strong>Median sTIL was 30% (IQR: 10-50%). sTIL was not significantly associated with fistula, recurrence, mortality, surgical approach, lymphovascular or perineural invasion, T stage, or differentiation grade (all p > 0.05). Mortality was associated with older age (68 vs. 60 years; p = 0.004). Deceased patients had longer observed follow-up, reflecting time-to-event structure rather than a prognostic association. Kaplan-Meier analysis showed no survival difference by sTIL group (log-rank p = 0.914). In the reduced multivariable Cox model, age (HR: 1.05; p = 0.043) and lymphovascular invasion (HR: 4.79; p < 0.001) were independently associated with mortality, whereas sTIL was not (HR: 1.01; p = 0.600).</p><p><strong>Conclusions: </strong>H&E-based sTIL scoring was not significantly associated with pharyngocutaneous fistula, recurrence, or overall survival. Given the limited number of fistula events, the fistula-related findings should be considered exploratory and hypothesis-generating. Age and lymphovascular invasion were independently associated with mortality. These non-confirmatory findings require validation in larger studies using spatial and phenotypic immune profiling.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}