European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery最新文献

{"title":"Role of hematological parameters and inflammatory indices in determining the severity of obstructive sleep apnea syndrome: reality or myth?","authors":"Ayşe Seçil Kayali Dinç, Nagihan Gülhan Yaşar, Agah Yeniçeri, İrem Ağgünlü, Nurcan Yurtsever Kum, Melih Çayönü","doi":"10.1007/s00405-025-09528-0","DOIUrl":"https://doi.org/10.1007/s00405-025-09528-0","url":null,"abstract":"<p><strong>Purpose: </strong>Obstructive sleep apnea syndrome (OSAS) affects a substantial portion of the adult population, and chronic inflammation plays a crucial role in its pathophysiology. This study aimed to investigate the effectiveness of blood parameters and inflammatory indices in predicting OSAS severity.</p><p><strong>Methods: </strong>Patients diagnosed with OSAS who presented to our clinic between December 2009 and December 2024 were included in the study. OSAS severity was determined based on polysomnography results. Blood parameters obtained during hospitalization were recorded. The following hematological indices were calculated from blood parameters: neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), prognostic nutritional index(PNI), pan-immune-inflammation value (PIV), and hemoglobin, albumin, lymphocyte, and platelet (HALP) index. Moreover, the potential role of these hematological parameters and indices in determining OSAS severity was investigated.</p><p><strong>Results: </strong>A total of 1009 patients were included in the study. Among them, 106 had simple snoring, 214 had mild OSAS, 224 had moderate OSAS, and 465 had severe OSAS. No significant association was observed between OSAS severity and blood parameters, including albumin level, hemoglobin level, leukocyte count, neutrophil count, lymphocyte count, and platelet count, delta neutrophil index (DNI) (p-values: 0.083, 0.483, 0.347, 0.555, 0.878, 0.220, 0.459, respectively). Additionally, no significant correlation was observed between OSAS severity and hematological inflammatory indices such as NLR, PLR, SII, PNI, PIV, and HALP Index (p-values: 0.919, 0.369, 0.701, 0.581, 0.397, 0.503, respectively).</p><p><strong>Conclusion: </strong>Inflammatory processes play a role in the pathophysiology of OSAS; however, the present study revealed no relationship between OSAS severity and hematological inflammatory indices.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abdominal visceral fat and laryngopharyngeal reflux in patients with obstructive sleep apnea.","authors":"Nuo Luo, Guan-Jiang Huang, Biao-Qing Lu","doi":"10.1007/s00405-025-09519-1","DOIUrl":"https://doi.org/10.1007/s00405-025-09519-1","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive modeling for score translation among patient-reported outcome measures in chronic rhinosinusitis with nasal polyps: a cross-sectional study.","authors":"J M García-Fernández, M S Sánchez-Torices, M A Feliz-Fernández, R Lomas-Vega, M A Montilla-Ibáñez","doi":"10.1007/s00405-025-09446-1","DOIUrl":"https://doi.org/10.1007/s00405-025-09446-1","url":null,"abstract":"<p><strong>Background: </strong>Patient-reported outcome (PRO) questionnaires are essential tools for evaluating symptom burden and quality of life in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). Instruments such as NOSE, SNOT-22, CRS-PRO, and NPQ are commonly used; however, the capability to translate scores between these instruments remains largely unexplored, limiting cross-study comparisons and continuity in patient care.</p><p><strong>Objective: </strong>To develop and validate predictive models quantifying relationships between widely utilized PRO questionnaires in CRSwNP and to assess their practical implications for clinical management and integration into research.</p><p><strong>Methods: </strong>In this observational cross-sectional study, 200 patients with CRSwNP completed the NOSE, SNOT-22, CRS-PRO, and NPQ questionnaires. Pairwise predictive models were constructed using linear and Random Forest regression methods. Model performance was evaluated through metrics such as R² and mean squared error (MSE). Model validity was ensured using the Durbin-Watson, Breusch-Pagan, Shapiro-Wilk, and variance inflation factor (VIF) tests. Clinical subgroup analyses based on variables such as asthma and prior nasal surgery were also conducted.</p><p><strong>Results: </strong>Strong correlations among questionnaires were observed (r=0.61-0.87). Linear regression models demonstrated high predictive accuracy, notably for SNOT-22 predicting NPQ (R²=0.76), NPQ predicting CRS-PRO (R²=0.76), and CRS-PRO predicting SNOT-22 (R²=0.74). Random Forest models showed minor performance enhancements (ΔR²≤0.03). Subgroup analyses indicated increased predictive precision in patients with asthma or previous nasal surgery. These predictive models enable clinicians to interpret scores across different instruments confidently, optimizing patient management decisions, particularly in monitoring treatment responses and longitudinal follow-ups.</p><p><strong>Results: </strong>Predictive modeling among PRO questionnaires in CRSwNP is both feasible and clinically impactful. These models facilitate the translation of scores between instruments, thus enhancing clinical decision-making, streamlining patient assessments, and supporting data harmonization in multicentric and longitudinal studies. Future research should pursue external and longitudinal validations to ensure broader applicability and reliability of these predictive tools.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supraglottoplasty outcomes and peri-operative care in congenital laryngomalacia.","authors":"Xue-Qing Gao, Ting Lei, Ding-Ling Zhao","doi":"10.1007/s00405-025-09520-8","DOIUrl":"https://doi.org/10.1007/s00405-025-09520-8","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laryngeal Bullous Pemphigoid: A challenging presentation of a rare disease.","authors":"Hussein Smaily, Matthieu Crouslé, Edith Hanna","doi":"10.1007/s00405-025-09506-6","DOIUrl":"https://doi.org/10.1007/s00405-025-09506-6","url":null,"abstract":"<p><strong>Introduction: </strong>Bullous pemphigoid (BP) is a rare autoimmune disorder characterized typically by skin manifestations and rarely mucosal involvement.</p><p><strong>Case report: </strong>We present here a very unusual and challenging case of BP with exclusive laryngeal involvement at presentation.</p><p><strong>Discussion and conclusion: </strong>This case highlights the challenges encountered in the diagnosis and management of BP with laryngeal mucosal involvement and underscores the importance of proper biopsy technique to enable an accurate and timely diagnosis.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT versus DeepSeek in head and neck cancer staging and treatment planning: guideline-based study.","authors":"Burcu Vural Camalan, Sumeyra Doluoglu, Nazlim Hilal Taraf, Mehmet Murat Gunay, Samet Ozlugedik","doi":"10.1007/s00405-025-09524-4","DOIUrl":"https://doi.org/10.1007/s00405-025-09524-4","url":null,"abstract":"<p><strong>Purpose: </strong>This prospective simulation study was conducted to evaluate and compare the performance of ChatGPT (o1, 2023) and DeepSeek (V3, 2024) in staging and treatment planning for head and neck cancers.</p><p><strong>Methods: </strong>This prospective simulation study was conducted in March 2025 to evaluate and compare the performance of two advanced artificial intelligence (AI) models, ChatGPT (o1, 2023) and DeepSeek (V3, 2024), in clinical decision-making for head and neck malignancies. A total of 50 hypothetical, guideline-based clinical scenarios were carefully designed in English by two otorhinolaryngologists in alignment with the National Comprehensive Cancer Network® (NCCN®) Guidelines Version 2.2025.</p><p><strong>Results: </strong>In the overall analysis of treatment planning performance, DeepSeek (V3, 2024) demonstrated statistically superior accuracy compared to ChatGPT (o1, 2023) (p = 0.04). Both models showed comparable performance in tumor staging (p = 0.83). Both DeepSeek (p = 0.0001) and ChatGPT (p = 0.02) were statistically successful in respect of staging accuracy and providing fully correct answers on the subject of treatment.</p><p><strong>Conclusion: </strong>Although DeepSeek V3 demonstrated promising capability for clinical decision support in head and neck oncology, these artificial intelligence tools cannot replace multidisciplinary tumor boards. However, they can significantly streamline clinical workflows by rapidly organizing patient data, thereby enhancing board efficiency. Future efforts should prioritize the development and integration of secure, institution-specific, local large language models tailored for oncological decision-making.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the letter to editor.","authors":"Zeynel Öztürk, Nuray Bayar Muluk, Rahime Koca, Necdet Özçelik, Elvin Alaskarov, İbrahim Çukurova, Erdem Atalay Çetinkaya, Özgür Yörük, Cengiz Bal, Arzu Tatar, Nihat Susaman, Nagehan Dilşad Erdoğmuş Küçükcan, Ayten Güner Atayoğlu, Enes Güngör, Burak Mustafa Taş, Cemal Cingi","doi":"10.1007/s00405-025-09518-2","DOIUrl":"https://doi.org/10.1007/s00405-025-09518-2","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory assessment of an endolaryngeal surgical model with a novel hyperangulated 3D printed laryngoscope.","authors":"Viola D Hahn, Gabriel L Gschwend, Linus L Kienle, Leon R Schild, Jens Greve, Thomas K Hoffmann, Patrick J Schuler, Felix Böhm","doi":"10.1007/s00405-025-09514-6","DOIUrl":"https://doi.org/10.1007/s00405-025-09514-6","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Presentation of complex laryngotracheal surgeries using CT-based 3D models and 3D printing: a technical note.","authors":"Zoltán Tóbiás, Ádám Perényi, Ádám Bach, Roland Nagy, Miklós Csanády, Zsolt Geretovszky, Martin Cseh, László Rovó","doi":"10.1007/s00405-025-09497-4","DOIUrl":"https://doi.org/10.1007/s00405-025-09497-4","url":null,"abstract":"<p><strong>Introduction: </strong>Slide laryngotracheopexy for cricotracheal stenosis and extended partial laryngectomy combined with tracheopexy for T2-T3 glottic tumors represent novel, complex laryngotracheal surgeries requiring meticulous preoperative planning.</p><p><strong>Methods: </strong>In addition to conventional diagnostic tools (imaging, endoscopy), digital/virtual 3D techniques along with 3D printing - also referred to as Additive Manufactoring (AM)- allow for the creation and application of CT-based virtual and 3D-printed models of the larynx and the trachea. These 3D technologies can facilitate surgical team preparation and provide an innovative approach to training on complex surgical solutions.</p><p><strong>Discussion: </strong>This paper presents the digital workflow for three cases where patient-specific 3D laryngotracheal models were developed and successfully applied in surgical planning and training. These models serve as high-fidelity anatomical representations for surgical rehearsal, training, and patient communication, demonstrating their potential for broader clinical implementation.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The changing profile of laryngeal cancer: a 20-year retrospective cohort analysis.","authors":"Kelten Clements, Rhona Hurley, David I Conway, Claire Paterson, Catriona M Douglas","doi":"10.1007/s00405-025-09500-y","DOIUrl":"https://doi.org/10.1007/s00405-025-09500-y","url":null,"abstract":"<p><strong>Background: </strong>Laryngeal cancer incidence has declined in the Western World, but subsite-specific trends are underreported. This study assessed changes in the profile of laryngeal cancer patients in a regional cancer network.</p><p><strong>Methods: </strong>Two patient cohorts from the west of Scotland were analysed: 326 patients diagnosed in 1999-2001 (historical cohort) and 386 diagnosed in 2018-2020 (contemporary cohort). Changes in risk factors, tumour characteristics, and treatment patterns were compared using Chi-square and Student's t-tests. Two-year survival was assessed using the Kaplan-Meier method and Cox proportional hazards models.</p><p><strong>Results: </strong>Overall proportion of supraglottic (C32.1) cancers increased from 38.0 to 58.0%, becoming the predominant subtype, while glottic (C32.0) cancers decreased from 56.7 to 32.6% (p < 0.001). Early-stage diagnosis of glottic cancers rose from 65.6 to 77.0% (p = 0.031), while supraglottic cancers continued present at advanced stages, 70.5% vs. 64.3% (p = 0.24). Surgical treatment for all laryngeal cancers increased from 10.4 to 38.2%, while radiotherapy declined from 57.7 to 38.2% (p < 0.001). Two-year risk of death for glottic cancers decreased by 42% in the contemporary cohort (p = 0.02), with no significant survival change for supraglottic or overall laryngeal cancers.</p><p><strong>Conclusion: </strong>Glottic cancers now represent a smaller proportion of laryngeal cancer cases, with earlier diagnosis and improved survival outcomes. Conversely, supraglottic cancers have become more prevalent, often diagnosed at advanced stages without improvements in overall survival.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}