{"title":"c反应蛋白及其与白蛋白的比值作为口腔癌不良预后的标志：一项系统综述和荟萃分析","authors":"Jiating Xuan, Xiaoqing Ma","doi":"10.1007/s00405-025-09702-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This review aims to examine the prognostic ability of C-reactive protein (CRP) and CRP-albumin ratio (CAR) for oral cancer.</p><p><strong>Methods: </strong>Repositories of PubMed, Scopus, Embase, and Web of Science were searched for studies reporting an association between CRP or CAR and overall survival (OS) or disease-free survival (DFS) in oral cancer patients. The search ended on 13th December 2024. Random-effects meta-analysis was conducted.</p><p><strong>Results: </strong>A total of 11 studies (six on CRP and five on CAR) were included. Meta-analysis showed that high CRP levels were associated with worse OS survival (HR: 1.80 95% CI: 1.11, 2.92 I<sup>2</sup> = 80%) and DFS in oral cancer patients (HR: 1.81 95% CI: 1.28, 2.56 I<sup>2</sup> = 0%). The pooled analysis also showed a statistically significant relationship between high CAR and poor OS (HR: 3.15 95% CI: 2.25, 4.42 I<sup>2</sup> = 0%) and DFS (HR: 2.50 95% CI: 1.38, 4.55 I<sup>2</sup> = 19%). Results of OS based on CRP were not robust on sensitivity and subgroup analysis. However, no change in the significance of results was noted for OS based on CAR on sensitivity and subgroup analysis.</p><p><strong>Conclusions: </strong>Both CRP and CAR could be potential biomarkers for predicting survival after oral cancer. Stronger association and better stability of results were seen with CAR. The low number of studies and high interstudy heterogeneity are limitations of current evidence.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"C-reactive protein and its ratio with albumin as a marker of poor prognosis in oral cancer: a systematic review and meta-analysis.\",\"authors\":\"Jiating Xuan, Xiaoqing Ma\",\"doi\":\"10.1007/s00405-025-09702-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This review aims to examine the prognostic ability of C-reactive protein (CRP) and CRP-albumin ratio (CAR) for oral cancer.</p><p><strong>Methods: </strong>Repositories of PubMed, Scopus, Embase, and Web of Science were searched for studies reporting an association between CRP or CAR and overall survival (OS) or disease-free survival (DFS) in oral cancer patients. The search ended on 13th December 2024. Random-effects meta-analysis was conducted.</p><p><strong>Results: </strong>A total of 11 studies (six on CRP and five on CAR) were included. Meta-analysis showed that high CRP levels were associated with worse OS survival (HR: 1.80 95% CI: 1.11, 2.92 I<sup>2</sup> = 80%) and DFS in oral cancer patients (HR: 1.81 95% CI: 1.28, 2.56 I<sup>2</sup> = 0%). The pooled analysis also showed a statistically significant relationship between high CAR and poor OS (HR: 3.15 95% CI: 2.25, 4.42 I<sup>2</sup> = 0%) and DFS (HR: 2.50 95% CI: 1.38, 4.55 I<sup>2</sup> = 19%). Results of OS based on CRP were not robust on sensitivity and subgroup analysis. However, no change in the significance of results was noted for OS based on CAR on sensitivity and subgroup analysis.</p><p><strong>Conclusions: </strong>Both CRP and CAR could be potential biomarkers for predicting survival after oral cancer. Stronger association and better stability of results were seen with CAR. The low number of studies and high interstudy heterogeneity are limitations of current evidence.</p>\",\"PeriodicalId\":520614,\"journal\":{\"name\":\"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-09-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s00405-025-09702-4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s00405-025-09702-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
C-reactive protein and its ratio with albumin as a marker of poor prognosis in oral cancer: a systematic review and meta-analysis.
Objective: This review aims to examine the prognostic ability of C-reactive protein (CRP) and CRP-albumin ratio (CAR) for oral cancer.
Methods: Repositories of PubMed, Scopus, Embase, and Web of Science were searched for studies reporting an association between CRP or CAR and overall survival (OS) or disease-free survival (DFS) in oral cancer patients. The search ended on 13th December 2024. Random-effects meta-analysis was conducted.
Results: A total of 11 studies (six on CRP and five on CAR) were included. Meta-analysis showed that high CRP levels were associated with worse OS survival (HR: 1.80 95% CI: 1.11, 2.92 I2 = 80%) and DFS in oral cancer patients (HR: 1.81 95% CI: 1.28, 2.56 I2 = 0%). The pooled analysis also showed a statistically significant relationship between high CAR and poor OS (HR: 3.15 95% CI: 2.25, 4.42 I2 = 0%) and DFS (HR: 2.50 95% CI: 1.38, 4.55 I2 = 19%). Results of OS based on CRP were not robust on sensitivity and subgroup analysis. However, no change in the significance of results was noted for OS based on CAR on sensitivity and subgroup analysis.
Conclusions: Both CRP and CAR could be potential biomarkers for predicting survival after oral cancer. Stronger association and better stability of results were seen with CAR. The low number of studies and high interstudy heterogeneity are limitations of current evidence.
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