European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery最新文献

{"title":"A comment on the search strategy in the sulcus vocalis bibliometric analysis.","authors":"Ahmet Ufuk Kilictas","doi":"10.1007/s00405-025-09617-0","DOIUrl":"https://doi.org/10.1007/s00405-025-09617-0","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic significance of nutritional and inflammatory markers in locoregional advanced laryngeal cancer undergoing total laryngectomy.","authors":"Elvan Onan, Muhammed Dagkiran, Berk Alsancak, Caglar Eker, Ozgur Surmelioglu, Ilda Tanrisever Pehlivan, Suleyman Ozdemir, Mustafa Mete Kiroglu","doi":"10.1007/s00405-025-09603-6","DOIUrl":"https://doi.org/10.1007/s00405-025-09603-6","url":null,"abstract":"<p><strong>Purpose: </strong>Advanced-stage laryngeal squamous cell carcinoma (LSCC) carries a poorprognosis despite advances in surgical and adjuvant therapies. Identifying reliable prognostic markers remains critical to improving risk stratification and tailoring treatment strategies. This study evaluated the prognostic significance of inflammatory and nutritional markers, notably the Prognostic Nutritional Index (PNI) and modified Glasgow Prognostic Score (mGPS), alongside conventional pathological parameters in patients undergoing total laryngectomy.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on 111 patients with locoregional advanced LSCC treated with primary total laryngectomy between 2013 and 2020. Clinical, histopathological, and laboratory variables were analyzed. Survival outcomes were assessed using Kaplan-Meier analysis and log-rank tests. Multivariate prognostic factors were identified through Cox proportional hazards modeling.</p><p><strong>Results: </strong>PNI < 45 was significantly associated with increased mortality (p = 0.001) and inferior mean survival (62 months vs. 98 months for PNI ≥ 45). In multivariate analysis, PNI < 45 (HR = 0.375; p < 0.001) and lymphovascular invasion (HR = 0.372; p = 0.012) emerged as independent predictors of overall survival. While nodal metastasis correlated with poor survival in univariate analysis, it did not retain significance in the multivariate model. Traditional inflammatory markers (mGPS, NLR, PLR) did not demonstrate prognostic relevance. Furthermore, PNI < 45 was associated with an increased risk of pharyngocutaneous fistula formation (p = 0.007), although neither fistula presence nor postoperative complications correlated with disease recurrence or survival.</p><p><strong>Conclusions: </strong>PNI and lymphovascular invasion are robust independent predictors of survival in patients with advanced LSCC undergoing total laryngectomy. Unlike mGPS, NLR, or PLR, PNI offers a simple, cost-effective prognostic tool that captures nutritional and immunological status. Integrating PNI into clinical practice may enhance individualized risk stratification, and prospective trials are warranted to explore whether preoperative nutritional optimization can improve outcomes in this high-risk population.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Critical appraisal: prediction accuracy of cochlear implant electrode insertion using the OTOPLAN software\".","authors":"Shafiullah","doi":"10.1007/s00405-025-09606-3","DOIUrl":"10.1007/s00405-025-09606-3","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor regarding \"Prediction accuracy of cochlear implant electrode insertion using the OTOPLAN software\".","authors":"Ziad Khan","doi":"10.1007/s00405-025-09608-1","DOIUrl":"10.1007/s00405-025-09608-1","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An overview of switching biological therapies for chronic rhinosinusitis with nasal polyposis (CRSwNP).","authors":"Talal Alharbi, Nawaf Alsubaie, Ahmad Alroqi","doi":"10.1007/s00405-025-09559-7","DOIUrl":"https://doi.org/10.1007/s00405-025-09559-7","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a type 2 inflammatory disease, which can lead to significant impact on quality of life due to symptoms of local and systemic inflammation and has a high recurrence rate despite optimal medical or surgical treatment. Recalcitrant CRSwNP can be treated with biological therapies with specific immunological targets, such as IgE (Omalizumab), IL4α receptors (Dupilumab), or IL-5 (Mepolizumab), which have been approved for this use. The purpose of this narrative review was to review the currently available literature on biological therapies for CRSwNP and their switching in cases of inadequate disease control.</p><p><strong>Methods: </strong>Keywords such as 'biologic'; 'anti-IgE'; 'anti-IL5'; 'anti-IL4'; 'sinusitis'; 'chronic rhinosinusitis'; 'nasal polyps'; 'switch'; and 'recurrence' were combined using the 'AND' or 'OR' Boolean operators to search databases including Google Scholar, Medline, and EMBASE; free-text search was also utilized for this purpose.</p><p><strong>Results: </strong>While there is sufficient evidence to support the use of biological therapies for recurrent and refractory CRSwNP despite the use of nasal corticosteroids as an add-on or adjunctive therapy, there is paucity of evidence regarding switching from one biologic to another. Evidence on biologic switching for recurrent CRSwNP supported the use of Dupilumab while switching from anti-IgE or anti-IL5 biologics, due to better symptom control and improved quality of life outcomes.</p><p><strong>Conclusion: </strong>Biological treatments for CRSwNP have good real-life efficacy in managing nasal symptoms and improving quality of life. Multidisciplinary consensus from immunologists or allergists, otorhinolaryngologists, and pulmonologists is essential for aiding decision-making regarding switching biologics.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative adjuvant immunotherapy versus standard of care in resectable locally advanced head and neck squamous cell carcinoma with intermediate- and high-risk factors: a real-world retrospective study.","authors":"Xiaoqiong Shi, Minhui Zhu, Jianqiao He, Yingna Gao, Yi Ma, Haopu Li, Guoning Yu, Lin Zhao, Hongliang Zheng, Caiyun Zhang","doi":"10.1007/s00405-025-09602-7","DOIUrl":"https://doi.org/10.1007/s00405-025-09602-7","url":null,"abstract":"<p><strong>Purpose: </strong>Improving the prognosis of patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC) who have intermediate- and high-risk factors has long been a priority for head and neck surgeons. This study aims to evaluate programmed death-1 (PD-1) inhibitors administered as maintenance monotherapy after standard of care in patients with postoperative intermediate- and high-risk LA-HNSCC.</p><p><strong>Methods: </strong>We retrospectively reviewed 47 postoperative intermediate- and high-risk patients with LA-HNSCC who underwent operative interventions between 2016 and 2022. These patients were divided into two groups: a standard therapy group (n = 24) and an adjuvant immunotherapy group (n = 23 standard therapy + immunotherapy). The primary endpoint was 2-year progression-free survival (PFS) and 2-year overall survival (OS). Stratification analysis according to baseline combined positivity score (CPS), with cutoffs set at CPS ≥ 20, was performed to analyze the correlation between CPS and treatment outcomes.</p><p><strong>Results: </strong>The 2-year PFS and OS rates in the adjuvant immunotherapy group were 82.6% and 96.0%, respectively, compared to 62.5% (χ2 = 2.376, P = 0.123) and 75.0% (χ2 = 3.646, P = 0.056) in the standard therapy group. Stratified analysis showed that the 2-year PFS and OS rates for patients in the adjuvant immunotherapy group with programmed death ligand 1 (PD-L1) combined positive score (CPS) ≥ 20 significantly improved compared to the standard therapy group (93.3% vs. 62.5%, χ2 = 4.573, P = 0.033), (100.0% vs. 75.0%, χ2 = 4.212, P = 0.040).</p><p><strong>Conclusion: </strong>This cohort study found that adjuvant immunotherapy after the standard of care improved PFS and OS in patients with postoperative intermediate- and high-risk LA-HNSCC, especially for those with a PD-L1 CPS of 20 or more.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: \"Prognostic Significance of Surgery-to-Postoperative Radiation Therapy Interval (S-PORT) and Total Treatment Package Time (TPT) in HNSCC\".","authors":"Efsun Somay, Erkan Topkan, Ugur Selek","doi":"10.1007/s00405-025-09595-3","DOIUrl":"https://doi.org/10.1007/s00405-025-09595-3","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to comment on \"Feasibility of improving vocal fold pathology image classification with synthetic images generated by DDPM-based GenAI: a pilot study\", by Daungsupawong and Wiwanitkit.","authors":"Iman Khazrak, Shahryar Zainaee, Mostafa M Rezaee, Mehran Ghasemi","doi":"10.1007/s00405-025-09618-z","DOIUrl":"https://doi.org/10.1007/s00405-025-09618-z","url":null,"abstract":"<p><p>In response to the recent commentary on our pilot study using denoising diffusion probabilistic models (DDPMs) for vocal fold structural pathology image augmentation, we clarify our study's rationale and methods. The original work evaluated the feasibility of synthetic image generation to address data scarcity and imbalance. We affirm that several concerns raised were already addressed and note that statistical testing was not conducted due to the study's exploratory nature. Additional clarifications are provided in this letter to address points raised in the commentary and to outline directions for future research.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First report on a case series of Patulous Eustachian tube following GLP-1 receptor agonist-induced weight loss.","authors":"Holger Sudhoff","doi":"10.1007/s00405-025-09604-5","DOIUrl":"https://doi.org/10.1007/s00405-025-09604-5","url":null,"abstract":"<p><strong>Objective: </strong>To describe seven cases of patulous Eustachian tube (PET, \"Tuba aperta\") arising in adult patients undergoing significant weight loss with GLP-1 receptor agonists (semaglutide [Ozempic^®] or tirzepatide [Mounjaro^®]).</p><p><strong>Methods: </strong>Retrospective descriptive case series of patients presenting to our otolaryngology clinic between June 2024 and June 2025 with symptoms of autophony, aural fullness, and audible breathing. All had initiated GLP-1 agonist therapy ≥ 3 months prior and achieved ≥ 8% body-weight reduction. Diagnosis of PET was confirmed by patient symptoms, otoscopy, digital volume tomography, reflex decay tympanometry and tubomanometry.</p><p><strong>Results: </strong>Seven patients (5 female, 2 male; age 28-56 years) developed bilateral (n = 5) or unilateral (n = 2) PET after 4-10 months of GLP-1 therapy. Weight loss ranged from 8.2 to 18.7% of baseline. Common symptoms were autophony (7/7), intermittent aural fullness (6/7), and hearing one's own breathing (5/7). Conservative management led to symptom improvement in one patient; six required injections of VOX-Implants^® into the affected Eustachian tubes with resolution of symptoms.</p><p><strong>Conclusion: </strong>Significant weight loss from GLP-1 receptor agonists may predispose susceptible individuals to PET. Clinicians should be aware of this potential otologic side effect and consider early conservative measures.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How does otitis media with effusion history affect spatial auditory processing and listening effort?","authors":"Matan Yosef, Avital Trau-Margalit, Tami Harel-Arbeli, Riki Taitelbaum-Swead","doi":"10.1007/s00405-025-09570-y","DOIUrl":"https://doi.org/10.1007/s00405-025-09570-y","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the impact of otitis media with effusion (OME) history on spatial auditory processing and listening effort (LE) in children with normal hearing thresholds.</p><p><strong>Methods: </strong>Seventeen children with a history of OME, whose hearing thresholds had returned to normal (mean age 7.8 years), and 22 age-matched controls (mean age 8 years) participated in the study. Assessments included audiometric evaluations, an adaptive speech-in-noise task under spatial and non-spatial conditions, pupillometry to measure changes in pupil dilation during sentence recognition in noise, and an auditory digit span task to assess working memory.</p><p><strong>Results: </strong>Children with a history of OME required higher signal-to-noise ratios (SNRs) under spatial separation conditions and exhibited greater pupil dilation in non-spatial conditions, reflecting increased LE. They also demonstrated significantly lower backward digit span scores than the control group.</p><p><strong>Conclusions: </strong>Results indicate that children with a history of OME required compensation (in speech reception thresholds in noise and increased pupil dilation) in each auditory condition. These findings suggest that OME may have long-term effects on auditory and cognitive functioning, even after hearing thresholds return to the normal range. Early identification and intervention are crucial to address these challenges. Long-term monitoring is also recommended, as sustained exposure to normal auditory input may support improvements in binaural processing and spatial listening abilities, reducing the impact of early fluctuating conductive hearing loss on learning and communication.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}