European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery最新文献

{"title":"The impact of bacterial lysate (OM-85) on clinical and immunological parameters in children with allergic rhinitis.","authors":"Huajie Yan, Jiayi Hong, Chunyun Zeng, Aihua Zhang, Yunan Yang, Mei Zhang, Fujiang Zhou","doi":"10.1007/s00405-025-09728-8","DOIUrl":"https://doi.org/10.1007/s00405-025-09728-8","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy and immunomodulatory effects of bacterial lysate (OM-85) in children with allergic rhinitis (AR).</p><p><strong>Method: </strong>A total of 40 children aged 5 to 14 years with AR were selected and divided into two groups: the control group (treated with mometasone furoate nasal spray and cetirizine) and the observation group (treated with the same regimen as the control group, plus OM-85). The changes in Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) scores, lymphocyte subsets, and serum immunoglobulin levels were compared before and after treatment between the two groups.</p><p><strong>Results: </strong>After treatment, both groups showed a significant reduction in the frequency of allergic rhinitis episodes (P < 0.05). The RQLQ scores indicated that the observation group showed more significant improvements in daily activities, rhinitis-related behaviors, nasal symptoms, emotional responses, and overall score (P < 0.05), while the control group showed improvements in only some of the indicators (P < 0.05). In the observation group, NK cell levels (6.28% [3.46; 8.55] vs. 7.80% [5.90; 13.87], P = 0.025), Treg cell levels (0.83 ± 0.50% vs. 1.20 ± 0.47%, P = 0.016), serum IgA (0.97 ± 0.34 vs. 1.49 ± 0.58 g/L, P = 0.001), and IgG levels (9.32 ± 2.85 vs. 11.11 ± 2.09 g/L, P = 0.019) were significantly increased, while CD8 + T cell levels decreased (28.84 ± 5.24% vs. 25.62 ± 5.85%, P = 0.037). No significant changes in immune parameters were observed in the control group (P > 0.05).</p><p><strong>Conclusion: </strong>OM-85 adjunctive therapy can enhance immune function, improve clinical symptoms, and enhance quality of life in children with allergic rhinitis.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fungal necrotizing otitis externa; challenges in diagnosis and therapy.","authors":"Gaelle Vofo, Ofir Zavdy, Rona Bourla, Hila Elinav, Maya Korem, Sarah Israel, Reut Book, Fatima Azhraa Haddad, Dvir Bar-On, Tomer Menzely, Ohad Hilly, Sagit Stern Shavit","doi":"10.1007/s00405-025-09685-2","DOIUrl":"https://doi.org/10.1007/s00405-025-09685-2","url":null,"abstract":"<p><strong>Purpose: </strong>Necrotizing otitis externa (NOE) is a severe infection with potential skull base involvement. The role of fungal pathogens and the need for antifungal treatment remain controversial. We aimed to evaluate clinical characteristics, diagnostic challenges, and microbiology results in fungal NOE and assess considerations for antifungal therapy.</p><p><strong>Methods: </strong>This retrospective cohort study was conducted at two tertiary centers. NOE patients, based on clinical and radiological findings, were retrospectively reviewed. Clinical characteristics, microbiological findings, and disease persistence were compared between patients categorized by antifungal treatment status: Combined antifungal-antibiotic therapy versus antibiotic therapy alone.</p><p><strong>Results: </strong>Of 125 patients, 25 received combined treatment (13 as initial treatment and 12 after persistent disease) and 100 received antibiotics alone. Combined treatment patients were younger, had prolonged symptoms, and more cranial nerve palsy, requiring longer treatment for persistent and aggressive disease. Fungi were found in 72% of combined-treatment cultures, but most were deemed unreliable by infectious diseases specialists, inconsistently leading to antifungal therapy.</p><p><strong>Conclusion: </strong>Antifungal therapy decisions in NOE lack standardization. We propose a protocol incorporating clinical and microbiological data to guide antifungal therapy. Prospective studies are needed to validate this protocol and establish standardized guidelines for fungal NOE treatment.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in pathological diagnosis of rare head and neck cancers: National survey and retrospective study.","authors":"Daria Maria Filippini, Francesca Carosi, Giulia Querzoli, Simone Sabbioni, Matteo Fermi, Francesco Chiari, Riccardo Gili, Maria Abbondanza Pantaleo, Giovanni Succo, Gabriele Molteni, Achille Tarsitano, Maria Pia Foschini, Laura D Locati","doi":"10.1007/s00405-025-09707-z","DOIUrl":"https://doi.org/10.1007/s00405-025-09707-z","url":null,"abstract":"<p><strong>Purpose: </strong>The complexity of head and neck cancers (HNC) makes histopathological diagnosis challenging, mainly for rare histotypes (r-HNCs) where a second opinion (2°op) is often required.</p><p><strong>Methods: </strong>In 2023, the Italian Association of Head and Neck Oncology (AIOCC) young task force conducted a 17-item survey on HNC multidisciplinary management and pathological diagnosis. A retrospective review was performed on r-HNC cases evaluated in the last 10 years by an HNC expert pathologist at a referral center. Major diagnostic discrepancies (MDD), defined as changes in pathological diagnosis that significantly influenced clinical management, were analyzed.</p><p><strong>Results: </strong>Among the 30 surveyed participants, 67% sought a 2°op for r-HNC, often leading to changes in diagnosis or treatment. In 130 reviewed cases, 66% had no initial pathological diagnosis; of the remaining 34% (44) with a previous diagnosis, 50% were changed after the review. Minor salivary gland tumors of the oral cavity (57%) had the highest rate of MDD, followed by the sinonasal tract (43%). 14% (6) involved only descriptive diagnosis reformulation/reclassification whereas of MDD (16%,7), 29% involved a change from benign to malignant, 14% a change from malignant to benign.</p><p><strong>Conclusions: </strong>According to the complexity of HNC district, a second opinion is often needed and when a preliminary histopathological diagnosis was formulated, a MDD results in 16%. An effective diagnostic network among HNC pathologists is warranted.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison of ABR and ASSR using narrow-band-chirp-stimuli in children with single-sided deafness of various etiology.","authors":"Donata Gellrich, Daniel Polterauer, Sophia Stoecklein, Patrick Huber, Tobias Rader, Katharina Eder","doi":"10.1007/s00405-025-09708-y","DOIUrl":"https://doi.org/10.1007/s00405-025-09708-y","url":null,"abstract":"<p><strong>Purpose: </strong>Auditory steady-state responses (ASSR) are available for frequency-dependent hearing threshold estimation in addition to the technique of conventional auditory brainstem responses (ABR). Although ABR and ASSR principally show strong correlations in hearing threshold estimation, there is preliminary evidence that temporal bone malformations might be associated with significantly greater differences between ABR- and ASSR-results. Therefore, the present study aimed to compare hearing threshold estimation derived from ABR and ASSR in a larger cohort of single-sided deafness (SSD) of various etiology, including temporal bone anomalies.</p><p><strong>Methods: </strong>The diagnostic consistency between ABR and ASSR using narrow-band-chirp-stimuli at 1000, 2000, and 4000 Hz was analyzed in 47 children with single-sided deafness with varying MRI-morphologic findings: cochlear nerve malformation (CNM, n = 24), cochlear malformation (CM, n = 7) vs. combined malformation (CM + CNM, n = 8) vs. absent temporal bone and inner ear pathology (n = 8). Children with additional health issues other than SSD were excluded.</p><p><strong>Results: </strong>ABR and ASSR showed a strong correlation in deaf ears without malformation (r = 0.728, p < 0.0001), a moderate correlation in isolated cochlear malformation (r = 0.574, p = 0.01), and a weak correlation in case of cochlear nerve anomaly (r = 0.189, p = 0.112 in CNM and r = 0.235, p = 0.268 in CM + CNM). Ears with isolated CNM showed an average discrepancy of 23.40 ± 15.19 dB, p < 0.00001 between ABR and ASSR (vs. 17.08 ± 15.81 dB, p = 0.0008 in CNM + CM, vs. 7.63 ± 8.56 dB, p = 0.008 in CM, vs. 4.38 ± 4.96 dB, p = 0.036 in ears without malformation and vs. 0.36 ± 4.75 dB, p = 0.748 in healthy control ears). In ears with highly discrepant ASSR and ABR values, enlarged ABR wave I and otoacoustic emissions were frequently present.</p><p><strong>Conclusion: </strong>In cochlear nerve malformation, ASSR and ABR frequently provide significantly discrepant hearing threshold estimations, probably derived from a cochlear origin. ASSR should only be used in conjunction with conventional ABR in the diagnostic management of suspected severe-profound hearing loss or deafness in children. A large difference between ASSR and ABR thresholds may indicate a cochlear nerve anomaly.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prediction of round window visibility at posterior-tympanotomy for cochlear implantation with \"black bone\" magnetic resonance imaging : Author lists.","authors":"Hoi Ming Kwok, Cameron Spence, Emily Hocknell, Irumee Pai, Steve Connor","doi":"10.1007/s00405-025-09718-w","DOIUrl":"https://doi.org/10.1007/s00405-025-09718-w","url":null,"abstract":"<p><strong>Purpose: </strong>Although computed tomography (CT) can predict round window (RW) visibility at posterior tympanotomy pre-operatively, there is a trend towards the application of using magnetic resonance imaging (MRI) alone for cochlear implant (CI) planning. This study assessed the potential of a novel \"Black Bone\" (BB) MRI sequence to determine RW visibility during posterior tympanotomy.</p><p><strong>Methods: </strong>Patients underwent BB MRI as part of pre-operative CI planning. Two independent radiologists performed 5 landmark-based MRI measurements. RW visibility was recorded during posterior tympanotomy as > 50% or < 50% visibility. Patients with undefinable landmarks or absent surgical grading were excluded. Mann-Whitney U or t-tests compared MRI measurements to RW visibility whilst step wise logistic regression determined significant predictors.</p><p><strong>Results: </strong>86 patients (40 male; median 10.5 years) and 129 implanted ears (43 unilateral, 43 bilateral; 52 adult, 77 paediatric) were evaluated. There were 109/129 ears with > 50% and 20/129 ears with < 50% RW visibility. The external auditory canal (EAC) angle was increased in paediatric patients with > 50% RW visibility (P = 0.033; AUROC 0.689; 73.4% sensitive, 69.2% specific with threshold 6.2^o) with ICC = 0.598. The facial recess distance, facial nerve location, and modified RW niche angle were increased in adult patients with > 50% RW visibility but only modified RW niche angle was significant on stepwise regression (P = 0.016; AUROC 0.805; 82.2% sensitive, 71.4% specific with threshold 17.95^o) with ICC = 0.578.</p><p><strong>Conclusion: </strong>The visibility of RW at posterior tympanotomy may be determined with pre-operative BB MRI. The optimal predictive measurements differ between adult and paediatric patients and there is superior performance in adults.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of alcohol-attributable laryngeal cancer: reflections on trends, risk, and research gaps.","authors":"Schawanya Kaewpitoon Rattanapitoon, Phornphitcha Pechdee, Jun Norkaew, Nathkapach Kaewpitoon Rattanapitoon","doi":"10.1007/s00405-025-09666-5","DOIUrl":"https://doi.org/10.1007/s00405-025-09666-5","url":null,"abstract":"<p><p>The recent study by Tong et al. provides compelling evidence on the global and regional burden of laryngeal cancer attributable to alcohol use, based on data from the Global Burden of Disease 2021 study. In this Letter, we reflect on the study's key findings, its public health implications, and areas requiring further investigation. While the observed decline in age-standardized mortality rates is encouraging, significant disparities-particularly in Eastern Europe, Central Asia, and parts of Southeast Asia-underscore persistent risk heterogeneity. Future research that integrates behavioral, genetic, and policy-level data will be crucial to guide targeted and equitable cancer prevention strategies.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Management of cocaine-induced midline lesion (CIMDL) extended to skull base: a case report and systematic review\".","authors":"Manish R Bhise, Jitesh Kumar, Pawan Mandal","doi":"10.1007/s00405-025-09729-7","DOIUrl":"https://doi.org/10.1007/s00405-025-09729-7","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of the combined approach in treating major salivary gland stones.","authors":"Jesper Stensig Aa, Joyce Dominique Horsmans Schultz, Lars Peter Schousboe","doi":"10.1007/s00405-025-09704-2","DOIUrl":"https://doi.org/10.1007/s00405-025-09704-2","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy and safety of the combined approach in managing large salivary gland stones, with specific focus on stone elimination, symptom resolution, and postoperative complications.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted at a tertiary referral centre, including patients diagnosed with sialolithiasis between 1 October 2018 and 1 October 2023. Patients treated with the combined approach were included; those managed solely with sialendoscopy, exclusively via incision, or conservative treatment were excluded. Medical records were reviewed for outcomes including stone removal success, symptom resolution, and complications.</p><p><strong>Results: </strong>Of 243 patients diagnosed with sialolithiasis, 33 underwent the combined approach - eight involving the parotid gland and 25 the submandibular gland. Complete stone removal was achieved in 28 cases (85%), and symptom resolution was observed in 29 cases (88%). Postoperative infections occurred in five parotid and four submandibular cases. Temporary tongue paraesthesia was noted in two submandibular cases; no nerve injuries were reported in parotid cases.</p><p><strong>Conclusion: </strong>The combined approach is a safe and effective gland-preserving technique for large salivary gland stones, with high success rates and minimal complications. Prophylactic antibiotics may be beneficial for parotid procedures, though prospective studies are needed to define infection criteria and guide antibiotic use.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct gut microbiota profiles in acute vs. chronic sinusitis: potential biomarkers.","authors":"Hongwei Cao, Yan Fan, Hanbing Yu, Dongsheng Xing, Aihui Yan","doi":"10.1007/s00405-025-09714-0","DOIUrl":"https://doi.org/10.1007/s00405-025-09714-0","url":null,"abstract":"<p><strong>Purpose: </strong>This study explored the causal association between genetically predicted gut microbiota and sinusitis.</p><p><strong>Methods: </strong>This two-sample Mendelian randomization (MR) study used summary data from genome-wide association studies of gut microbiota (n = 211) and acute and chronic sinusitis. The main analysis was conducted using the inverse variance weighted (IVW) method as primary statistical analysis, with robustness tested using the weighted median, weighted mode, and MR-Egger regression methods. Sensitivity analyses included MR-Egger, MR-PRESSO, Cochran's Q, and leave-one-out for the detection of heterogeneity and pleiotropy.</p><p><strong>Results: </strong>Suggestive associations with acute sinusitis were identified for order Rhodospirillales (OR = 1.20, P = 0.01) and family Prevotellaceae (OR = 1.19, P = 0.02). Protective associations included genus Subdoligranulum (OR = 0.78, P = 0.01). For chronic sinusitis, significant associations were found for genus Coprobacter (OR = 1.23, P = 0.01), while protective associations included family Defluviitaleaceae (OR = 0.84, P = 0.04) and genus Tyzzerella3 (OR = 0.87, P = 0.011). Additional significant protective associations were observed across various other taxa, including order Burkholderiales and family Erysipelotrichaceae. However, none of these associations remained statistically significant after FDR correction. Sensitivity analyses supported the overall robustness of the findings.</p><p><strong>Conclusion: </strong>This MR study provides exploratory evidence for potential associations between gut microbiota and sinusitis subtypes. Although these findings did not remain significant after correction for multiple testing, they highlight distinct microbial patterns in acute versus chronic sinusitis and may serve as hypotheses for future research. Further studies with larger cohorts are required to validate these associations and assess their clinical relevance.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considerations on multiportal compartmental approach extended to the temporal fossa.","authors":"Enrico Fazio, Luca Gazzini, Giulia Gobbo, Monir Abousiam, Giovanni Giorgetti, Aurel Nebiaj, Giuseppe Nucera, Alberto Schreiber, Luca Calabrese","doi":"10.1007/s00405-025-09674-5","DOIUrl":"https://doi.org/10.1007/s00405-025-09674-5","url":null,"abstract":"<p><strong>Purpose: </strong>To illustrate the applicability of compartmental surgery (CS) principles in the radical management of advanced oral cavity squamous cell carcinoma (OSCC) involving the high infratemporal fossa (ITF), in cases where neoadjuvant therapy is not feasible.</p><p><strong>Methods: </strong>We report a case of recurrent OSCC of the retromolar trigone with extensive involvement of the masticatory space, including the medial and lateral pterygoid, masseter, and temporalis muscles. A multiportal surgical approach was employed, integrating a transnasal endoscopic route with extended transoral and transcervical corridors. Surgical steps followed the CS concept, including en-bloc resection of tumour spread pathways and musculature insertions.</p><p><strong>Results: </strong>Radical resection including the involved masticatory musculature and temporalis muscle insertions was achieved. The final histopathology confirmed advanced-stage disease (rpT4b N3b R0 L1 V0 pn1 G2), with complete macroscopic and microscopic tumour removal.</p><p><strong>Conclusion: </strong>This case supports the feasibility and oncologic efficacy of a CS-based multiportal approach in selected advanced OSCC involving the ITF. Further studies are needed to validate its role and define standardized protocols.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}