European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery最新文献

{"title":"Platelet-rich plasma (PRP) therapy to decrease postoperative tonsillectomy pain and bleeding.","authors":"Pannipa Wiriyaamornchai, Alena Santeerapharp","doi":"10.1007/s00405-025-09530-6","DOIUrl":"https://doi.org/10.1007/s00405-025-09530-6","url":null,"abstract":"<p><strong>Purpose: </strong>This prospective double-blind randomized controlled trial aimed to assess the benefits of PRP therapy in enhancing wound healing, reducing post-operative bleeding, and alleviating pain in patients undergoing tonsillectomy. By comparing the outcomes of tonsillectomy wounds treated with PRP versus saline.</p><p><strong>Methods: </strong>The study included 30 patients undergoing tonsillectomy, who were randomly assigned to receive PRP injections on one side and saline injections on the other side at the wound base. Pain levels, wound healing characteristics, and surgical complications such as bleeding were assessed for 28 days post-surgery.</p><p><strong>Results: </strong>In this study, there were no cases of post-operative bleeding in the surgical wounds on both sides of all patients. The pain level of the side injected with PRP is statistically significantly lower than the control side from the first day to the 5th day after surgery, there is no statistically significant difference in the pain level between both groups after the 6th day after surgery. The side injected with PRP had significantly faster re-epithelialization on days 7 and 14 post-surgery.</p><p><strong>Conclusion: </strong>This study demonstrates the potential benefits of using PRP in promoting wound healing and reducing pain after tonsillectomy. The findings indicate that PRP injections can be a safe and effective treatment option for patients undergoing tonsillectomy.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144513049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and risk factors correlated with otitis media with effusion in pediatric patients with obstructive sleep apnea: a retrospective nationwide inpatient sample database study.","authors":"Yan Gao, Jin Wang, Meihua Sun, Xiuli Ma, Fan Lou, Cheng Ming, Jing Ma","doi":"10.1007/s00405-025-09457-y","DOIUrl":"https://doi.org/10.1007/s00405-025-09457-y","url":null,"abstract":"<p><strong>Objective: </strong>To examine incidence and risk factors of Otitis Media with Effusion (OME) in pediatric patients with obstructive sleep apnea (OSA) using a large-scale national database.</p><p><strong>Materials and methods: </strong>A retrospective database analysis was conducted utilizing the Nationwide Inpatient Sample (NIS) dataset spanning from 2010 to 2019. Patients diagnosed with OSA were included in the study. Patient demographics, hospital characteristics, length of stay (LOS), total hospital charges, in-hospital mortality, pre-operative comorbidities, and perioperative complications were evaluated. Multivariate logistic regression was employed to identify independent risk factors associated with OME in the OSA patient population.</p><p><strong>Results: </strong>The overall incidence of OME among pediatric OSA patients was 1.8%, demonstrating fluctuations annually. Patients with OME tended to be younger, predominantly male, with fewer comorbidities, shorter LOS, and lower total charges. Independent risk factors for OME included younger age (1-2 years), male sex, Native American ethnicity, pre-operative comorbidities of drug abuse and obesity, and pre-operative diagnoses of Down syndrome, Hypertrophy of tonsils alone, Hypertrophy of adenoids alone, and Hypertrophy of tonsils with adenoid complications.</p><p><strong>Conclusion: </strong>Investigating risk factors associated with OME in children with OSA is essential for implementing preventive measures and optimizing patient outcomes.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144513048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Actinomyces findings in tonsillectomy specimens- comparison between adults and pediatrics populations.","authors":"Yotam Aharon Shiner, Shoham Caplan, Ilana Doweck","doi":"10.1007/s00405-025-09481-y","DOIUrl":"https://doi.org/10.1007/s00405-025-09481-y","url":null,"abstract":"<p><strong>Background: </strong>Tonsillectomy is a common surgical procedure primarily performed for obstructive sleep apnea (OSA) and recurrent acute tonsillitis. Actinomyces are gram-positive, anaerobic bacteria commonly found in the oral cavity and known to form part of the human microbiome, occasionally associated with localized infections. While Actinomyces bacterial colonization in tonsils has been previously studied, its correlation with surgical indications and outcomes remains unclear.</p><p><strong>Objectives: </strong>The study aimed to investigate the relationship between Actinomyces colonization in tonsillar specimens and surgical indications, and to examine whether Actinomyces presence influences tonsillectomy outcomes, specifically post-operative hemorrhage and hospital stay.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed electronic medical records from Lady Davis Carmel Medical Centre between 2011 and 2021. The study included 1,333 patients who underwent extra-capsular tonsillectomies. Patient demographics, surgical indications, length of hospital stay, post-surgical complications, and pathological reports were collected and analyzed using IBM SPSS Statistics 28.0.</p><p><strong>Results: </strong>The study population consisted of 760 (57%) males and 573 (43%) females, with an age range of 0.98 to 67.5 years (mean 9.1 years). Actinomyces was present in 13.2% of specimens from patients with infectious indications compared to 4.5% in patients with obstructive indications (p < 0.001). A statistically significant age difference was observed between patients with (17.78 years) and without (8.55 years) Actinomyces. Multivariate analysis revealed that age was the most significant predictor of Actinomyces presence (OR 1.047, p < 0.0001).</p><p><strong>Conclusions: </strong>The study found a significant correlation between Actinomyces presence, older age, and infectious surgical indications. While Actinomyces colonization did not demonstrate a direct influence on surgical complications, the findings suggest potential clinical relevance that merits further research to elucidate the bacterium's role in tonsillar pathology.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NOD-m: a novel clinical score for predicting hearing loss in inherited metabolic disorders.","authors":"Merve Koç Yekedüz, İlayda Kütükkiran, İlknur Sürücü Kara, Mobin Shamsaee, Feyza Nur Irem Mengüç, Engin Köse, Fatma Tuba Eminoğlu","doi":"10.1007/s00405-025-09477-8","DOIUrl":"https://doi.org/10.1007/s00405-025-09477-8","url":null,"abstract":"<p><strong>Objectives: </strong>Inherited metabolic disorders (IMD) are rare genetic conditions resulting from disruptions in metabolic pathways, often leading to multisystemic complications. Hearing loss (HL) is a significant but under-recognized manifestation of IMD. Its prevalence, subtypes, timing, and systemic associations remain poorly characterized. This study aims to systematically evaluate the prevalence and characteristics of HL in a large cohort of patients with IMD, emphasizing associated clinical and laboratory findings.</p><p><strong>Methods: </strong>A retrospective review was conducted on 996 patients diagnosed with IMD between June 2012 and January 2024. Data on demographics, disease-specific features, HL subtypes, timing of diagnosis, and associated findings were analyzed. Descriptive statistics were used to summarize the findings.</p><p><strong>Results: </strong>Hearing loss was identified in 31 patients (3.1%), with lysosomal storage disorder (LSD, 30.3%) and mitochondrial disease (MD, 25.8%) being the most frequent diagnoses. Of these patients, 19 (61.2%) were male, and the mean age at the time of IMD diagnosis was 73 ± 49 months. The most common type of HL observed was sensorineural. Most common systemic findings associated with HL (HL+) included neuromotor-cognitive delay (87.1%), organomegaly (51.6%), and dysmorphism (41.9%), alongside elevated lactate levels (38.7%) and metabolic acidosis (35.5%). The most common findings in patients with hearing loss were neuromotor-cognitive delay, organomegaly, dysmorphism, and metabolic acidosis. A composite clinical score based on these features (NOD-m) demonstrated good discriminatory performance (AUC = 0.78) for predicting hearing loss in IMD patients. The \"NOD-m\" code serves as a mnemonic clinical construct to aid in the early recognition of IMDs in patients with hearing loss. \"NOD\" reflects universal nonverbal communication, aligning with the context of auditory impairment, while \"m\" denotes both metabolism and metabolic acidosis-key features in the pathophysiology of these disorders.</p><p><strong>Conclusions: </strong>Hearing loss in IMD patients is frequently associated with distinct clinical and metabolic features that can guide early recognition. The NOD-m score may serve as a practical screening aid to prompt further metabolic evaluation in patients presenting with HL.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction accuracy of cochlear implant electrode insertion using the OTOPLAN software.","authors":"Caterina Vazzana, Marten Geisen, Uwe Baumann, Dennis Sakmen, Esther Knörle, Timo Stöver, Silke Helbig","doi":"10.1007/s00405-025-09525-3","DOIUrl":"https://doi.org/10.1007/s00405-025-09525-3","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Failure of gamma knife radiosurgery for sporadic vestibular schwannomas: a systematic review and meta-analysis.","authors":"April N Taniguchi-Lo, Christian M Shannon, Charlotte I Rivers, Shaun A Nguyen, Paul R Lambert","doi":"10.1007/s00405-025-09527-1","DOIUrl":"https://doi.org/10.1007/s00405-025-09527-1","url":null,"abstract":"<p><strong>Purpose: </strong>This review aims to characterize the limitations of Gamma Knife radiosurgery (GKRS) with investigation of failure rates for primary and salvage (post-surgical) cases, identification of risk factors associated with increased rates of treatment failure, and evaluation adverse outcomes.</p><p><strong>Methods: </strong>A systematic search (Cochrane Library, PubMed, SCOPUS, and CINAHL) of studies on sporadic vestibular schwannomas treated with Gamma Knife radiosurgery was conducted in accordance with PRISMA guidelines. Primary outcome measures included continuous measures (mean), proportions (%), and relative risks (RR) with 95% confidence intervals (CI).</p><p><strong>Results: </strong>Forty-three studies (n = 5619 patients) were included. The proportion of GKRS failure for primary (6.4% [95% CI 4.8-7.7]) and salvage treatment (9.0% [5.9-12.8]) did not differ (2.8%, [-0.2-6.9], p = 0.06). When stratified by various thresholds on imaging, an increase of greater than 15% in a tumor's volume was seen 3.2% [2.1-4.6] which was less than rates in other volumetric thresholds of failure (p = 0.0001). Treatment edema identified by brainstem hyperintensity on imaging was the most frequent toxicity (8.8% [7.1-10.8]) with symptomatic management in about 1 in 4 cases. New onset cranial nerve adverse outcomes occurred for trigeminal neuralgia 4.9% [2.8-7.6%], trigeminal numbness 4.3% [2.7-6.2%], and temporary facial paresis 3.2% [1.3-5.9%].</p><p><strong>Conclusion: </strong>Gamma Knife radiosurgery is an effective treatment for sporadic vestibular schwannomas with low rates of failure. Our findings suggest failure rates are not affected by treatment timing and comparable for the smaller sized tumors. Gamma Knife radiosurgery is safe with minimal adverse outcomes such as cranial nerve dysfunction, required retreatment, or other radiation toxicity.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment package time (TPT) and surgery to post-operative radiotherapy (S-PORT) interval in head and neck cancers: A systematic review and meta-analysis.","authors":"Mario Sánchez-Canteli, Juana M García-Pedrero, Juan P Rodrigo","doi":"10.1007/s00405-025-09517-3","DOIUrl":"10.1007/s00405-025-09517-3","url":null,"abstract":"<p><strong>Background: </strong>The impact of key treatment intervals on head and neck squamous cell carcinoma (HNSCC) survival remains unclear.</p><p><strong>Methods: </strong>This systematic review and meta-analysis, conducted following PRISMA guidelines, assessed 22 cohort studies including 322,569 patients. The mean threshold for prolonged total treatment package time (TPT) was 95.21 days, while for surgery-to-postoperative radiotherapy (S-PORT), it was 6.9 weeks.</p><p><strong>Results: </strong>Both prolonged TPT and S-PORT intervals were significantly associated with reduced survival (TPT: HR = 1.25; S-PORT: HR = 1.03; p < 0.0001). However, the negative impact of extended TPT was more pronounced compared to S-PORT delays.</p><p><strong>Conclusion: </strong>These findings suggest that minimizing TPT delays is critical for optimizing HNSCC outcomes. However, substantial heterogeneity across studies limits the generalizability of results. Further research is needed to establish standardized treatment timelines and improve survival rates in HNSCC patients.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital health tools in the management of allergic rhinitis: a systematic review.","authors":"Abdullah D Alotaibi, Abdulaziz S AlQahtani, Mohammed Alateeq, Mohd Saleem, Mohd Shahid Khan","doi":"10.1007/s00405-025-09526-2","DOIUrl":"https://doi.org/10.1007/s00405-025-09526-2","url":null,"abstract":"<p><strong>Background: </strong>Allergic rhinitis (AR) is an IgE-related condition that causes problems for patients and adds stress to healthcare systems everywhere. Though there are many effective drugs available, it is still difficult to keep track of symptoms, get people to stick with their medications and provide customized care.</p><p><strong>Objective: </strong>We aim to assess whether digital health interventions-specifically those that make use of AI-improve outcomes for managing AR.</p><p><strong>Methods: </strong>We searched for studies using PRISMA guidelines, looking in PubMed, MEDLINE, Web of Science and Scopus from January 2010 to January 2025. We included studies that measured digital approaches (mobile apps, telemedicine tools, wearable devices, electronic diaries and AI in medicine) and reported results for symptom control, following treatment plans, patient satisfaction or accuracy of tests.</p><p><strong>Results: </strong>In all, 120 studies were included in the review, including 80 randomized controlled trials, 30 observational studies and 10 qualitative analyses. These systems showed significant improvement in managing symptoms (as much as 82%) and taking medicines as recommended (as many as 90%) when used by patients. The accuracy of diagnostic tests increased when additional devices such as FeNO and nasal resistance were worn. Using telemedicine lowered the number of visits required and made patients happier. AIs helped provide real-time, custom suggestions, but today's systems mostly depend on what people say and their environment.</p><p><strong>Conclusion: </strong>All in all, digital tools help manage AR in many reliable ways. They should be paired with molecular tools and made practical for doctors everywhere for easy acceptance. It is recommended that future studies work on confirming biomarkers, making them available and ensuring fair application.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of transoral laser microsurgery for locally advanced glottic cancer.","authors":"Wei-Zhe Hong, Guan-Jiang Huang","doi":"10.1007/s00405-025-09486-7","DOIUrl":"https://doi.org/10.1007/s00405-025-09486-7","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the role of miRNA in laryngeal squamous cell carcinoma progression.","authors":"Zhong-Ping Huang, Guan-Jiang Huang, Biao-Qing Lu","doi":"10.1007/s00405-025-09487-6","DOIUrl":"https://doi.org/10.1007/s00405-025-09487-6","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}