{"title":"Alginates and laryngopharyngeal reflux: where we stand. A systematic review.","authors":"Christos Tsilivigkos, Konstantinos Papantoniou, Evangelos N Vitkos, Eleftherios Ferekidis, Athanasia Warnecke","doi":"10.1007/s00405-025-09693-2","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Laryngopharyngeal reflux (LPR) is a medical condition in which gastric contents reflux, directly or indirectly, causing morphological and neurological alterations in the upper aerodigestive system. Alginates are a common solution to this problem.</p><p><strong>Methods: </strong>We conducted a PRISMA-compliant systematic review of the MEDLINE (via PubMed), Cochrane Central Register for Controlled Trials, and Scopus databases without temporal limitations. Our goal was to gather all available data published in English on the use of alginates in patients with LPR.</p><p><strong>Results: </strong>A total of 134 articles were screened, and 16 met the inclusion criteria. The included studies comprised three surveys, one experience study, four observational cohort studies, two cross-sectional studies, one case series, four experimental randomized studies, and one non-randomized study. The remaining 12 clinical studies enrolled a total of 994 individuals, including 274 patients with both LPR and dry eye syndrome in two of these studies. Three key themes emerged from the included texts: decision-making and awareness among clinicians treating patients with LPR regarding alginate use, the effect of alginates in treating LPR symptoms, the effect of alginates in patients with both LPR and dry eye syndrome. The main outcome measures in the clinical studies on LPR patients included RSS, RSA, RSI, RFS, symptom resolution, VAS scores, treatment tolerance, and drug-related adverse events.</p><p><strong>Conclusion: </strong>Alginates demonstrate a beneficial role both as monotherapy and as adjunct therapy with proton pump inhibitors (PPIs). Larger randomized studies are needed to further define their effectiveness in treating LPR.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2000,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s00405-025-09693-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Purpose: Laryngopharyngeal reflux (LPR) is a medical condition in which gastric contents reflux, directly or indirectly, causing morphological and neurological alterations in the upper aerodigestive system. Alginates are a common solution to this problem.
Methods: We conducted a PRISMA-compliant systematic review of the MEDLINE (via PubMed), Cochrane Central Register for Controlled Trials, and Scopus databases without temporal limitations. Our goal was to gather all available data published in English on the use of alginates in patients with LPR.
Results: A total of 134 articles were screened, and 16 met the inclusion criteria. The included studies comprised three surveys, one experience study, four observational cohort studies, two cross-sectional studies, one case series, four experimental randomized studies, and one non-randomized study. The remaining 12 clinical studies enrolled a total of 994 individuals, including 274 patients with both LPR and dry eye syndrome in two of these studies. Three key themes emerged from the included texts: decision-making and awareness among clinicians treating patients with LPR regarding alginate use, the effect of alginates in treating LPR symptoms, the effect of alginates in patients with both LPR and dry eye syndrome. The main outcome measures in the clinical studies on LPR patients included RSS, RSA, RSI, RFS, symptom resolution, VAS scores, treatment tolerance, and drug-related adverse events.
Conclusion: Alginates demonstrate a beneficial role both as monotherapy and as adjunct therapy with proton pump inhibitors (PPIs). Larger randomized studies are needed to further define their effectiveness in treating LPR.
目的:喉咽反流(LPR)是胃内容物反流直接或间接引起上气消化系统形态学和神经学改变的一种医学病症。海藻酸盐是解决这个问题的常用方法。方法:我们对MEDLINE(通过PubMed)、Cochrane Central Register for Controlled Trials和Scopus数据库进行了一项符合prisma标准的系统评价,没有时间限制。我们的目标是收集关于LPR患者使用海藻酸盐的所有可用英文发表的数据。结果:共筛选134篇文献,符合纳入标准的文献有16篇。纳入的研究包括3项调查、1项经验研究、4项观察性队列研究、2项横断面研究、1项病例系列研究、4项实验性随机研究和1项非随机研究。其余12项临床研究共招募了994名患者,其中两项研究中包括274名同时患有LPR和干眼综合征的患者。从所包括的文本中出现了三个关键主题:治疗LPR患者的临床医生对海藻酸盐使用的决策和认识,海藻酸盐治疗LPR症状的效果,海藻酸盐对LPR和干眼综合征患者的影响。LPR患者临床研究的主要结局指标包括RSS、RSA、RSI、RFS、症状缓解、VAS评分、治疗耐受性、药物相关不良事件。结论:海藻酸盐作为质子泵抑制剂(PPIs)的单一治疗和辅助治疗均有良好的疗效。需要更大规模的随机研究来进一步确定其治疗LPR的有效性。