European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery最新文献

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Surgery of T1/2 N0 M0 glottic cancer results in a better laryngeal preservation time compared to radiotherapy in a large German patient cohort. 在一项大型德国患者队列中,与放疗相比,手术治疗T1/2 N0 M0声门癌可获得更好的喉保存时间。
Manuel Christoph Ketterer, Thomas K Hoffmann, Simon Laban, Alexander Berghaus, Martin Canis, Christian Jacobi, Jens Peter Klussmann, Wendelin Foeringer, Roland Laszig, Jens Pfeiffer, Henning Bier, Andreas Knopf
{"title":"Surgery of T1/2 N0 M0 glottic cancer results in a better laryngeal preservation time compared to radiotherapy in a large German patient cohort.","authors":"Manuel Christoph Ketterer, Thomas K Hoffmann, Simon Laban, Alexander Berghaus, Martin Canis, Christian Jacobi, Jens Peter Klussmann, Wendelin Foeringer, Roland Laszig, Jens Pfeiffer, Henning Bier, Andreas Knopf","doi":"10.1007/s00405-025-09460-3","DOIUrl":"https://doi.org/10.1007/s00405-025-09460-3","url":null,"abstract":"<p><strong>Objective: </strong>This retrospective study examined overall survival (OS), recurrence free survival (RFS), and laryngeal preservation time in a large cohort of 663 patients with T1/2 N0 M0 glottic cancer after transoral laser or open surgery vs radiotherapy.</p><p><strong>Methods: </strong>A total of 595 surgically treated patients and 68 individuals after definitive radio(chemo)therapy (R (C)-T) were studied. Patient characteristics including sociological, surgical, and pathological data, OS and RFS as well as laryngeal preservation time were recorded and compared between various groups/cohorts.</p><p><strong>Results: </strong>There were no significant differences in OS and RFS between surgically treated and conservatively treated patients. However, laryngeal preservation time was significantly higher in surgically treated patients (p < 0.001) (mean: 138.3 ± 2.2 months, versus 102.8 ± 7.6 months) than those under conservative treatment. The surgical treatment method (transoral vs. open partial resection) did not influence OS or RFS. Additionally, the rate of transoral vs. open surgery did not change over a decade. T2-stage patients showed significantly lower RFS than T1-stage patients. Initial R status significantly influenced OS and tumor recurrence.</p><p><strong>Conclusion: </strong>The findings of this study exhibited a significantly longer laryngeal preservation time in patients with T1/2 N0 M0 glottic cancer treated surgically than in those treated with radiotherapy. No significant differences in OS or RFS were observed between open partial laryngectomy and transoral laser surgery. The R status had a significant impact on OS and RFS, with OS being significantly associated with an R0 status, regardless of T status or the surgical approach (open versus transoral). Laryngeal preservation surgery is recommended as a central therapeutic strategy for T1/2 N0 M0 glottic cancer because it has a higher laryngeal preservation rate than the conservative treatment. Given the high recurrence rate (18.5%) and the necessity of laryngo- (pharyng) ectomy in a substantial proportion of recurrent patients (7.7%), the choice of initial therapeutic approach is critical.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The importance of the bow and lean test as an initial positional test for diagnosing BPPV. 俯卧检查作为诊断BPPV的初始位置检查的重要性。
Ercan Karababa, Sanem Can Sarıoğlu, Fatma Ceyda Akın Öçal, Deniz Uğur Cengiz, Mehmet Arslan, Bülent Satar
{"title":"The importance of the bow and lean test as an initial positional test for diagnosing BPPV.","authors":"Ercan Karababa, Sanem Can Sarıoğlu, Fatma Ceyda Akın Öçal, Deniz Uğur Cengiz, Mehmet Arslan, Bülent Satar","doi":"10.1007/s00405-025-09512-8","DOIUrl":"https://doi.org/10.1007/s00405-025-09512-8","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the diagnostic potential of nystagmus direction observed during bow and lean tests (BLTs) in patients with posterior canal canalolithiasis BPPV (P-BPPV), lateral canal canalolithiasis BPPV (Lca-BPPV), and lateral canal cupulolithiasis BPPV (Lcu-BPPV).</p><p><strong>Methods: </strong>A total of 62 patients (40 women, 22 men; aged 24-70 years) with clinically suspected BPPV were enrolled. Diagnoses included 39 cases of P-BPPV, 15 of Lca-BPPV, and 8 of Lcu-BPPV. Each participant underwent the Dix-Hallpike Test (DH), Head Roll Test (HRT), and bow and lean tests for diagnostic assessment. The primary outcome was the presence and direction of nystagmus during BLTs, in relation to BPPV subtype.</p><p><strong>Results: </strong>Nystagmus was detected in 77.4% of subjects during the bow test and in 46.8% during the lean test. A statistically significant difference was found in nystagmus direction across BPPV subtypes (p < 0.05). Right-beating horizontal nystagmus during the bow test was significantly more frequent in right-sided Lca-BPPV. Right down-beating torsional nystagmus during the bow test occurred exclusively in left P-BPPV, while left down-beating torsional nystagmus was seen only in right P-BPPV. Right up-beating torsional nystagmus was significantly associated with right P-BPPV, and left up-beating torsional nystagmus with left P-BPPV (p < 0.05).</p><p><strong>Conclusions: </strong>In P-BPPV, DH-induced nystagmus direction was opposite in the bow position but matched in the lean position. These findings underscore the diagnostic value of BLTs, particularly the bow test, in identifying the affected canal in posterior and lateral canal BPPV.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-dose radiotherapy as a definitive treatment for Kimura's disease. 低剂量放疗作为木村病的决定性治疗方法。
Kento Ko, Takeshi Takahashi, Hironori Baba, Genki Iwai, Nao Takahashi, Atsushi Ohta, Arata Horii
{"title":"Low-dose radiotherapy as a definitive treatment for Kimura's disease.","authors":"Kento Ko, Takeshi Takahashi, Hironori Baba, Genki Iwai, Nao Takahashi, Atsushi Ohta, Arata Horii","doi":"10.1007/s00405-025-09521-7","DOIUrl":"https://doi.org/10.1007/s00405-025-09521-7","url":null,"abstract":"<p><strong>Purpose: </strong>Kimura disease (KD) is characterized by inflammatory granulomas with eosinophilic infiltration in young males. The characteristic large mass in the head and neck region poses esthetic concerns. Treatment may include corticosteroid administration, surgery, or both; however, these often result in recurrence. Low-dose radiation therapy (RT) is a second-line treatment option for KD and is mainly used for recurrence or as adjuvant therapy after surgery. In this study, we aimed to evaluate the outcomes of RT alone as a definitive treatment for seven patients with KD refractory to oral corticosteroids.</p><p><strong>Methods: </strong>This study included male patients with a median age of 37 years and median disease duration of 9 years. The lesion sites included the unilateral or bilateral cheek and auricular areas. RT was administered at a dose of 1.8 Gy per fraction five times per week for a total of 30.6 Gy. Their adverse events and predictive biomarkers were evaluated.</p><p><strong>Results: </strong>The maximal diameter of the mass significantly reduced from 10 ± 3.8 cm (mean ± SD) to 4.1 ± 1.9 cm without regrowth for 99 months. Peripheral blood eosinophil counts significantly decreased from 2,435 ± 241 to 1,106 ± 411/µL at one year after RT. The acute adverse events included grade 1 dermatitis and dry mouth in five patients, pharyngitis in 3, and alopecia in 2, all of which improved a few months after RT.</p><p><strong>Conclusion: </strong>RT is a satisfactory treatment for patients with corticosteroid-resistant KD with acceptable adverse events. The peripheral blood eosinophil count may be a useful biomarker for determining the disease status of KD.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is endoscopic diving technique effective in surgical management of functioning pituitary adenomas? A prospective randomized study. 内镜潜水技术在功能性垂体腺瘤的手术治疗中有效吗?一项前瞻性随机研究。
Donata Sukyte-Raube, Davide Locatelli, Paolo Castelnuovo, Mustafa Haseeb Alali, Eugenijus Lesinskas
{"title":"Is endoscopic diving technique effective in surgical management of functioning pituitary adenomas? A prospective randomized study.","authors":"Donata Sukyte-Raube, Davide Locatelli, Paolo Castelnuovo, Mustafa Haseeb Alali, Eugenijus Lesinskas","doi":"10.1007/s00405-025-09516-4","DOIUrl":"https://doi.org/10.1007/s00405-025-09516-4","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the effectiveness of the Endoscopic Diving Technique (EDT) as an adjunct to endoscopic endonasal transsphenoidal surgery in improving remission rates in patients with functional pituitary adenomas. The primary research question was whether EDT enhances early endocrinological and radiological remission without increasing surgical complications.</p><p><strong>Methods: </strong>A prospective randomized trial was conducted at Vilnius University Hospital Santaros Klinikos between 2021 and 2023, with 141 patients diagnosed with functional pituitary adenomas. Seventy-eight patients met inclusion criteria and were randomly assigned to either the EDT group (n = 43), which included an additional endoscopic hydroscopy step, or the non-EDT group (n = 35). Follow-up assessments were performed at 3, 12, and 24 months to evaluate endocrinological and radiological remission. Additional parameters analyzed included surgical complications, operative duration, and water volume used for EDT.</p><p><strong>Results: </strong>The EDT group demonstrated significantly higher early endocrine remission rates (83.7% vs. 60.0%, p = 0.023) and fewer radiological relapses at 3 months (86.0% vs. 68.6%, p = 0.097), 12 months (81.4% vs. 62.9%, p = 0.078), and 24 months (69.8% vs. 42.9%, p = 0.022). Surgical complication rates were comparable between the groups (4.7% vs. 2.9%, p = 1.000).</p><p><strong>Conclusion: </strong>The implementation of EDT as an adjunct to transsphenoidal surgery is associated with improved endocrinological and radiological remission rates in functional pituitary adenomas without increasing surgical risk. EDT enhances visualization of the sellar cavity, facilitates tumor removal, and reduces venous hemorrhage, making it a valuable addition to standard surgical practice.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of lifestyle-modification approach (a randomized-controlled program of diet restriction and treadmill walking exercise) on elderly's metabolic syndrome-associated subjective tinnitus. 生活方式改变方法(饮食限制和跑步机步行运动的随机对照方案)对老年人代谢综合征相关的主观性耳鸣的有效性。
Ali Mohamed Ali Ismail, Ahmed Mahmoud Nasr Tolba
{"title":"Effectiveness of lifestyle-modification approach (a randomized-controlled program of diet restriction and treadmill walking exercise) on elderly's metabolic syndrome-associated subjective tinnitus.","authors":"Ali Mohamed Ali Ismail, Ahmed Mahmoud Nasr Tolba","doi":"10.1007/s00405-025-09494-7","DOIUrl":"https://doi.org/10.1007/s00405-025-09494-7","url":null,"abstract":"<p><strong>Introduction: </strong>Chronic subjective tinnitus complaint (CSTC) is highly prevalent in metabolic syndrome (MS) elderly. In 60 obese MS elderly with CSTC, studying the response of CSTC-related discomfort, MS components, and CSTC severity to lifestyle-modification approach was the aim of this study.</p><p><strong>Methods: </strong>In this randomized/controlled lifestyle-modification trial, the recruitment of 60 obese MS elderly with CSTC from a local general hospital was randomly executed. The recruited elderly with MS and CSTC were randomly assigned to a study group (performed lifestyle-modification approach and the components of this 12-week approach were on-electrical treadmill walking plus diet restriction) or waitlist/control group (n = 30). Besides MS components/variables such as elderly's waist circumference (WC), elderly's fasting glucose in serum (FGIS), elderly's triglycerides (TriGly), elderly's blood pressure, and elderly's high-density lipoprotein (HDLipo), lifestyle-modification approach's outcomes of this trial were elderly's body mass index, visual analogue scale (VAS) of CSTC-related discomfort, tinnitus handicap inventory (THI), and VAS of CSTC severity.</p><p><strong>Results: </strong>Tracking all outcomes of this lifestyle-modification approach in the study group (n = 30 MS elderly with CSTC) showed significant improvements while the control group's outcome did not improve.</p><p><strong>Conclusion: </strong>BMI, VAS of CSTC severity, components of MS (WC, FGIS, blood pressure, TriGly, and HDLipo), THI, and VAS of CSTC-related discomfort could be improved after involving obese MS elderly with CSTS in a 12-week lifestyle-modification approach.</p><p><strong>Trial registration number: </strong>NCT06702085.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the Editor: on the use of odds ratios in diagnostic reviews: comment on Shan et al.'s review on biomarkers for pediatric obstructive sleep apnea. 致编辑的信:关于比值比在诊断评价中的应用:对Shan等人关于儿童阻塞性睡眠呼吸暂停生物标志物的综述的评论。
Javier Arredondo Montero
{"title":"Letter to the Editor: on the use of odds ratios in diagnostic reviews: comment on Shan et al.'s review on biomarkers for pediatric obstructive sleep apnea.","authors":"Javier Arredondo Montero","doi":"10.1007/s00405-025-09510-w","DOIUrl":"https://doi.org/10.1007/s00405-025-09510-w","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of nasal septum surgery on anterior maxillary teeth sensation - a prospective study. 鼻中隔手术对上颌前牙感觉影响的前瞻性研究。
Dan Littner, Shibli Alsleibi, Elena Pichkhadze, Nir Abraham Gecel, Hadas Knoller, Shay Izhak Duvdevani
{"title":"The effect of nasal septum surgery on anterior maxillary teeth sensation - a prospective study.","authors":"Dan Littner, Shibli Alsleibi, Elena Pichkhadze, Nir Abraham Gecel, Hadas Knoller, Shay Izhak Duvdevani","doi":"10.1007/s00405-025-09469-8","DOIUrl":"https://doi.org/10.1007/s00405-025-09469-8","url":null,"abstract":"<p><strong>Introduction: </strong>Nasal septum surgery has been associated with postoperative numbness or paresthesia of the anterior maxillary teeth, primarily involving the incisors and canines, with an incidence reported between 3% and 30%. This sensory alteration may result from trauma to the nasopalatine nerve or anterior superior alveolar nerve, which innervate the anterior maxilla. Current literature on this topic is limited, outdated, and primarily based on retrospective studies that lack long term follow-up. This study aims to investigate the impact of nasal septal surgery on anterior maxillary teeth sensation, focusing on the incidence, predisposing factors, and the timeline for sensory recovery.</p><p><strong>Methods: </strong>This prospective study included 21 patients who underwent nasal septum surgery from September 2023 to September 2024. Patients with pre-existing conditions affecting dental sensation or those who recently underwent dental procedures were excluded. Sensory assessments were conducted preoperatively, post-topical anesthesia application, and at 10 days, one month, and three months post-surgery. Demographic data, surgical approach, and medical history were recorded.</p><p><strong>Results: </strong>The cohort had an average age of 32.6 years (range 20-62), with 52% male participants. Significant temporary sensory loss was observed following the application of topical anesthesia (p=0.007). Postoperatively, sensory reduction occurred in two patients, resulting in a 9.5% incidence of sensory disturbances (p=0.4): one patient experienced numbness in all four incisors, while another reported numbness in the two central incisors. Both patients regained full sensation within one month after surgery. Multivariate analysis did not identify any significant predictive factors for sensory impairment, including surgical approach, presence of nasal fracture, or history of prior nasal surgeries.</p><p><strong>Conclusion: </strong>Nasal septal surgery is associated with a low incidence of transient sensory disturbances in the anterior maxillary teeth, with full recovery typically occurring within one to three months. These findings suggest that careful surgical technique can minimize nerve injury and that the risk of permanent sensory loss is low. Additional research with larger patient cohorts is needed to validate these findings and identify possible risk factors, thus improving patient counseling and surgical techniques.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Echoes of immunity: exploring hidden signals in sudden hearing loss. 免疫的回声:探索突发性听力损失的隐藏信号。
Antiga Muradova, Mohammad Nihad Rasmi Ali
{"title":"Echoes of immunity: exploring hidden signals in sudden hearing loss.","authors":"Antiga Muradova, Mohammad Nihad Rasmi Ali","doi":"10.1007/s00405-025-09513-7","DOIUrl":"https://doi.org/10.1007/s00405-025-09513-7","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of platelet rich plasma on healing of mastoid cavity after canal wall down mastoidectomy. 富血小板血浆对乳突根治术后乳突腔愈合的影响。
Mohammad El-Sayed Abd Elbary, Ibrahim Ahmed Khaled, Mohammad Waheed El-Anwar, Hoda Ismael Abdelhamid
{"title":"Effect of platelet rich plasma on healing of mastoid cavity after canal wall down mastoidectomy.","authors":"Mohammad El-Sayed Abd Elbary, Ibrahim Ahmed Khaled, Mohammad Waheed El-Anwar, Hoda Ismael Abdelhamid","doi":"10.1007/s00405-025-09511-9","DOIUrl":"https://doi.org/10.1007/s00405-025-09511-9","url":null,"abstract":"<p><strong>Objective: </strong>To assess the effectiveness of platelet rich plasma (PRP) in promoting epithelialization and healing of mastoid cavity after canal wall down mastoidectomy.</p><p><strong>Subjects and methods: </strong>This study was applied on 20 patients with chronic sappurative otitis media who were operated by canal wall down mastoidectomy and PRP was added along sidewalls of the mastoid cavity. The patients were followed up clinically by otoscopic examination every 2 weeks for 4 months for detection of complete healing, otorrea or crustations.</p><p><strong>Results: </strong>During the follow up period, all cases show early epithelialization and good healing of the mastoid cavity with no infection; wound dehiscence, granulation tissue formation, otorrea; or debris accumulation.</p><p><strong>Conclusion: </strong>Coating the bare bony wall of the opened mastoid cavity after CWD mastoidectomy by PRP is a novel and effective method promoting healing and decreasing mastoid cavity problems.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of intratympanic corticosteroid on otitis media with effusion: A randomized clinical trial. 鼓室内皮质类固醇治疗中耳炎伴积液的疗效:一项随机临床试验。
Behrouz Barati, Mahboobe Asadi, Matin Ghazizadeh, Keyarmin Ghavam, Batool Ghorbani Yekta
{"title":"Effect of intratympanic corticosteroid on otitis media with effusion: A randomized clinical trial.","authors":"Behrouz Barati, Mahboobe Asadi, Matin Ghazizadeh, Keyarmin Ghavam, Batool Ghorbani Yekta","doi":"10.1007/s00405-025-09448-z","DOIUrl":"https://doi.org/10.1007/s00405-025-09448-z","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the effectiveness of intratympanic corticosteroid (ITS) therapy compared to standard therapy alone in improving hearing and tympanometric outcomes in adults with unilateral and bilateral OME.</p><p><strong>Methods: </strong>A randomized controlled clinical trial was conducted with 56 adult patients at Taleghani Hospital, Tehran. Participants were assigned to either a control group receiving standard therapy (saline irrigation and intranasal corticosteroids) or an experimental group receiving intratympanic corticosteroid injections in addition to standard therapy. Hearing thresholds and tympanometric results were assessed at one-month, two-month, and three-month follow-ups.</p><p><strong>Results: </strong>At one month, the ITS group demonstrated greater improvement in hearing than the control group (mean air-bone gap 16.4 dB vs 24.7 dB; p = 0.019). By two months, 43.8% of ITS-treated patients achieved a Type A tympanogram compared to 16.7% of controls (p < 0.001). At three months, 74% versus 66.7% of patients had Type A tympanograms (ITS vs control; p = 0.005), indicating a narrowing difference as the control group improved. No significant adverse effects were observed.</p><p><strong>Conclusion: </strong>Intratympanic corticosteroid therapy is an effective treatment for OME in adults, significantly improving hearing and middle ear function compared to standard therapy alone.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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