Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale最新文献

{"title":"Prediction of difficult laryngeal exposure in microlaryngoscopy: a scoping review.","authors":"Claudia Valenziano, Alberto Paderno, Camilla Zimello, Giuseppe Mercante","doi":"10.14639/0392-100X-A1618","DOIUrl":"10.14639/0392-100X-A1618","url":null,"abstract":"<p><strong>Objective: </strong>To conduct a scoping review on difficult laryngeal exposure (DLE) prediction in microlaryngoscopy (MLS). The aim was to identify effective predictive scoring systems or parameters for predicting transoral exposure.</p><p><strong>Methods: </strong>A comprehensive search was conducted in PubMed and Scopus, with the final search performed on December 19^th, 2024. Studies assessing preoperative predictors of DLE in MLS were included if they reported accuracy measures. Studies not in English, with insufficient data, and with sample size < 5 patients were excluded.</p><p><strong>Results: </strong>Sixteen studies were analysed. Common predictors included body mass index, neck circumference, inter-incisor gap, thyromental distance, dental status, and the modified Mallampati index. Scoring systems like the Laryngoscore and the mini-Laryngoscore showed promise but varied in external validation.</p><p><strong>Conclusions: </strong>DLE prediction for MLS remains underdeveloped. Validated predictive tools could improve patient selection, reduce operative times, and optimise oncological outcomes by ensuring effective exposure. Further research is needed to establish robust predictive models.</p>","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":"46 4","pages":"256-264"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148908667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating nasoseptal flap length for sellar reconstruction: a surgical and radiological study.","authors":"Fabio Portella Gazmenga, Marcelo Hamilton Sampaio, Thiago Luis Infanger Serrano, Emerson Taro Inoue Sakuma, Mateus Dal Fabbro, Eulalia Sakano","doi":"10.14639/0392-100X-A1655","DOIUrl":"10.14639/0392-100X-A1655","url":null,"abstract":"<p><strong>Objective: </strong>To assess whether computed tomography (CT) can predict the nasoseptal flap length necessary for reconstruction after endoscopic approaches to the sellar region.</p><p><strong>Methods: </strong>Twenty consecutive patients who underwent endoscopic resection of pituitary adenoma were included, and data were obtained prospectively in 2 stages, one radiological and one surgical. The length of the flap as estimated by CT (CT-Est) was compared with the flap length considered optimal (Ideal Flap), after intraoperative measurements. Correlation between the 2 values was assessed with the Spearman correlation test.</p><p><strong>Results: </strong>The mean length estimated on CT scans was 63.8 ± 2.3 mm, and the mean Ideal Flap was 59.1 ± 2.3 mm. The mean difference (Δ CT-Est - Ideal Flap) between these 2 values was 4.7 ± 0.7 mm. The Spearman coefficient of correlation between Ideal Flap and CT-Est was 0.938 (95% CI = 0.843 to 0.976), with p = 0.001, denoting a very strong and statistically significant correlation.</p><p><strong>Conclusions: </strong>CT-based estimates closely approximated the nasoseptal flap length required for reconstruction of a sellar approach defect. CT has the potential to be a useful tool for preoperative planning of tailored flaps.</p>","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":"46 4","pages":"328-334"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148908581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative outcomes of nasalisation vs functional endoscopic sinus surgery in chronic rhinosinusitis with nasal polyposis: a 10-year retrospective study.","authors":"Dubravko Manestar, Ema Ahel Ledić, Svjetlana Janković, Marko Velepiĉ, Olivia Perković, Tamara Braut","doi":"10.14639/0392-100X-A1764","DOIUrl":"10.14639/0392-100X-A1764","url":null,"abstract":"<p><strong>Objective: </strong>To compare outcomes of functional endoscopic sinus surgery (FESS) and nasalisation (radical ethmoidectomy) in chronic rhinosinusitis with nasal polyposis (CRSwNP), and to identify subgroups benefiting most from nasalisation.</p><p><strong>Methods: </strong>We retrospectively analysed 480 surgeries (374 FESS, 106 nasalisation) from 2012 to 2022. Nasalisation patients had more severe baseline disease than FESS patients (mean Nasal Obstruction Symptom Evaluation [NOSE] score: 76.88 ± 6.18 <i>vs</i> 73.55 ± 7.25; mean Visual Analogue Scale [VAS] olfaction score: 6.53 ± 1.1 <i>vs</i> 8.8 ± 1.15; mean Lildholdt score: 2.09 ± 0.76 <i>vs</i> 1.57 ± 0.83; all p < 0.001). Subjective (NOSE, VAS) and objective (Lildholdt) scores were recorded preoperatively and at one, 3, 6, 12, and 24 months postoperatively.</p><p><strong>Results: </strong>Despite worse baseline status, nasalisation showed greater improvements in subjective and objective measures, and was particularly effective in diffuse extensive polyposis. Paired t-tests confirmed significant postoperative enhancements (all p < 0.001; Cohen's d > 0.8). At 24 months, nasalisation showed superior outcomes: NOSE (24.5 ± 5.5 <i>vs</i> 41 ± 6), VAS olfaction (1.95 ± 1.05 <i>vs</i> 3.95 ± 1.15) (both p < 0.001); Lildholdt scores were similar (0.5 ± 0.6 <i>vs</i> 0.53 ± 0.65; p = 0.68).</p><p><strong>Conclusions: </strong>The preliminary results of this retrospective study showed that nasalisation in more severe cases of CRSwNP yielded better long-term clinical outcomes. These results motivate for further investigation through a prospective study that will include comprehensive olfactory testing, quality of life measures, and a more complete methodology with refined variables to address the limitations of the current data set.</p>","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":"46 4","pages":"288-297"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148908590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of hearing loss above 2 kHz on temporal resolution and speech understanding in noise.","authors":"Büşra Gökçe, Rabia Aygün, Zahra Polat","doi":"10.14639/0392-100X-A1310","DOIUrl":"10.14639/0392-100X-A1310","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate temporal resolution, speech understanding in noise, and daily communication difficulties in individuals with sensorineural hearing loss above 2 kHz.</p><p><strong>Method: </strong>Thirty adults aged 38-59 years with high-frequency sensorineural hearing loss (HF-SNHL) were included as the study group, and 30 individuals aged 37-59 years with normal hearing as the control group. Participants completed the Gap Detection, Random Gap Detection, Turkish Matrix Test (TMT), and the Speech, Spatial Perception, and Hearing Quality (SSQ) scale. Statistical comparisons and decision-tree analyses were conducted.</p><p><strong>Results: </strong>Significant differences between groups were observed in temporal resolution tests, speech recognition thresholds (SRT), and speech intelligibility percentages in -5 dB signal to noise ratio condition of the TMT, as well as in SSQ results. Decision-tree analysis indicated that the Speech Perception subscale of the SSQ and the TMT SRT in noise procedure were considered useful for identifying HF-SNHL.</p><p><strong>Conclusions: </strong>Temporal resolution was found to be reduced, and speech comprehension in noise impaired in individuals with HF-SNHL. The SSQ played a decisive role in identifying individuals with HF-SNHL.</p>","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":"46 4","pages":"317-327"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148908631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medico-legal implications of functional septorhinoplasty according to Sulsenti: distinction from aesthetic surgery.","authors":"Filippo Ricciardiello, Domenico Di Maria, Ignazio Tasca, Giuseppe Tortoriello, Luigi D'Avino, Roberto Imperatore, Giovanni Caparco","doi":"10.14639/0392-100X-A1857","DOIUrl":"10.14639/0392-100X-A1857","url":null,"abstract":"","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":"46 4","pages":"335-336"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148908657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical utility and advances of liquid biopsy in hypopharyngeal carcinoma: a systematic review and meta-analysis.","authors":"Jing Liang, Yilang Wang, Liangyu Zou, Jianing Zhang, Lianhe Li","doi":"10.14639/0392-100X-A1729","DOIUrl":"https://doi.org/10.14639/0392-100X-A1729","url":null,"abstract":"<p><strong>Background: </strong>Hypopharyngeal carcinoma (HPC) is an aggressive malignancy with poor prognosis due to difficult early diagnosis, frequent recurrence, and distant metastasis. Although surgery, radiotherapy, chemotherapy, and immunotherapy have progressed, accurate prognostic assessment and real-time monitoring remain limited. Liquid biopsy, a minimally invasive method detecting circulating tumour DNA (ctDNA), circulating tumour cells (CTCs), and microRNAs (miRNAs), shows promise in solid tumours, but its role in HPC is underexplored.</p><p><strong>Methods: </strong>A systematic search of PubMed, Embase, and Web of Science was conducted to September 2025 following PRISMA guidelines. Eligible studies evaluated ctDNA, CTCs, or miRNAs for diagnosis, treatment monitoring, or prognosis of HPC, reporting sensitivity, specificity, diagnostic odds ratio, or hazard ratio for meta-analysis.</p><p><strong>Results: </strong>Twenty-four studies with 933 patients were included. Pooled estimates showed sensitivity 88.3% (95% CI: 84.7-91.6) and specificity 95.9% (95% CI: 93.3-97.9), with predictive intervals sensitivity 0.74-0.98 and specificity 0.85-1.00. Heterogeneity was moderate (I² sensitivity = 52.3%; specificity = 48.5%), and no publication bias was observed. Subgroup analyses indicated ctDNA was advantageous for treatment monitoring, CTCs were consistent in prognosis, and miRNAs were strong candidates due to stability and detection sensitivity. Sensitivity analyses confirmed robustness.</p><p><strong>Conclusions: </strong>Liquid biopsy shows strong potential for diagnosis, monitoring, and prognosis in HPC. Large-scale, multicentre studies are required to validate its clinical application and integration into patient-management pathways.</p>","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148355510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of aryepiglottic fold release as an adjuvant step in surgery for Type I laryngomalacia.","authors":"Mohamed E El-Deeb, Saad Elzayat, Ahmed El-Sobki, Abeer Salamah, Ali Gamal, Cesare Piazza","doi":"10.14639/0392-100X-A1378","DOIUrl":"10.14639/0392-100X-A1378","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the efficacy of unilateral aryepiglottic fold release as an adjunctive surgical step in the management of Type I laryngomalacia.</p><p><strong>Methods: </strong>This study was prospectively conducted on a sample of paediatric patients with laryngomalacia. Our patients were randomly divided into Group A (study group, n = 25), undergoing adjuvant aryepiglottic fold release (AEFR), and Group B (control group, n = 25), who did not undergo adjuvant AEFR. Demographic data, clinical features, and outcome measures were compared between groups.</p><p><strong>Results: </strong>A highly significant difference was observed in the time to resolution of postoperative stridor, with the study group demonstrating markedly earlier symptom resolution compared to the control group. Furthermore, the percentage change in oxygen saturation in both states was also significantly greater in the study group, reflecting a highly significant intergroup difference. Additionally, the incidence of perioperative respiratory adverse events (PRAEs) was significantly lower in the study group than in the control group.</p><p><strong>Conclusions: </strong>Unilateral AEFR, as an adjunctive procedure, marks a significant advancement in management of Type I laryngomalacia. It offers targeted improvement in oxygen saturation levels during both wakefulness and sleep. Furthermore, the technique has been shown to decrease the incidence of PRAEs, delivering significant clinical and operational benefits.</p>","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":"46 3","pages":"203-212"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148298559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of depression in patients with oropharyngeal cancer: a systematic review.","authors":"Ida Salskov, Camilla Juul Kibsgaard, Amanda-Louise Fenger Carlander, Anne Sofie Kvist, Kathrine Kronberg Jakobsen, Christian Grønhøj, Christian von Buchwald","doi":"10.14639/0392-100X-A1264","DOIUrl":"10.14639/0392-100X-A1264","url":null,"abstract":"<p><strong>Objective: </strong>The incidence of oropharyngeal cancer (OPC) has increased in the Western world. OPC affects quality of life, although the risk of depression in patients with OPC remains unknown. We investigated the risk of developing depression in patients with OPC.</p><p><strong>Methods: </strong>Studies were identified through a systematic search in PubMed and EMBASE following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.</p><p><strong>Results: </strong>Four studies comprising 3,736 OPC patients (range, 130-2,497 patients) from the United States (US/SEER and US/Texas), Australia, and the United Kingdom (UK) were included. The studies differed in methodology. The UK study showed that 47% of OPC patients had depressive symptoms compared to 14% of OPC patients with mild, moderate, or severe depression in the Australian study at 12 months after diagnosis. The US/SEER study found a cumulative probability of 19% for developing depression within 5 years after diagnosis, while the US/Texas study found that 15% of the OPC patients had symptoms of major depression after OPC diagnosis but before radiotherapy.</p><p><strong>Conclusions: </strong>Overall, this study indicates that OPC patients are at risk of developing depression, although studies are heterogenous. Screening for depression among OPC patients should be considered in future treatment regimens.</p>","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":"46 3","pages":"161-171"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148298604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Italian validation of the ENS6Q: a disease-specific questionnaire for empty nose syndrome.","authors":"Matteo Alicandri-Ciufelli, Luigi Raguso, Sofia Passaseo, Graziella Pellegrini, Davide Adamo, Giulia Galaverni, Gian Maria Galeazzi, Daniele Marchioni, Daniela Lucidi, Luca Pingani","doi":"10.14639/0392-100X-A2029","DOIUrl":"10.14639/0392-100X-A2029","url":null,"abstract":"","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":"46 3","pages":"246-248"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148298608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modular approach to the parapharyngeal space based on transoral robotic surgery.","authors":"Giacomo Pietrobon, Stefano Filippo Zorzi, Francesco Bandi, Francesco Chu, Chiara Mossinelli, Francesca Ruju, Gioacchino Giugliano, Mohssen Ansarin","doi":"10.14639/0392-100X-A1101","DOIUrl":"10.14639/0392-100X-A1101","url":null,"abstract":"<p><strong>Objective: </strong>Lesions of the parapharyngeal space can be resected through a variety of approaches, depending on their location and biology, as well as on the surgeon's experience. Historically, the transcervical approach has been the most employed, while the transoral has been neglected because of its intrinsic limitations. The advent of robotic surgery has expanded the indications of transoral resection thanks to its reduced morbidity and the possibility of combination with other accesses.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of patients submitted to transoral robotic surgery (TORS) for parapharyngeal lesions at the European Institute of Oncology. We further focused on patients treated with a combined transoral-transcervical approach.</p><p><strong>Results: </strong>Between 2013 and 2024, 43 patients underwent TORS for a parapharyngeal lesion, with curative intent in the majority of cases (93%). In 9 cases (19%), a transcervical/trans-parotid approach was combined with TORS. A transmandibular approach was never necessary. The postoperative course was uneventful for all patients. The majority of lesions were benign (79%).</p><p><strong>Conclusions: </strong>TORS has proven to be a viable option for lesions of the parapharyngeal space. A combined modular approach is feasible to lessen surgical morbidity.</p>","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":"46 3","pages":"186-193"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148298590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}