Flurin Müller-Diesing, Matti Sievert, Bharat Akhanda Panuganti, Marc Aubreville, Nils Porsche, Stephan Hackenberg, Manuel Stöth, Laura Ackermann, Agmal Scherzad, Till Jasper Meyer, Miguel Goncalves
{"title":"Probe-based confocal laser endomicroscopy for optical biopsy of basal cell carcinoma of the auricle.","authors":"Flurin Müller-Diesing, Matti Sievert, Bharat Akhanda Panuganti, Marc Aubreville, Nils Porsche, Stephan Hackenberg, Manuel Stöth, Laura Ackermann, Agmal Scherzad, Till Jasper Meyer, Miguel Goncalves","doi":"10.14639/0392-100X-A1388","DOIUrl":"10.14639/0392-100X-A1388","url":null,"abstract":"<p><strong>Objective: </strong>The resection of skin tumours of the auricle is confronted with the challenge of keeping the resection defect as small as possible and at the same time achieving a complete resection. Probe-based confocal laser endomicroscopy (CLE) is an optical procedure that enables real-time, non-invasive assessment of the epithelium with up to 1000x magnification in vivo. The aim is to evaluate the feasibility of CLE in basal cell carcinoma (BCC) of the auricle.</p><p><strong>Methods: </strong>Sixty-four video sequences (4,872 images) of CLE images of 8 different patients with BCC on the auricle were analysed. Each video sequence was assigned a histologic diagnosis. The sequences were presented to 4 physicians with experience in CLE in a blinded fashion. Dignity was assessed dichotomously using criteria such as cell size, tissue homogeneity and fibrosis.</p><p><strong>Results: </strong>BCC is characterised by inhomogeneous tissue with enlarged, poorly demarcated cells, partly interrupted by cell-free fibrosis. The assessment of dignity based on the CLE sequences achieved an average sensitivity of 86.7% and a specificity of 94.5%. The interrater reliability (Fleiss Kappa) showed substantial agreement (κ = 0.76).</p><p><strong>Conclusions: </strong>The results demonstrate the initial feasibility of intraoperative CLE for optical biopsy of facial skin tumours. The technique has the potential to serve as a non-invasive diagnostic tool in intraoperative decision making. Further studies are needed to evaluate its use as an adjunct to optimise or reduce the use of invasive frozen section pathology in the treatment of BCC.</p>","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":"46 4","pages":"265-271"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148908615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Octavio Garaycochea, Isam Alobid, Carla Rodríguez-Zanetti, Laura Pujol-Vilà, Marta Calvo-Imirazaldu, Secundino Fernández
{"title":"Radiologic and cadaveric spatial relation between nasopalatine canal and the middle turbinate axilla.","authors":"Octavio Garaycochea, Isam Alobid, Carla Rodríguez-Zanetti, Laura Pujol-Vilà, Marta Calvo-Imirazaldu, Secundino Fernández","doi":"10.14639/0392-100X-A1231","DOIUrl":"10.14639/0392-100X-A1231","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to describe the spatial relation (SR) between the nasopalatine canal (NPC) and the septal projection of the middle turbinate axilla (MTA-SP), 2 anatomical landmarks used in rhinology.</p><p><strong>Methods: </strong>A retrospective study was conducted in patients who underwent a cone bean computed tomography. Two radiological measurements were assessed by 2 examiners: the distance between the perpendicular line corresponding to the MTA-SP to the posterior border of the NPC and the distance between the anterior and posterior border of the NPC. Also, an anatomical dissection was performed on a cadaveric head and NPC was cannulated to visually assess the SR through a radiological reconstruction.</p><p><strong>Results: </strong>Among 30 patients, 14 females and 16 males with a mean age of 46.6 (SD 18.8) years, the mean distance between the perpendicular line corresponding to the MTA-SP to the posterior border of the NPC was -0.08 mm (SD 2.4 mm) and the mean distance between the anterior and posterior border of the NSP was 2.7 mm (SD 1.4 mm).</p><p><strong>Conclusions: </strong>The septal projection of the middle turbinate axilla is above and slightly in front to the NPC, at a mean distance of 0.08 mm. Understanding this relationship provides essential information about structure and spatial orientation of the nasal cavity.</p>","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":"46 4","pages":"281-287"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148908641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cesare Piazza, Aurora Pinacoli, Vincent Gregoire, Laura Deborah Locati, Davide Farina, Marco Ravanelli, Erika Crosetti, Giovanni Succo, Snehal G Patel
{"title":"Glottic tumours involving the anterior vs posterior paraglottic space have different prognosis. Opportunity for refinement of the TNM 8<sup>th</sup> Edition.","authors":"Cesare Piazza, Aurora Pinacoli, Vincent Gregoire, Laura Deborah Locati, Davide Farina, Marco Ravanelli, Erika Crosetti, Giovanni Succo, Snehal G Patel","doi":"10.14639/0392-100X-suppl.1-46-2026-A1748","DOIUrl":"10.14639/0392-100X-suppl.1-46-2026-A1748","url":null,"abstract":"","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":"46 Suppl. 1","pages":"S28-S37"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Isabel Vilaseca, Vincent Gregoire, Aurora Pinacoli, Filippo Marchi, Marco Ravanelli, Vincent Vander Poorten, Paolo Rondi, Giuseppe Sanguineti, Malgorzata Wierzbicka, Paolo Bossi, Elisa Bellini, Davide Farina, Cecilia Molendi, Andy Bertolin, Snehal G Patel, Cesare Piazza
{"title":"Impaired vocal cord mobility due to thyroarytenoid muscle involvement predicts poorer prognosis in T2 glottic cancer. Opportunity for refinement of the TNM 8<sup>th</sup> Edition.","authors":"Isabel Vilaseca, Vincent Gregoire, Aurora Pinacoli, Filippo Marchi, Marco Ravanelli, Vincent Vander Poorten, Paolo Rondi, Giuseppe Sanguineti, Malgorzata Wierzbicka, Paolo Bossi, Elisa Bellini, Davide Farina, Cecilia Molendi, Andy Bertolin, Snehal G Patel, Cesare Piazza","doi":"10.14639/0392-100X-suppl.1-46-2026-A2522","DOIUrl":"10.14639/0392-100X-suppl.1-46-2026-A2522","url":null,"abstract":"","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":"46 Suppl. 1","pages":"S16-S27"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557150/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Filippo Marchi, Cesare Piazza, Snehal G Patel, Elisa Bellini, Aurora Pinacoli, Cecilia Molendi, Marco Ravanelli, Davide Farina, Elizabeth Sjogren, Giuseppe Sanguineti, Giorgio Peretti
{"title":"Glottic tumours involving the anterior commissure in a horizontal vs vertical mode have different prognosis. Opportunity for refinement of the TNM 8<sup>th</sup> Edition.","authors":"Filippo Marchi, Cesare Piazza, Snehal G Patel, Elisa Bellini, Aurora Pinacoli, Cecilia Molendi, Marco Ravanelli, Davide Farina, Elizabeth Sjogren, Giuseppe Sanguineti, Giorgio Peretti","doi":"10.14639/0392-100X-suppl.1-46-2026-A1850","DOIUrl":"10.14639/0392-100X-suppl.1-46-2026-A1850","url":null,"abstract":"","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":"46 Suppl. 1","pages":"S3-S15"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Raffaella Marchese, Lucia D'Alatri, Daniela Rodolico, Jacopo Galli
{"title":"Comprehensive description of clinical features of laryngeal dystonia and dystonic vocal tremor.","authors":"Maria Raffaella Marchese, Lucia D'Alatri, Daniela Rodolico, Jacopo Galli","doi":"10.14639/0392-100X-N3150","DOIUrl":"10.14639/0392-100X-N3150","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to characterise laryngeal dystonia (LD) phenotypes using combined classification criteria and to evaluate treatment outcomes with botulinum neurotoxin type A (BoNT-A).</p><p><strong>Methods: </strong>The study retrospectively reviewed patient medical records from our clinic over 5 years to identify cases of LD. We classified LD subtypes (adductor, abductor, mixed) and dystonic vocal tremor (DVT) based on updated criteria.</p><p><strong>Results: </strong>We analysed 75 cases, predominantly adductor LD (60%) and DVT (28%). In all, 84% of patients were females, diagnosed around 68 years of age. The DVT group had late-onset dysphonia that worsened over time and was associated with essential tremor in almost half of cases. Subjects with mixed LD had the greatest increase in Voice Handicap Index (VHI) over time and the longest duration of disease in all cases associated with DVT. Abductor LD cases had the most severe dysphonia (VHI: 73.3). Two-thirds of cases received BoNT-A therapy; most had adductor LD and had received treatment for longer times and had the lowest rate of treatment refusal.</p><p><strong>Conclusions: </strong>Correct LD classification aids in diagnosis, prognosis and treatment; it should be dynamic and evolve with the patient's history. However, there is a lack of data in the literature on certain aspects of LD, emphasising the need for further research to improve clinical practice.</p>","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":"46 4","pages":"272-280"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549217/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148908599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Modern insights into laryngeal cancer spread: possible implications for revision of the TNM Staging System.","authors":"Cesare Piazza, Snehal G Patel","doi":"10.14639/0392-100X-suppl.1-46-2026-A2560","DOIUrl":"10.14639/0392-100X-suppl.1-46-2026-A2560","url":null,"abstract":"","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":"46 Suppl. 1","pages":"S1-S2"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557148/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148901867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between tracheo-oesophageal fistula and anti-angiogenic therapy in locally advanced/metastatic tumours. A narrative review.","authors":"Fatima Ezzahra Nassih, Claudia Montenegro, Davide Mattavelli, Davide Lancini, Vittorio Rampinelli, Cesare Piazza","doi":"10.14639/0392-100X-A1876","DOIUrl":"10.14639/0392-100X-A1876","url":null,"abstract":"","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":" ","pages":"249-255"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148355438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashley Baguant, Vincent Pean, Fabien Seldran, Kamalkishore Baguant, Sebastien Schmerber, Raphaele Quatre
{"title":"Evaluation of neural transmission in implanted patients with Meniere's disease.","authors":"Ashley Baguant, Vincent Pean, Fabien Seldran, Kamalkishore Baguant, Sebastien Schmerber, Raphaele Quatre","doi":"10.14639/0392-100X-A1663","DOIUrl":"10.14639/0392-100X-A1663","url":null,"abstract":"<p><strong>Introduction: </strong>Meniere's disease (MD) is characterised by fluctuating hearing loss. When hearing loss is severe or profound, rehabilitation requires cochlear implantation. The aim of this retrospective study was to compare cochlear implant (CI) fittings and electrode impedances between patients implanted because of MD and those with other aetiologies.</p><p><strong>Materials and methods: </strong>This study involved patients who received cochlear implantation with MED-EL CI at our centre between 2005 and 2022. We first compared speech recognition in a quiet environment at one year after cochlear implantation. We then performed a comparative study of the electrode impedances and most comfortable levels at activation, 2, 3, 6, and 12 months after activation.</p><p><strong>Results: </strong>Out of the 218 patients included in our study, 21 were diagnosed with MD. There was no significant difference in speech intelligibility in a quiet environment between the 2 groups. Electrode impedances were statistically comparable in both groups. However, MCLs for the 2 most apical electrodes were higher in the MD group during the first 2 months after surgery.</p><p><strong>Conclusions: </strong>This study found a need for electrical stimulation at higher intensities in low-frequency electrodes during the early months after cochlear implantation in MD.</p>","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":"46 4","pages":"307-316"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148908570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Claudia Valenziano, Alberto Paderno, Camilla Zimello, Giuseppe Mercante
{"title":"Prediction of difficult laryngeal exposure in microlaryngoscopy: a scoping review.","authors":"Claudia Valenziano, Alberto Paderno, Camilla Zimello, Giuseppe Mercante","doi":"10.14639/0392-100X-A1618","DOIUrl":"10.14639/0392-100X-A1618","url":null,"abstract":"<p><strong>Objective: </strong>To conduct a scoping review on difficult laryngeal exposure (DLE) prediction in microlaryngoscopy (MLS). The aim was to identify effective predictive scoring systems or parameters for predicting transoral exposure.</p><p><strong>Methods: </strong>A comprehensive search was conducted in PubMed and Scopus, with the final search performed on December 19<sup>th</sup>, 2024. Studies assessing preoperative predictors of DLE in MLS were included if they reported accuracy measures. Studies not in English, with insufficient data, and with sample size < 5 patients were excluded.</p><p><strong>Results: </strong>Sixteen studies were analysed. Common predictors included body mass index, neck circumference, inter-incisor gap, thyromental distance, dental status, and the modified Mallampati index. Scoring systems like the Laryngoscore and the mini-Laryngoscore showed promise but varied in external validation.</p><p><strong>Conclusions: </strong>DLE prediction for MLS remains underdeveloped. Validated predictive tools could improve patient selection, reduce operative times, and optimise oncological outcomes by ensuring effective exposure. Further research is needed to establish robust predictive models.</p>","PeriodicalId":520544,"journal":{"name":"Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale","volume":"46 4","pages":"256-264"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148908667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}